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SV2018005610A - Derivados de oxopiridina sustituidos - Google Patents

Derivados de oxopiridina sustituidos

Info

Publication number
SV2018005610A
SV2018005610A SV2018005610A SV2018005610A SV2018005610A SV 2018005610 A SV2018005610 A SV 2018005610A SV 2018005610 A SV2018005610 A SV 2018005610A SV 2018005610 A SV2018005610 A SV 2018005610A SV 2018005610 A SV2018005610 A SV 2018005610A
Authority
SV
El Salvador
Prior art keywords
oxopiridine
derivatives
substituted
thermal
bottombodious
Prior art date
Application number
SV2018005610A
Other languages
English (en)
Inventor
Nunes Eloisa Jimenez
Jens Ackerstaff
Susanne Röhrig
Alexander Hillisch
Katharina Meier
Jan Stampfuss
Pascal Ellerbrock
Daniel Meibom
Dieter Lang
Stefan Heitmeier
Adrian Tersteegen
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of SV2018005610A publication Critical patent/SV2018005610A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

LA INVENCIÓN SE REFIERE A DERIVADOS DE OXOPIRIDINA SUSTITUIDOS Y A PROCESOS PARA SU PREPARACIÓN, Y TAMBIÉN A SU USO PARA PREPARAR MEDICAMENTOS PARA EL TRATAMIENTO Y/O PROFILAXIS DE ENFERMEDADES, EN PARTICULAR ENFERMEDADES CARDIOVASCULARES, PREFERENTEMENTE TRASTORNOS TROMBÓTICOS O TROMBOEMBÓLICOS, Y EDEMAS, Y TAMBIÉN TRASTORNOS OFTÁLMICOS
SV2018005610A 2015-07-09 2018-01-08 Derivados de oxopiridina sustituidos SV2018005610A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15176099 2015-07-09
EP16157350 2016-02-25

Publications (1)

Publication Number Publication Date
SV2018005610A true SV2018005610A (es) 2018-04-27

Family

ID=56345141

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2018005610A SV2018005610A (es) 2015-07-09 2018-01-08 Derivados de oxopiridina sustituidos

Country Status (39)

Country Link
US (4) US10421742B2 (es)
EP (1) EP3319956B1 (es)
JP (1) JP6871180B2 (es)
KR (1) KR102596164B1 (es)
CN (2) CN108026072B (es)
AU (1) AU2016289746B2 (es)
CA (1) CA2990901C (es)
CL (1) CL2018000039A1 (es)
CO (1) CO2018000113A2 (es)
CR (1) CR20180017A (es)
CU (1) CU24512B1 (es)
CY (1) CY1123996T1 (es)
DK (1) DK3319956T3 (es)
DO (1) DOP2018000004A (es)
EA (1) EA036208B1 (es)
EC (1) ECSP18001308A (es)
ES (1) ES2856554T3 (es)
GE (1) GEP20197046B (es)
HR (1) HRP20210459T1 (es)
HU (1) HUE053552T2 (es)
IL (1) IL256556B (es)
JO (1) JO3703B1 (es)
LT (1) LT3319956T (es)
MA (1) MA42376B1 (es)
MX (1) MX377903B (es)
MY (1) MY196640A (es)
NI (1) NI201800001A (es)
PE (1) PE20180538A1 (es)
PH (1) PH12018500057A1 (es)
PL (1) PL3319956T3 (es)
RS (1) RS61584B1 (es)
SI (1) SI3319956T1 (es)
SV (1) SV2018005610A (es)
TN (1) TN2018000011A1 (es)
TW (1) TWI717367B (es)
UA (1) UA122341C2 (es)
UY (1) UY36780A (es)
WO (1) WO2017005725A1 (es)
ZA (1) ZA201800826B (es)

