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UY37214A - Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2- hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)-piridine-2- carboxamida - Google Patents

Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2- hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)-piridine-2- carboxamida

Info

Publication number
UY37214A
UY37214A UY0001037214A UY37214A UY37214A UY 37214 A UY37214 A UY 37214A UY 0001037214 A UY0001037214 A UY 0001037214A UY 37214 A UY37214 A UY 37214A UY 37214 A UY37214 A UY 37214A
Authority
UY
Uruguay
Prior art keywords
indazol
hidroxipropan
carboxamida
trifluorometil
methylbuty
Prior art date
Application number
UY0001037214A
Other languages
English (en)
Inventor
Johannes Platzek Dr
Tobias Thaler Dr
Nicolas Guimond Dr
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of UY37214A publication Critical patent/UY37214A/es

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    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Organic Chemistry (AREA)
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  • Dermatology (AREA)
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  • Neurology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a las formas de N-[2-(3-Hidroxi-3-metilbutil)-6-(2-hidroxipropan- 2-il)-2H-indazol-5-il]-6-(trifluorometil)piridini-2-carboxamida, a los procesos para su preparación, a las composiciones farmacéuticas que las comprenden y a su uso en el control de trastornos.
UY0001037214A 2016-04-29 2017-04-28 Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2- hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)-piridine-2- carboxamida UY37214A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16167650 2016-04-29
EP16167649 2016-04-29

Publications (1)

Publication Number Publication Date
UY37214A true UY37214A (es) 2017-11-30

Family

ID=58579196

Family Applications (2)

Application Number Title Priority Date Filing Date
UY0001037217A UY37217A (es) 2016-04-29 2017-04-28 Síntesis de indazoles
UY0001037214A UY37214A (es) 2016-04-29 2017-04-28 Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2- hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)-piridine-2- carboxamida

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UY0001037217A UY37217A (es) 2016-04-29 2017-04-28 Síntesis de indazoles

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US (2) US10633365B2 (es)
EP (2) EP3448849B1 (es)
JP (2) JP6916207B2 (es)
KR (2) KR102379948B1 (es)
CN (4) CN112898269A (es)
AU (2) AU2017257208B2 (es)
BR (1) BR112018072247A2 (es)
CA (1) CA3022327C (es)
CL (2) CL2018003085A1 (es)
CO (2) CO2018011607A2 (es)
CU (1) CU24593B1 (es)
DK (1) DK3448849T3 (es)
DO (1) DOP2018000236A (es)
EA (1) EA038103B1 (es)
EC (1) ECSP18081451A (es)
ES (1) ES2801800T3 (es)
GE (1) GEP20217230B (es)
HU (1) HUE049331T2 (es)
IL (2) IL262391B (es)
JO (2) JOP20170102B1 (es)
LT (1) LT3448849T (es)
MA (1) MA44758A (es)
MX (2) MX380550B (es)
NI (1) NI201800111A (es)
NZ (1) NZ746868A (es)
PE (2) PE20190172A1 (es)
PH (1) PH12018502288B1 (es)
PL (1) PL3448849T3 (es)
PT (1) PT3448849T (es)
RS (1) RS60419B1 (es)
SG (2) SG11201808686VA (es)
SI (1) SI3448849T1 (es)
SV (1) SV2018005776A (es)
TN (1) TN2018000359A1 (es)
TW (3) TW201936599A (es)
UA (2) UA122882C2 (es)
UY (2) UY37217A (es)
WO (2) WO2017186693A1 (es)

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MA44759B1 (fr) 2016-04-29 2024-01-31 Bayer Pharma AG Forme polymorphe de n-(6-(2-hydroxypropan-2-yl)-2-[2-(méthylsulfonyl)éthyl]-2h-indazol-5-yl)-6-(trifluorométhyl)pyridine-2-carboxamide
LT3448849T (lt) 2016-04-29 2020-09-25 Bayer Pharma Aktiengesellschaft Indazolo sintezė
CN120531733A (zh) 2016-06-01 2025-08-26 礼蓝动物保健有限公司 用于治疗和预防动物的过敏性和/或炎症性疾病的取代吲唑
JP7099966B2 (ja) * 2016-06-01 2022-07-12 バイエル・ファルマ・アクティエンゲゼルシャフト 自己免疫疾患を治療および予防するための２－置換インダゾールの使用
EP3816164B9 (en) 2018-06-25 2024-07-10 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Isothiazolo[5,4-d]pyrimidine compound as irak4 inhibitor
KR102392788B1 (ko) 2019-01-08 2022-04-28 주식회사 엘지에너지솔루션 폴더블 사이드 플레이트를 구비하는 배터리 모듈 및 그 제조 방법
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LT3448849T (lt) 2016-04-29 2020-09-25 Bayer Pharma Aktiengesellschaft Indazolo sintezė
JP7099966B2 (ja) 2016-06-01 2022-07-12 バイエル・ファルマ・アクティエンゲゼルシャフト 自己免疫疾患を治療および予防するための２－置換インダゾールの使用
CN120531733A (zh) 2016-06-01 2025-08-26 礼蓝动物保健有限公司 用于治疗和预防动物的过敏性和/或炎症性疾病的取代吲唑

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ES2801800T3 (es) 2021-01-13
BR112018072213A2 (pt) 2019-02-12
UA122882C2 (uk) 2021-01-13
TW201738233A (zh) 2017-11-01
MX2018013232A (es) 2019-02-13
WO2017186693A1 (en) 2017-11-02
TW201738231A (zh) 2017-11-01
MX380550B (es) 2025-03-12
PH12018502288A1 (en) 2019-07-15
CU24593B1 (es) 2022-05-11
US20190152944A1 (en) 2019-05-23
SG11201809172WA (en) 2018-11-29
IL262391A (en) 2018-12-31
IL262413B (en) 2021-05-31
EP3448849A1 (en) 2019-03-06
TWI651316B (zh) 2019-02-21
CL2018003097A1 (es) 2019-02-15
JOP20170102B1 (ar) 2023-09-17
IL262413A (en) 2018-12-31
MX2018013227A (es) 2019-02-13
CO2018011655A2 (es) 2018-11-13
CN109415339A (zh) 2019-03-01
BR112018072247A2 (pt) 2019-02-12
TWI671291B (zh) 2019-09-11
CN112898269A (zh) 2021-06-04
EP3448847A1 (en) 2019-03-06
JP6916207B2 (ja) 2021-08-11
SG11201808686VA (en) 2018-11-29
AU2017257208A1 (en) 2018-11-01
AU2017256659A1 (en) 2018-10-25
DOP2018000236A (es) 2019-01-15
IL262391B (en) 2022-03-01
US10633365B2 (en) 2020-04-28
ECSP18081451A (es) 2018-11-30
HUE049331T2 (hu) 2020-09-28
US10501437B2 (en) 2019-12-10
LT3448849T (lt) 2020-09-25
CA3022329A1 (en) 2017-11-02
EA201892407A1 (ru) 2019-05-31
CL2018003085A1 (es) 2019-02-15
JP2019514921A (ja) 2019-06-06
PL3448849T3 (pl) 2020-12-14
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EA038103B1 (ru) 2021-07-06
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SI3448849T1 (sl) 2020-07-31
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KR20180137498A (ko) 2018-12-27
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