SI0869958T1 - Novel indole-2,3-dione-3-oxime derivatives - Google Patents

Novel indole-2,3-dione-3-oxime derivatives

Info

Publication number: SI0869958T1
Authority: SI; Slovenia
Prior art keywords: dione; het; oxime derivatives; novel indole; ring
Prior art date: 1996-10-01

Application number

SI9730698T

Other languages

English (en)

Slovenian (sl)

Inventor

Frank W�Tjen

Jorgen Drejer

Original Assignee

Neurosearch A/S

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-01

Filing date

1997-10-01

Publication date

2005-06-30

1997-10-01 Application filed by Neurosearch A/S filed Critical Neurosearch A/S

2005-06-30 Publication of SI0869958T1 publication Critical patent/SI0869958T1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

SI9730698T 1996-10-01 1997-10-01 Novel indole-2,3-dione-3-oxime derivatives SI0869958T1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DK106996		1996-10-01
DK127796		1996-11-13
EP97941880A EP0869958B1 (en)	1996-10-01	1997-10-01	Novel indole-2,3-dione-3-oxime derivatives
PCT/DK1997/000418 WO1998014447A1 (en)	1996-10-01	1997-10-01	Novel indole-2,3-dione-3-oxime derivatives

Publications (1)

Publication Number	Publication Date
SI0869958T1 true SI0869958T1 (en)	2005-06-30

Family

ID=26065167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9730698T SI0869958T1 (en)	1996-10-01	1997-10-01	Novel indole-2,3-dione-3-oxime derivatives

Country Status (28)

Country	Link
US (3)	US6124285A (xx)
EP (1)	EP0869958B1 (xx)
JP (1)	JP3319762B2 (xx)
KR (1)	KR100492052B1 (xx)
CN (1)	CN1093859C (xx)
AT (1)	ATE286052T1 (xx)
AU (1)	AU716435B2 (xx)
BG (1)	BG63874B1 (xx)
BR (1)	BR9706765A (xx)
CA (1)	CA2238410C (xx)
CZ (1)	CZ297938B6 (xx)
DE (1)	DE69732090T2 (xx)
DK (1)	DK0869958T3 (xx)
EE (1)	EE9800144A (xx)
ES (1)	ES2235253T3 (xx)
HU (1)	HU225145B1 (xx)
IL (1)	IL124563A (xx)
IS (1)	IS2123B (xx)
NO (1)	NO310722B1 (xx)
NZ (1)	NZ330456A (xx)
PL (1)	PL193041B1 (xx)
PT (1)	PT869958E (xx)
RU (1)	RU2190612C2 (xx)
SI (1)	SI0869958T1 (xx)
SK (1)	SK282729B6 (xx)
TR (1)	TR199800956T1 (xx)
UA (1)	UA54403C2 (xx)
WO (1)	WO1998014447A1 (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
WO1999049864A1 (en) *	1998-03-31	1999-10-07	Neurosearch A/S	Indole-2,3-dione-3-oxime derivatives for therapeutic use
AU4910500A (en)	1999-05-19	2000-12-12	Neurosearch A/S	Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
DE60120925T2 (de)	2000-01-24	2006-11-09	Neurosearch A/S	Isatinderivate mit neurotropen aktivität
IT1318636B1 (it) *	2000-07-21	2003-08-27	Roberto Pellicciari	Derivati dell'acido 2- o 3- tenoico ad attivita' antagonista deirecettori del glutammato.
WO2002064139A1 (en) *	2001-02-15	2002-08-22	Neurosearch A/S	Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity
JP2005522408A (ja)	2001-07-13	2005-07-28	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	５−ＨＴ受容体リガントとしてのヘキサヒドロアゼピノ（４，５−ｇ）インドールおよびインドリン
WO2004018466A2 (en) *	2002-08-22	2004-03-04	Neurosearch A/S	A method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives
GB0507298D0 (en)	2005-04-11	2005-05-18	Novartis Ag	Organic compounds
JP2009516712A (ja) *	2005-11-23	2009-04-23	ペインセプターファーマコーポレーション	依存性イオンチャネルを調節するための組成物および方法
US20080004282A1 (en) *	2006-04-10	2008-01-03	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
US20080021034A1 (en) *	2006-04-10	2008-01-24	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
EP2066323A2 (en) *	2006-09-12	2009-06-10	NeuroSearch AS	Pharmaceutical compositions comprising combinations of an ampa/kainate antagonistic compound and an inhibitor of a multidrug resistance protein
US20080108603A1 (en) *	2006-10-19	2008-05-08	Eisenach James C	Combination therapy for the treatment of pain
US20080108622A1 (en) *	2006-10-19	2008-05-08	Eisenach James C	Combination therapy for the treatment of pain
WO2010104324A2 (ko) *	2009-03-10	2010-09-16	한국과학기술연구원	베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도
CN102653538A (zh) *	2011-03-04	2012-09-05	爱斯医药科技(南京)有限公司	Spd-502的制备方法
CN107567452B (zh)	2015-04-29	2020-07-07	詹森药业有限公司	咪唑并哌嗪和吡唑并嘧啶以及它们作为ampa受体调节剂的用途
UY36654A (es)	2015-04-29	2016-10-31	Janssen Pharmaceutica Nv	Azabenzimidazoles con propiedades moduladoras del receptor ampa y composiciones farmacéuticas que los contienen
US10611730B2 (en)	2015-04-29	2020-04-07	Janssen Pharmaceutica Nv	Benzimidazolone and benzothiazolone compounds and their use as AMPA receptor modulators
BR112017023200A2 (pt)	2015-04-29	2018-08-07	Janssen Pharmaceutica Nv	compostos de indolona e seu uso como moduladores do receptor de ampa

