SI0869958T1 - Novel indole-2,3-dione-3-oxime derivatives - Google Patents

Novel indole-2,3-dione-3-oxime derivatives

Info

Publication number: SI0869958T1
Authority: SI; Slovenia
Prior art keywords: dione; het; oxime derivatives; novel indole; ring
Prior art date: 1996-10-01

Application number

SI9730698T

Other languages

English (en)

Slovenian (sl)

Inventor

Frank W�Tjen

Jorgen Drejer

Original Assignee

Neurosearch A/S

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-01

Filing date

1997-10-01

Publication date

2005-06-30

1997-10-01 Application filed by Neurosearch A/S filed Critical Neurosearch A/S

2005-06-30 Publication of SI0869958T1 publication Critical patent/SI0869958T1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

SI9730698T 1996-10-01 1997-10-01 Novel indole-2,3-dione-3-oxime derivatives SI0869958T1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DK106996		1996-10-01
DK127796		1996-11-13
PCT/DK1997/000418 WO1998014447A1 (fr)	1996-10-01	1997-10-01	Nouveaux derives d'indol-2,3-dion-3-oxime
EP97941880A EP0869958B1 (fr)	1996-10-01	1997-10-01	Nouveaux derives d'indol-2,3-dion-3-oxime

Publications (1)

Publication Number	Publication Date
SI0869958T1 true SI0869958T1 (en)	2005-06-30

Family

ID=26065167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9730698T SI0869958T1 (en)	1996-10-01	1997-10-01	Novel indole-2,3-dione-3-oxime derivatives

Country Status (28)

Country	Link
US (3)	USRE38200E1 (fr)
EP (1)	EP0869958B1 (fr)
JP (1)	JP3319762B2 (fr)
KR (1)	KR100492052B1 (fr)
CN (1)	CN1093859C (fr)
AT (1)	ATE286052T1 (fr)
AU (1)	AU716435B2 (fr)
BG (1)	BG63874B1 (fr)
BR (1)	BR9706765A (fr)
CA (1)	CA2238410C (fr)
CZ (1)	CZ297938B6 (fr)
DE (1)	DE69732090T2 (fr)
DK (1)	DK0869958T3 (fr)
EE (1)	EE9800144A (fr)
ES (1)	ES2235253T3 (fr)
HU (1)	HU225145B1 (fr)
IL (1)	IL124563A (fr)
IS (1)	IS2123B (fr)
NO (1)	NO310722B1 (fr)
NZ (1)	NZ330456A (fr)
PL (1)	PL193041B1 (fr)
PT (1)	PT869958E (fr)
RU (1)	RU2190612C2 (fr)
SI (1)	SI0869958T1 (fr)
SK (1)	SK282729B6 (fr)
TR (1)	TR199800956T1 (fr)
UA (1)	UA54403C2 (fr)
WO (1)	WO1998014447A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
DE69922936T2 (de)	1998-03-31	2005-12-08	Neurosearch A/S	Verwendung von indol-2,3-dione-3-oximderivate als ampa-antagonisten
DE60041399D1 (de)	1999-05-19	2009-03-05	Painceptor Pharma Corp	Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen
EP1736468A3 (fr) *	2000-01-24	2007-01-03	NeuroSearch A/S	Dérivés d'isatine à activité neurotrophique utiles pour le traitement de maladies induites par l'activation de NGF
IT1318636B1 (it) *	2000-07-21	2003-08-27	Roberto Pellicciari	Derivati dell'acido 2- o 3- tenoico ad attivita' antagonista deirecettori del glutammato.
WO2002064139A1 (fr) *	2001-02-15	2002-08-22	Neurosearch A/S	Traitement de la maladie de parkinson par l'action combinee d'un compose a activite neurorophique et un compose a activite dopamine
WO2003006466A1 (fr)	2001-07-13	2003-01-23	Pharmacia & Upjohn Company	Hexahydroazepino (4, 5-g) indoles et indolines, ligands du recepteur 5-ht
NZ537810A (en) *	2002-08-22	2006-10-27	Neurosearch As	A method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives
GB0507298D0 (en)	2005-04-11	2005-05-18	Novartis Ag	Organic compounds
EP1957486A4 (fr)	2005-11-23	2009-11-11	Painceptor Pharma Corp	Compositions et procedes de modulation des canaux ioniques
CA2652109A1 (fr) *	2006-04-10	2007-10-18	Painceptor Pharma Corporation	Compositions et methodes pour canaux ioniques commandes par porte
WO2007115403A1 (fr) *	2006-04-10	2007-10-18	Painceptor Pharma Corporation	Compositions et procedes de modulation de canaux ioniques
US20100041691A1 (en) *	2006-09-12	2010-02-18	Neurosearch A/S	Pharmaceutical compositions comprising combinations of an ampa/kainate antagonistic compound and an inhibitor of a multidrug resistance protein
US20080108622A1 (en) *	2006-10-19	2008-05-08	Eisenach James C	Combination therapy for the treatment of pain
US20080108603A1 (en) *	2006-10-19	2008-05-08	Eisenach James C	Combination therapy for the treatment of pain
WO2010104324A2 (fr) *	2009-03-10	2010-09-16	한국과학기술연구원	Composés iso-indoles halogénés avec une affinité de liaison supérieure aux agrégats de bêta-amyloïde et aux fibrilles, leur procédé de préparation et leur utilisation
CN102653538A (zh) *	2011-03-04	2012-09-05	爱斯医药科技(南京)有限公司	Spd-502的制备方法
US10604484B2 (en)	2015-04-29	2020-03-31	Janssen Pharmaceutica Nv	Indolone compounds and their use as AMPA receptor modulators
ES2865330T3 (es)	2015-04-29	2021-10-15	Janssen Pharmaceutica Nv	Azabenzimidazoles y su uso como moduladores del receptor AMPA
CA2984290C (fr)	2015-04-29	2022-03-01	Janssen Pharmaceutica Nv	Composes de benzimidazolone et de benzothiazolone et leur utilisation comme modulateurs des recepteurs ampa
JP6800885B2 (ja)	2015-04-29	2020-12-16	ヤンセンファーマシューティカエヌ．ベー．	イミダゾピラジン及びピラゾロピリミジン、並びにａｍｐａ受容体調節物質としてのこれらの使用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE69677B1 (en) *	1989-12-11	1996-10-02	Neurosearch As	Isatine derivatives their preparation and use
MX9204914A (es) *	1991-08-28	1993-07-01	Frank Watjen	Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende.
JP3419539B2 (ja) *	1993-02-17	2003-06-23	中外製薬株式会社	インドリン−２−オン誘導体
US5721230A (en)	1993-05-10	1998-02-24	Hoffmann-La Roche Inc.	Substituted pyrroles
FI954965L (fi) *	1993-05-13	1995-11-10	Neurosearch As	AMPA-antagonisteja ja hoitomenetelmä, jossa niitä käytetään
DK81593D0 (da) *	1993-07-07	1993-07-07	Neurosearch As	Nye isatinoximderivater, deres fremstilling og anvendelse
CA2199613C (fr) *	1994-09-14	2000-02-29	Peter Moldt	Derives d'indole-2,3-dione-3-oxime, leur preparation et leur utilisation
EP0781285B1 (fr) *	1994-09-14	2000-01-12	Neurosearch A/S	Derives d'indole et de quinoxaline condenses, leur preparation et leur utilisation comme antagonistes de glutamate
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму

1997
- 1997-01-10 UA UA98052752A patent/UA54403C2/uk unknown
- 1997-10-01 AT AT97941880T patent/ATE286052T1/de not_active IP Right Cessation
- 1997-10-01 NZ NZ330456A patent/NZ330456A/en unknown
- 1997-10-01 WO PCT/DK1997/000418 patent/WO1998014447A1/fr not_active Ceased
- 1997-10-01 TR TR1998/00956T patent/TR199800956T1/xx unknown
- 1997-10-01 EE EE9800144A patent/EE9800144A/xx unknown
- 1997-10-01 US US09/956,892 patent/USRE38200E1/en not_active Expired - Fee Related
- 1997-10-01 IL IL12456397A patent/IL124563A/xx not_active IP Right Cessation
- 1997-10-01 US US09/077,554 patent/US6124285A/en not_active Expired - Lifetime
- 1997-10-01 PT PT97941880T patent/PT869958E/pt unknown
- 1997-10-01 DE DE69732090T patent/DE69732090T2/de not_active Expired - Lifetime
- 1997-10-01 HU HU9901630A patent/HU225145B1/hu not_active IP Right Cessation
- 1997-10-01 AU AU43768/97A patent/AU716435B2/en not_active Ceased
- 1997-10-01 EP EP97941880A patent/EP0869958B1/fr not_active Expired - Lifetime
- 1997-10-01 JP JP51615898A patent/JP3319762B2/ja not_active Expired - Fee Related
- 1997-10-01 DK DK97941880T patent/DK0869958T3/da active
- 1997-10-01 ES ES97941880T patent/ES2235253T3/es not_active Expired - Lifetime
- 1997-10-01 PL PL327073A patent/PL193041B1/pl not_active IP Right Cessation
- 1997-10-01 RU RU98112237/04A patent/RU2190612C2/ru not_active IP Right Cessation
- 1997-10-01 BR BR9706765-2A patent/BR9706765A/pt not_active Application Discontinuation
- 1997-10-01 CA CA002238410A patent/CA2238410C/fr not_active Expired - Fee Related
- 1997-10-01 CN CN97191602A patent/CN1093859C/zh not_active Expired - Fee Related
- 1997-10-01 SI SI9730698T patent/SI0869958T1/xx unknown
- 1997-10-01 KR KR10-1998-0704103A patent/KR100492052B1/ko not_active Expired - Fee Related
- 1997-10-01 SK SK676-98A patent/SK282729B6/sk not_active IP Right Cessation
- 1997-10-01 CZ CZ0160698A patent/CZ297938B6/cs not_active IP Right Cessation
1998
- 1998-05-18 IS IS4748A patent/IS2123B/xx unknown
- 1998-05-26 BG BG102489A patent/BG63874B1/bg unknown
- 1998-05-29 NO NO19982466A patent/NO310722B1/no not_active IP Right Cessation
2000
- 2000-05-31 US US09/584,117 patent/US6693111B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
SK282729B6 (sk)	2002-11-06
TR199800956T1 (xx)	1998-12-21
KR19990071823A (ko)	1999-09-27
PL193041B1 (pl)	2007-01-31
PT869958E (pt)	2005-05-31
DK0869958T3 (da)	2005-04-18
EP0869958B1 (fr)	2004-12-29
BR9706765A (pt)	1999-09-14
JP3319762B2 (ja)	2002-09-03
HUP9901630A3 (en)	2001-11-28
DE69732090T2 (de)	2005-12-29
BG63874B1 (bg)	2003-04-30
CA2238410A1 (fr)	1998-04-09
ES2235253T3 (es)	2005-07-01
HU225145B1 (en)	2006-07-28
USRE38200E1 (en)	2003-07-22
CA2238410C (fr)	2007-06-12
BG102489A (en)	1999-04-30
US6693111B1 (en)	2004-02-17
RU2190612C2 (ru)	2002-10-10
PL327073A1 (en)	1998-11-23
DE69732090D1 (de)	2005-02-03
AU4376897A (en)	1998-04-24
JP2000501432A (ja)	2000-02-08
SK67698A3 (en)	1998-11-04
WO1998014447A1 (fr)	1998-04-09
CN1207100A (zh)	1999-02-03
NO982466D0 (no)	1998-05-29
US6124285A (en)	2000-09-26
EE9800144A (et)	1998-10-15
AU716435B2 (en)	2000-02-24
CN1093859C (zh)	2002-11-06
MX9804365A (es)	1998-10-31
NZ330456A (en)	1998-11-25
IS4748A (is)	1998-05-18
IL124563A0 (en)	1998-12-06
CZ297938B6 (cs)	2007-05-02
NO310722B1 (no)	2001-08-20
ATE286052T1 (de)	2005-01-15
UA54403C2 (uk)	2003-03-17
IS2123B (is)	2006-07-14
IL124563A (en)	2005-05-17
HK1017682A1 (en)	1999-11-26
HUP9901630A2 (hu)	1999-08-30
CZ160698A3 (cs)	1998-10-14
EP0869958A1 (fr)	1998-10-14
KR100492052B1 (ko)	2005-09-30
NO982466L (no)	1998-07-31

