|
US172808A
(en)
*
|
|
1876-01-25 |
|
Improvement in balanced valves |
|
US5563250A
(en)
|
1987-12-02 |
1996-10-08 |
Neorx Corporation |
Cleavable conjugates for the delivery and release of agents in native form
|
|
US6140496A
(en)
|
1990-10-09 |
2000-10-31 |
Benner; Steven Albert |
Precursors for deoxyribonucleotides containing non-standard nucleosides
|
|
US5505931A
(en)
|
1993-03-04 |
1996-04-09 |
The Dow Chemical Company |
Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents
|
|
US5681702A
(en)
|
1994-08-30 |
1997-10-28 |
Chiron Corporation |
Reduction of nonspecific hybridization by using novel base-pairing schemes
|
|
US5585108A
(en)
|
1994-12-30 |
1996-12-17 |
Nanosystems L.L.C. |
Formulations of oral gastrointestinal therapeutic agents in combination with pharmaceutically acceptable clays
|
|
US5795587A
(en)
|
1995-01-23 |
1998-08-18 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
|
US6265389B1
(en)
|
1995-08-31 |
2001-07-24 |
Alkermes Controlled Therapeutics, Inc. |
Microencapsulation and sustained release of oligonucleotides
|
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
|
US20030073640A1
(en)
|
1997-07-23 |
2003-04-17 |
Ribozyme Pharmaceuticals, Inc. |
Novel compositions for the delivery of negatively charged molecules
|
|
US6426086B1
(en)
|
1998-02-03 |
2002-07-30 |
The Regents Of The University Of California |
pH-sensitive, serum-stable liposomes
|
|
WO1999054455A1
(fr)
|
1998-04-23 |
1999-10-28 |
Takara Shuzo Co., Ltd. |
Procede de synthese de l'adn
|
|
JP2002537102A
(ja)
|
1999-02-26 |
2002-11-05 |
カイロン コーポレイション |
吸着された高分子および微粒子を有するミクロエマルジョン
|
|
US7098032B2
(en)
|
2001-01-02 |
2006-08-29 |
Mirus Bio Corporation |
Compositions and methods for drug delivery using pH sensitive molecules
|
|
EP1102785B1
(en)
|
1999-06-07 |
2013-02-13 |
Arrowhead Research Corporation |
COMPOSITIONS FOR DRUG DELIVERY USING pH SENSITIVE MOLECULES
|
|
EP1212422B1
(en)
|
1999-08-24 |
2007-02-21 |
Medarex, Inc. |
Human ctla-4 antibodies and their uses
|
|
US6998115B2
(en)
|
2000-10-10 |
2006-02-14 |
Massachusetts Institute Of Technology |
Biodegradable poly(β-amino esters) and uses thereof
|
|
US6649138B2
(en)
|
2000-10-13 |
2003-11-18 |
Quantum Dot Corporation |
Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
|
|
US7708915B2
(en)
|
2004-05-06 |
2010-05-04 |
Castor Trevor P |
Polymer microspheres/nanospheres and encapsulating therapeutic proteins therein
|
|
US6897196B1
(en)
|
2001-02-07 |
2005-05-24 |
The Regents Of The University Of California |
pH sensitive lipids based on ortho ester linkers, composition and method
|
|
WO2003011443A2
(en)
|
2001-07-27 |
2003-02-13 |
President And Fellows Of Harvard College |
Laminar mixing apparatus and methods
|
|
WO2003028657A2
(en)
|
2001-10-03 |
2003-04-10 |
The Johns Hopkins University |
Compositions for oral gene therapy and methods of using same
|
|
WO2003042383A1
(en)
|
2001-11-14 |
2003-05-22 |
Toyo Boseki Kabushiki Kaisha |
Dna synthesis promoters, dna polymerase-associated factors and utilization thereof
|
|
CA2409775C
(en)
|
2001-12-03 |
2010-07-13 |
F. Hoffmann-La Roche Ag |
Reversibly modified thermostable enzymes for dna synthesis and amplification in vitro
|
|
ES2349235T3
(es)
|
2001-12-21 |
2010-12-29 |
Alcon, Inc. |
Uso de nanopartículas inorgánicas sintéticas como vehículos para farmacos oftálmicos.