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JO3703B1 (ar) * 2015-07-09 2021-01-31 Bayer Pharma AG مشتقات أوكسوبيريدين مستبدلة
CN108495850B (zh) 2016-08-31 2021-11-26 江苏恒瑞医药股份有限公司 氧代吡啶酰胺类衍生物、其制备方法及其在医药上的应用
CN111770917B (zh) 2018-03-15 2023-09-26 拜耳股份公司 两种化合物的制备方法
WO2019197244A1 (en) 2018-04-10 2019-10-17 Bayer Pharma Aktiengesellschaft A substituted oxopyridine derivative
WO2020007256A1 (zh) 2018-07-02 2020-01-09 江苏恒瑞医药股份有限公司 一种氧代吡啶酰胺类衍生物的晶型及制备方法
AR115870A1 (es) 2018-07-31 2021-03-10 Sumitomo Chemical Co MÉTODO PARA CONTROLAR EL HONGO DE LA ROYA DE LA SOJA QUE TIENE RESISTENCIA AL INHIBIDOR DE SITIO Qₒ
EP3898611A1 (en) * 2018-12-17 2021-10-27 Bayer Aktiengesellschaft Substituted oxopyridine derivatives for the treatment and/or prophylaxis of thrombotic or thromboembolic disorders and/or thrombotic or thromboembolic complications
WO2020127508A1 (en) 2018-12-21 2020-06-25 Bayer Aktiengesellschaft Substituted oxopyridine derivatives
PE20211790A1 (es) 2018-12-21 2021-09-09 Bayer Ag Derivados de oxopiridina sustituidos
CA3152667A1 (en) 2019-09-27 2021-04-01 Shenzhen Salubris Pharmaceuticals Co. Ltd. Fxia inhibitors and preparation method therefor and pharmaceutical use thereof
CN116348109B (zh) 2020-09-17 2025-01-21 浙江海正药业股份有限公司 哌嗪类衍生物及其制备方法和用途
CN114621140B (zh) * 2020-12-10 2023-08-11 中国科学院上海药物研究所 芳基二氟乙酰胺化合物及其制备方法和用途
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IL305235A (en) 2021-03-09 2023-10-01 Bayer Ag Pharmaceutical dosage forms comprising (4s)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32,5- dioxo-14-(trifluoromethyl)-32h-6-aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola-2(1,2),7(1)- dibenzenaheptaphane-74-carboxamide
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US11814364B2 (en) 2021-03-18 2023-11-14 Janssen Pharmaceutica Nv Pyridine N-oxide derivatives useful as factor XIa inhibitors
US11919881B2 (en) 2021-03-18 2024-03-05 Janssen Pharmaceutica Nv Substituted pyridine N-oxide derivatives useful as a factor XIa inhibitors
CN113666826B (zh) * 2021-07-30 2024-03-26 五邑大学 一种芳基或杂芳基甲氧基化反应的方法
CN116199672A (zh) * 2021-11-30 2023-06-02 成都泰和伟业生物科技有限公司 一种嘧啶酰胺类衍生物及其制备方法和用途
WO2023174399A1 (zh) * 2022-03-18 2023-09-21 苏州晶云药物科技股份有限公司 取代的氧代吡啶类衍生物的晶型及其制备方法
CN116262740A (zh) * 2022-11-18 2023-06-16 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其制备方法和用途
CN116262734B (zh) * 2022-11-18 2025-05-13 成都施贝康生物医药科技有限公司 氧代吡啶类化合物及其制备方法和用途
CN116262735B (zh) * 2022-11-18 2025-05-13 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其制备方法和用途
CN116082303B (zh) 2022-12-21 2025-02-25 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其中间体和应用
CN116262736B (zh) * 2022-12-26 2025-05-13 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其制备方法和用途
AU2024248738A1 (en) 2023-03-31 2025-09-11 Bayer Aktiengesellschaft Pharmaceutical dosage forms comprising (4s)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32,5- dioxo-14-(trifluoromethyl)-32h-6-aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola-2(1,2),7(1)-dibenzenaheptaphane-74-carboxamide