Publication	Publication Date	Title
IL124563A0 (en)	1998-12-06	Novel indole-2, 3-dione-3-oxime
TW349098B (en)	1999-01-01	Naphthalene derivatives, process for the preparation thereof, and intermediates therefor
HUP0204418A2 (hu)	2003-04-28	NHE-1 inhibitor hatású N-[(helyettesített öttagú, di- vagy triaza-, kétszeresen telítetlen gyűrű)-karbonil]-guanidin-származékok és alkalmazásuk
BG105969A (en)	2002-05-31	Amine derivatives as protein inhibitors
ATE157355T1 (de)	1997-09-15	3-benzyliden-1-carbamoyl-2-pyrrolidon-analoga
NZ334531A (en)	2000-09-29	Quinoxalin derivatives as Protein kinase C inhibitors
ES2189234T3 (es)	2003-07-01	Nuevos derivados de taxano.
IL102703A (en)	1997-03-18	N-sulfonyl indoline derivatives carrying an amide functional group, their preparation and pharmaceutical compositions containing them
MY135841A (en)	2008-07-31	Novel benzodioxoles
NO905066L (no)	1991-05-24	Isoindolonderivater, deres fremstilling og anvendelser.
SE9103572D0 (sv)	1991-11-29	Organic salts of n,n'-diacetyl cystine
ES2162466T3 (es)	2001-12-16	Derivados de 1,2,4-triazolo(4,3-b)pirido(3,2-d)piridazina y composiciones farmaceuticas que los contienen.
DE69924292D1 (de)	2005-04-21	Pyrazol verbindungen und ihre verwendung
BG94282A (bg)	1993-12-24	2,9-дизаместени-4н-пиридо/1,2,-а/пиримидин-4-они
NO305287B1 (no)	1999-05-03	AMPA antagonister
DE59710816D1 (de)	2003-11-06	Neue thiazol-derivate mit phosphodiesterase inhibierender wirkung
ATE302772T1 (de)	2005-09-15	2-(1h-indol-3-yl)-2-oxo-acetamide mit antitumoraler wirkung
CO5140116A1 (es)	2002-03-22	Compuestos espiro derivados de imidazo-benzazepina con actividad antihistaminica y sus procesos de obtencion a partir de sus intermediarios de sintesis
DE69726716D1 (de)	2004-01-22	Antikachektische zusammensetzung
IL91648A (en)	1997-03-18	Amino acid quinoline and naphthyridine derivatives, their preparation and pharmaceutical compositions containing them
TW367328B (en)	1999-08-21	Benzofuro[3,2-b]pyridine derivatives, process for the preparation thereof and pharmaceutical composition containing the same
AP2002002595A0 (en)	2002-09-30	Heterocyclic amide derivatives.
AR019390A1 (es)	2002-02-20	Derivados de acidos sulfonilaminofosfinicos y sulfonilaminofosfonicos, procedimiento para su preparacion, compuestos intermediarios, medicamentos, procedimiento para su preparacion y empleo de dichos derivados para la preparacion de un medicamento.
HUP9801810A2 (hu)	1998-11-30	Imidazo[1,5-a]piridin-csoporttal helyettesített szerin-proteáz inhibitorok, ezek előállítása és ezeket tartalmazó gyógyszerkészítmények
ES455436A1 (es)	1978-04-16	Procedimiento de preparacion de acidos tienotienilcarbonife-nilalcanoicos.