|
|
US20050222064A1
(en)
|
2002-02-20 |
2005-10-06 |
Sirna Therapeutics, Inc. |
Polycationic compositions for cellular delivery of polynucleotides
|
|
JP4679822B2
(ja)
|
2002-03-13 |
2011-05-11 |
ノバルティス アーゲー |
医薬微粒子
|
|
AU2003217531A1
(en)
|
2002-05-02 |
2003-11-17 |
Massachusetts Eye And Ear Infirmary |
Ocular drug delivery systems and use thereof
|
|
WO2005007819A2
(en)
|
2003-07-09 |
2005-01-27 |
Wisconsin Alumni Research Foundation |
Charge-dynamic polymers and delivery of anionic compounds
|
|
US8957034B2
(en)
|
2004-01-28 |
2015-02-17 |
Johns Hopkins University |
Drugs and gene carrier particles that rapidly move through mucous barriers
|
|
US20050232981A1
(en)
|
2004-04-15 |
2005-10-20 |
Ben-Sasson Shmuel A |
Compositions capable of facilitating penetration across a biological barrier
|
|
JP2008502739A
(ja)
|
2004-06-11 |
2008-01-31 |
トラスティーズ オブ タフツ カレッジ |
絹に基づく薬物送達システム
|
|
WO2006063249A2
(en)
|
2004-12-10 |
2006-06-15 |
Justin Hanes |
Functionalized poly (ether-anhydride) block copolymers
|
|
US8192718B1
(en)
|
2005-01-04 |
2012-06-05 |
Gp Medical, Inc. |
Pharmaceutical composition of nanoparticles
|
|
US7404969B2
(en)
|
2005-02-14 |
2008-07-29 |
Sirna Therapeutics, Inc. |
Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
|
|
WO2007086883A2
(en)
|
2005-02-14 |
2007-08-02 |
Sirna Therapeutics, Inc. |
Cationic lipids and formulated molecular compositions containing them
|
|
US7638558B2
(en)
|
2005-04-01 |
2009-12-29 |
Intezyne Technologies, Inc. |
Polymeric micelles for drug delivery
|
|
WO2006110776A2
(en)
|
2005-04-12 |
2006-10-19 |
Nektar Therapeutics Al, Corporation |
Polyethylene glycol cojugates of antimicrobial agents
|
|
CN109485727A
(zh)
|
2005-05-09 |
2019-03-19 |
小野药品工业株式会社 |
程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
|
|
US7550264B2
(en)
|
2005-06-10 |
2009-06-23 |
Datascope Investment Corporation |
Methods and kits for sense RNA synthesis
|
|
WO2006138572A2
(en)
|
2005-06-16 |
2006-12-28 |
Nektar Therapeutics Al, Corporation |
Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
|
|
AU2006282042B2
(en)
|
2005-06-17 |
2011-12-22 |
The University Of North Carolina At Chapel Hill |
Nanoparticle fabrication methods, systems, and materials
|
|
AU2006265896B2
(en)
|
2005-06-30 |
2012-05-31 |
Archemix Corp. |
Materials and methods for the generation of fully 2'-modified nucleic acid transcripts
|
|
US8101385B2
(en)
|
2005-06-30 |
2012-01-24 |
Archemix Corp. |
Materials and methods for the generation of transcripts comprising modified nucleotides
|
|
KR101411165B1
(ko)
|
2005-07-01 |
2014-06-25 |
메다렉스, 엘.엘.시. |
예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체
|
|
DE102005046490A1
(de)
|
2005-09-28 |
2007-03-29 |
Johannes-Gutenberg-Universität Mainz |
Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
|
|
EP1986695B1
(en)
|
2006-02-21 |
2015-06-03 |
Nektar Therapeutics |
Segmented degradable polymers and conjugates made therefrom
|
|
CN101415405A
(zh)
|
2006-04-04 |
2009-04-22 |
Stc.Unm公司 |
用于药物递送的可溶胀颗粒
|
|
EP2007423A2
(en)
|
2006-04-05 |
2008-12-31 |
Pfizer Products Incorporated |
Ctla4 antibody combination therapy
|
|
JP5630998B2
(ja)
|
2006-05-15 |
2014-11-26 |
マサチューセッツ インスティテュート オブ テクノロジー |
機能的粒子のためのポリマー
|
|
ES2360538T3
(es)
|
2006-09-08 |
2011-06-06 |
Johns Hopkins University |
Composiciones para aumentar el transporte a través de moco.
