SI1092429T1 - Pharmaceutical preparations for drugs of low solubility - Google Patents

Pharmaceutical preparations for drugs of low solubility

Info

Publication number: SI1092429T1
Authority: SI; Slovenia
Prior art keywords: active agent; component; drugs; iii; pharmaceutical preparations
Prior art date: 1993-07-08

Application number

SI9430465T

Other languages

English (en)

Slovenian (sl)

Inventor

Ulrich Posanski

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-08

Filing date

1994-07-08

Publication date

2004-08-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6492300&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1092429(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-07-08 Application filed by Novartis Ag filed Critical Novartis Ag

2004-08-31 Publication of SI1092429T1 publication Critical patent/SI1092429T1/xx

Links

239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
239000013543 active substance Substances 0.000 abstract 4
-1 fatty acid ester Chemical class 0.000 abstract 3
235000014113 dietary fatty acids Nutrition 0.000 abstract 2
229930195729 fatty acid Natural products 0.000 abstract 2
239000000194 fatty acid Substances 0.000 abstract 2
AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
UIAGMCDKSXEBJQ-IBGZPJMESA-N 3-o-(2-methoxyethyl) 5-o-propan-2-yl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-IBGZPJMESA-N 0.000 abstract 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 1
229930105110 Cyclosporin A Natural products 0.000 abstract 1
108010036949 Cyclosporine Proteins 0.000 abstract 1
HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 abstract 1
QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 abstract 1
229960001265 ciclosporin Drugs 0.000 abstract 1
229930182912 cyclosporin Natural products 0.000 abstract 1
239000012153 distilled water Substances 0.000 abstract 1
VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 abstract 1
229960005420 etoposide Drugs 0.000 abstract 1
229960001680 ibuprofen Drugs 0.000 abstract 1
235000019136 lipoic acid Nutrition 0.000 abstract 1
HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 abstract 1
229960001597 nifedipine Drugs 0.000 abstract 1
229960000715 nimodipine Drugs 0.000 abstract 1
239000002736 nonionic surfactant Substances 0.000 abstract 1
ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 abstract 1
229960002930 sirolimus Drugs 0.000 abstract 1
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 abstract 1
229960001967 tacrolimus Drugs 0.000 abstract 1
QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 abstract 1
229960002663 thioctic acid Drugs 0.000 abstract 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Oil, Petroleum & Natural Gas (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Transplantation (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

SI9430465T 1993-07-08 1994-07-08 Pharmaceutical preparations for drugs of low solubility SI1092429T1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4322826A DE4322826A1 (de)	1993-07-08	1993-07-08	Pharmazeutisches Präparat
EP00122248A EP1092429B1 (de)	1993-07-08	1994-07-08	Pharmazeutische Präparate für schwerlösliche Wirkstoffe

Publications (1)

Publication Number	Publication Date
SI1092429T1 true SI1092429T1 (en)	2004-08-31

Family

ID=6492300

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9430465T SI1092429T1 (en)	1993-07-08	1994-07-08	Pharmaceutical preparations for drugs of low solubility

Country Status (24)

