SK285099B6 - Spôsob výroby retardovaného viaczložkového prípravku s riadeným a od pohybu nezávislým uvoľňovaním, jeho použitie a prípravok - Google Patents
Spôsob výroby retardovaného viaczložkového prípravku s riadeným a od pohybu nezávislým uvoľňovaním, jeho použitie a prípravok Download PDFInfo
- Publication number
- SK285099B6 SK285099B6 SK372-2001A SK3722001A SK285099B6 SK 285099 B6 SK285099 B6 SK 285099B6 SK 3722001 A SK3722001 A SK 3722001A SK 285099 B6 SK285099 B6 SK 285099B6
- Authority
- SK
- Slovakia
- Prior art keywords
- release
- polymer
- active ingredient
- hydroxypropylcellulose
- particles
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 20
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 11
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- 238000013268 sustained release Methods 0.000 title claims abstract description 5
- 239000012730 sustained-release form Substances 0.000 title claims abstract description 5
- 238000013019 agitation Methods 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 claims abstract description 27
- 239000002245 particle Substances 0.000 claims abstract description 20
- 229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 9
- 150000001875 compounds Chemical class 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 45
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 25
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 25
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 25
- 239000004480 active ingredient Substances 0.000 claims description 22
- 239000003814 drug Substances 0.000 claims description 20
- 238000002156 mixing Methods 0.000 claims description 19
- 238000001125 extrusion Methods 0.000 claims description 10
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical group COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims description 10
- 229960001597 nifedipine Drugs 0.000 claims description 10
- 239000002775 capsule Substances 0.000 claims description 9
- 238000009472 formulation Methods 0.000 claims description 8
- 238000013270 controlled release Methods 0.000 claims description 6
- 238000005469 granulation Methods 0.000 claims description 6
- 230000003179 granulation Effects 0.000 claims description 6
- -1 controlled release Substances 0.000 claims description 5
- 230000003628 erosive effect Effects 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 4
- 230000000979 retarding effect Effects 0.000 claims description 4
- 238000006467 substitution reaction Methods 0.000 claims description 3
- 239000000470 constituent Substances 0.000 claims 1
- 229920002959 polymer blend Polymers 0.000 claims 1
- 239000008185 minitablet Substances 0.000 description 19
- 229940079593 drug Drugs 0.000 description 18
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 18
- 239000008187 granular material Substances 0.000 description 12
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 12
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 11
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 11
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 11
- 239000004922 lacquer Substances 0.000 description 11
- 239000003826 tablet Substances 0.000 description 11
- 239000000546 pharmaceutical excipient Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 235000019359 magnesium stearate Nutrition 0.000 description 9
- 239000013543 active substance Substances 0.000 description 8
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- 230000009246 food effect Effects 0.000 description 7
- 210000001035 gastrointestinal tract Anatomy 0.000 description 7
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- 239000002552 dosage form Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 235000021471 food effect Nutrition 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 5
- 239000008188 pellet Substances 0.000 description 5
- 229920001213 Polysorbate 20 Polymers 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000004014 plasticizer Substances 0.000 description 4
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 4
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 3
- 229920003163 Eudragit® NE 30 D Polymers 0.000 description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 239000007900 aqueous suspension Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 239000007903 gelatin capsule Substances 0.000 description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 229920003160 Eudragit® RS PO Polymers 0.000 description 2
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 2
- 239000003524 antilipemic agent Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229940124531 pharmaceutical excipient Drugs 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000001069 triethyl citrate Substances 0.000 description 2
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 2
- 235000013769 triethyl citrate Nutrition 0.000 description 2
- UIAGMCDKSXEBJQ-IBGZPJMESA-N 3-o-(2-methoxyethyl) 5-o-propan-2-yl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-IBGZPJMESA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- 229920003153 Eudragit® NE polymer Polymers 0.000 description 1
- 208000010235 Food Addiction Diseases 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000001088 anti-asthma Effects 0.000 description 1
- 230000002205 anti-dementic effect Effects 0.000 description 1
- 230000003556 anti-epileptic effect Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 239000003416 antiarrhythmic agent Substances 0.000 description 1
- 239000000924 antiasthmatic agent Substances 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 229960003965 antiepileptics Drugs 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 229960005475 antiinfective agent Drugs 0.000 description 1
- 239000003430 antimalarial agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000000824 cytostatic agent Substances 0.000 description 1
- 230000001085 cytostatic effect Effects 0.000 description 1
- 239000000850 decongestant Substances 0.000 description 1
- 229940124581 decongestants Drugs 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- VKQFCGNPDRICFG-UHFFFAOYSA-N methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1C1=CC=CC=C1[N+]([O-])=O VKQFCGNPDRICFG-UHFFFAOYSA-N 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229960000715 nimodipine Drugs 0.000 description 1
- 229960000227 nisoldipine Drugs 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000120 polyethyl acrylate Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
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- 150000003839 salts Chemical class 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
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- 239000008279 sol Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 229920003176 water-insoluble polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- General Preparation And Processing Of Foods (AREA)
- Nonmetallic Welding Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19842753A DE19842753A1 (de) | 1998-09-18 | 1998-09-18 | Agitationsunabhängige pharmazeutische Retardzubereitungen und Verfahren zu ihrer Herstellung |
| PCT/EP1999/006882 WO2000016748A1 (fr) | 1998-09-18 | 1999-09-17 | Preparations pharmaceutiques a liberation controlee en fonction de l'agitation et leur procede de production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK3722001A3 SK3722001A3 (en) | 2001-10-08 |
| SK285099B6 true SK285099B6 (sk) | 2006-06-01 |
Family
ID=7881376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK372-2001A SK285099B6 (sk) | 1998-09-18 | 1999-09-17 | Spôsob výroby retardovaného viaczložkového prípravku s riadeným a od pohybu nezávislým uvoľňovaním, jeho použitie a prípravok |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6805881B1 (fr) |
| EP (1) | EP1113787B1 (fr) |
| JP (1) | JP2002526437A (fr) |
| KR (1) | KR100660072B1 (fr) |
| CN (1) | CN1178650C (fr) |
| AT (1) | ATE260645T1 (fr) |
| AU (2) | AU5861499A (fr) |
| BG (1) | BG105325A (fr) |
| BR (1) | BR9913839A (fr) |
| CA (1) | CA2344372C (fr) |
| DE (2) | DE19842753A1 (fr) |
| DK (1) | DK1113787T3 (fr) |
| EE (1) | EE04700B1 (fr) |
| ES (1) | ES2215404T3 (fr) |
| HK (1) | HK1040932B (fr) |
| HR (1) | HRP20010198A2 (fr) |
| HU (1) | HUP0103669A3 (fr) |
| ID (1) | ID28735A (fr) |
| IL (2) | IL141532A0 (fr) |
| NO (1) | NO20011211L (fr) |
| NZ (1) | NZ510563A (fr) |
| PL (1) | PL195543B1 (fr) |
| PT (1) | PT1113787E (fr) |
| RU (1) | RU2235540C2 (fr) |
| SK (1) | SK285099B6 (fr) |
| TR (1) | TR200100756T2 (fr) |
| UA (1) | UA73097C2 (fr) |
| WO (2) | WO2000016747A1 (fr) |
| ZA (1) | ZA200101485B (fr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| US20020044962A1 (en) * | 2000-06-06 | 2002-04-18 | Cherukuri S. Rao | Encapsulation products for controlled or extended release |
| DE10129725A1 (de) | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| AR034813A1 (es) † | 2001-07-20 | 2004-03-17 | Novartis Ag | Composiciones farmaceuticas y uso de las mismas |
| US7718189B2 (en) * | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
| DE10300111A1 (de) * | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
| DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
| NZ555693A (en) | 2004-12-27 | 2010-10-29 | Eisai R&D Man Co Ltd | Matrix type sustained-release preparation containing donepezil |
| US20070129402A1 (en) * | 2004-12-27 | 2007-06-07 | Eisai Research Institute | Sustained release formulations |
| EP1685841A1 (fr) | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention et traitement de troubles thromboemboliques |
| DE102005012561B4 (de) | 2005-03-18 | 2008-06-19 | Christian Beer | Verfahren zum Betrieb eines Werkstück-Transfersystems |
| DE102005045518A1 (de) * | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
| DE102005047558A1 (de) * | 2005-10-04 | 2008-02-07 | Bayer Healthcare Ag | Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen |
| PT1934208E (pt) | 2005-10-04 | 2011-06-01 | Bayer Schering Pharma Ag | Nova forma polimorfa de 5-cloro-n-({(5s)-2-oxo-3-[4-(3- oxo-4-morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2- tiofenocarboxamida |
| DE102005047561A1 (de) * | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
| CN100448432C (zh) * | 2006-10-26 | 2009-01-07 | 徐竹青 | 高溶出度尼莫地平分散片的制备方法 |
| DE102006051625A1 (de) * | 2006-11-02 | 2008-05-08 | Bayer Materialscience Ag | Kombinationstherapie substituierter Oxazolidinone |
| US7952167B2 (en) * | 2007-04-27 | 2011-05-31 | Taiwan Semiconductor Manufacturing Company, Ltd. | Scribe line layout design |
| TWI478712B (zh) | 2008-09-30 | 2015-04-01 | Astellas Pharma Inc | 釋控性醫藥組成物 |
| US20110287100A1 (en) * | 2009-01-28 | 2011-11-24 | Sabine Desset-Brethes | Galenic Formulations of Organic Compounds |
| US20100247646A1 (en) * | 2009-03-26 | 2010-09-30 | Ranbaxy Laboratories Limited | Extended release tablets of nisoldipine |
| JP5849947B2 (ja) | 2010-03-29 | 2016-02-03 | アステラス製薬株式会社 | 放出制御医薬組成物 |
| JP2023553274A (ja) * | 2020-11-18 | 2023-12-21 | エフビー－エイチアールエス リミテッド ライアビリティ カンパニー | ドフェチリド及びメキシレチンを含有する組成物並びにその使用 |
| US12097189B1 (en) | 2024-02-09 | 2024-09-24 | Astellas Pharma Inc. | Pharmaceutical composition for modified release |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5482525A (en) | 1977-12-13 | 1979-06-30 | Aisan Ind Co Ltd | Exhaust gas recirculation system |
| US4226849A (en) * | 1979-06-14 | 1980-10-07 | Forest Laboratories Inc. | Sustained release therapeutic compositions |
| US4327725A (en) | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
| US4369172A (en) * | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
| US4449983A (en) | 1982-03-22 | 1984-05-22 | Alza Corporation | Simultaneous delivery of two drugs from unit delivery device |
| US4389393A (en) * | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| GB8514665D0 (en) * | 1985-06-11 | 1985-07-10 | Eroceltique Sa | Oral pharmaceutical composition |
| SE455836B (sv) * | 1985-10-11 | 1988-08-15 | Haessle Ab | Beredning med kontrollerad frisettning innehallande ett salt av metoprolol samt metod for framstellning av denna beredning |
| DE3612211A1 (de) | 1986-04-11 | 1987-10-15 | Basf Ag | Kontinuierliches verfahren zum tablettieren |
| DE3612212A1 (de) | 1986-04-11 | 1987-10-15 | Basf Ag | Verfahren zur herstellung von festen pharmazeutischen formen |
| JPS63222121A (ja) * | 1987-03-10 | 1988-09-16 | Nippon Soda Co Ltd | 徐放性ゲル製剤 |
| DE3720757A1 (de) | 1987-06-24 | 1989-01-05 | Bayer Ag | Dhp-manteltablette |
| JPH02174722A (ja) * | 1988-09-01 | 1990-07-06 | Kureha Chem Ind Co Ltd | かわらたけ由来の蛋白多糖体の粒状製剤 |
| DE3830353A1 (de) | 1988-09-07 | 1990-03-15 | Basf Ag | Verfahren zur kontinuierlichen herstellung von festen pharmazeutischen formen |
| JPH03101615A (ja) * | 1989-09-14 | 1991-04-26 | Sumitomo Pharmaceut Co Ltd | 胃内滞留型持続性製剤 |
| JPH03145418A (ja) | 1989-10-27 | 1991-06-20 | Sumitomo Pharmaceut Co Ltd | 塩基性薬物塩酸塩の徐放性製剤 |
| JP3078859B2 (ja) * | 1990-02-23 | 2000-08-21 | 武田薬品工業株式会社 | 安定な放出制御性製剤用コーティング剤 |
| EP0580860B2 (fr) | 1991-04-16 | 2004-12-15 | Nippon Shinyaku Company, Limited | Procede de production d'une dispersion solide |
| DE4138513A1 (de) | 1991-11-23 | 1993-05-27 | Basf Ag | Feste pharmazeutische retardform |
| JP3059004B2 (ja) * | 1992-09-18 | 2000-07-04 | ダイセル化学工業株式会社 | アルカリ水溶液に対する溶解性の高い低置換度ヒドロキシプロピルセルロース及びその製造法 |
| DE4413350A1 (de) | 1994-04-18 | 1995-10-19 | Basf Ag | Retard-Matrixpellets und Verfahren zu ihrer Herstellung |
| SE9402422D0 (sv) * | 1994-07-08 | 1994-07-08 | Astra Ab | New beads for controlled release and a pharmaceutical preparation containing the same |
| FR2725624B1 (fr) | 1994-10-14 | 1997-01-17 | Jouveinal Inst Rech | Procede de preparation de formes pharmaceutiques a liberation controlee |
| DE19504831A1 (de) | 1995-02-14 | 1996-09-05 | Basf Ag | Feste Wirkstoffzubereitungen enthaltend Hydroxypropylcellulose |
-
1998
- 1998-09-18 DE DE19842753A patent/DE19842753A1/de not_active Withdrawn
-
1999
- 1999-09-08 AU AU58614/99A patent/AU5861499A/en not_active Abandoned
- 1999-09-08 WO PCT/EP1999/006608 patent/WO2000016747A1/fr not_active Ceased
- 1999-09-17 JP JP2000573709A patent/JP2002526437A/ja not_active Ceased
- 1999-09-17 EP EP99948770A patent/EP1113787B1/fr not_active Expired - Lifetime
- 1999-09-17 AT AT99948770T patent/ATE260645T1/de not_active IP Right Cessation
- 1999-09-17 PL PL99346535A patent/PL195543B1/pl unknown
- 1999-09-17 BR BR9913839-5A patent/BR9913839A/pt not_active Application Discontinuation
- 1999-09-17 ID IDW20010651A patent/ID28735A/id unknown
- 1999-09-17 TR TR2001/00756T patent/TR200100756T2/xx unknown
- 1999-09-17 UA UA2001042576A patent/UA73097C2/uk unknown
- 1999-09-17 DE DE59908764T patent/DE59908764D1/de not_active Expired - Lifetime
- 1999-09-17 RU RU2001110355/15A patent/RU2235540C2/ru not_active IP Right Cessation
- 1999-09-17 EE EEP200100161A patent/EE04700B1/xx not_active IP Right Cessation
- 1999-09-17 ES ES99948770T patent/ES2215404T3/es not_active Expired - Lifetime
- 1999-09-17 AU AU61918/99A patent/AU750617B2/en not_active Ceased
- 1999-09-17 PT PT99948770T patent/PT1113787E/pt unknown
- 1999-09-17 SK SK372-2001A patent/SK285099B6/sk unknown
- 1999-09-17 NZ NZ510563A patent/NZ510563A/xx unknown
- 1999-09-17 DK DK99948770T patent/DK1113787T3/da active
- 1999-09-17 HK HK02102756.8A patent/HK1040932B/zh not_active IP Right Cessation
- 1999-09-17 HR HR20010198A patent/HRP20010198A2/hr not_active Application Discontinuation
- 1999-09-17 US US09/787,229 patent/US6805881B1/en not_active Expired - Fee Related
- 1999-09-17 WO PCT/EP1999/006882 patent/WO2000016748A1/fr not_active Ceased
- 1999-09-17 CN CNB998110299A patent/CN1178650C/zh not_active Expired - Fee Related
- 1999-09-17 HU HU0103669A patent/HUP0103669A3/hu unknown
- 1999-09-17 CA CA002344372A patent/CA2344372C/fr not_active Expired - Fee Related
- 1999-09-17 IL IL14153299A patent/IL141532A0/xx not_active IP Right Cessation
- 1999-09-17 KR KR1020017003495A patent/KR100660072B1/ko not_active Expired - Fee Related
-
2001
- 2001-02-20 IL IL141532A patent/IL141532A/en unknown
- 2001-02-22 ZA ZA200101485A patent/ZA200101485B/en unknown
- 2001-03-09 BG BG105325A patent/BG105325A/bg unknown
- 2001-03-09 NO NO20011211A patent/NO20011211L/no not_active Application Discontinuation
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