|
|
AU2007333528B2
(en)
|
2006-10-05 |
2013-10-17 |
The Johns Hopkins University |
Water-dispersible oral, parenteral, and topical formulations for poorly water soluble drugs using smart polymeric nanoparticles
|
|
EP2500015A1
(en)
|
2006-12-05 |
2012-09-19 |
Landec Corporation |
Delivery of drugs
|
|
US8399007B2
(en)
|
2006-12-05 |
2013-03-19 |
Landec Corporation |
Method for formulating a controlled-release pharmaceutical formulation
|
|
ES2447516T3
(es)
|
2006-12-21 |
2014-03-12 |
Stryker Corporation |
Formulaciones de liberación sostenida que comprenden cristales BMP-7
|
|
EP2207891B1
(en)
|
2006-12-22 |
2012-07-25 |
Archemix LLC |
Materials and methods for the generation of transcripts comprising modified nucleotides
|
|
US20100015218A1
(en)
|
2007-02-16 |
2010-01-21 |
Vasant Jadhav |
Compositions and methods for potentiated activity of biologically active molecules
|
|
EP2120876B1
(en)
|
2007-03-05 |
2015-03-04 |
Washington University |
Nanoparticle delivery systems for membrane-integrating peptides
|
|
JP5475643B2
(ja)
|
2007-05-04 |
2014-04-16 |
マリーナ バイオテック,インコーポレイテッド |
アミノ酸脂質およびその使用
|
|
NZ600758A
(en)
|
2007-06-18 |
2013-09-27 |
Merck Sharp & Dohme |
Antibodies to human programmed death receptor pd-1
|
|
US20130108663A1
(en)
*
|
2007-09-14 |
2013-05-02 |
Vrije Universiteit Brussel |
Enhancing the t-cell stimulatory capacity of human antigen presenting cells in vitro and in vivo and their use in vaccination
|
|
CN101855233B
(zh)
|
2007-09-26 |
2014-05-07 |
英特瑞克斯顿股份有限公司 |
合成5’utr、表达载体以及增强转基因表达的方法
|
|
ES2376175T3
(es)
|
2007-09-28 |
2012-03-09 |
Bind Biosciences, Inc. |
Direccionamiento a células de c�?ncer usando nanopart�?culas.
|
|
EP2527439B1
(en)
|
2007-12-11 |
2014-03-26 |
The Scripps Research Institute |
Compositions and methods related to mRNA translational enhancer elements
|
|
US8058069B2
(en)
|
2008-04-15 |
2011-11-15 |
Protiva Biotherapeutics, Inc. |
Lipid formulations for nucleic acid delivery
|
|
MX2010011680A
(es)
|
2008-04-25 |
2011-05-03 |
Univ Northwestern |
Nanoestructuras adecuadas para secuestrar colesterol y otras moleculas.
|
|
PL215513B1
(pl)
|
2008-06-06 |
2013-12-31 |
Univ Warszawski |
Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka
|
|
EP2309991B1
(en)
|
2008-06-16 |
2019-03-06 |
Pfizer Inc |
Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same
|
|
JP2012501965A
(ja)
|
2008-06-16 |
2012-01-26 |
バインド バイオサイエンシズ インコーポレイテッド |
薬剤を装填したポリマーナノ粒子及びその製造方法と使用方法
|
|
WO2010005726A2
(en)
|
2008-06-16 |
2010-01-14 |
Bind Biosciences Inc. |
Therapeutic polymeric nanoparticles with mtor inhibitors and methods of making and using same
|
|
WO2010005740A2
(en)
|
2008-06-16 |
2010-01-14 |
Bind Biosciences, Inc. |
Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles
|
|
US20110224447A1
(en)
|
2008-08-18 |
2011-09-15 |
Bowman Keith A |
Novel Lipid Nanoparticles and Novel Components for Delivery of Nucleic Acids
|
|
EP2927240A1
(en)
|
2008-08-25 |
2015-10-07 |
Amplimmune, Inc. |
Compositions of pd-1 antagonists and methods of use
|
|
US20100087337A1
(en)
|
2008-09-10 |
2010-04-08 |
Bind Biosciences, Inc. |
High Throughput Fabrication of Nanoparticles
|
|
US20100075072A1
(en)
|
2008-09-25 |
2010-03-25 |
Tsung-Wei Chen |
Decorative structure of tree-shaped bells
|
|
MX353900B
(es)
|
2008-11-07 |
2018-02-01 |
Massachusetts Inst Technology |
Lipidoides de aminoalcohol y usos de los mismos.