Country	Link
EP (3)	EP0710104B1 (el)
JP (4)	JPH08512303A (el)
KR (2)	KR100386533B1 (el)
CN (2)	CN1121853C (el)
AT (3)	ATE172876T1 (el)
AU (2)	AU7385094A (el)
BR (1)	BR9407002A (el)
CA (2)	CA2166204C (el)
CY (2)	CY2308B1 (el)
CZ (1)	CZ291401B6 (el)
DE (6)	DE4322826A1 (el)
DK (3)	DK0710104T3 (el)
ES (3)	ES2218046T3 (el)
FI (2)	FI116197B (el)
GR (1)	GR3036571T3 (el)
HU (2)	HU223073B1 (el)
NO (2)	NO306763B1 (el)
NZ (2)	NZ269808A (el)
PL (1)	PL179717B1 (el)
PT (2)	PT1092429E (el)
RU (1)	RU2140291C1 (el)
SI (1)	SI1092429T1 (el)
SK (1)	SK280615B6 (el)
WO (2)	WO1995001786A1 (el)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
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US6458373B1 (en)	1997-01-07	2002-10-01	Sonus Pharmaceuticals, Inc.	Emulsion vehicle for poorly soluble drugs
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JP4221762B2 (ja) *	1997-04-11	2009-02-12	アステラス製薬株式会社	医薬組成物
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JP2002534370A (ja)	1998-12-30	2002-10-15	デクセルリミテッド	サイクロスポリンを送達するための分散可能な濃縮物
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US20020035107A1 (en)	2000-06-20	2002-03-21	Stefan Henke	Highly concentrated stable meloxicam solutions
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DE10161077A1 (de)	2001-12-12	2003-06-18	Boehringer Ingelheim Vetmed	Hochkonzentrierte stabile Meloxicamlösungen zur nadellosen Injektion
BR0117197A (pt)	2001-12-14	2004-12-14	Jagotec Ag	Formulação de medicamento contendo ciclosporina aplicação do mesmo
RU2217170C2 (ru) *	2002-02-08	2003-11-27	Мельников Глеб Евгеньевич	Дезинфицирующее средство
RU2217169C2 (ru) *	2002-02-08	2003-11-27	Мельников Глеб Евгеньевич	Дезинфицирующее средство
KR100533458B1 (ko)	2002-07-20	2005-12-07	대화제약 주식회사	파클리탁셀의 가용화용 조성물 및 그의 제조 방법
GB2391473B (en) *	2002-08-02	2004-07-07	Satishchandra Punambhai Patel	Pharmaceutical compositions
US8992980B2 (en)	2002-10-25	2015-03-31	Boehringer Ingelheim Vetmedica Gmbh	Water-soluble meloxicam granules
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1993
- 1993-07-08 DE DE4322826A patent/DE4322826A1/de not_active Withdrawn
1994
- 1994-07-08 EP EP94923715A patent/EP0710104B1/de not_active Expired - Lifetime
- 1994-07-08 PT PT00122248T patent/PT1092429E/pt unknown
- 1994-07-08 DK DK94923715T patent/DK0710104T3/da active
- 1994-07-08 DE DE59410365T patent/DE59410365D1/de not_active Expired - Lifetime
- 1994-07-08 AT AT94923715T patent/ATE172876T1/de not_active IP Right Cessation
- 1994-07-08 DE DE4494850T patent/DE4494850D2/de not_active Expired - Fee Related
- 1994-07-08 JP JP7503833A patent/JPH08512303A/ja active Pending
- 1994-07-08 DE DE4494851T patent/DE4494851D2/de not_active Expired - Fee Related
- 1994-07-08 WO PCT/EP1994/002248 patent/WO1995001786A1/de not_active Ceased
- 1994-07-08 ES ES00122248T patent/ES2218046T3/es not_active Expired - Lifetime
- 1994-07-08 DK DK94922269T patent/DK0710103T3/da active
- 1994-07-08 DK DK00122248T patent/DK1092429T3/da active
- 1994-07-08 AU AU73850/94A patent/AU7385094A/en not_active Abandoned
- 1994-07-08 ES ES94923715T patent/ES2124420T3/es not_active Expired - Lifetime
- 1994-07-08 BR BR9407002A patent/BR9407002A/pt not_active Application Discontinuation
- 1994-07-08 EP EP94922269A patent/EP0710103B1/de not_active Expired - Lifetime
- 1994-07-08 NZ NZ269808A patent/NZ269808A/xx not_active IP Right Cessation
- 1994-07-08 NZ NZ269552A patent/NZ269552A/xx not_active IP Right Cessation
- 1994-07-08 WO PCT/EP1994/002238 patent/WO1995001785A1/de not_active Ceased
- 1994-07-08 CZ CZ199645A patent/CZ291401B6/cs not_active IP Right Cessation
- 1994-07-08 AT AT00122248T patent/ATE261720T1/de active
- 1994-07-08 JP JP7503830A patent/JPH08512301A/ja active Pending
- 1994-07-08 HU HU9503868A patent/HU223073B1/hu active IP Right Grant
- 1994-07-08 CA CA002166204A patent/CA2166204C/en not_active Expired - Fee Related
- 1994-07-08 EP EP00122248A patent/EP1092429B1/de not_active Expired - Lifetime
- 1994-07-08 CN CN94192714A patent/CN1121853C/zh not_active Expired - Lifetime
- 1994-07-08 ES ES94922269T patent/ES2159564T3/es not_active Expired - Lifetime
- 1994-07-08 CN CNB031522890A patent/CN1313154C/zh not_active Expired - Lifetime
- 1994-07-08 PL PL94312255A patent/PL179717B1/pl unknown
- 1994-07-08 HU HU9503965A patent/HU228127B1/hu not_active IP Right Cessation
- 1994-07-08 PT PT94922269T patent/PT710103E/pt unknown
- 1994-07-08 AT AT94922269T patent/ATE201985T1/de active
- 1994-07-08 RU RU96102012A patent/RU2140291C1/ru active
- 1994-07-08 AU AU73457/94A patent/AU689486B2/en not_active Expired
- 1994-07-08 SK SK19-96A patent/SK280615B6/sk not_active IP Right Cessation
- 1994-07-08 KR KR1019960700026A patent/KR100386533B1/ko not_active Expired - Lifetime
- 1994-07-08 DE DE59409787T patent/DE59409787D1/de not_active Expired - Lifetime
- 1994-07-08 KR KR1019960700042A patent/KR100359044B1/ko not_active Expired - Fee Related
- 1994-07-08 SI SI9430465T patent/SI1092429T1/xx unknown
- 1994-07-08 DE DE59407239T patent/DE59407239D1/de not_active Expired - Fee Related
- 1994-07-08 CA CA002164100A patent/CA2164100A1/en not_active Abandoned
1996
- 1996-01-03 FI FI960032A patent/FI116197B/fi active IP Right Grant
- 1996-01-04 FI FI960042A patent/FI116714B/fi not_active IP Right Cessation
- 1996-01-05 NO NO960069A patent/NO306763B1/no not_active IP Right Cessation
- 1996-01-05 NO NO960062A patent/NO306929B1/no not_active IP Right Cessation
2001
- 2001-09-10 GR GR20010401428T patent/GR3036571T3/el unknown
2002
- 2002-12-12 CY CY0200068A patent/CY2308B1/xx unknown
2005
- 2005-09-08 CY CY0500049A patent/CY2604B2/el unknown
2009
- 2009-02-04 JP JP2009023837A patent/JP2009138008A/ja not_active Withdrawn
2011
- 2011-03-24 JP JP2011066324A patent/JP2011153150A/ja active Pending

