[go: up one dir, main page]

TN2010000209A1 - Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents - Google Patents

Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents

Info

Publication number
TN2010000209A1
TN2010000209A1 TN2010000209A TN2010000209A TN2010000209A1 TN 2010000209 A1 TN2010000209 A1 TN 2010000209A1 TN 2010000209 A TN2010000209 A TN 2010000209A TN 2010000209 A TN2010000209 A TN 2010000209A TN 2010000209 A1 TN2010000209 A1 TN 2010000209A1
Authority
TN
Tunisia
Prior art keywords
cancer
parp inhibitor
combination
treatment
tumor agents
Prior art date
Application number
TN2010000209A
Other languages
English (en)
Inventor
Barry M Sherman
Charles Bradley
Valeria S Ossovskaya
Original Assignee
Bipar Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40623903&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2010000209(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bipar Sciences Inc filed Critical Bipar Sciences Inc
Publication of TN2010000209A1 publication Critical patent/TN2010000209A1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/212IFN-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/215IFN-beta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/217IFN-gamma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TN2010000209A 2007-11-12 2010-05-11 Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents TN2010000209A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US98733507P 2007-11-12 2007-11-12
US1236407P 2007-12-07 2007-12-07
US5852808P 2008-06-03 2008-06-03
PCT/US2008/012757 WO2009064444A2 (fr) 2007-11-12 2008-11-12 Traitement du cancer de l'utérus et du cancer de l'ovaire avec un inhibiteur parp utilisé seul ou en combinaison avec des antitumoraux

Publications (1)

Publication Number Publication Date
TN2010000209A1 true TN2010000209A1 (en) 2011-11-11

Family

ID=40623903

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2010000209A TN2010000209A1 (en) 2007-11-12 2010-05-11 Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents

Country Status (20)