|
|
WO2010077634A1
(en)
|
2008-12-09 |
2010-07-08 |
Genentech, Inc. |
Anti-pd-l1 antibodies and their use to enhance t-cell function
|
|
EP2379064B1
(en)
|
2008-12-15 |
2020-02-26 |
Pfizer Inc. |
Long circulating nanoparticles for sustained release of therapeutic agents
|
|
WO2010080724A1
(en)
|
2009-01-12 |
2010-07-15 |
Merck Sharp & Dohme Corp. |
Novel lipid nanoparticles and novel components for delivery of nucleic acids
|
|
WO2010087791A1
(en)
|
2009-01-27 |
2010-08-05 |
Utc Power Corporation |
Distributively cooled, integrated water-gas shift reactor and vaporizer
|
|
US8714214B2
(en)
|
2009-03-12 |
2014-05-06 |
Illinois Tool Works |
Mis-fuel inhibitor
|
|
JP5622254B2
(ja)
|
2009-03-31 |
2014-11-12 |
国立大学法人東京大学 |
二本鎖リボ核酸ポリイオンコンプレックス
|
|
CA2759332A1
(en)
|
2009-04-21 |
2010-10-28 |
Selecta Biosciences, Inc. |
Immunonanotherapeutics providing a th1-biased response
|
|
WO2010127159A2
(en)
|
2009-04-30 |
2010-11-04 |
Intezyne Technologies, Incorporated |
Polymeric micelles for polynucleotide encapsulation
|
|
DE202009007116U1
(de)
|
2009-05-18 |
2010-10-14 |
Amoena Medizin-Orthopädie-Technik GmbH |
Antidekubituskissen
|
|
WO2010138193A2
(en)
|
2009-05-27 |
2010-12-02 |
Selecta Biosciences, Inc. |
Targeted synthetic nanocarriers with ph sensitive release of immunomodulatory agents
|
|
KR20230098713A
(ko)
|
2009-06-10 |
2023-07-04 |
알닐람 파마슈티칼스 인코포레이티드 |
향상된 지질 조성물
|
|
US8569256B2
(en)
|
2009-07-01 |
2013-10-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
EP2449114B9
(en)
|
2009-07-01 |
2017-04-19 |
Protiva Biotherapeutics Inc. |
Novel lipid formulations for delivery of therapeutic agents to solid tumors
|
|
US9181295B2
(en)
|
2009-08-20 |
2015-11-10 |
Sirna Therapeutics, Inc. |
Cationic lipids with various head groups for oligonucleotide delivery
|
|
WO2011043913A2
(en)
|
2009-10-08 |
2011-04-14 |
Merck Sharp & Dohme Corp. |
Novel cationic lipids with short lipid chains for oligonucleotide delivery
|
|
JP5823405B2
(ja)
|
2009-11-04 |
2015-11-25 |
ザ ユニバーシティ オブ ブリティッシュ コロンビア |
核酸含有脂質粒子および関連方法
|
|
US8449916B1
(en)
|
2009-11-06 |
2013-05-28 |
Iowa State University Research Foundation, Inc. |
Antimicrobial compositions and methods
|
|
GB0920304D0
(en)
|
2009-11-20 |
2010-01-06 |
Medical Res Council |
Novel liposome nanoparticles for tumour magnetic resonance imaging
|
|
US20130017199A1
(en)
|
2009-11-24 |
2013-01-17 |
AMPLIMMUNE ,Inc. a corporation |
Simultaneous inhibition of pd-l1/pd-l2
|
|
EP3403647A1
(en)
|
2009-12-01 |
2018-11-21 |
Translate Bio, Inc. |
Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases
|
|
WO2011069529A1
(en)
|
2009-12-09 |
2011-06-16 |
Curevac Gmbh |
Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids
|
|
WO2011072218A2
(en)
|
2009-12-11 |
2011-06-16 |
Bind Biosciences |
Stable formulations for lyophilizing therapeutic particles
|
|
ES2780156T3
(es)
|
2009-12-15 |
2020-08-24 |
Pfizer |
Composiciones terapéuticas de nanopartículas poliméricas con alta temperatura de transición vítrea o copolímeros de alto peso molecular
|
|
EA201290497A1
(ru)
|
2009-12-15 |
2013-01-30 |
Байнд Байосайенсиз, Инк. |
Терапевтические полимерные наночастицы, включающие кортикостероиды, и способы получения таковых
|
|
WO2011084521A2
(en)
|
2009-12-15 |
2011-07-14 |
Bind Biosciences, Inc. |
Therapeutic polymeric nanoparticles comprising epothilone and methods of making and using same
|
|
DE102009058769A1
(de)
|
2009-12-16 |
2011-06-22 |
MagForce Nanotechnologies AG, 10589 |
Temperaturabhängige Aktivierung von katalytischen Nukleinsäuren zur kontrollierten Wirkstofffreisetzung
|
|
EP3721943A1
(en)
|
2009-12-23 |
2020-10-14 |
Novartis AG |
Lipids, lipid compositions and methods of using them
|
|
EP2525781A1
(en)
|
2010-01-22 |
2012-11-28 |
Schering Corporation |
Novel cationic lipids for oligonucleotide delivery
|
|
US20130101609A1
(en)
|
2010-01-24 |
2013-04-25 |
Novartis Ag |