Also Published As

Publication number	Publication date
SK280615B6 (sk)	2000-05-16
EP0710104A1 (de)	1996-05-08
CA2164100A1 (en)	1995-01-19
NO960069L (no)	1996-01-05
FI960042A0 (fi)	1996-01-04
JP2011153150A (ja)	2011-08-11
FI116197B (fi)	2005-10-14
CZ291401B6 (cs)	2003-03-12
FI960042L (fi)	1996-01-04
CZ4596A3 (en)	1996-04-17
PT1092429E (pt)	2004-08-31
JPH08512301A (ja)	1996-12-24
ES2159564T3 (es)	2001-10-16
HU9503965D0 (en)	1996-03-28
HU9503868D0 (en)	1996-02-28
RU2140291C1 (ru)	1999-10-27
AU689486B2 (en)	1998-04-02
PL179717B1 (pl)	2000-10-31
DE4494850D2 (de)	1996-08-22
CN1496743A (zh)	2004-05-19
SK1996A3 (en)	1997-04-09
DE59407239D1 (de)	1998-12-10
DE59409787D1 (de)	2001-07-19
BR9407002A (pt)	1996-09-03
KR100359044B1 (ko)	2003-02-05
PL312255A1 (en)	1996-04-01
NO960062L (no)	1996-01-05
ATE172876T1 (de)	1998-11-15
CN1313154C (zh)	2007-05-02
GR3036571T3 (en)	2001-12-31
EP0710104B1 (de)	1998-11-04
FI960032A0 (fi)	1996-01-03
JPH08512303A (ja)	1996-12-24
ES2124420T3 (es)	1999-02-01
DK1092429T3 (da)	2004-07-19
DE4494851D2 (de)	1996-12-19
NO960069D0 (no)	1996-01-05
PT710103E (pt)	2001-11-30
HUT73427A (en)	1996-07-29
DE4322826A1 (de)	1995-01-12
EP0710103A1 (de)	1996-05-08
CY2308B1 (en)	2003-11-14
CN1121853C (zh)	2003-09-24
ATE261720T1 (de)	2004-04-15
AU7345794A (en)	1995-02-06
DE59410365D1 (de)	2004-04-22
ES2218046T3 (es)	2004-11-16
CA2166204C (en)	2009-04-14
HU223073B1 (hu)	2004-03-01
HU228127B1 (en)	2012-12-28
NZ269552A (en)	1996-07-26
CA2166204A1 (en)	1995-01-19
EP0710103B1 (de)	2001-06-13
NZ269808A (en)	1996-07-26
NO306763B1 (no)	1999-12-20
FI116714B (fi)	2006-02-15
WO1995001786A1 (de)	1995-01-19
JP2009138008A (ja)	2009-06-25
WO1995001785A1 (de)	1995-01-19
CN1128495A (zh)	1996-08-07
ATE201985T1 (de)	2001-06-15
KR100386533B1 (ko)	2003-08-21
AU7385094A (en)	1995-02-06
DK0710104T3 (da)	1999-07-19
EP1092429A1 (de)	2001-04-18
EP1092429B1 (de)	2004-03-17
CY2604B2 (el)	2010-04-28
HUT73661A (en)	1996-09-30
FI960032L (fi)	1996-02-09
NO960062D0 (no)	1996-01-05
DK0710103T3 (da)	2001-09-24
NO306929B1 (no)	2000-01-17

Publication	Publication Date	Title
SI1092429T1 (en)	2004-08-31	Pharmaceutical preparations for drugs of low solubility
PT787011E (pt)	2009-01-23	Pré-concentrado de microemulsão compreendendo um macrólido