SMT202000328T1 - Uso dell'inibitore di telomelstat per il trattamento di sindrome mielodisplastica - Google Patents

Uso dell'inibitore di telomelstat per il trattamento di sindrome mielodisplastica

Info

Publication number: SMT202000328T1
Authority: SM; San Marino
Prior art keywords: treatment; myelodysplastic syndrome; telomerase inhibitor; imetelstat; inhibitor imetelstat
Prior art date: 2012-12-07

Application number

SM20200328T

Other languages

English (en)

Inventor

Monic J Stuart

Stephen Kelsey

Original Assignee

Geron Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-12-07

Filing date

2013-11-15

Publication date

2020-07-08

2013-03-15 Priority claimed from US13/841,711 external-priority patent/US9375485B2/en

2013-11-15 Application filed by Geron Corp filed Critical Geron Corp

2020-07-08 Publication of SMT202000328T1 publication Critical patent/SMT202000328T1/it

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/314—Phosphoramidates
- C12N2310/3145—Phosphoramidates with the nitrogen in 3' or 5'-position
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Hematology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Diabetes (AREA)
Virology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Dermatology (AREA)
Medicinal Preparation (AREA)
Otolaryngology (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

SM20200328T 2012-12-07 2013-11-15 Uso dell'inibitore di telomelstat per il trattamento di sindrome mielodisplastica SMT202000328T1 (it)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US201261734941P	2012-12-07	2012-12-07
US201361799069P	2013-03-15	2013-03-15
US13/841,711 US9375485B2 (en)	2012-12-07	2013-03-15	Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
US201361900347P	2013-11-05	2013-11-05
EP18196690.4A EP3456333B8 (en)	2012-12-07	2013-11-15	Use of the telomerase inhibitor imetelstat for the treatment of myelodysplastic syndrome

Publications (1)

Publication Number	Publication Date
SMT202000328T1 true SMT202000328T1 (it)	2020-07-08

Family

ID=50883867

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SM20190567T SMT201900567T1 (it)	2012-12-07	2013-11-15	Uso dell’inibitore di telomerasi imetelstat per il trattamento di mielofibrosi
SM20200328T SMT202000328T1 (it)	2012-12-07	2013-11-15	Uso dell'inibitore di telomelstat per il trattamento di sindrome mielodisplastica

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
SM20190567T SMT201900567T1 (it)	2012-12-07	2013-11-15	Uso dell’inibitore di telomerasi imetelstat per il trattamento di mielofibrosi

Country Status (37)

Country	Link
EP (3)	EP3456333B8 (it)
JP (6)	JP6433911B2 (it)
KR (4)	KR102294819B1 (it)
CN (2)	CN111617252A (it)
AP (1)	AP2015008504A0 (it)
AU (4)	AU2013356533B2 (it)
BR (1)	BR112015013260A2 (it)
CA (2)	CA3188494A1 (it)
CL (2)	CL2015001530A1 (it)
CY (2)	CY1122169T1 (it)
DK (3)	DK3646876T3 (it)
EA (1)	EA032973B1 (it)
ES (3)	ES2982897T3 (it)
FI (2)	FI3646876T3 (it)
FR (1)	FR25C1016I1 (it)
HK (1)	HK1210940A1 (it)
HR (3)	HRP20240624T1 (it)
HU (4)	HUE066402T2 (it)
IL (3)	IL280144B2 (it)
LT (4)	LT3646876T (it)
MA (2)	MA45504B1 (it)
ME (1)	ME03538B (it)
MX (3)	MX372753B (it)
MY (2)	MY180634A (it)
NL (1)	NL301326I2 (it)
NZ (1)	NZ708920A (it)
PH (2)	PH12019501008A1 (it)
PL (3)	PL2928477T3 (it)
PT (3)	PT3456333T (it)
RS (2)	RS59363B1 (it)
SG (3)	SG11201504383TA (it)
SI (3)	SI3456333T1 (it)
SM (2)	SMT201900567T1 (it)
TN (1)	TN2015000249A1 (it)
UA (3)	UA128370C2 (it)
WO (1)	WO2014088785A1 (it)
ZA (3)	ZA201504124B (it)

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RS56361B1 (sr)	2004-07-02	2017-12-29	Geron Corp	Sinteza zaštićenih 3'-amino nukleozidnih monomera
US9375485B2 (en)	2012-12-07	2016-06-28	Geron Corporation	Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
WO2015021153A1 (en)	2013-08-07	2015-02-12	Incyte Corporation	Sustained release dosage forms for a jak1 inhibitor
ES2717777T3 (es) *	2013-11-06	2019-06-25	Mayo Found Medical Education & Res	Métodos y materiales para tratar neoplasias hematológicas
MA42569B1 (fr)	2015-04-23	2020-08-31	Geron Corp	Procédés de préparation de polynucléotides à l'aide de compositions de sel cationique multivalent
EP3318276A1 (en) *	2016-11-04	2018-05-09	Janssen Biotech, Inc.	Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers
TWI879717B (zh)	2017-07-28	2025-04-11	美商傑龍公司	治療骨髓增生不良症候群之方法
IL319432A (en)	2018-04-30	2025-05-01	Kartos Therapeutics Inc	Methods of treating cancer
KR20210043499A (ko)	2018-05-25	2021-04-21	카토스 테라퓨틱스, 인크.	골수증식성 신생물 치료 방법
EP3829651A4 (en) *	2018-07-31	2022-05-04	Geron Corporation	METHODS OF IDENTIFYING PATIENTS WHO WILL BENEFIT FROM TREATMENT WITH A TELOMERASE INHIBITOR
SG11202105573PA (en)	2018-11-29	2021-06-29	Geron Corp	Methods of treating myelodysplastic syndrome
EP4054594A4 (en) *	2019-11-04	2023-12-13	Geron Corporation	USE OF A JANUS KINASE INHIBITOR AND A TELOMERASE INHIBITOR FOR THE TREATMENT OF MYELOPROLIFERATIVE NEOPLASMS
JP2021157248A (ja) *	2020-03-25	2021-10-07	パイオニア株式会社	状況出力装置
CN115776909A (zh) *	2020-07-17	2023-03-10	美国杰龙生物医药公司	皮下端粒酶抑制剂组合物及其使用方法
WO2022159760A1 (en) *	2021-01-22	2022-07-28	The Regents Of The University Of California	Methods for treating and ameliorating cancer
WO2024259369A1 (en) *	2023-06-14	2024-12-19	Rarecells Inc.	Compositions targeting giant cells in blood disorders