Irradiated biodegradable polymer microparticles
|
|
US9149432B2
(en)
|
2010-03-19 |
2015-10-06 |
Massachusetts Institute Of Technology |
Lipid vesicle compositions and methods of use
|
|
WO2011119262A1
(en)
|
2010-03-26 |
2011-09-29 |
Cerulean Pharma Inc. |
Methods and systems for generating nanoparticles
|
|
EP3391877A1
(en)
|
2010-04-08 |
2018-10-24 |
The Trustees of Princeton University |
Preparation of lipid nanoparticles
|
|
EP3175844A1
(en)
|
2010-04-09 |
2017-06-07 |
Pacira Pharmaceuticals, Inc. |
Large diameter synthetic membrane vesicles
|
|
US20110262491A1
(en)
|
2010-04-12 |
2011-10-27 |
Selecta Biosciences, Inc. |
Emulsions and methods of making nanocarriers
|
|
WO2011139911A2
(en)
|
2010-04-29 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
|
WO2011143230A1
(en)
|
2010-05-10 |
2011-11-17 |
Alnylam Pharmaceuticals |
Methods and compositions for delivery of active agents
|
|
US20130123338A1
(en)
|
2010-05-12 |
2013-05-16 |
Protiva Biotherapeutics, Inc. |
Novel cationic lipids and methods of use thereof
|
|
EP2575895A2
(en)
|
2010-05-24 |
2013-04-10 |
Merck Sharp & Dohme Corp. |
Novel amino alcohol cationic lipids for oligonucleotide delivery
|
|
US9376679B2
(en)
|
2010-05-26 |
2016-06-28 |
Micromedmark Biotech Co. Ltd. |
Microvesicles carrying small interfering RNAs, preparation methods and uses thereof
|
|
EP2575767B1
(en)
|
2010-06-04 |
2017-01-04 |
Sirna Therapeutics, Inc. |
Novel low molecular weight cationic lipids for oligonucleotide delivery
|
|
BRPI1001959A2
(pt)
|
2010-06-15 |
2012-03-06 |
Instituto De Pesquisas Tecnológicas Do Est. S. Paulo S/a - Ipt |
Nanocarreadores coloidais para ativos hidrofílicos e processo de produção
|
|
WO2011163483A2
(en)
|
2010-06-25 |
2011-12-29 |
Massachusetts Institute Of Technology |
Polymers for biomaterials and therapeutics
|
|
BR112013000244A2
(pt)
|
2010-07-06 |
2016-05-17 |
Novartis Ag |
lipossomas com lipídeos apresentando pka vantajoso para administração de rna
|
|
ES2649896T3
(es)
|
2010-07-06 |
2018-01-16 |
Glaxosmithkline Biologicals Sa |
Emulsiones catiónicas de aceite en agua
|
|
PL2590676T3
(pl)
|
2010-07-06 |
2017-02-28 |
Glaxosmithkline Biologicals Sa |
Wirionopodobne cząstki dostarczające dla autoreplikujących się cząsteczek rna
|
|
DE102010032758B4
(de)
|
2010-07-29 |
2012-02-23 |
Fujitsu Technology Solutions Intellectual Property Gmbh |
Computersystem, Verfahren zum Programmieren einer Echtzeituhr und Computerprogrammprodukt
|
|
CA2801523C
(en)
|
2010-07-30 |
2021-08-03 |
Curevac Gmbh |
Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation
|
|
CA2807552A1
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
WO2012021516A2
(en)
|
2010-08-09 |
2012-02-16 |
The Trustees Of The University Of Pennsylvania |
Nanoparticle-oligonucletide hybrid structures and methods of use thereof
|
|
US8956646B2
(en)
|
2010-08-14 |
2015-02-17 |
The Regents Of The University Of California |
Zwitterionic lipids
|
|
EA201390145A1
(ru)
|
2010-08-20 |
2013-11-29 |
Серулин Фарма Инк. |
Конъюгаты, частицы, композиции и связанные с ними способы
|
|
MX341989B
(es)
|
2010-08-31 |
2016-09-09 |
Novartis Ag * |
Liposomas pequeños para el suministro de arn que codifica el inmunogeno.
|
|
JP5908477B2
(ja)
|
2010-08-31 |
2016-04-26 |
ノバルティス アーゲー |
タンパク質をコードするrnaのリポソームによる送達に適した脂質
|
|
RS63315B1
(sr)
|
2010-08-31 |
2022-07-29 |
Glaxosmithkline Biologicals Sa |
Pegilovani lipozomi za isporuku rnk koja kodira imunogen
|
|
WO2012039979A2
(en)
|
2010-09-10 |
2012-03-29 |
The Johns Hopkins University |
Rapid diffusion of large polymeric nanoparticles in the mammalian brain
|
|
US8466122B2
(en)
|
2010-09-17 |
2013-06-18 |
Protiva Biotherapeutics, Inc. |
Trialkyl cationic lipids and methods of use thereof
|
|
MX349088B
(es)
|
2010-09-20 |
2017-07-10 |
Merck Sharp & Dohme |
Lípidos catiónicos novedosos de bajo peso molecular para la entrega de oligonucleótidos.
|
|
EP2619307A1
(en)
|
2010-09-21 |
2013-07-31 |
RiboxX GmbH |
Method for synthesizing rna using dna template
|
|
JP2013545723A
(ja)
|
2010-09-30 |
2013-12-26 |
メルク・シャープ・エンド・ドーム・コーポレイション |
オリゴヌクレオチドの送達のための低分子量カチオン性脂質
|
|
WO2012051220A1
(en)
|
2010-10-11 |
2012-04-19 |
Wichita State University |
Composite magnetic nanoparticle drug delivery system
|
|
JP2013545727A
(ja)
|
2010-10-21 |
2013-12-26 |
メルク・シャープ・アンド・ドーム・コーポレーション |
オリゴヌクレオチド送達用の新規低分子量カチオン性脂質
|
|
EA201390600A1
(ru)
|
2010-10-22 |
2013-09-30 |
Байнд Терапьютикс, Инк. |
Терапевтические наночастицы с сополимерами с большим молекулярным весом
|
|
CA2816977C
(en)
|
2010-11-05 |
2019-10-29 |
The Johns Hopkins University |
Compositions and methods relating to reduced mucoadhesion
|
|
DK2635265T3
(en)
|
2010-11-05 |
2018-07-16 |
Sirna Therapeutics Inc |
New low molecular weight cyclic amine-containing cationic lipids for oligonucleotide delivery
|
|
WO2012092552A1
(en)
|
2010-12-30 |
2012-07-05 |
Selecta Biosciences, Inc. |
Synthetic nanocarriers with reactive groups that release biologically active agents
|
|
AU2012207606B2
(en)
|
2011-01-11 |
2017-02-23 |
Alnylam Pharmaceuticals, Inc. |
Pegylated lipids and their use for drug delivery
|
|
DE102011082231A1
(de)
|
2011-01-12 |
2012-07-12 |
Robert Bosch Gmbh |
Zündspule, insbesondere für kleinbauende Motoren
|
|
WO2012099805A2
(en)
|
2011-01-19 |
2012-07-26 |
Ocean Nanotech, Llc |
Nanoparticle based immunological stimulation
|
|
WO2012109121A1
(en)
|
2011-02-07 |
2012-08-16 |
Purdue Research Foundation |
Carbohydrate nanoparticles for prolonged efficacy of antimicrobial peptide
|
|
US8846850B2
(en)
|
2011-02-22 |
2014-09-30 |
Rutgers, The State University Of New Jersey |
Amphiphilic macromolecules for nucleic acid delivery
|
|
US9107887B2
(en)
|
2011-03-10 |
2015-08-18 |
Provectus Pharmaceuticals, Inc. |
Combination of local and systemic immunomodulative therapies for enhanced treatment of cancer
|
|
EA201391392A1
(ru)
|
2011-03-25 |
2014-04-30 |
Селекта Байосайенсиз, Инк. |
Синтетические наноносители с осмотически опосредованным высвобождением
|
|
WO2012135805A2
(en)
|
2011-03-31 |
2012-10-04 |
modeRNA Therapeutics |
Delivery and formulation of engineered nucleic acids
|
|
WO2012131104A2
(en)
|
2011-03-31 |
2012-10-04 |
Ingell Technologies Holding B.V. |
Biodegradable compositions suitable for controlled release
|
|
EP2691078A1
(en)
|
2011-03-31 |
2014-02-05 |
Ingell Technologies Holding B.V. |
Biodegradable compositions suitable for controlled release
|
|
US20120283503A1
(en)
|
2011-04-29 |
2012-11-08 |
The Johns Hopkins University |
Nanoparticle loaded stem cells and their use in mri guided hyperthermia
|
|
CN103501812A
(zh)
|
2011-04-29 |
2014-01-08 |
西莱克塔生物科技公司 |
用于过敏症治疗的致耐受性合成纳米载体
|
|
US8691750B2
(en)
|
2011-05-17 |
2014-04-08 |
Axolabs Gmbh |
Lipids and compositions for intracellular delivery of biologically active compounds
|
|
US20140308363A1
(en)
|
2011-05-31 |
2014-10-16 |
Bind Therapeutics, Inc. |
Drug loaded polymeric nanoparticles and methods of making and using same
|
|
JP6100762B2
(ja)
|
2011-06-02 |
2017-03-22 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
膜で被包されたナノ粒子および使用方法
|
|
US20140206753A1
(en)
|
2011-06-08 |
2014-07-24 |
Shire Human Genetic Therapies, Inc. |
Lipid nanoparticle compositions and methods for mrna delivery
|
|
CA3198966A1
(en)
|
2011-06-08 |
2012-12-13 |
Translate Bio, Inc. |
Cleavable lipids
|
|
EP4115875A1
(en)
|
2011-07-06 |
2023-01-11 |
GlaxoSmithKline Biologicals S.A. |
Liposomes having useful n:p ratio for delivery of rna molecules
|
|
ES2653205T3
(es)
|
2011-07-08 |
2018-02-06 |
Bayer Intellectual Property Gmbh |
Procedimiento de preparación de derivados de diamida del ácido antranílico sustituidos con tetrazol mediante la reacción de ácidos de pirazol con ésteres del ácido antranílico
|
|
CN103732211B
(zh)
|
2011-07-21 |
2017-03-01 |
禾大国际股份公开有限公司 |
支化的聚醚‑聚酰胺嵌段共聚物及其制造与使用方法
|
|
CN109172819A
(zh)
|
2011-07-29 |
2019-01-11 |
西莱克塔生物科技公司 |
产生体液和细胞毒性t淋巴细胞(ctl)免疫应答的合成纳米载体
|
|
MX2014001971A
(es)
|
2011-08-26 |
2014-03-31 |
Arrowhead Res Corp |
Polimeros de poli(vinilester) para suministro de acido nucleico in vivo.
