TR201814710T4 - Yeni Geliştirilmiş Değişik Halkalı Heterosiklik Türevler Ve Bunların Kullanımı - Google Patents
Yeni Geliştirilmiş Değişik Halkalı Heterosiklik Türevler Ve Bunların Kullanımı Download PDFInfo
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- TR201814710T4 TR201814710T4 TR2018/14710T TR201814710T TR201814710T4 TR 201814710 T4 TR201814710 T4 TR 201814710T4 TR 2018/14710 T TR2018/14710 T TR 2018/14710T TR 201814710 T TR201814710 T TR 201814710T TR 201814710 T4 TR201814710 T4 TR 201814710T4
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- pain
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- 125000000623 heterocyclic group Chemical group 0.000 title 1
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- 208000002193 Pain Diseases 0.000 abstract 2
- 206010060932 Postoperative adhesion Diseases 0.000 abstract 2
- 208000003251 Pruritus Diseases 0.000 abstract 2
- 201000004681 Psoriasis Diseases 0.000 abstract 2
- 206010009887 colitis Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 201000006417 multiple sclerosis Diseases 0.000 abstract 2
- 206010039083 rhinitis Diseases 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 206010009137 Chronic sinusitis Diseases 0.000 abstract 1
- 206010010741 Conjunctivitis Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 abstract 1
- 206010013774 Dry eye Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 206010065390 Inflammatory pain Diseases 0.000 abstract 1
- 208000027601 Inner ear disease Diseases 0.000 abstract 1
- 208000000592 Nasal Polyps Diseases 0.000 abstract 1
- 206010028735 Nasal congestion Diseases 0.000 abstract 1
- 206010052437 Nasal discomfort Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010039710 Scleroderma Diseases 0.000 abstract 1
- 208000024780 Urticaria Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 208000010928 autoimmune thyroid disease Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 208000027157 chronic rhinosinusitis Diseases 0.000 abstract 1
- 208000024376 chronic urticaria Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 206010023332 keratitis Diseases 0.000 abstract 1
- 201000010666 keratoconjunctivitis Diseases 0.000 abstract 1
- 206010025135 lupus erythematosus Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 208000027491 vestibular disease Diseases 0.000 abstract 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/4965—Non-condensed pyrazines
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Mevcut buluş, histamin 4 reseptörünün/alıcısının çeşitli işlevleriyle ilişkili hastalıkların tedavisi için ilaçların hazırlanmasında yararlı olan yeni geliştirilmiş heterosiklik bileşiklerle ilgilidir. Söz konusu ilaçlar bilhassa, inflamatuar hastalıklar, alerji, ağrı, burun polipleri, rinit /burun iltihabı, kronik sinüzit, burun tıkanıklığı, burun kaşıntısı, astım, kronik obstrüktif akciğer hastalığı, eklem iltihabı/romatoid artrit, atopik dermatit, psoriazis/sedef hastalığı, egzama, prürit, kaşıntılı deri, ürtiker, nedeni bilinmeyen idiopatik kronik ürtiker, skleroderma, konjonktivit, keratokonjonktivit, oküler inflamasyon, göz kuruluğu, kardiyak disfonksiyonu, aritmi, aterosikreroz, mültiple skleröz (MS), inflamatuar bağırsak hastalığı (kolit, Crohn hastalığı, ülseratif kolit dahil), inflamatuar ağrı, nöropatik ağrı, osteoartrit ağrı, otoimmün tiroid hastalığı, immün sistem aracılı (tip I olarak da bilinen) diyabet, lupus, ameliyat sonrası yapışmalar /post-operatif adezyonlar, vestibüler düzensizlikler ve kanserin tedavisinde yararlıdırlar.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20110100369 | 2011-09-30 | ||
| KR20120033444 | 2012-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201814710T4 true TR201814710T4 (tr) | 2019-01-21 |