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE69677B1 (en) *	1989-12-11	1996-10-02	Neurosearch As	Isatine derivatives their preparation and use
MX9204914A (es) *	1991-08-28	1993-07-01	Frank Watjen	Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende.
TW281669B (xx) *	1993-02-17	1996-07-21	Chugai Pharmaceutical Co Ltd
US5721230A (en)	1993-05-10	1998-02-24	Hoffmann-La Roche Inc.	Substituted pyrroles
DK0698025T3 (da) *	1993-05-13	1998-08-24	Neurosearch As	Ampa-antagonister samt fremgangsmåde til behandling dermed
DK81593D0 (da) *	1993-07-07	1993-07-07	Neurosearch As	Nye isatinoximderivater, deres fremstilling og anvendelse
EP0781284B1 (en) *	1994-09-14	2000-01-12	Neurosearch A/S	Indole-2,3-dione-3-oxime derivatives, their preparation and use
WO1996008495A1 (en) *	1994-09-14	1996-03-21	Neurosearch A/S	Fused indole and quinoxaline derivatives, their preparation and use
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму

1997
- 1997-01-10 UA UA98052752A patent/UA54403C2/uk unknown
- 1997-10-01 CN CN97191602A patent/CN1093859C/zh not_active Expired - Fee Related
- 1997-10-01 DK DK97941880T patent/DK0869958T3/da active
- 1997-10-01 CZ CZ0160698A patent/CZ297938B6/cs not_active IP Right Cessation
- 1997-10-01 SK SK676-98A patent/SK282729B6/sk not_active IP Right Cessation
- 1997-10-01 PL PL327073A patent/PL193041B1/pl not_active IP Right Cessation
- 1997-10-01 US US09/077,554 patent/US6124285A/en not_active Expired - Lifetime
- 1997-10-01 ES ES97941880T patent/ES2235253T3/es not_active Expired - Lifetime
- 1997-10-01 TR TR1998/00956T patent/TR199800956T1/xx unknown
- 1997-10-01 JP JP51615898A patent/JP3319762B2/ja not_active Expired - Fee Related
- 1997-10-01 AU AU43768/97A patent/AU716435B2/en not_active Ceased
- 1997-10-01 AT AT97941880T patent/ATE286052T1/de not_active IP Right Cessation
- 1997-10-01 SI SI9730698T patent/SI0869958T1/xx unknown
- 1997-10-01 CA CA002238410A patent/CA2238410C/en not_active Expired - Fee Related
- 1997-10-01 US US09/956,892 patent/USRE38200E1/en not_active Expired - Fee Related
- 1997-10-01 IL IL12456397A patent/IL124563A/xx not_active IP Right Cessation
- 1997-10-01 EP EP97941880A patent/EP0869958B1/en not_active Expired - Lifetime
- 1997-10-01 EE EE9800144A patent/EE9800144A/xx unknown
