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SV2018005709A - 3-azabiciclo[3.1.0]hexanos sustituidos como inhibidores de cetohexoquinasa - Google Patents

3-azabiciclo[3.1.0]hexanos sustituidos como inhibidores de cetohexoquinasa

Info

Publication number
SV2018005709A
SV2018005709A SV2018005709A SV2018005709A SV2018005709A SV 2018005709 A SV2018005709 A SV 2018005709A SV 2018005709 A SV2018005709 A SV 2018005709A SV 2018005709 A SV2018005709 A SV 2018005709A SV 2018005709 A SV2018005709 A SV 2018005709A
Authority
SV
El Salvador
Prior art keywords
cetohexoquinase
azabiciclo
inhibitors
replaced
hexanos
Prior art date
Application number
SV2018005709A
Other languages
English (en)
Inventor
Matthew Dowling
Dilinie Fernando
Kentaro Futatsugi
Kim Huard
Thomas Victor Magee
Bryan Raymer
Andre Shavna
Aaron Smith
Benjamin Thuma
Andy Tsai
Mehiua Tu
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SV2018005709A publication Critical patent/SV2018005709A/es

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract

EN LA PRESENTE SE PROPORCIONAN 3-AZABICICLO[3.1.0]HEXANOS SUSTITUIDOS COMO INHIBIDORES DE CETOHEXOQUINASA, PROCESOS PARA LA ELABORACIÓN DE ESTOS COMPUESTOS, Y MÉTODOS QUE COMPRENDEN ADMINISTRAR ESTOS COMPUESTOS A UN MAMÍFERO QUE LO NECESITA.
SV2018005709A 2015-12-29 2018-06-13 3-azabiciclo[3.1.0]hexanos sustituidos como inhibidores de cetohexoquinasa SV2018005709A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562272598P 2015-12-29 2015-12-29
US201662423549P 2016-11-17 2016-11-17

Publications (1)

Publication Number Publication Date
SV2018005709A true SV2018005709A (es) 2018-09-10

Family

ID=57755415

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2018005709A SV2018005709A (es) 2015-12-29 2018-06-13 3-azabiciclo[3.1.0]hexanos sustituidos como inhibidores de cetohexoquinasa

Country Status (38)

Country Link
US (6) US9809579B2 (es)
EP (1) EP3397631B1 (es)
JP (1) JP6503515B2 (es)
KR (1) KR102073048B1 (es)
CN (1) CN108473469B (es)
AU (1) AU2016380920B2 (es)
CA (1) CA2952466C (es)
CL (1) CL2018001667A1 (es)
CO (1) CO2018006714A2 (es)
CU (1) CU24540B1 (es)
CY (1) CY1124389T1 (es)
DK (1) DK3397631T3 (es)
EC (1) ECSP18048517A (es)
ES (1) ES2871251T3 (es)
GE (1) GEP20207147B (es)
HR (1) HRP20210769T1 (es)
HU (1) HUE054380T2 (es)
IL (1) IL260330B (es)
LT (1) LT3397631T (es)
MA (1) MA43518B1 (es)
MD (1) MD3397631T2 (es)
MX (1) MX376072B (es)
NI (1) NI201800072A (es)
PE (1) PE20181289A1 (es)
PH (1) PH12018501375A1 (es)
PL (1) PL3397631T3 (es)
PT (1) PT3397631T (es)
RS (1) RS61896B1 (es)
RU (1) RU2696269C1 (es)
SG (1) SG11201804363UA (es)
SI (1) SI3397631T1 (es)
SV (1) SV2018005709A (es)
TN (1) TN2018000198A1 (es)
TW (1) TWI653232B (es)
UA (1) UA121271C2 (es)
UY (1) UY37051A (es)
WO (1) WO2017115205A1 (es)
ZA (1) ZA201803449B (es)

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EP3872080B1 (en) 2016-09-02 2023-08-16 Cyclerion Therapeutics, Inc. Fused bicyclic sgc stimulators
US10558874B1 (en) 2017-01-19 2020-02-11 State Farm Mutual Automobile Insurance Company Apparatuses, systems and methods for generation and transmission of vehicle operation mode data
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TWI707683B (zh) 2018-06-13 2020-10-21 美商輝瑞股份有限公司 Ｇｌｐ－１受體促效劑及其用途
TWI718644B (zh) * 2018-08-31 2021-02-11 美商輝瑞股份有限公司 用於治療ｎａｓｈ／ｎａｆｌｄ和相關疾病之組合
TWI714231B (zh) * 2018-09-04 2020-12-21 美商美國禮來大藥廠 2,6-二胺基吡啶化合物
KR102558308B1 (ko) * 2018-09-27 2023-07-24 주식회사 엘지화학 3-아자바이사이클로[3,1,1]헵탄 유도체 및 이를 포함하는 약제학적 조성물
CN113412260B (zh) * 2019-01-29 2022-08-02 山东轩竹医药科技有限公司 己酮糖激酶抑制剂及其用途
US20220184172A1 (en) * 2019-04-19 2022-06-16 The Regents Of The University Of California Ampk/caspase-6 axis controls liver damage in nonalcoholic steatohepatitis
EP3972596B1 (en) * 2019-05-20 2025-07-16 Pfizer Inc. Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases
CN111978296A (zh) * 2019-05-22 2020-11-24 山东轩竹医药科技有限公司 己酮糖激酶抑制剂及其用途
WO2020243423A1 (en) 2019-05-31 2020-12-03 Ikena Oncology, Inc. Tead inhibitors and uses thereof
TWI750685B (zh) * 2019-06-17 2021-12-21 美商美國禮來大藥廠 二取代吡唑化合物
TWI809334B (zh) 2019-12-10 2023-07-21 美商輝瑞股份有限公司 ２－（（４－（（Ｓ）－２－（５－氯吡啶－２－基）－２－甲基苯并〔ｄ〕〔１，３〕二氧呃－４－基）哌啶－１－基）甲基）－１－（（（Ｓ）－氧呾－２－基）甲基）－１Ｈ－苯并〔ｄ〕咪唑－６－羧酸１，３－二羥基－２－（羥基甲基）丙烷－２－胺鹽之固體形式
CN114846009B (zh) * 2019-12-24 2023-12-12 杭州中美华东制药有限公司 具有khk抑制作用的化合物
CN114846008B (zh) * 2019-12-25 2024-05-28 杭州中美华东制药有限公司 具有果糖激酶(khk)抑制作用的嘧啶类化合物
GB202001856D0 (en) * 2020-02-11 2020-03-25 Inorbit Therapeutics Ab Compounds useful in inhibiting ketohexokinase and methods of making and using the same
CN115361999B (zh) * 2020-02-13 2024-06-11 伊莱利利公司 2-[2-甲基氮杂环丁烷-1-基]-4-苯基-6-(三氟甲基)-嘧啶化合物
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