Family
ID=47996667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2018/14710T TR201814710T4 (tr) | 2011-09-30 | 2012-09-28 | Yeni Geliştirilmiş Değişik Halkalı Heterosiklik Türevler Ve Bunların Kullanımı |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9586959B2 (tr) |
| EP (2) | EP3461825B1 (tr) |
| JP (1) | JP6031107B2 (tr) |
| KR (1) | KR101800749B1 (tr) |
| CN (1) | CN103889986B (tr) |
| AR (1) | AR088085A1 (tr) |
| AU (1) | AU2012316912B9 (tr) |
| BR (1) | BR112014007645A2 (tr) |
| CA (1) | CA2848154C (tr) |
| CY (1) | CY1121292T1 (tr) |
| DK (2) | DK3461825T3 (tr) |
| ES (2) | ES2954303T3 (tr) |
| FI (1) | FI3461825T3 (tr) |
| HR (2) | HRP20181310T1 (tr) |
| HU (2) | HUE062842T2 (tr) |
| LT (2) | LT3461825T (tr) |
| MX (1) | MX355795B (tr) |
| PL (2) | PL2760865T3 (tr) |
| PT (2) | PT3461825T (tr) |
| RS (2) | RS57854B1 (tr) |
| RU (1) | RU2628074C2 (tr) |
| SG (1) | SG11201400484RA (tr) |
| SI (2) | SI2760865T1 (tr) |
| TR (1) | TR201814710T4 (tr) |
| TW (1) | TWI551600B (tr) |
| WO (1) | WO2013048214A2 (tr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3016949B1 (en) | 2013-07-02 | 2020-05-13 | Syngenta Participations AG | Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents |
| CN103435561B (zh) * | 2013-08-19 | 2016-08-10 | 上海交通大学 | 一种新型d-氨基酸氧化酶抑制剂及其制备和应用 |
| CN104016909B (zh) * | 2014-04-03 | 2016-04-20 | 定陶县友帮化工有限公司 | 一种2-氨基-3-溴-5-氯吡啶的合成方法 |
| CN104016911A (zh) * | 2014-04-03 | 2014-09-03 | 定陶县友帮化工有限公司 | 一种2-氨基-3,5-二溴吡啶的合成方法 |
| CN106187793A (zh) * | 2016-01-26 | 2016-12-07 | 赵鸣 | 5‑氨基酮戊酸及其衍生物的盐化合物和应用 |
| CN109789143A (zh) | 2016-07-01 | 2019-05-21 | G1治疗公司 | 基于嘧啶的抗增殖剂 |
| EP3556363B1 (en) * | 2016-12-14 | 2024-03-06 | SK Biopharmaceuticals Co., Ltd. | Use of carbamate compound for prevention, alleviation or treatment of pruritus |
| WO2018139876A1 (ko) * | 2017-01-26 | 2018-08-02 | 동화약품주식회사 | 신규한 [1, 2, 4] 트리아졸로 [4, 3-a]퀴녹살린 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 bet 단백질 관련 질환의 예방 또는 치료용 약학적 조성물 |
| WO2018153373A1 (zh) | 2017-02-27 | 2018-08-30 | 贝达药业股份有限公司 | Fgfr抑制剂及其应用 |
| TW202021969A (zh) * | 2018-05-31 | 2020-06-16 | 南韓商Ｃ＆Ｃ新藥研究所 | 雜環衍生物及其用途 |
| GB2575490A (en) * | 2018-07-12 | 2020-01-15 | Recordati Ind Chimica E Farmaceutica Spa | P2X3 receptor antagonists |
| US11718622B2 (en) | 2020-03-16 | 2023-08-08 | Exelixis Inc. | Heterocyclic adenosine receptor antagonists |
| WO2021236650A1 (en) | 2020-05-19 | 2021-11-25 | G1 Therapeutics, Inc. | Cyclin-dependent kinase inhibiting compounds for the treatment of medical disorders |
| EP4067357A1 (en) * | 2021-03-30 | 2022-10-05 | JW Pharmaceutical Corporation | Novel crystalline form of 1-(8-bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-n-methylazetidin-3-amine hydrogen sulfate monohydrate |
| TW202317568A (zh) * | 2021-06-22 | 2023-05-01 | 丹麥商理奧藥品公司 | 1-(8-溴化吡啶并[2,3-e][1,2,4]三唑并[4,3-a]吡嗪-4-基)-n-甲基吖丁啶-3-胺半琥珀酸鹽之新穎結晶形式 |
| TW202423429A (zh) * | 2022-09-29 | 2024-06-16 | 韓商Ｊｗ製藥公司 | 1-(8-溴化吡啶并[2,3-e][1,2,4]三唑并[4,3-a]吡嗪-4-基)-n-甲基吖丁啶-3-胺之鹽及結晶形式之製備方法以及新穎的結晶形式 |
| TW202428578A (zh) * | 2022-09-29 | 2024-07-16 | 韓商Ｊｗ製藥公司 | １－（８－溴化吡啶并［２，３－ｅ］［１，２，４］三唑并［４，３－ａ］吡嗪－４－基）－ｎ－甲基吖丁啶－３－胺之新穎結晶型 |
| TW202425977A (zh) * | 2022-09-30 | 2024-07-01 | 韓商Ｊｗ製藥公司 | １－（８－溴化吡啶并［２，３－ｅ］［１，２，４］三唑并［４，３－ａ］吡嗪－４－基）－ｎ－甲基吖丁啶－３－胺單琥珀酸鹽之新穎結晶型 |
| US12122775B1 (en) | 2024-01-16 | 2024-10-22 | King Faisal University | Substituted pyrido[4,3-e]pyrrolo[1,2-a]pyrazines as CK2 inhibitors |
| US12173001B1 (en) | 2024-01-16 | 2024-12-24 | King Faisal University | Pyrido[3,4-e][1,2,4]triazolo[4,3-c]pyrimidines as CK2 inhibitors |
| US12129252B1 (en) | 2024-02-15 | 2024-10-29 | King Faisal University | Pyrrolo[2,3-c][2,6]naphthyridine-8-carboxylic acids as CK2 inhibitors |
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