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SV2018005776A - Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)-piridin-2-carboxamida - Google Patents

Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)-piridin-2-carboxamida

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Publication number
SV2018005776A
SV2018005776A SV2018005776A SV2018005776A SV2018005776A SV 2018005776 A SV2018005776 A SV 2018005776A SV 2018005776 A SV2018005776 A SV 2018005776A SV 2018005776 A SV2018005776 A SV 2018005776A SV 2018005776 A SV2018005776 A SV 2018005776A
Authority
SV
El Salvador
Prior art keywords
trifluorometil
methylbuty
piridin
indazol
carboxamide
Prior art date
Application number
SV2018005776A
Other languages
English (en)
Inventor
Tobias Thaler
Johannes Platzek
Nicolas Guimond
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of SV2018005776A publication Critical patent/SV2018005776A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • C07B2200/13—Crystalline forms, e.g. polymorphs

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Abstract

LA PRESENTE INVENCIÓN SE REFIERE A LAS FORMAS DE N-[2-(3-HIDROXI-3-METILBUTIL)-6-(2- HIDROXIPROPAN-2-IL)-2H-INDAZOL-5-IL]-6-(TRIFLUOROMETIL)PIRIDIN-2-CARBOXAMIDA, A LOS PROCESOS PARA SU PREPARACIÓN, A LAS COMPOSICIONES FARMACÉUTICAS QUE LAS COMPRENDEN Y A SU USO EN EL CONTROL DE TRASTORNOS
SV2018005776A 2016-04-29 2018-10-29 Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)-piridin-2-carboxamida SV2018005776A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16167650 2016-04-29
EP16167649 2016-04-29

Publications (1)

Publication Number Publication Date
SV2018005776A true SV2018005776A (es) 2019-03-18

Family

ID=58579196

Family Applications (1)

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SV2018005776A SV2018005776A (es) 2016-04-29 2018-10-29 Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)-piridin-2-carboxamida

Country Status (38)

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US (2) US10633365B2 (es)
EP (2) EP3448847A1 (es)
JP (2) JP6916207B2 (es)
KR (2) KR102379948B1 (es)
CN (4) CN118184628A (es)
AU (2) AU2017256659B2 (es)
BR (1) BR112018072247A2 (es)
CA (2) CA3022327C (es)
CL (2) CL2018003097A1 (es)
CO (2) CO2018011607A2 (es)
CU (1) CU24593B1 (es)
DK (1) DK3448849T3 (es)
DO (1) DOP2018000236A (es)
EA (1) EA038103B1 (es)
EC (1) ECSP18081451A (es)
ES (1) ES2801800T3 (es)
GE (1) GEP20217230B (es)
HU (1) HUE049331T2 (es)
IL (2) IL262391B (es)
JO (2) JOP20170101B1 (es)
LT (1) LT3448849T (es)
MA (1) MA44758A (es)
MX (2) MX385470B (es)
NI (1) NI201800111A (es)
NZ (1) NZ746868A (es)
PE (2) PE20190172A1 (es)
PH (1) PH12018502288B1 (es)
PL (1) PL3448849T3 (es)
PT (1) PT3448849T (es)
RS (1) RS60419B1 (es)
SG (2) SG11201809172WA (es)
SI (1) SI3448849T1 (es)
SV (1) SV2018005776A (es)
TN (1) TN2018000359A1 (es)
TW (3) TWI671291B (es)
UA (2) UA123550C2 (es)
UY (2) UY37217A (es)
WO (2) WO2017186693A1 (es)

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US10435396B2 (en) 2016-03-03 2019-10-08 Bayer Pharma Aktiegesellschaft 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs
PT3448849T (pt) 2016-04-29 2020-06-30 Bayer Pharma AG Síntese de indazóis
PL3448848T3 (pl) 2016-04-29 2024-03-11 Bayer Pharma Aktiengesellschaft Postać polimorficzna N-{6-(2-hydroksypropan-2-ylo)-2-[2-(metylosulfonylo)etylo]-2H-indazol-5-ilo}-6-(trifluorometylo)pirydyno-2-karboksyamidu
AU2017272505B9 (en) * 2016-06-01 2021-10-28 Bayer Pharma Aktiengesellschaft Substituted indazoles useful for treatment and prevention of allergic and/or inflammatory diseases in animals
CN109152771B (zh) * 2016-06-01 2022-07-19 拜耳医药股份有限公司 2-取代的吲唑用于治疗和预防自身免疫疾病的用途
BR112020026507A8 (pt) 2018-06-25 2023-01-31 Chia Tai Tianqing Pharmaceutical Group Co Ltd Composto de isotiazolo[5,4-d]pirimidinas como inibidor de irak4
KR102392788B1 (ko) 2019-01-08 2022-04-28 주식회사 엘지에너지솔루션 폴더블 사이드 플레이트를 구비하는 배터리 모듈 및 그 제조 방법
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JO3705B1 (ar) * 2014-11-26 2021-01-31 Bayer Pharma AG إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية
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PL3448848T3 (pl) 2016-04-29 2024-03-11 Bayer Pharma Aktiengesellschaft Postać polimorficzna N-{6-(2-hydroksypropan-2-ylo)-2-[2-(metylosulfonylo)etylo]-2H-indazol-5-ilo}-6-(trifluorometylo)pirydyno-2-karboksyamidu
PT3448849T (pt) 2016-04-29 2020-06-30 Bayer Pharma AG Síntese de indazóis
AU2017272505B9 (en) 2016-06-01 2021-10-28 Bayer Pharma Aktiengesellschaft Substituted indazoles useful for treatment and prevention of allergic and/or inflammatory diseases in animals
CN109152771B (zh) 2016-06-01 2022-07-19 拜耳医药股份有限公司 2-取代的吲唑用于治疗和预防自身免疫疾病的用途

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CN112898269A (zh) 2021-06-04
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JP2019514924A (ja) 2019-06-06
ES2801800T3 (es) 2021-01-13
PE20240651A1 (es) 2024-04-04
IL262391A (en) 2018-12-31
US20190152944A1 (en) 2019-05-23
BR112018072247A2 (pt) 2019-02-12
SG11201808686VA (en) 2018-11-29
KR102379948B1 (ko) 2022-03-31
US10633365B2 (en) 2020-04-28
MX2018013227A (es) 2019-02-13
NZ746868A (en) 2025-05-30
AU2017256659B2 (en) 2021-05-27
UA122882C2 (uk) 2021-01-13
EA038103B1 (ru) 2021-07-06
SG11201809172WA (en) 2018-11-29
JOP20170102B1 (ar) 2023-09-17
CL2018003097A1 (es) 2019-02-15
ECSP18081451A (es) 2018-11-30
WO2017186693A1 (en) 2017-11-02
JP6821701B2 (ja) 2021-01-27
HUE049331T2 (hu) 2020-09-28
PT3448849T (pt) 2020-06-30
EP3448847A1 (en) 2019-03-06
CU20180130A7 (es) 2019-06-04
UY37217A (es) 2017-11-30
KR20190002468A (ko) 2019-01-08
NI201800111A (es) 2019-08-29
TWI671291B (zh) 2019-09-11
US20190144420A1 (en) 2019-05-16
PH12018502288B1 (en) 2022-06-10
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US10501437B2 (en) 2019-12-10
CN109071491B (zh) 2020-08-21
UY37214A (es) 2017-11-30
SI3448849T1 (sl) 2020-07-31
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DK3448849T3 (da) 2020-06-29
UA123550C2 (uk) 2021-04-21
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