NZ599815A - N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors - Google Patents
N1-pyrazolospiroketone acetyl-coa carboxylase inhibitorsInfo
- Publication number
- NZ599815A NZ599815A NZ599815A NZ59981510A NZ599815A NZ 599815 A NZ599815 A NZ 599815A NZ 599815 A NZ599815 A NZ 599815A NZ 59981510 A NZ59981510 A NZ 59981510A NZ 599815 A NZ599815 A NZ 599815A
- Authority
- NZ
- New Zealand
- Prior art keywords
- coa carboxylase
- acetyl
- carboxylase inhibitors
- dihydrospiro
- indazole
- Prior art date
Links
- 229940121373 acetyl-coa carboxylase inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- BDXXSFOJPYSYOC-UHFFFAOYSA-N 1'-(2-methyl-3h-benzimidazole-5-carbonyl)-1-propan-2-ylspiro[4,6-dihydroindazole-5,4'-piperidine]-7-one Chemical compound C1=C2NC(C)=NC2=CC(C(=O)N2CCC3(CC=4C=NN(C=4C(=O)C3)C(C)C)CC2)=C1 BDXXSFOJPYSYOC-UHFFFAOYSA-N 0.000 abstract 1
- QOPWTEZWCHPGGC-UHFFFAOYSA-N 1-propan-2-yl-1'-(1h-pyrrolo[3,2-b]pyridine-6-carbonyl)spiro[4,6-dihydroindazole-5,4'-piperidine]-7-one Chemical compound N1=C2C=CNC2=CC(C(=O)N2CCC3(CC=4C=NN(C=4C(=O)C3)C(C)C)CC2)=C1 QOPWTEZWCHPGGC-UHFFFAOYSA-N 0.000 abstract 1
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 abstract 1
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 abstract 1
- 108010018763 Biotin carboxylase Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
599815 The disclosure provides a compound of Formula (I) or a pharmaceutically acceptable salt of the compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl- CoA carboxylase enzyme(s) in an animal. Examples of compounds of formula (I) are: 1-isopropyl-1'-(1 H-pyrrolo[3,2-b]pyridine-6-carbonyl)-4,6-dihydrospiro[indazole-5,4'-piperidin]-7(1H)-one and 1-isopropyl-1'-(2-methyl-1 H-benzo[d]imidazole-6-carbonyl)-4,6-dihydrospiro[indazole-5,4'-piperidin]-7(1H)-one.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25982309P | 2009-11-10 | 2009-11-10 | |
| PCT/IB2010/054908 WO2011058474A1 (en) | 2009-11-10 | 2010-10-29 | N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ599815A true NZ599815A (en) | 2013-04-26 |
Family
ID=43357094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ599815A NZ599815A (en) | 2009-11-10 | 2010-10-29 | N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors |
Country Status (39)
| Country | Link |
|---|---|
| US (4) | US8288405B2 (en) |
| EP (3) | EP2499139B1 (en) |
| JP (1) | JP5114610B1 (en) |
| KR (2) | KR101550557B1 (en) |
| CN (1) | CN102695708B (en) |
| AP (1) | AP3283A (en) |
| AR (1) | AR078944A1 (en) |
| AU (1) | AU2010317501B2 (en) |
| BR (1) | BR112012011072A2 (en) |
| CA (1) | CA2778886C (en) |
| CL (1) | CL2012000999A1 (en) |
| CO (1) | CO6541569A2 (en) |
| CR (1) | CR20120190A (en) |
| CU (1) | CU24077B1 (en) |
| DK (1) | DK2499139T3 (en) |
| DO (1) | DOP2012000128A (en) |
| EA (1) | EA020153B1 (en) |
| EC (1) | ECSP12011880A (en) |
| ES (1) | ES2444543T3 (en) |
| GE (1) | GEP20146169B (en) |
| HN (1) | HN2012000973A (en) |
| HR (1) | HRP20140025T1 (en) |
| IL (1) | IL219373A (en) |
| MA (1) | MA33734B1 (en) |
| MX (1) | MX2012005429A (en) |
| NI (1) | NI201200089A (en) |
| NZ (1) | NZ599815A (en) |
| PE (1) | PE20121469A1 (en) |
| PH (1) | PH12012500903A1 (en) |
| PL (1) | PL2499139T3 (en) |
| PT (1) | PT2499139E (en) |
| RS (1) | RS53156B (en) |
| SI (1) | SI2499139T1 (en) |
| TN (1) | TN2012000192A1 (en) |
| TW (1) | TWI394756B (en) |
| UA (1) | UA102336C2 (en) |
| UY (1) | UY33020A (en) |
| WO (1) | WO2011058474A1 (en) |
| ZA (1) | ZA201204231B (en) |
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| ES2545231T3 (en) | 2008-05-28 | 2015-09-09 | Pfizer Inc. | Pyrazoloespirocetone acetyl-CoA carboxylase inhibitors |