CN116535392B (zh) * 2023-06-26 2023-09-05 成都施贝康生物医药科技有限公司 一种氧代吡啶类化合物的制备方法及中间体和应用
WO2024251276A1 (zh) * 2023-06-09 2024-12-12 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体和应用
CN116751136B (zh) * 2023-06-21 2025-08-29 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116621728B (zh) * 2023-06-09 2025-07-29 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116621742B (zh) * 2023-06-09 2025-05-06 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116730861A (zh) * 2023-06-21 2023-09-12 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116874387B (zh) * 2023-06-21 2025-08-26 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN117164562B (zh) * 2023-09-07 2025-06-13 成都施贝康生物医药科技有限公司 一种氧代哒嗪类化合物及其制备方法和用途
CN117164564B (zh) * 2023-09-07 2025-07-08 成都施贝康生物医药科技有限公司 氧代哒嗪类化合物及其制备方法和用途
CN117164563B (zh) * 2023-09-07 2025-06-10 成都施贝康生物医药科技有限公司 氧代嘧啶类化合物及其制备方法和用途
CN117164565B (zh) * 2023-09-07 2025-05-27 成都施贝康生物医药科技有限公司 一种氧代嘧啶类化合物及其制备方法和用途
CN117164561A (zh) * 2023-09-07 2023-12-05 成都施贝康生物医药科技有限公司 一种氧代嘧啶类化合物及其制备方法和用途
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US20230024752A1 (en) 2023-01-26
CU24512B1 (es) 2021-05-12
JO3703B1 (ar) 2021-01-31
HRP20210459T1 (hr) 2021-05-14
PE20180538A1 (es) 2018-03-20
CN108026072A (zh) 2018-05-11
AU2016289746A1 (en) 2018-01-25
CN113292539A (zh) 2021-08-24
DK3319956T3 (da) 2021-03-29
ECSP18001308A (es) 2018-03-31
CL2018000039A1 (es) 2018-07-13
RS61584B1 (sr) 2021-04-29
MA42376B1 (fr) 2021-04-30
MX2018000076A (es) 2018-02-26
LT3319956T (lt) 2021-02-10
TN2018000011A1 (en) 2019-07-08
US11180471B2 (en) 2021-11-23
IL256556B (en) 2021-02-28
MY196640A (en) 2023-04-25
BR112018000209A2 (pt) 2018-09-04
CO2018000113A2 (es) 2018-06-12
GEP20197046B (en) 2019-12-10
IL256556A (en) 2018-02-28
EP3319956B1 (en) 2021-01-06
CA2990901A1 (en) 2017-01-12
HUE053552T2 (hu) 2021-07-28
CA2990901C (en) 2024-11-12
JP2018519323A (ja) 2018-07-19
NZ739109A (en) 2024-09-27
ZA201800826B (en) 2021-08-25
CR20180017A (es) 2018-03-07
KR20180026761A (ko) 2018-03-13
JP6871180B2 (ja) 2021-05-12
MX377903B (es) 2025-03-10
CN113292539B (zh) 2023-12-22
PL3319956T3 (pl) 2021-07-05
CN108026072B (zh) 2021-08-17
TWI717367B (zh) 2021-02-01
US20190367478A1 (en) 2019-12-05
US10421742B2 (en) 2019-09-24
CU20180001A7 (es) 2018-06-05
AU2016289746B2 (en) 2020-08-20
NI201800001A (es) 2018-10-19
HK1255045A1 (zh) 2019-08-02
EA036208B1 (ru) 2020-10-14
SI3319956T1 (sl) 2021-02-26
CY1123996T1 (el) 2022-07-22
EP3319956A1 (en) 2018-05-16
UA122341C2 (uk) 2020-10-26
US20250282748A1 (en) 2025-09-11
US20180194745A1 (en) 2018-07-12
ES2856554T3 (es) 2021-09-27
MA42376A (fr) 2018-05-16
WO2017005725A1 (en) 2017-01-12
KR102596164B1 (ko) 2023-11-01
TW201706261A (zh) 2017-02-16
DOP2018000004A (es) 2018-01-31
EA201890111A1 (ru) 2018-06-29
UY36780A (es) 2017-01-31
PH12018500057A1 (en) 2018-07-09

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