|
|
US9126966B2
(en)
|
2011-08-31 |
2015-09-08 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods of use thereof
|
|
BR112014004544A2
(pt)
|
2011-08-31 |
2017-04-04 |
Mallinckrodt Llc |
modificação com peg de nanopartículas com h-fosfonatos
|
|
WO2013039857A1
(en)
|
2011-09-12 |
2013-03-21 |
modeRNA Therapeutics |
Engineered nucleic acids and methods of use thereof
|
|
JP2014531456A
(ja)
|
2011-09-22 |
2014-11-27 |
バインド セラピューティックス インコーポレイテッド |
治療用ナノ粒子と癌を治療する方法
|
|
WO2013072929A2
(en)
|
2011-09-23 |
2013-05-23 |
Indian Institute Of Technology |
Nanop article based cosmetic composition
|
|
EP2763701B1
(en)
|
2011-10-03 |
2018-12-19 |
Moderna Therapeutics, Inc. |
Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
|
|
US20150272885A1
(en)
|
2011-10-14 |
2015-10-01 |
Stc.Unm |
Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery including transdermal delivery of cargo and methods thereof
|
|
WO2013059496A1
(en)
|
2011-10-18 |
2013-04-25 |
Dicerna Pharmaceuticals, Inc. |
Amine cationic lipids and uses thereof
|
|
CA2853316C
(en)
|
2011-10-25 |
2018-11-27 |
The University Of British Columbia |
Limit size lipid nanoparticles and related methods
|
|
PE20181541A1
(es)
|
2011-10-27 |
2018-09-26 |
Massachusetts Inst Technology |
Derivados de aminoacidos funcionalizados en la terminal n capaces de formar microesferas encapsuladoras de farmaco
|
|
AU2012328457A1
(en)
|
2011-10-28 |
2014-04-24 |
Presage Biosciences, Inc. |
Methods for drug delivery
|
|
CA2853689C
(en)
|
2011-11-04 |
2020-06-30 |
Nitto Denko Corporation |
Method of producing lipid nanoparticles for drug delivery
|
|
ES2810003T3
(es)
|
2011-11-18 |
2021-03-08 |
Regeneron Pharma |
Micropartícula que contiene proteína terapéutica recubierta con polímero biodegradable para uso médico
|
|
EP2785375B1
(en)
|
2011-11-28 |
2020-07-22 |
Merck Patent GmbH |
Anti-pd-l1 antibodies and uses thereof
|
|
WO2013082111A2
(en)
|
2011-11-29 |
2013-06-06 |
The University Of North Carolina At Chapel Hill |
Geometrically engineered particles and methods for modulating macrophage or immune responses
|
|
CA2856742A1
(en)
|
2011-12-07 |
2013-06-13 |
Alnylam Pharmaceuticals, Inc. |
Biodegradable lipids for the delivery of active agents
|
|
WO2013086373A1
(en)
|
2011-12-07 |
2013-06-13 |
Alnylam Pharmaceuticals, Inc. |
Lipids for the delivery of active agents
|
|
GB201121070D0
(en)
|
2011-12-07 |
2012-01-18 |
Isis Innovation |
composition for delivery of biotherapeutics
|
|
EP2787977A4
(en)
|
2011-12-09 |
2015-05-06 |
Univ California |
LIPOSOMAL ACTIVE INVERTING
|
|
SI2790668T1
(sl)
|
2011-12-13 |
2021-01-29 |
Engeneic Molecular Delivery Pty Ltd. |
Iz bakterij izhajajoče intaktne minicelice za dostavo terapevtskih sredstev v možganske tumorje
|
|
KR20140102759A
(ko)
|
2011-12-16 |
2014-08-22 |
모더나 세라퓨틱스, 인코포레이티드 |
변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
|
|
WO2013090601A2
(en)
|
2011-12-16 |
2013-06-20 |
Massachusetts Institute Of Technology |
Compact nanoparticles for biological applications
|
|
WO2013105101A1
(en)
|
2012-01-13 |
2013-07-18 |
Department Of Biotechnology |
