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TR201908635T4 - Protein kodlayıcı rna?nın lipozomal verilmesine uygun lipitler. - Google Patents

Protein kodlayıcı rna?nın lipozomal verilmesine uygun lipitler. Download PDF

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Publication number
TR201908635T4
TR201908635T4 TR2019/08635T TR201908635T TR201908635T4 TR 201908635 T4 TR201908635 T4 TR 201908635T4 TR 2019/08635 T TR2019/08635 T TR 2019/08635T TR 201908635 T TR201908635 T TR 201908635T TR 201908635 T4 TR201908635 T4 TR 201908635T4
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TR
Turkey
Prior art keywords
protein encoding
encoding rna
liposomal delivery
lipids suitable
rna
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Application number
TR2019/08635T
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English (en)
Inventor
Geall Andrew
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Glaxosmithkline Biologicals Sa
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Publication of TR201908635T4 publication Critical patent/TR201908635T4/tr

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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
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    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
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    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

RNA, in vivo verme için bir lipozom içerisine kapsüle edilir. RNA, immünizasyon amaçları için bir ilgili polipeptidi, örn., bir immünojeni şifreler. Lipozom, formül (I) ve formül (XI)'e ait bileşiklerin oluşturduğu gruptan seçilen en azından bir bileşik içerir.
TR2019/08635T 2010-08-31 2011-08-31 Protein kodlayıcı rna?nın lipozomal verilmesine uygun lipitler. TR201908635T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37883310P 2010-08-31 2010-08-31

Publications (1)

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TR201908635T4 true TR201908635T4 (tr) 2019-07-22

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TR2019/08635T TR201908635T4 (tr) 2010-08-31 2011-08-31 Protein kodlayıcı rna?nın lipozomal verilmesine uygun lipitler.

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Country Link
US (1) US20130189351A1 (tr)
EP (2) EP2611420B1 (tr)
JP (2) JP5908477B2 (tr)
CN (1) CN103384515B (tr)
AU (3) AU2011295938B2 (tr)
BR (1) BR112013004865A2 (tr)
CA (1) CA2809863A1 (tr)
ES (1) ES2727583T3 (tr)
MX (1) MX2013002332A (tr)
RU (1) RU2577983C2 (tr)
TR (1) TR201908635T4 (tr)
WO (1) WO2012031046A2 (tr)

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