Country Link
US (2) US20090123419A1 (fr)
EP (1) EP2217244A4 (fr)
JP (1) JP2011503071A (fr)
KR (1) KR20100102607A (fr)
CN (1) CN101918003A (fr)
AU (1) AU2008321382A1 (fr)
CA (1) CA2705417A1 (fr)
CO (1) CO6290649A2 (fr)
CR (1) CR11486A (fr)
DO (2) DOP2010000142A (fr)
EC (1) ECSP10010235A (fr)
GT (1) GT201000137A (fr)
IL (1) IL205633A0 (fr)
MA (1) MA32748B1 (fr)
MX (1) MX2010005221A (fr)
NI (1) NI201000084A (fr)
NZ (1) NZ586123A (fr)
SG (1) SG185954A1 (fr)
TN (1) TN2010000209A1 (fr)
WO (1) WO2009064444A2 (fr)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200800907B (en) 2005-07-18 2010-04-28 Bipar Sciences Inc Treatment of cancer
US20100279327A1 (en) * 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
EP2038654A4 (fr) * 2006-06-12 2010-08-11 Bipar Sciences Inc Procédé permettant de traiter des maladies avec des inhibiteurs de parp
US20100160442A1 (en) * 2006-07-18 2010-06-24 Ossovskaya Valeria S Formulations for cancer treatment
US7538252B2 (en) * 2006-09-05 2009-05-26 Bipar Sciences, Inc. Drug design for tubulin inhibitors, compositions, and methods of treatment thereof
AU2007292302A1 (en) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Methods for designing PARP inhibitors and uses thereof
JP2010502730A (ja) * 2006-09-05 2010-01-28 バイパー サイエンシズ,インコーポレイティド 癌の治療法
JP2010502731A (ja) 2006-09-05 2010-01-28 バイパー サイエンシズ,インコーポレイティド Parp阻害剤による脂肪酸合成の阻害、及びその治療方法
NZ586123A (en) * 2007-11-12 2012-12-21 Bipar Sciences Inc Treatment of ovarian cancer with 4-iodo-3-nitrobenzamide in combination with topoisomerase inhibitors
CN101917982B (zh) * 2007-11-12 2013-03-20 彼帕科学公司 使用4-碘-3-硝基苯甲酰胺与抗肿瘤剂组合治疗乳腺癌
RU2010128107A (ru) * 2007-12-07 2012-01-20 Байпар Сайенсиз, Инк. (Us) Лечение рака ингибиторами топоизомеразы в комбинации с ингибиторами parp
WO2011060380A1 (fr) * 2009-11-14 2011-05-19 The Regents Of The University Of California L'état de mutation de pik3ca et l'expression de sash1 prédisent la synergie entre le lapatinib et un inhibiteur d'akt dans le cancer du sein her2 positif
US20130345164A1 (en) * 2010-04-21 2013-12-26 University Of Medicine And Dentistry Of New Jersey Treatments for cellular proliferative disorders and identification thereof
WO2011153382A1 (fr) * 2010-06-04 2011-12-08 Bipar Sciences, Inc. Procédés de traitement d'un cancer des ovaires récurrent et sensible au platine avec du 4-iodo-3-nitrobenzamide en combinaison avec un antimétabolite et un composé de platine.
WO2011153383A1 (fr) * 2010-06-04 2011-12-08 Bipar Science, Inc. Procédés de traitement d'un cancer des ovaires récurrent et résistant au platine avec du 4-iodo-3-nitrobenzamide en combinaison avec un antimétabolite et un composé de platine.
US20130274281A1 (en) * 2010-07-19 2013-10-17 Bipar Sciences, Inc. Methods of treating metastatic breast cancer with 4-iodo-3-nitrobenzamide and irinotecan
EP2636667B1 (fr) * 2010-11-05 2019-01-09 Zhejiang Hisun Pharmaceutical Co. Ltd. Dérivé benzamide doté d'une activité anticancéreuse, procédé d'élaboration, et utilisation correspondante
US20140296281A1 (en) * 2011-11-25 2014-10-02 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for screening a brca1 loss-of-function in a subject suffering from a cancer
FR2984750B1 (fr) * 2011-12-23 2014-01-10 Lfb Biotechnologies Nouvelles compositions pharmaceutiques comprenant un anticorps liant le recepteur humain de l'hormone anti-mullerienne de type ii
WO2013123236A1 (fr) * 2012-02-14 2013-08-22 Purdue Pharma L.P. Systèmes et procédés de quantification d'analytes dans des échantillons kératinisés
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
TWI444358B (zh) * 2012-07-09 2014-07-11 Univ Chang Gung 一種含有5-硝基苯之衍生物,透過抑制腫瘤細胞誘發血小板凝集反應作為癌症轉移治療方式
US20140186293A1 (en) * 2012-12-31 2014-07-03 University Of Louisville Research Foundation, Inc. Immunoglobulin-bound extracellular vesicles and uses thereof
EP2970878B1 (fr) * 2013-03-15 2018-05-23 Truckee Applied Genomics, LLC Procédés et réactifs pour maintenir la viabilité de cellules cancéreuses dans du tissu enlevé par voie chirurgicale