| CN104945420A (en) | 2009-06-29 | 2015-09-30 | 因塞特公司 | Pyrimidinones as PI3K inhibitors |
| ES2444543T3 (en) | 2009-11-10 | 2014-02-25 | Pfizer Inc | N1-pyrazoloespirocetone acetyl-CoA carboxylase inhibitors |
| US8759359B2 (en) | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
| EP2345643A1 (en) * | 2009-12-29 | 2011-07-20 | Polichem S.A. | New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof |
| JP5816678B2 (en) | 2010-04-14 | 2015-11-18 | インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ | Condensed derivatives as PI3Kδ inhibitors |
| US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
| US8859577B2 (en) * | 2010-09-30 | 2014-10-14 | Pfizer Inc. | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors |
| ES2546465T3 (en) * | 2010-10-29 | 2015-09-23 | Pfizer Inc | N1 / N2-lactam acetyl-CoA carboxylase inhibitors |
| CA2822070C (en) | 2010-12-20 | 2019-09-17 | Incyte Corporation | N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors |
| US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
| WO2012135009A1 (en) | 2011-03-25 | 2012-10-04 | Incyte Corporation | Pyrimidine-4,6-diamine derivatives as pi3k inhibitors |
| WO2012143813A1 (en) * | 2011-04-22 | 2012-10-26 | Pfizer Inc. | Pyrazolospiroketone derivatives for use as acetyl - coa carboxylase inhibitors |
| ES2873001T3 (en) | 2011-09-02 | 2021-11-03 | Incyte Holdings Corp | Heterocyclamines as PI3K inhibitors |
| AR090548A1 (en) | 2012-04-02 | 2014-11-19 | Incyte Corp | BICYCLIC AZAHETEROCICLOBENCILAMINS AS PI3K INHIBITORS |
| TW201444798A (en) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors |
| WO2014134391A1 (en) | 2013-02-28 | 2014-09-04 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
| ES2731773T3 (en) | 2013-03-14 | 2019-11-19 | Celgene Quanticel Res Inc | Histone Demethylase Inhibitors |
| EP3043800A1 (en) | 2013-09-12 | 2016-07-20 | Pfizer Inc. | Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris |
| US10150728B2 (en) | 2013-10-17 | 2018-12-11 | Shionogi & Co., Ltd. | Alkylene derivatives |
| WO2015191677A1 (en) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors |
| US9896436B2 (en) | 2014-09-16 | 2018-02-20 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| BR112017005128A2 (en) | 2014-09-16 | 2018-07-31 | Celgene Quanticel Res Inc | histone demethylase inhibitors |
| ES2751464T3 (en) * | 2014-09-17 | 2020-03-31 | Celgene Quanticel Res Inc | Histone demethylase inhibitors |
| EP3228731B1 (en) | 2014-11-10 | 2020-04-22 | National University Corporation Yokohama National University | Oxygen-generating anode |
| JP6816005B2 (en) | 2015-02-27 | 2021-01-20 | インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ | Salts of PI3K inhibitors and processes for their preparation |
| WO2016183060A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| US9988401B2 (en) | 2015-05-11 | 2018-06-05 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
| CA3068623A1 (en) | 2017-06-30 | 2019-01-03 | Quixgen, Inc. | Novel spirolactone compounds |
| SG11202003600QA (en) | 2017-11-21 | 2020-06-29 | Pfizer | Crystalline 2-amino-2-(hydroxymethyl)propane-1,3-diol salt of 4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoic acid |
| WO2019178480A1 (en) * | 2018-03-15 | 2019-09-19 | Yale University | Pyrazole-containing macrophage migration inhibitory factor inhibitors |
| MA52761A (en) | 2018-06-01 | 2021-04-14 | Incyte Corp | DOSAGE REGIMEN FOR THE TREATMENT OF PI3K-RELATED DISORDERS |
| US20230210822A1 (en) | 2020-05-21 | 2023-07-06 | Shionogi & Co., Ltd. | Pharmaceutical composition for treating fatty liver disease |