Solid lipid nanoparticles entrapping hydrophilic/ amphiphilic drug and a process for preparing the same
|
|
KR101811917B1
(ko)
|
2012-01-19 |
2017-12-22 |
더 존스 홉킨스 유니버시티 |
점액 침투 강화를 나타내는 나노 입자 제형
|
|
WO2013116126A1
(en)
|
2012-02-01 |
2013-08-08 |
Merck Sharp & Dohme Corp. |
Novel low molecular weight, biodegradable cationic lipids for oligonucleotide delivery
|
|
WO2013116804A2
(en)
|
2012-02-03 |
2013-08-08 |
Rutgers, The State Of University Of New Jersey |
Polymeric biomaterials derived from phenolic monomers and their medical uses
|
|
WO2013119602A1
(en)
|
2012-02-06 |
2013-08-15 |
President And Fellows Of Harvard College |
Arrdc1-mediated microvesicles (armms) and uses thereof
|
|
CN104245745B
(zh)
|
2012-02-09 |
2017-03-29 |
生命技术公司 |
亲水性聚合物颗粒及其制备方法
|
|
EP2812383A1
(en)
|
2012-02-10 |
2014-12-17 |
E. I. Du Pont de Nemours and Company |
Preparation, purification and use of high-x diblock copolymers
|
|
WO2013123523A1
(en)
|
2012-02-19 |
2013-08-22 |
Nvigen, Inc. |
Uses of porous nanostructure in delivery
|
|
WO2013126803A1
(en)
|
2012-02-24 |
2013-08-29 |
Protiva Biotherapeutics Inc. |
Trialkyl cationic lipids and methods of use thereof
|
|
AU2013243949A1
(en)
|
2012-04-02 |
2014-10-30 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of biologics and proteins associated with human disease
|
|
DE18200782T1
(de)
|
2012-04-02 |
2021-10-21 |
Modernatx, Inc. |
Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
|
|
US9856320B2
(en)
|
2012-05-15 |
2018-01-02 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
|
|
EP2885419A4
(en)
|
2012-08-14 |
2016-05-25 |
Moderna Therapeutics Inc |
ENZYMES AND POLYMERASES FOR RNA SYNTHESIS
|
|
WO2014093924A1
(en)
|
2012-12-13 |
2014-06-19 |
Moderna Therapeutics, Inc. |
Modified nucleic acid molecules and uses thereof
|
|
HK1217215A1
(zh)
|
2013-01-17 |
2016-12-30 |
Modernatx, Inc. |
用於改变细胞表型的信号传感器多核苷酸
|
|
US20160022840A1
(en)
|
2013-03-09 |
2016-01-28 |
Moderna Therapeutics, Inc. |
Heterologous untranslated regions for mrna
|
|
WO2015007871A2
(en)
*
|
2013-07-17 |
2015-01-22 |
Ospedale San Raffaele S.R.L. |
Micrornas and autoimmune-immune mediated inflammatory disease
|
|
ES2792183T3
(es)
|
2013-09-13 |
2020-11-10 |
Beigene Switzerland Gmbh |
Anticuerpos anti-PD1 y su uso como productos terapéuticos y de diagnóstico
|
|
US10023626B2
(en)
*
|
2013-09-30 |
2018-07-17 |
Modernatx, Inc. |
Polynucleotides encoding immune modulating polypeptides
|
|
AU2016251687C1
(en)
*
|
2015-04-22 |
2023-07-27 |
CureVac SE |
RNA containing composition for treatment of tumor diseases
|
|
EP4039699A1
(en)
|
2015-12-23 |
2022-08-10 |
ModernaTX, Inc. |
Methods of using ox40 ligand encoding polynucleotides
|
|
EP3452101A2
(en)
|
2016-05-04 |
2019-03-13 |
CureVac AG |
Rna encoding a therapeutic protein
|
|
WO2017201352A1
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Mrna combination therapy for the treatment of cancer
|
|
DK3458474T3
(da)
*
|
2016-05-18 |
2022-09-26 |
Modernatx Inc |
Kombinationer af mrna'er, der koder for immunmodulerende polypeptider og anvendelser deraf
|