AU2015240465B2 (en) 2014-04-04 2020-02-27 Del Mar Pharmaceuticals Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
HK1249944A1 (zh) * 2015-06-12 2018-11-16 Genea Ip Holdings Pty Limited 用於病人和生物样本识别和跟踪的方法和系统
CA2992789A1 (fr) 2015-08-20 2017-02-23 Ipsen Biopharm Ltd. Traitement combine utilisant l'irinotecan liposomal et un inhibiteur de parp pour un traitement anticancereux
TW202126293A (zh) 2015-08-21 2021-07-16 英商益普生生物製藥有限公司 使用包含微脂伊立替康(irinotecan)及奧沙利鉑(oxaliplatin)之組合療法治療轉移性胰臟癌的方法
WO2017123603A1 (fr) * 2016-01-11 2017-07-20 Syndevrx, Inc. Traitement de tumeurs induites par un dysfonctionnement métabolique
MX2018010223A (es) * 2016-02-29 2018-11-09 Synta Pharmaceuticals Corp Terapia combinada para tratamiento de cancer de ovario.
KR20190015361A (ko) 2016-06-06 2019-02-13 비욘드스프링 파마수티컬스, 인코포레이티드. 호중구감소증을 줄이는 조성물 및 방법
AU2017290244B2 (en) * 2016-06-29 2023-03-02 Tesaro, Inc. Methods of treating ovarian cancer
US11202782B2 (en) * 2016-09-27 2021-12-21 Beigene, Ltd. Treatment cancers using a combination comprising PARP inhibitors
TWI791467B (zh) 2016-11-02 2023-02-11 英商益普生生物製藥有限公司 使用包含微脂體伊立替康(irinotecan)、奧沙利鉑(oxaliplatin)、5-氟尿嘧啶及甲醯四氫葉酸(leucovorin)之組合療法治療胃癌
JP2020503363A (ja) 2017-01-06 2020-01-30 ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド チューブリン結合化合物およびその治療的使用
WO2018144764A1 (fr) 2017-02-01 2018-08-09 Beyondspring Pharmaceuticals, Inc. Méthode de réduction de la neutropénie
EP3576534A4 (fr) * 2017-02-06 2020-12-16 City of Hope Traitement du cancer
US20200061054A1 (en) * 2017-02-28 2020-02-27 Del Mar Pharmaceuticals (Bc) Ltd. Use of dianhydrogalactitol or analogs and derivatives in combination with a p53 modulator or a parp inhibitor
JP2020519621A (ja) 2017-05-09 2020-07-02 テサロ, インコーポレイテッド 癌を治療するための併用療法
US11622961B2 (en) 2017-05-18 2023-04-11 Tesaro, Inc. Combination therapies for treating cancer
US11433074B2 (en) 2017-06-22 2022-09-06 Triact Therapeutics, Inc. Methods of treating glioblastoma
US20200121703A1 (en) * 2017-06-26 2020-04-23 The Cleveland Clinic Foundation Cancer treatment
US11628144B2 (en) 2017-09-29 2023-04-18 Triact Therapeutics, Inc. Iniparib formulations and uses thereof
BR112020006286A2 (pt) 2017-09-30 2020-10-20 Tesaro, Inc. terapias de combinação para tratamento do câncer
JP6915865B2 (ja) * 2017-10-03 2021-08-04 学校法人 愛知医科大学 No産生抑制剤及び固形腫瘍に対する転移・浸潤抑制剤
MA50618A (fr) * 2017-10-06 2020-08-12 Tesaro Inc Polyrhérapies et leurs utilisations
EP3773592B1 (fr) 2018-04-05 2025-09-10 Noviga Research AB Nouvelles associations d'un inhibiteur de polymérisation de la tubuline et d'un inhibiteur de la poly(adp-ribose) polymérase (parp) destinées à être utilisées dans le traitement du cancer
JP2022521209A (ja) * 2019-02-21 2022-04-06 エフ.ホフマン-ラ ロシュ アーゲー 改良された核酸標的濃縮および関連方法
WO2020232133A1 (fr) * 2019-05-14 2020-11-19 Georgetown University Procédés de traitement de cancers gastro-intestinaux et de leurs tumeurs faisant intervenir une polythérapie
US11704494B2 (en) 2019-05-31 2023-07-18 Ab Initio Technology Llc Discovering a semantic meaning of data fields from profile data of the data fields
CN110600098A (zh) * 2019-08-09 2019-12-20 广州中医药大学第一附属医院 一种临床化学自动审核方法、系统、装置和存储介质
JP2023510853A (ja) * 2020-01-13 2023-03-15 グラダリス,インコーポレイティド Gm-csfをコードするポリヌクレオチドと追加薬剤を用いてがんを治療する方法
US11886399B2 (en) 2020-02-26 2024-01-30 Ab Initio Technology Llc Generating rules for data processing values of data fields from semantic labels of the data fields
CN112316149A (zh) * 2020-11-11 2021-02-05 王海涛 一种治疗tp53突变的晚期难治性实体瘤的药物及应用
CA3215047A1 (fr) 2021-04-09 2022-10-13 Lan Huang Compositions therapeutiques et methodes de traitement de tumeurs
AU2023347913A1 (en) 2022-09-20 2025-03-27 Ab Initio Technology Llc Techniques for discovering and updating semantic meaning of data fields
US12396696B2 (en) 2022-11-18 2025-08-26 University Of South Florida Physiological modeling of multiphase intra-arterial CT angiography for hepatic embolization therapy
WO2024191805A1 (fr) * 2023-03-10 2024-09-19 Beyondspring Pharmaceuticals, Inc. Polythérapie oncologique et méthodes d'utilisation
CN120496814B (zh) * 2025-07-09 2025-09-12 四川省肿瘤医院 基于多模态深度学习的卵巢附件肿瘤风险分级系统

