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TN2012000192A1 - N1-pyrazolospirocetones inhibitrices d'acetyl-coa-carboxylase - Google Patents

N1-pyrazolospirocetones inhibitrices d'acetyl-coa-carboxylase

Info

Publication number
TN2012000192A1
TN2012000192A1 TNP2012000192A TN2012000192A TN2012000192A1 TN 2012000192 A1 TN2012000192 A1 TN 2012000192A1 TN P2012000192 A TNP2012000192 A TN P2012000192A TN 2012000192 A TN2012000192 A TN 2012000192A TN 2012000192 A1 TN2012000192 A1 TN 2012000192A1
Authority
TN
Tunisia
Prior art keywords
acetyl
coa
pyrazolospirocetones
carboxylase inhibitor
compound
Prior art date
Application number
TNP2012000192A
Other languages
English (en)
Inventor
Scott William Bagley
David Andrew Griffith
Daniel Wei-Shung Kung
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TN2012000192A1 publication Critical patent/TN2012000192A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un composé de formule (I) ou un sel pharmaceutiquement acceptable du composé, dans lequel R1, R2, R3 et R4 sont tels que présentement décrits; des compositions pharmaceutiques de celui-ci; et l'utilisation de celui-ci dans le traitement de maladies, affections ou troubles modulés par l'inhibition d'une ou des enzyme(s) acétyl-CoA carboxylase(s) chez un animal.
TNP2012000192A 2009-11-10 2012-04-25 N1-pyrazolospirocetones inhibitrices d'acetyl-coa-carboxylase TN2012000192A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25982309P 2009-11-10 2009-11-10
PCT/IB2010/054908 WO2011058474A1 (fr) 2009-11-10 2010-10-29 Inhibiteurs de n1-pyrazolospirocétone acétyl-coa carboxylase

Publications (1)

Publication Number Publication Date
TN2012000192A1 true TN2012000192A1 (fr) 2013-12-12

Family

ID=43357094

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2012000192A TN2012000192A1 (fr) 2009-11-10 2012-04-25 N1-pyrazolospirocetones inhibitrices d'acetyl-coa-carboxylase

Country Status (39)

Country Link
US (4) US8288405B2 (fr)
EP (3) EP2499139B1 (fr)
JP (1) JP5114610B1 (fr)
KR (2) KR101550557B1 (fr)
CN (1) CN102695708B (fr)
AP (1) AP3283A (fr)
AR (1) AR078944A1 (fr)
AU (1) AU2010317501B2 (fr)
BR (1) BR112012011072A2 (fr)
CA (1) CA2778886C (fr)
CL (1) CL2012000999A1 (fr)
CO (1) CO6541569A2 (fr)
CR (1) CR20120190A (fr)
CU (1) CU24077B1 (fr)
DK (1) DK2499139T3 (fr)
DO (1) DOP2012000128A (fr)
EA (1) EA020153B1 (fr)
EC (1) ECSP12011880A (fr)
ES (1) ES2444543T3 (fr)
GE (1) GEP20146169B (fr)
HN (1) HN2012000973A (fr)
HR (1) HRP20140025T1 (fr)
IL (1) IL219373A (fr)
MA (1) MA33734B1 (fr)
MX (1) MX2012005429A (fr)
NI (1) NI201200089A (fr)
NZ (1) NZ599815A (fr)
PE (1) PE20121469A1 (fr)
PH (1) PH12012500903A1 (fr)
PL (1) PL2499139T3 (fr)
PT (1) PT2499139E (fr)
RS (1) RS53156B (fr)
SI (1) SI2499139T1 (fr)
TN (1) TN2012000192A1 (fr)
TW (1) TWI394756B (fr)
UA (1) UA102336C2 (fr)
UY (1) UY33020A (fr)
WO (1) WO2011058474A1 (fr)
ZA (1) ZA201204231B (fr)

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Also Published As

Publication number Publication date
EP2676958B1 (fr) 2015-07-01
WO2011058474A1 (fr) 2011-05-19
US20110111046A1 (en) 2011-05-12
KR20140034919A (ko) 2014-03-20
EP2499139B1 (fr) 2013-12-11
US20140288111A1 (en) 2014-09-25
TWI394756B (zh) 2013-05-01
HK1173724A1 (en) 2013-05-24
US8802690B2 (en) 2014-08-12
EP2947082A1 (fr) 2015-11-25
CN102695708A (zh) 2012-09-26
AP2012006269A0 (en) 2012-06-30
CN102695708B (zh) 2014-10-15
ES2444543T3 (es) 2014-02-25
JP5114610B1 (ja) 2013-01-09
PL2499139T3 (pl) 2014-04-30
US9139587B2 (en) 2015-09-22
NI201200089A (es) 2012-08-20
EA020153B1 (ru) 2014-09-30
BR112012011072A2 (pt) 2017-06-20
UA102336C2 (uk) 2013-06-25
US20130030181A1 (en) 2013-01-31
AP3283A (en) 2015-05-31
AU2010317501A1 (en) 2012-05-17
CO6541569A2 (es) 2012-10-16
CL2012000999A1 (es) 2012-07-20
CU20120071A7 (es) 2013-05-31
SI2499139T1 (sl) 2014-01-31
NZ599815A (en) 2013-04-26
JP2013510192A (ja) 2013-03-21
DOP2012000128A (es) 2012-08-31
PE20121469A1 (es) 2012-11-01
EP2499139A1 (fr) 2012-09-19
TW201127838A (en) 2011-08-16
KR20120099460A (ko) 2012-09-10
UY33020A (es) 2011-06-30
GEP20146169B (en) 2014-09-25
HN2012000973A (es) 2015-03-02
KR101550557B1 (ko) 2015-09-04
ZA201204231B (en) 2013-02-27
CR20120190A (es) 2012-05-24
MX2012005429A (es) 2012-06-19
MA33734B1 (fr) 2012-11-01
AR078944A1 (es) 2011-12-14
PT2499139E (pt) 2014-02-10
CA2778886C (fr) 2014-01-07
US8507681B2 (en) 2013-08-13
KR101478517B1 (ko) 2015-01-02
CU24077B1 (es) 2015-03-30
RS53156B (sr) 2014-06-30
PH12012500903A1 (en) 2014-09-24
CA2778886A1 (fr) 2011-05-19
DK2499139T3 (da) 2014-01-27
HRP20140025T1 (hr) 2014-02-14
EA201290191A1 (ru) 2012-12-28
AU2010317501B2 (en) 2013-06-06
US20130296319A1 (en) 2013-11-07
IL219373A0 (en) 2012-06-28
EP2676958A1 (fr) 2013-12-25
IL219373A (en) 2014-04-30
US8288405B2 (en) 2012-10-16
ECSP12011880A (es) 2012-07-31
WO2011058474A8 (fr) 2012-04-26

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