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US5583016A (en)	1994-07-07	1996-12-10	Geron Corporation	Mammalian telomerase
US5958680A (en)	1994-07-07	1999-09-28	Geron Corporation	Mammalian telomerase
US5863936A (en)	1995-04-18	1999-01-26	Geron Corporation	Telomerase inhibitors
US5656638A (en)	1995-04-18	1997-08-12	Geron Corporation	Telomerase inhibitors
US5760062A (en)	1995-04-18	1998-06-02	Geron Corporation	Telomerase inhibitors
US5770613A (en)	1995-09-29	1998-06-23	Geron Corporation	Telomerase inhibitors
US5767278A (en)	1995-10-06	1998-06-16	Geron Corporation	Telomerase inhibitors
US6261836B1 (en)	1996-10-01	2001-07-17	Geron Corporation	Telomerase
US6444650B1 (en)	1996-10-01	2002-09-03	Geron Corporation	Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
AU733610B2 (en)	1996-12-20	2001-05-17	Geron Corporation	Methods for detecting and inhibiting the RNA component of telomerase
US6331399B1 (en)	2000-05-16	2001-12-18	Isis Pharmaceuticals, Inc.	Antisense inhibition of tert expression
AU2004209428A1 (en) *	2003-01-31	2004-08-19	Jessie L.-S. Au	Methods and compositions for using suramin, pentosan polysulfate, telomerase antisense, and telomerase inhibitors
CN1244592C (zh) *	2003-07-11	2006-03-08	暨南大学	抑制白血病细胞端粒酶活性的反义核酸及其应用
JP4690324B2 (ja)	2003-09-09	2011-06-01	ジェロン・コーポレーション	テロメラーゼ阻害のための改変オリゴヌクレオチド
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PL2101789T3 (pl)	2006-10-30	2015-05-29	Geron Corp	Inhibitor telomerazy skojarzony z gemcytabiną do leczenia nowotworu
CN101220044B (zh) *	2008-01-21	2010-06-02	中国药科大学	端粒酶抑制剂及其制备方法和用途

2013
- 2013-11-15 RS RSP20191271 patent/RS59363B1/sr unknown
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- 2013-11-15 SM SM20190567T patent/SMT201900567T1/it unknown
- 2013-11-15 EP EP18196690.4A patent/EP3456333B8/en active Active
- 2013-11-15 SG SG11201504383TA patent/SG11201504383TA/en unknown
- 2013-11-15 SM SM20200328T patent/SMT202000328T1/it unknown
- 2013-11-15 DK DK19187756.2T patent/DK3646876T3/da active
- 2013-11-15 AU AU2013356533A patent/AU2013356533B2/en active Active
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- 2013-11-15 KR KR1020237005641A patent/KR20230028590A/ko not_active Ceased
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- 2013-11-15 KR KR1020217026717A patent/KR102662590B1/ko active Active
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2015
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- 2015-06-07 IL IL23926615A patent/IL239266B/en active IP Right Grant
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2017
- 2017-08-24 CL CL2017002156A patent/CL2017002156A1/es unknown
- 2017-12-04 JP JP2017232485A patent/JP6998191B2/ja active Active
2018
- 2018-12-20 AU AU2018282364A patent/AU2018282364A1/en not_active Abandoned
2019
- 2019-10-14 CY CY20191101076T patent/CY1122169T1/el unknown
- 2019-12-23 JP JP2019231517A patent/JP2020041001A/ja active Pending
2020
- 2020-06-23 CY CY20201100568T patent/CY1123206T1/el unknown
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2021
- 2021-11-12 ZA ZA2021/08991A patent/ZA202108991B/en unknown
2022
- 2022-01-06 JP JP2022000951A patent/JP7288098B2/ja active Active
- 2022-10-12 JP JP2022163881A patent/JP2022179684A/ja not_active Withdrawn
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2024
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2025
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FI3646876T3 (fi)	2024-05-14
JP2016504307A (ja)	2016-02-12
PT3646876T (pt)	2024-05-15
DK2928477T3 (da)	2019-10-07
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MY200076A (en)	2023-12-06
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MX2020003276A (es)	2020-07-20
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JP2025109842A (ja)	2025-07-25
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IL239266B (en)	2019-11-28
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EP2928477A4 (en)	2016-09-21
HK1212226A1 (en)	2016-06-10
SG10201802926XA (en)	2018-05-30

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