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2669583A (en) * 1954-02-16 X-amroo-zralkoxbbenzamdjes
US2006735A (en) * 1932-11-17 1935-07-02 Gen Aniline Works Inc Nitro-aryl amino-aryl amines
NL247377A (fr) * 1957-11-25
US3228833A (en) * 1962-12-17 1966-01-11 Sterling Drug Inc Anticoccidial compositions and methods of using same
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US5215738A (en) * 1985-05-03 1993-06-01 Sri International Benzamide and nicotinamide radiosensitizers
US5032617A (en) * 1985-05-03 1991-07-16 Sri International Substituted benzamide radiosensitizers
US6407079B1 (en) * 1985-07-03 2002-06-18 Janssen Pharmaceutica N.V. Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation
ATE107705T1 (de) * 1986-01-17 1994-07-15 Ronald W Pero Test zur feststellung der empfänglichkeit für dns-assoziierte krankheiten.
US5283352A (en) * 1986-11-28 1994-02-01 Orion-Yhtyma Oy Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US5177075A (en) * 1988-08-19 1993-01-05 Warner-Lambert Company Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process
US5719151A (en) * 1990-05-04 1998-02-17 Shall; Sydney Substituted benzene compounds
US5633282A (en) * 1990-05-25 1997-05-27 British Technology Group Limited Inhibition of viral infection
US5637618A (en) * 1990-06-01 1997-06-10 Bioresearch, Inc. Specific eatable taste modifiers
US5631038A (en) * 1990-06-01 1997-05-20 Bioresearch, Inc. Specific eatable taste modifiers
CZ51593A3 (en) * 1990-09-28 1994-01-19 Smithkline Beecham Corp Water-soluble analogs of camptothecine, process of their preparation and use
US5484951A (en) * 1990-10-19 1996-01-16 Octamer, Incorporated 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents
US5200524A (en) * 1990-12-20 1993-04-06 North Carolina State University Camptothecin intermediates and method of making same
US5191082A (en) * 1990-12-20 1993-03-02 North Carolina State University Camptothecin intermediate and method of making camptothecin intermediates
US5162532A (en) * 1990-12-20 1992-11-10 North Carolina State University Intermediates and method of making camptothecin and camptothecin analogs
US5482975A (en) * 1991-10-22 1996-01-09 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
US5516941A (en) * 1991-10-22 1996-05-14 Octamer, Inc. Specific inactivators of "retroviral" (asymmetric) zinc fingers
US5464871A (en) * 1993-05-12 1995-11-07 Octamer, Inc. Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents
US5753674A (en) * 1991-10-22 1998-05-19 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents, anti-retroviral agents and anti-tumor agents
US5877185A (en) * 1991-10-22 1999-03-02 Octamer, Inc. Synergistic compositions useful as anti-tumor agents
US5783599A (en) * 1993-02-24 1998-07-21 Octamer Inc Methods of treating cancer and viral infections with 5-iodo-6-amino-and 5-iodo-6-nitroso-1 2-benzopyrones
JP3025602B2 (ja) * 1993-05-21 2000-03-27 デビオファーム エス.アー. 光学的に高純度なシス−オキザラート(トランス−l−1,2−シクロヘキサンジアミン)白金(II)錯体の製造方法
US6015792A (en) * 1993-05-26 2000-01-18 Bioresearch, Inc. Specific eatable taste modifiers
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
US5589483A (en) * 1994-12-21 1996-12-31 Geron Corporation Isoquinoline poly (ADP-ribose) polymerase inhibitors to treat skin diseases associated with cellular senescence
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5736576A (en) * 1996-06-04 1998-04-07 Octamer, Inc. Method of treating malignant tumors with thyroxine analogues having no significant hormonal activity
US6017958A (en) * 1996-06-04 2000-01-25 Octamer, Inc. Method of treating malignant tumors with thyroxine analogues having no significant hormonal activity
WO1998042328A1 (fr) * 1997-03-26 1998-10-01 Biosource Technologies, Inc. Ethers di-aryle et leurs derives utilises comme agents anticancereux
US5908861A (en) * 1997-05-13 1999-06-01 Octamer, Inc. Methods for treating inflammation and inflammatory disease using pADPRT inhibitors
US6235748B1 (en) * 1997-09-03 2001-05-22 Guilford Pharmaceuticals Inc. Oxo-substituted compounds, process of making, and compositions and methods for inhibiting parp activity
US6514983B1 (en) * 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6380193B1 (en) * 1998-05-15 2002-04-30 Guilford Pharmaceuticals Inc. Fused tricyclic compounds, methods and compositions for inhibiting PARP activity
US6395749B1 (en) * 1998-05-15 2002-05-28 Guilford Pharmaceuticals Inc. Carboxamide compounds, methods, and compositions for inhibiting PARP activity
