LT2928477T - Telomerazės inhibitoriaus imetelstato panaudojimas mielofibrozės gydymui - Google Patents

Telomerazės inhibitoriaus imetelstato panaudojimas mielofibrozės gydymui

Info

Publication number: LT2928477T
Authority: LT; Lithuania
Prior art keywords: myelofibrose; imetelstate; treatment; telomerase inhibitor; telomerase
Prior art date: 2012-12-07

Application number

LTEP13861008.4T

Other languages

English (en)

Inventor

Monic STUART

Stephen Kelsey

Original Assignee

Geron Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-12-07

Filing date

2013-11-15

Publication date

2019-10-10

2013-03-15 Priority claimed from US13/841,711 external-priority patent/US9375485B2/en

2013-11-15 Application filed by Geron Corporation filed Critical Geron Corporation

2019-10-10 Publication of LT2928477T publication Critical patent/LT2928477T/lt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/314—Phosphoramidates
- C12N2310/3145—Phosphoramidates with the nitrogen in 3' or 5'-position
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Hematology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Zoology (AREA)
Diabetes (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Virology (AREA)
Microbiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Dermatology (AREA)
Medicinal Preparation (AREA)
Physiology (AREA)
Otolaryngology (AREA)
Nutrition Science (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

LTEP13861008.4T 2012-12-07 2013-11-15 Telomerazės inhibitoriaus imetelstato panaudojimas mielofibrozės gydymui LT2928477T (lt)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US201261734941P	2012-12-07	2012-12-07
US201361799069P	2013-03-15	2013-03-15
US13/841,711 US9375485B2 (en)	2012-12-07	2013-03-15	Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
US201361900347P	2013-11-05	2013-11-05
PCT/US2013/070437 WO2014088785A1 (en)	2012-12-07	2013-11-15	Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms

Publications (1)

Publication Number	Publication Date
LT2928477T true LT2928477T (lt)	2019-10-10

Family

ID=50883867

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
LTEP18196690.4T LT3456333T (lt)	2012-12-07	2013-11-15	Telomerazės inhibitoriaus imetelstato panaudojimas mielodisplastinio sindromo gydymui
LTEP19187756.2T LT3646876T (lt)	2012-12-07	2013-11-15	Telomerazės inhibitorius imetelstatas, skirtas mieloproliferacinių sutrikimų ir mieloproliferacinių navikų gydymui
LTEP13861008.4T LT2928477T (lt)	2012-12-07	2013-11-15	Telomerazės inhibitoriaus imetelstato panaudojimas mielofibrozės gydymui
LTPA2025517C LTPA2025517I1 (lt)	2012-12-07	2025-05-06

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
LTEP18196690.4T LT3456333T (lt)	2012-12-07	2013-11-15	Telomerazės inhibitoriaus imetelstato panaudojimas mielodisplastinio sindromo gydymui
LTEP19187756.2T LT3646876T (lt)	2012-12-07	2013-11-15	Telomerazės inhibitorius imetelstatas, skirtas mieloproliferacinių sutrikimų ir mieloproliferacinių navikų gydymui

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
LTPA2025517C LTPA2025517I1 (lt)	2012-12-07	2025-05-06

Country Status (37)

