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MX2017001352A - Derivados de pirrolidinona como inhibidores de metionina aminopeptidasa 2 (metap-2). - Google Patents

Derivados de pirrolidinona como inhibidores de metionina aminopeptidasa 2 (metap-2).

Info

Publication number
MX2017001352A
MX2017001352A MX2017001352A MX2017001352A MX2017001352A MX 2017001352 A MX2017001352 A MX 2017001352A MX 2017001352 A MX2017001352 A MX 2017001352A MX 2017001352 A MX2017001352 A MX 2017001352A MX 2017001352 A MX2017001352 A MX 2017001352A
Authority
MX
Mexico
Prior art keywords
inhibitors
aminopeptidase
pirrolidinone
metionin
metap
Prior art date
Application number
MX2017001352A
Other languages
English (en)
Other versions
MX375438B (es
Inventor
Zenke Frank
Friese-Hamim Manja
Heinrich Timo
Rohdich Felix
Hahn Diane
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2017001352A publication Critical patent/MX2017001352A/es
Publication of MX375438B publication Critical patent/MX375438B/es

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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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Abstract

Compuestos de conformidad con la reivindicación 1 como inhibidores de la metionina aminopeptidasa y que se pueden emplear para el tratamiento de tumores.
MX2017001352A 2014-08-04 2015-07-10 Derivados de pirrolidinona como inhibidores de metionina aminopeptidasa 2 (metap-2). MX375438B (es)

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PCT/EP2015/001421 WO2016020031A1 (en) 2014-08-04 2015-07-10 Pyrrolidinone derivatives as metap-2 inhibitors

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WO2018098781A1 (en) * 2016-12-01 2018-06-07 Eli Lilly And Company Pyrrolidinone compounds
JP2020536898A (ja) 2017-10-10 2020-12-17 バイオジェン インコーポレイテッド スピロ誘導体を調製するためのプロセス
BR112021014220A2 (pt) * 2019-01-22 2022-01-18 Merck Patent Gmbh Derivados heterocíclicos
RS65436B1 (sr) 2019-07-03 2024-05-31 Merck Patent Gmbh Postupak za proizvodnju (s)-3-hidroksi-1-(1h-indol-5-il)-2-okso-pirolidin-3-karboksilne kiseline 3,5-difluoro-benzilamida
CN112480100B (zh) * 2019-09-11 2022-10-14 康威(广州)生物科技有限公司 吡咯烷酮衍生物
CN111728969B (zh) * 2020-08-25 2021-03-19 广州市万千粉丝化妆品有限公司 抗衰老抗氧化的化合物在制备药物或者抗衰老化妆品中的用途
CN111840278B (zh) * 2020-09-12 2021-09-03 自然堂生物科技(广州)有限公司 化合物与维生素e的组合在制备抗衰老药物或者化妆品中的用途
EP4313944A4 (en) * 2021-03-28 2025-03-12 Canwell Biotech Limited Metap-2 inhibitors, pharmaceutical compositions and therapeutic methods thereof
WO2023144053A1 (en) 2022-01-26 2023-08-03 Merck Patent Gmbh Heterocyclic derivatives
WO2023178255A1 (en) * 2022-03-16 2023-09-21 Syndevrx, Inc. Combinations comprising metap2 inhibitors for the treatment of cancer

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DE102010048374A1 (de) * 2010-10-13 2012-04-19 Merck Patent Gmbh Pyrrolidinone als MetAP-2 Inhibitoren
DE102012006884A1 (de) 2012-04-04 2013-10-10 Merck Patent Gmbh Cyclische Amide als MetAP-2 Inhibitoren

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BR112017000730B8 (pt) 2023-01-10
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HUE042064T2 (hu) 2019-06-28
BR112017000730A2 (pt) 2017-11-14
KR102485537B1 (ko) 2023-01-05
DK3177603T3 (en) 2019-01-14
CN106660989A (zh) 2017-05-10
EP3177603B1 (en) 2018-10-31
LT3177603T (lt) 2019-02-11
NZ728847A (en) 2023-05-26
EP3177603A1 (en) 2017-06-14
HRP20190127T1 (hr) 2019-03-22
US20170226080A1 (en) 2017-08-10
JP6619420B2 (ja) 2019-12-11
RU2017107089A (ru) 2018-09-07
IL250422B (en) 2020-03-31
CN106660989B (zh) 2020-07-28
IL250422A0 (en) 2017-03-30
TR201901348T4 (tr) 2019-02-21
AR101414A1 (es) 2016-12-14
WO2016020031A1 (en) 2016-02-11
US10005756B2 (en) 2018-06-26
RS58302B1 (sr) 2019-03-29
JP2017523995A (ja) 2017-08-24
ES2708981T3 (es) 2019-04-12
AU2015299431A1 (en) 2017-03-16
RU2694624C2 (ru) 2019-07-17
CA2957154C (en) 2023-01-10
SI3177603T1 (sl) 2019-02-28
AU2015299431B2 (en) 2019-11-07
MX375438B (es) 2025-03-06
CA2957154A1 (en) 2016-02-11
RU2017107089A3 (es) 2019-01-21
PL3177603T3 (pl) 2019-03-29
PT3177603T (pt) 2019-02-06
SG11201700832YA (en) 2017-03-30

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