NZ511825A (en) * 1998-11-27 2003-08-29 Basf Ag Substituted benzimidazoles and their use as parp inhibitors
US6387902B1 (en) * 1998-12-31 2002-05-14 Guilford Pharmaceuticals, Inc. Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP
US6201020B1 (en) * 1998-12-31 2001-03-13 Guilford Pharmaceuticals, Inc. Ortho-diphenol compounds, methods and pharmaceutical compositions for inhibiting parp
AU3076700A (en) * 1999-01-26 2000-08-18 Ono Pharmaceutical Co. Ltd. 2h-phthalazin-1-one derivatives and drugs comprising these derivatives as the active ingredient
DE19921567A1 (de) * 1999-05-11 2000-11-16 Basf Ag Verwendung von Phthalazine-Derivaten
ECSP003637A (es) * 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
US7122679B2 (en) * 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
WO2001090077A1 (fr) * 2000-05-19 2001-11-29 Guilford Pharmaceuticals, Inc. Derives de sulfonamide et de carbamide de 6(5h) phenanthridinones et utilisations de ceux-ci
ITMI20002358A1 (it) * 2000-10-31 2002-05-01 Flavio Moroni Derivati di tieno ,2, 3-c|isochinolin-3-one come inibitori della poli(a dp-ribosio)polimerasi
AUPR201600A0 (en) * 2000-12-11 2001-01-11 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivative
US20050113283A1 (en) * 2002-01-18 2005-05-26 David Solow-Cordero Methods of treating conditions associated with an EDG-4 receptor
AUPS019702A0 (en) * 2002-01-29 2002-02-21 Fujisawa Pharmaceutical Co., Ltd. Condensed heterocyclic compounds
US20040034078A1 (en) * 2002-06-14 2004-02-19 Agouron Pharmaceuticals, Inc. Benzimidazole inhibitors of poly(ADP-ribosyl) polymerase
JP2006508126A (ja) * 2002-11-06 2006-03-09 アザヤ セラピューティクス インコーポレイティッド 薬学的製剤のタンパク質安定化されたリポソーム製剤
EP2365001A3 (fr) * 2003-05-01 2012-03-28 Imclone LLC Anticorps humains dirigés contre le récepteur de facteur 1 de croissance de type insuline humaine
ES2396334T3 (es) * 2003-05-28 2013-02-20 Eisai Inc. Compuestos, métodos y composiciones farmacéuticas para la inhibición de PARP
NZ544989A (en) * 2003-07-25 2009-10-30 Cancer Rec Tech Ltd Tricyclic PARP inhibitors
WO2005018677A2 (fr) * 2003-08-01 2005-03-03 Wyeth Holdings Corporation Utilisation d'un melange d'un inhibiteur de la kinase du recepteur de facteur de croissance epidermique et d'agents cytotoxiques dans le traitement et l'inhibition de cancer
CA2537097A1 (fr) * 2003-09-04 2005-03-17 Aventis Pharmaceuticals Inc. Indoles substitues comme inhibiteurs de polymerase de poly(adp-ribose) (parp)
WO2005023765A1 (fr) * 2003-09-11 2005-03-17 Pharmacia & Upjohn Company Llc Methode de catalyse de reactions d'amidation au moyen de co2
GB0419072D0 (en) * 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
AU2005286190A1 (en) * 2004-09-22 2006-03-30 Cancer Research Technology Ltd. Therapeutic combinations comprising poly(ADP-ribose) polymerases inhibitor
CA2581025C (fr) * 2004-09-22 2011-06-07 Pfizer Inc. Formules polymorphes et amorphes de sel de phosphate de 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one
US20060094676A1 (en) * 2004-10-29 2006-05-04 Ronit Lahav Compositions and methods for treating cancer using compositions comprising an inhibitor of endothelin receptor activity
BRPI0611814A2 (pt) * 2005-06-10 2008-12-09 Bipar Sciences Inc moduladores parp e tratamento de cÂnceres
ZA200800907B (en) * 2005-07-18 2010-04-28 Bipar Sciences Inc Treatment of cancer
DE102006037399A1 (de) * 2006-08-10 2008-02-14 Archimica Gmbh Verfahren zur Herstellung von Arylaminen
US7538252B2 (en) * 2006-09-05 2009-05-26 Bipar Sciences, Inc. Drug design for tubulin inhibitors, compositions, and methods of treatment thereof
AU2007292302A1 (en) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Methods for designing PARP inhibitors and uses thereof
JP2010502731A (ja) * 2006-09-05 2010-01-28 バイパー サイエンシズ,インコーポレイティド Parp阻害剤による脂肪酸合成の阻害、及びその治療方法
JP2010502730A (ja) * 2006-09-05 2010-01-28 バイパー サイエンシズ,インコーポレイティド 癌の治療法
EP2211854A4 (fr) * 2007-10-19 2011-01-12 Bipar Sciences Inc Procédés et compositions pour le traitement du cancer au moyen d'inhibiteurs de parp de type benzopyrone
CN101917982B (zh) * 2007-11-12 2013-03-20 彼帕科学公司 使用4-碘-3-硝基苯甲酰胺与抗肿瘤剂组合治疗乳腺癌
NZ586123A (en) * 2007-11-12 2012-12-21 Bipar Sciences Inc Treatment of ovarian cancer with 4-iodo-3-nitrobenzamide in combination with topoisomerase inhibitors
RU2010128107A (ru) * 2007-12-07 2012-01-20 Байпар Сайенсиз, Инк. (Us) Лечение рака ингибиторами топоизомеразы в комбинации с ингибиторами parp