Country	Link
EP (3)	EP3456333B8 (lt)
JP (6)	JP6433911B2 (lt)
KR (4)	KR102662590B1 (lt)
CN (2)	CN111617252A (lt)
AP (1)	AP2015008504A0 (lt)
AU (4)	AU2013356533B2 (lt)
BR (1)	BR112015013260A2 (lt)
CA (2)	CA2892907C (lt)
CL (2)	CL2015001530A1 (lt)
CY (2)	CY1122169T1 (lt)
DK (3)	DK2928477T3 (lt)
EA (1)	EA032973B1 (lt)
ES (3)	ES2789176T3 (lt)
FI (2)	FI3646876T3 (lt)
FR (1)	FR25C1016I1 (lt)
HK (1)	HK1210940A1 (lt)
HR (3)	HRP20240624T1 (lt)
HU (4)	HUE066402T2 (lt)
IL (3)	IL280144B2 (lt)
LT (4)	LT3456333T (lt)
MA (2)	MA38193B1 (lt)
ME (1)	ME03538B (lt)
MX (3)	MX372753B (lt)
MY (2)	MY200076A (lt)
NL (1)	NL301326I2 (lt)
NZ (1)	NZ708920A (lt)
PH (2)	PH12019501008A1 (lt)
PL (3)	PL2928477T3 (lt)
PT (3)	PT3456333T (lt)
RS (2)	RS59363B1 (lt)
SG (3)	SG10202103341SA (lt)
SI (3)	SI3646876T1 (lt)
SM (2)	SMT202000328T1 (lt)
TN (1)	TN2015000249A1 (lt)
UA (3)	UA128370C2 (lt)
WO (1)	WO2014088785A1 (lt)
ZA (3)	ZA201504124B (lt)

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EP3296312B1 (en)	2004-07-02	2021-03-17	Geron Corporation	Synthesis of protected 3'-amino 5'-phosphoramidite nucleoside monomers
US9375485B2 (en)	2012-12-07	2016-06-28	Geron Corporation	Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
KR20160045081A (ko)	2013-08-07	2016-04-26	인사이트 코포레이션	Jak1 억제제용 지속 방출 복용 형태
AU2014346840B2 (en) *	2013-11-06	2020-02-06	Mayo Foundation For Medical Education And Research	Methods and materials for treating hematological malignancies
EA035885B1 (ru)	2015-04-23	2020-08-27	Джерон Корпорейшн	Способы получения полинуклеотидов с использованием композиций солей поливалентных катионов
EP3318276A1 (en) *	2016-11-04	2018-05-09	Janssen Biotech, Inc.	Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers
KR20250151565A (ko) *	2017-07-28	2025-10-21	제론 코포레이션	골수형성이상 증후군의 치료 방법
IL308399B2 (en)	2018-04-30	2025-08-01	Kartos Therapeutics Inc	Methods of treating cancer
US12268681B2 (en)	2018-05-25	2025-04-08	Kartos Therapeutics, Inc.	Methods of treating myeloproliferative neoplasms
CN112770783B (zh) *	2018-07-31	2025-02-25	美国杰龙生物医药公司	鉴定可能从端粒酶抑制剂治疗中受益的患者的方法
AU2019389005B2 (en)	2018-11-29	2024-06-20	Geron Corporation	Methods of treating myelodysplastic syndrome
JP7767279B2 (ja) *	2019-11-04	2025-11-11	ジェロン・コーポレーション	骨髄増殖性腫瘍の治療のためのヤヌスキナーゼ阻害剤およびテロメラーゼ阻害剤の使用
JP2021157248A (ja) *	2020-03-25	2021-10-07	パイオニア株式会社	状況出力装置
KR20230041707A (ko) *	2020-07-17	2023-03-24	제론 코포레이션	피하 텔로머라제 억제제 조성물 및 이의 사용 방법
EP4281560A4 (en) *	2021-01-22	2025-04-16	The Regents of the University of California	METHODS FOR THE TREATMENT AND Palliation of Cancer
WO2024259369A1 (en) *	2023-06-14	2024-12-19	Rarecells Inc.	Compositions targeting giant cells in blood disorders