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| WO2025133948A1 (en) * | 2023-12-21 | 2025-06-26 | Pfizer Inc. | Acetyl coa-carboxylase (acc) inhibitors |
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| ES2444543T3 (en) * | 2009-11-10 | 2014-02-25 | Pfizer Inc | N1-pyrazoloespirocetone acetyl-CoA carboxylase inhibitors |
| WO2011058473A1 (en) | 2009-11-10 | 2011-05-19 | Pfizer Inc. | N2-pyrazolospiroketone acetyl-coa carboxylase inhibitors |
| US8859577B2 (en) | 2010-09-30 | 2014-10-14 | Pfizer Inc. | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors |
| WO2012143813A1 (en) * | 2011-04-22 | 2012-10-26 | Pfizer Inc. | Pyrazolospiroketone derivatives for use as acetyl - coa carboxylase inhibitors |
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2010
- 2010-10-29 ES ES10776438.3T patent/ES2444543T3/en active Active
- 2010-10-29 NZ NZ599815A patent/NZ599815A/en not_active IP Right Cessation
- 2010-10-29 BR BR112012011072A patent/BR112012011072A2/en not_active IP Right Cessation
- 2010-10-29 SI SI201030476T patent/SI2499139T1/en unknown
- 2010-10-29 RS RS20140068A patent/RS53156B/en unknown
- 2010-10-29 DK DK10776438.3T patent/DK2499139T3/en active
- 2010-10-29 AP AP2012006269A patent/AP3283A/en active
- 2010-10-29 AU AU2010317501A patent/AU2010317501B2/en not_active Ceased
- 2010-10-29 MX MX2012005429A patent/MX2012005429A/en active IP Right Grant
- 2010-10-29 EP EP10776438.3A patent/EP2499139B1/en active Active
- 2010-10-29 JP JP2012538444A patent/JP5114610B1/en not_active Expired - Fee Related
- 2010-10-29 CA CA2778886A patent/CA2778886C/en active Active
- 2010-10-29 KR KR1020147003056A patent/KR101550557B1/en not_active Expired - Fee Related
- 2010-10-29 PL PL10776438T patent/PL2499139T3/en unknown
- 2010-10-29 PH PH1/2012/500903A patent/PH12012500903A1/en unknown
- 2010-10-29 CN CN201080059647.1A patent/CN102695708B/en not_active Expired - Fee Related
- 2010-10-29 PE PE2012000630A patent/PE20121469A1/en not_active Application Discontinuation
- 2010-10-29 WO PCT/IB2010/054908 patent/WO2011058474A1/en not_active Ceased
- 2010-10-29 GE GEAP201012700A patent/GEP20146169B/en unknown
- 2010-10-29 PT PT107764383T patent/PT2499139E/en unknown
- 2010-10-29 UA UAA201205709A patent/UA102336C2/en unknown
- 2010-10-29 EP EP13183518.3A patent/EP2676958B1/en active Active
- 2010-10-29 KR KR1020127014916A patent/KR101478517B1/en not_active Expired - Fee Related
- 2010-10-29 EP EP15172294.9A patent/EP2947082A1/en not_active Withdrawn
- 2010-10-29 EA EA201290191A patent/EA020153B1/en not_active IP Right Cessation
- 2010-10-29 HR HRP20140025AT patent/HRP20140025T1/en unknown
- 2010-10-29 CU CU2012000071A patent/CU24077B1/en active IP Right Grant
- 2010-11-05 TW TW099138179A patent/TWI394756B/en not_active IP Right Cessation
- 2010-11-08 US US12/941,133 patent/US8288405B2/en active Active
- 2010-11-08 AR ARP100104147A patent/AR078944A1/en unknown
- 2010-11-10 UY UY0001033020A patent/UY33020A/en not_active Application Discontinuation
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2012
- 2012-04-18 CR CR20120190A patent/CR20120190A/en unknown
- 2012-04-19 CL CL2012000999A patent/CL2012000999A1/en unknown
- 2012-04-23 IL IL219373A patent/IL219373A/en not_active IP Right Cessation
- 2012-04-25 TN TNP2012000192A patent/TN2012000192A1/en unknown
- 2012-05-07 HN HN2012000973A patent/HN2012000973A/en unknown
- 2012-05-08 DO DO2012000128A patent/DOP2012000128A/en unknown
- 2012-05-09 NI NI201200089A patent/NI201200089A/en unknown
- 2012-05-10 CO CO12077270A patent/CO6541569A2/en unknown
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