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TR200200688T2 - Doğrudan tablet şeklinde preslenebilen ultra ince asetaminofen terkipleri ve bu terkiplerin üretim prosesi - Google Patents

Doğrudan tablet şeklinde preslenebilen ultra ince asetaminofen terkipleri ve bu terkiplerin üretim prosesi

Info

Publication number
TR200200688T2
TR200200688T2 TR2002/00688T TR200200688T TR200200688T2 TR 200200688 T2 TR200200688 T2 TR 200200688T2 TR 2002/00688 T TR2002/00688 T TR 2002/00688T TR 200200688 T TR200200688 T TR 200200688T TR 200200688 T2 TR200200688 T2 TR 200200688T2
Authority
TR
Turkey
Prior art keywords
acetaminophen
granulation
compositions
polyvinylpyrrolidone
granulation composition
Prior art date
Application number
TR2002/00688T
Other languages
English (en)
Inventor
Upadhyay Ajay
Original Assignee
Rhodia, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhodia, Inc. filed Critical Rhodia, Inc.
Publication of TR200200688T2 publication Critical patent/TR200200688T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Bir asetominofen tableti seklinde dogrudan preslenebilen ultra ince asetaminofen granül terkibi ,~ %85 ila 95 ag.asetaminofen ;~ % 1-4 suda-erimez tablet/kapsül çözümü; ~ % 0.5-5.0 polivinilpirrolidon ;~ % 0.5-5.0 önceden jelatinize edilmis nisasta;~ % 0.25-3.0 akinlastirici madde;~ %0.25-3.0 yumusatici;ve tercihe göre %10'a kadar ko-aktif bir içerik maddesi içerir; agirlik yüzdeleri granül terkibinin kuru komponentlerinin toplam agirligi bazindadir; granülasyon ayrica granül terkibinin kuru komponentlerinin toplam agirligi bazinda ~ %1.5'e yakin bir nem içerigi vardir. Söz konusu dogrudan preslenebilen ultra ince asetaminofen granül terkibi,bir üstten püskürtmeli akici katman granülatöründe, isitilmis havasi,suda eritilmis polivinilpirrolidon'un büyük bir bölümünün ilk isitilmis birlestirici solüsyonu, polivinilpirrolidon'un küçük bölümünün ikinci isitilmis birlestirici solüsyonu ve bir porsiyon önceden jelatinize edilmis nisasta ile tercihe göre bir yumusatici kullanilarak üretilir.
TR2002/00688T 1999-09-16 2000-09-11 Doğrudan tablet şeklinde preslenebilen ultra ince asetaminofen terkipleri ve bu terkiplerin üretim prosesi TR200200688T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/397,356 US6264983B1 (en) 1999-09-16 1999-09-16 Directly compressible, ultra fine acetaminophen compositions and process for producing same

Publications (1)

Publication Number Publication Date
TR200200688T2 true TR200200688T2 (tr) 2002-06-21

Family

ID=23570864

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/00688T TR200200688T2 (tr) 1999-09-16 2000-09-11 Doğrudan tablet şeklinde preslenebilen ultra ince asetaminofen terkipleri ve bu terkiplerin üretim prosesi

Country Status (11)

Country Link
US (3) US6264983B1 (tr)
EP (1) EP1231911B1 (tr)
JP (1) JP5080711B2 (tr)
CN (1) CN1204882C (tr)
AT (1) ATE261300T1 (tr)
AU (1) AU767671B2 (tr)
DE (1) DE60008912T2 (tr)
ES (1) ES2213056T3 (tr)
MX (1) MXPA02002669A (tr)
TR (1) TR200200688T2 (tr)
WO (1) WO2001019363A1 (tr)

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Also Published As

Publication number Publication date
DE60008912D1 (de) 2004-04-15
US6607750B2 (en) 2003-08-19
DE60008912T2 (de) 2004-08-19
US6264983B1 (en) 2001-07-24
AU767671B2 (en) 2003-11-20
WO2001019363A1 (en) 2001-03-22
EP1231911B1 (en) 2004-03-10
JP2003509368A (ja) 2003-03-11
CN1204882C (zh) 2005-06-08
US20030215504A1 (en) 2003-11-20
AU1251301A (en) 2001-04-17
JP5080711B2 (ja) 2012-11-21
MXPA02002669A (es) 2002-10-23
EP1231911A1 (en) 2002-08-21
US20010044472A1 (en) 2001-11-22
ES2213056T3 (es) 2004-08-16
CN1374862A (zh) 2002-10-16
ATE261300T1 (de) 2004-03-15

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