- 1997-10-01 DE DE69732090T patent/DE69732090T2/de not_active Expired - Lifetime
- 1997-10-01 KR KR10-1998-0704103A patent/KR100492052B1/ko not_active Expired - Fee Related
- 1997-10-01 HU HU9901630A patent/HU225145B1/hu not_active IP Right Cessation
- 1997-10-01 BR BR9706765-2A patent/BR9706765A/pt not_active Application Discontinuation
- 1997-10-01 RU RU98112237/04A patent/RU2190612C2/ru not_active IP Right Cessation
- 1997-10-01 WO PCT/DK1997/000418 patent/WO1998014447A1/en not_active Ceased
- 1997-10-01 PT PT97941880T patent/PT869958E/pt unknown
- 1997-10-01 NZ NZ330456A patent/NZ330456A/en unknown
1998
- 1998-05-18 IS IS4748A patent/IS2123B/xx unknown
- 1998-05-26 BG BG102489A patent/BG63874B1/bg unknown
- 1998-05-29 NO NO19982466A patent/NO310722B1/no not_active IP Right Cessation
2000
- 2000-05-31 US US09/584,117 patent/US6693111B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69732090T2 (de)	2005-12-29
US6124285A (en)	2000-09-26
BG102489A (en)	1999-04-30
TR199800956T1 (xx)	1998-12-21
US6693111B1 (en)	2004-02-17
ES2235253T3 (es)	2005-07-01
DK0869958T3 (da)	2005-04-18
NO982466L (no)	1998-07-31
HK1017682A1 (en)	1999-11-26
EE9800144A (et)	1998-10-15
USRE38200E1 (en)	2003-07-22
KR19990071823A (ko)	1999-09-27
SK67698A3 (en)	1998-11-04
KR100492052B1 (ko)	2005-09-30
CN1093859C (zh)	2002-11-06
JP2000501432A (ja)	2000-02-08
UA54403C2 (uk)	2003-03-17
IS4748A (is)	1998-05-18
JP3319762B2 (ja)	2002-09-03
CZ160698A3 (cs)	1998-10-14
CA2238410C (en)	2007-06-12
PL193041B1 (pl)	2007-01-31
HU225145B1 (en)	2006-07-28
CZ297938B6 (cs)	2007-05-02
PT869958E (pt)	2005-05-31
NZ330456A (en)	1998-11-25
CN1207100A (zh)	1999-02-03
BG63874B1 (bg)	2003-04-30
CA2238410A1 (en)	1998-04-09
EP0869958B1 (en)	2004-12-29
IS2123B (is)	2006-07-14
IL124563A0 (en)	1998-12-06
ATE286052T1 (de)	2005-01-15
DE69732090D1 (de)	2005-02-03
AU4376897A (en)	1998-04-24
SK282729B6 (sk)	2002-11-06
AU716435B2 (en)	2000-02-24
RU2190612C2 (ru)	2002-10-10
HUP9901630A3 (en)	2001-11-28
PL327073A1 (en)	1998-11-23
BR9706765A (pt)	1999-09-14
MX9804365A (es)	1998-10-31
WO1998014447A1 (en)	1998-04-09
NO310722B1 (no)	2001-08-20
NO982466D0 (no)	1998-05-29
EP0869958A1 (en)	1998-10-14
IL124563A (en)	2005-05-17
HUP9901630A2 (hu)	1999-08-30