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2013
- 2013-11-15 UA UAA202100419A patent/UA128370C2/uk unknown
- 2013-11-15 BR BR112015013260-0A patent/BR112015013260A2/pt not_active Application Discontinuation
- 2013-11-15 DK DK13861008.4T patent/DK2928477T3/da active
- 2013-11-15 HU HUE19187756A patent/HUE066402T2/hu unknown
- 2013-11-15 KR KR1020217026717A patent/KR102662590B1/ko active Active
- 2013-11-15 ES ES18196690T patent/ES2789176T3/es active Active
- 2013-11-15 HK HK15111700.1A patent/HK1210940A1/xx unknown
- 2013-11-15 SG SG10202103341SA patent/SG10202103341SA/en unknown
- 2013-11-15 CA CA2892907A patent/CA2892907C/en active Active
- 2013-11-15 ES ES19187756T patent/ES2982897T3/es active Active
- 2013-11-15 ME MEP-2019-273A patent/ME03538B/me unknown
- 2013-11-15 PH PH1/2019/501008A patent/PH12019501008A1/en unknown
- 2013-11-15 SG SG10201802926XA patent/SG10201802926XA/en unknown
- 2013-11-15 MA MA38193A patent/MA38193B1/fr unknown
- 2013-11-15 HU HUE13861008A patent/HUE045098T2/hu unknown
- 2013-11-15 KR KR1020157017240A patent/KR102294819B1/ko active Active
- 2013-11-15 LT LTEP18196690.4T patent/LT3456333T/lt unknown
- 2013-11-15 EP EP18196690.4A patent/EP3456333B8/en active Active
- 2013-11-15 UA UAA201505480A patent/UA117116C2/uk unknown
- 2013-11-15 EA EA201590878A patent/EA032973B1/ru unknown
- 2013-11-15 RS RSP20191271 patent/RS59363B1/sr unknown
- 2013-11-15 SG SG11201504383TA patent/SG11201504383TA/en unknown
- 2013-11-15 PT PT181966904T patent/PT3456333T/pt unknown
- 2013-11-15 EP EP19187756.2A patent/EP3646876B1/en active Active
- 2013-11-15 HR HRP20240624TT patent/HRP20240624T1/hr unknown
- 2013-11-15 CA CA3188494A patent/CA3188494A1/en active Pending
- 2013-11-15 RS RS20200723A patent/RS60401B1/sr unknown
- 2013-11-15 HR HRP20191784TT patent/HRP20191784T1/hr unknown
- 2013-11-15 WO PCT/US2013/070437 patent/WO2014088785A1/en not_active Ceased
- 2013-11-15 LT LTEP19187756.2T patent/LT3646876T/lt unknown
- 2013-11-15 DK DK18196690.4T patent/DK3456333T3/da active
- 2013-11-15 IL IL280144A patent/IL280144B2/en unknown
- 2013-11-15 MY MYPI2020000946A patent/MY200076A/en unknown
- 2013-11-15 FI FIEP19187756.2T patent/FI3646876T3/fi active
- 2013-11-15 KR KR1020237005641A patent/KR20230028590A/ko not_active Ceased
- 2013-11-15 MA MA45504A patent/MA45504B1/fr unknown
- 2013-11-15 PT PT138610084T patent/PT2928477T/pt unknown
- 2013-11-15 ES ES13861008T patent/ES2744790T3/es active Active
- 2013-11-15 IL IL317233A patent/IL317233A/en unknown
- 2013-11-15 SM SM20200328T patent/SMT202000328T1/it unknown
- 2013-11-15 DK DK19187756.2T patent/DK3646876T3/da active
- 2013-11-15 PT PT191877562T patent/PT3646876T/pt unknown
- 2013-11-15 CN CN202010575187.3A patent/CN111617252A/zh active Pending
- 2013-11-15 SI SI201332080T patent/SI3646876T1/sl unknown
- 2013-11-15 AU AU2013356533A patent/AU2013356533B2/en active Active
- 2013-11-15 HU HUE18196690A patent/HUE049858T2/hu unknown
- 2013-11-15 NZ NZ708920A patent/NZ708920A/en unknown
- 2013-11-15 UA UAA201800703A patent/UA126015C2/uk unknown
- 2013-11-15 LT LTEP13861008.4T patent/LT2928477T/lt unknown
- 2013-11-15 JP JP2015546492A patent/JP6433911B2/ja active Active
- 2013-11-15 CN CN201380069553.6A patent/CN104936602B/zh active Active
- 2013-11-15 AP AP2015008504A patent/AP2015008504A0/xx unknown
- 2013-11-15 MX MX2015007169A patent/MX372753B/es active IP Right Grant
- 2013-11-15 SI SI201331556T patent/SI2928477T1/sl unknown
- 2013-11-15 PL PL13861008T patent/PL2928477T3/pl unknown
- 2013-11-15 EP EP13861008.4A patent/EP2928477B1/en active Active
- 2013-11-15 SI SI201331716T patent/SI3456333T1/sl unknown
- 2013-11-15 PL PL18196690T patent/PL3456333T3/pl unknown
- 2013-11-15 MY MYPI2015001459A patent/MY180634A/en unknown
- 2013-11-15 SM SM20190567T patent/SMT201900567T1/it unknown
- 2013-11-15 KR KR1020257024576A patent/KR20250114449A/ko active Pending
- 2013-11-15 PL PL19187756.2T patent/PL3646876T3/pl unknown
2015
- 2015-06-04 CL CL2015001530A patent/CL2015001530A1/es unknown
- 2015-06-05 MX MX2020003276A patent/MX2020003276A/es unknown
- 2015-06-05 PH PH12015501282A patent/PH12015501282B1/en unknown
- 2015-06-05 TN TNP2015000249A patent/TN2015000249A1/fr unknown
- 2015-06-05 MX MX2022015437A patent/MX2022015437A/es unknown
- 2015-06-07 IL IL23926615A patent/IL239266B/en active IP Right Grant
- 2015-06-08 ZA ZA2015/04124A patent/ZA201504124B/en unknown
2017
- 2017-08-24 CL CL2017002156A patent/CL2017002156A1/es unknown
- 2017-12-04 JP JP2017232485A patent/JP6998191B2/ja active Active
2018
- 2018-12-20 AU AU2018282364A patent/AU2018282364A1/en not_active Abandoned
2019
- 2019-10-14 CY CY20191101076T patent/CY1122169T1/el unknown
- 2019-12-23 JP JP2019231517A patent/JP2020041001A/ja active Pending
2020
- 2020-06-23 CY CY20201100568T patent/CY1123206T1/el unknown
- 2020-06-24 HR HRP20200993TT patent/HRP20200993T1/hr unknown
- 2020-11-09 AU AU2020267142A patent/AU2020267142C1/en active Active
2021
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MY180634A (en)	2020-12-03
CY1123206T1 (el)	2021-10-29
MA45504A1 (fr)	2020-05-29
EP3456333B1 (en)	2020-04-01
SG10201802926XA (en)	2018-05-30
MA45504B1 (fr)	2021-10-29
JP2018035196A (ja)	2018-03-08
RS60401B1 (sr)	2020-07-31
EA201590878A1 (ru)	2016-04-29
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NZ708920A (en)	2020-08-28
CY1122169T1 (el)	2020-11-25
PH12015501282B1 (en)	2015-08-24
CN111617252A (zh)	2020-09-04
KR20230028590A (ko)	2023-02-28
KR20250114449A (ko)	2025-07-29
AU2020267142A1 (en)	2020-12-03
FI3646876T3 (fi)	2024-05-14
AU2020267142C1 (en)	2024-08-08
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SI2928477T1 (sl)	2019-11-29
TN2015000249A1 (en)	2016-10-03
KR102294819B1 (ko)	2021-09-01
AU2020267142B2 (en)	2024-05-16
KR102662590B1 (ko)	2024-05-03
MA38193B1 (fr)	2018-12-31
CA2892907A1 (en)	2014-06-12
HK1212226A1 (en)	2016-06-10
EP2928477A1 (en)	2015-10-14
HUE049858T2 (hu)	2020-11-30
EP2928477B1 (en)	2019-07-24
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LTPA2025517I1 (lt)	2025-05-26
JP2022050537A (ja)	2022-03-30
JP2016504307A (ja)	2016-02-12
AU2024203138A1 (en)	2024-07-25
ME03538B (me)	2020-07-20
MX372753B (es)	2020-06-26

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