Also Published As

Publication number Publication date
EP2217244A2 (fr) 2010-08-18
MA32748B1 (fr) 2011-11-01
IL205633A0 (en) 2010-11-30
KR20100102607A (ko) 2010-09-24
CN101918003A (zh) 2010-12-15
WO2009064444A9 (fr) 2009-07-02
SG185954A1 (en) 2012-12-28
JP2011503071A (ja) 2011-01-27
AU2008321382A1 (en) 2009-05-22
GT201000137A (es) 2012-04-23
NI201000084A (es) 2011-04-27
EP2217244A4 (fr) 2011-08-31
MX2010005221A (es) 2010-09-28
WO2009064444A2 (fr) 2009-05-22
ECSP10010235A (es) 2010-07-30
CA2705417A1 (fr) 2009-05-22
CR11486A (es) 2013-08-09
US20100009930A1 (en) 2010-01-14
DOP2010000142A (es) 2010-07-31
DOP2012000290A (es) 2013-03-31
CO6290649A2 (es) 2011-06-20
NZ586123A (en) 2012-12-21
US20090123419A1 (en) 2009-05-14

Similar Documents

Publication Publication Date Title
TN2010000209A1 (en) Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents
TN2010000208A1 (en) Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents
IN2012DN02018A (fr)
MX394667B (es) El uso de 1-(4-ciano-3-trifluorometil-fenil)-3-[7-(4- ciano-3-trifluorometll-fen|l)-6-tioxo-5-p-tolilo-5,7-diazaespiro[3.4]oct-8-ilideno]-tiourea.
MX2010006991A (es) Tratamientos de cancer terapeuticos.
MX354099B (es) Antagonistas de activina-actriia y usos para tratar o prevenir cancer de mama.
MX2009010066A (es) Composiciones y metodos para la ablacion especifica de la evasion mutacional de terapias especificas para cancer.
PT2139483E (pt) Terapias de combinação que compreendem um inibidor de quinoxalina de pi3k-alfa para utilizar no tratamento de cancro
MX2009006466A (es) Metodos de tratamiento de cancer con inhibidores del receptor del factor 1 de crecimiento similar a la insulina.
UA95310C2 (ru) Композиция, содержащая ингибитор chk1 и циклодекстрин, для лечения рака
NZ587057A (en) Method of treating prostate cancer with the gnrh antagonist degarelix
JO2886B1 (en) Useful compounds in the inhibition of CHK1
TW200738262A (en) Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis
JO3262B1 (ar) توليفة من ديسيتابين مع مثبط سيتيدين دي أميناز واستخدامها في علاج السرطان
MXPA05011501A (es) Combinacion terapeutica de un inhibidor de cox-2 y un inhibidor de aromatasa.
MXPA05011213A (es) Combinacion de un inhibidor de ciclooxigenasa-2 y un agente antineoplasico tipo alquilacion para tratamiento de neoplasia.
NZ617989A (en) Use of pnp inhibitors such as forodesine in combination with alkylating agents for treating hematologic cancers
UA100869C2 (ru) Лечение рака яичника с помощью соединения йодонитробензамида в комбинации с противоопухолевыми средствами
TW200603792A (en) Monotherapy for the treatment of psoriasis with cyclooxygenase-2 selective inhibitors
UA96736C2 (ru) Ингибиторы pi3k для лечения эндометриоза
UA99934C2 (ru) Лечение рака молочной железы с помощью соединения 4-йодо-3-нитробензамида в комбинации с противоопухолевыми средствами
WO2005082353A3 (fr) B-lapachone et procede de traitement de cancers
WO2009138780A3 (fr) Traitement thérapeutique - 355
UA29209U (ru) Способ хирургического лечения рака молочной железы
HK1147070A (en) Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents