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SI1224175T1 - Benzodiazepine derivatives as metabotropic glutamate receptor antagonists - Google Patents

Benzodiazepine derivatives as metabotropic glutamate receptor antagonists

Info

Publication number
SI1224175T1
SI1224175T1 SI200030395T SI200030395T SI1224175T1 SI 1224175 T1 SI1224175 T1 SI 1224175T1 SI 200030395 T SI200030395 T SI 200030395T SI 200030395 T SI200030395 T SI 200030395T SI 1224175 T1 SI1224175 T1 SI 1224175T1
Authority
SI
Slovenia
Prior art keywords
receptor antagonists
glutamate receptor
metabotropic glutamate
benzodiazepine derivatives
benzodiazepine
Prior art date
Application number
SI200030395T
Other languages
English (en)
Slovenian (sl)
Inventor
Geo Adam
Alexander Alanine
Erwin Goetschi
Vincent Mutel
Thomas Johannes Woltering
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of SI1224175T1 publication Critical patent/SI1224175T1/xx

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
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SI200030395T 1999-10-15 2000-09-29 Benzodiazepine derivatives as metabotropic glutamate receptor antagonists SI1224175T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99120519 1999-10-15
PCT/EP2000/009554 WO2001029012A2 (en) 1999-10-15 2000-09-29 Benzodiazepine derivatives as metabotropic glutamate receptor antagonists
EP00971302A EP1224175B1 (de) 1999-10-15 2000-09-29 Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten

Publications (1)

Publication Number Publication Date
SI1224175T1 true SI1224175T1 (en) 2004-08-31

Family

ID=8239206

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030395T SI1224175T1 (en) 1999-10-15 2000-09-29 Benzodiazepine derivatives as metabotropic glutamate receptor antagonists

Country Status (35)

Country Link
US (4) US6509328B1 (de)
EP (1) EP1224175B1 (de)
JP (1) JP3886805B2 (de)
KR (1) KR100481386B1 (de)
CN (1) CN1199954C (de)
AR (1) AR026028A1 (de)
AT (1) ATE261945T1 (de)
AU (1) AU779874B2 (de)
BR (1) BR0014761A (de)
CA (1) CA2386980C (de)
CO (1) CO5251454A1 (de)
CZ (1) CZ20021663A3 (de)
DE (1) DE60009116T2 (de)
DK (1) DK1224175T3 (de)
ES (1) ES2215738T3 (de)
GC (1) GC0000207A (de)
HR (1) HRP20020260B1 (de)
HU (1) HUP0203294A3 (de)
IL (2) IL149104A0 (de)
JO (1) JO2299B1 (de)
MA (1) MA26832A1 (de)
MX (1) MXPA02003740A (de)
MY (1) MY125506A (de)
NO (1) NO20021691L (de)
NZ (1) NZ518037A (de)
PE (1) PE20010759A1 (de)
PL (1) PL357433A1 (de)
PT (1) PT1224175E (de)
RU (1) RU2257382C2 (de)
SI (1) SI1224175T1 (de)
TR (1) TR200201026T2 (de)
TW (1) TWI254044B (de)
WO (1) WO2001029012A2 (de)
YU (1) YU27902A (de)
ZA (1) ZA200202654B (de)

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