Publication	Publication Date	Title
PL327073A1 (en)	1998-11-23	Novel derivatives of indolo-2,3-diono-3-oxime
TW349098B (en)	1999-01-01	Naphthalene derivatives, process for the preparation thereof, and intermediates therefor
HUP0204418A2 (hu)	2003-04-28	NHE-1 inhibitor hatású N-[(helyettesített öttagú, di- vagy triaza-, kétszeresen telítetlen gyűrű)-karbonil]-guanidin-származékok és alkalmazásuk
BG105969A (en)	2002-05-31	Amine derivatives as protein inhibitors
UY25679A1 (es)	2000-03-31	Derivados de quinolin-2-ona inhibidores de la farnesil proteína transferasa útiles como agentes contra el cáncer
ATE157355T1 (de)	1997-09-15	3-benzyliden-1-carbamoyl-2-pyrrolidon-analoga
NZ334531A (en)	2000-09-29	Quinoxalin derivatives as Protein kinase C inhibitors
ES2189234T3 (es)	2003-07-01	Nuevos derivados de taxano.
IL102703A (en)	1997-03-18	N-sulfonyl indoline derivatives carrying an amide functional group, their preparation and pharmaceutical compositions containing them
YU64092A (sh)	1995-03-27	Fluoralkoksibenzamino derivati heterocikličnih jedinjenja koja sadrže azot
MY135841A (en)	2008-07-31	Novel benzodioxoles
SE9103572D0 (sv)	1991-11-29	Organic salts of n,n'-diacetyl cystine
ES2162466T3 (es)	2001-12-16	Derivados de 1,2,4-triazolo(4,3-b)pirido(3,2-d)piridazina y composiciones farmaceuticas que los contienen.
DE69924292D1 (de)	2005-04-21	Pyrazol verbindungen und ihre verwendung
BG94282A (bg)	1993-12-24	2,9-дизаместени-4н-пиридо/1,2,-а/пиримидин-4-они
NO305287B1 (no)	1999-05-03	AMPA antagonister
DE59710816D1 (de)	2003-11-06	Neue thiazol-derivate mit phosphodiesterase inhibierender wirkung
ATE302772T1 (de)	2005-09-15	2-(1h-indol-3-yl)-2-oxo-acetamide mit antitumoraler wirkung
CO5140116A1 (es)	2002-03-22	Compuestos espiro derivados de imidazo-benzazepina con actividad antihistaminica y sus procesos de obtencion a partir de sus intermediarios de sintesis
IL91648A (en)	1997-03-18	Amino acid quinoline and naphthyridine derivatives, their preparation and pharmaceutical compositions containing them
TW367328B (en)	1999-08-21	Benzofuro[3,2-b]pyridine derivatives, process for the preparation thereof and pharmaceutical composition containing the same
AP2002002595A0 (en)	2002-09-30	Heterocyclic amide derivatives.
AR019390A1 (es)	2002-02-20	Derivados de acidos sulfonilaminofosfinicos y sulfonilaminofosfonicos, procedimiento para su preparacion, compuestos intermediarios, medicamentos, procedimiento para su preparacion y empleo de dichos derivados para la preparacion de un medicamento.
TW333525B (en)	1998-06-11	New perhydroisoindole derivatives, their preparation and the pharmaceutical compositions which contain them the invention relates to perhydroisoindole derivatives of general formula (I), and their salts when they exist advantageously as neurokinin A antagonists.
HUP9801810A2 (hu)	1998-11-30	Imidazo[1,5-a]piridin-csoporttal helyettesített szerin-proteáz inhibitorok, ezek előállítása és ezeket tartalmazó gyógyszerkészítmények