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SG161281A1 - Hgf beta chain variants - Google Patents

Hgf beta chain variants

Info

Publication number
SG161281A1
SG161281A1 SG201002641-7A SG2010026417A SG161281A1 SG 161281 A1 SG161281 A1 SG 161281A1 SG 2010026417 A SG2010026417 A SG 2010026417A SG 161281 A1 SG161281 A1 SG 161281A1
Authority
SG
Singapore
Prior art keywords
hgf
beta chain
chain variants
hgf beta
regions
Prior art date
Application number
SG201002641-7A
Other languages
English (en)
Inventor
Daniel K Kirchhofer
Robert A Lazarus
Christian Wiesmann
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of SG161281A1 publication Critical patent/SG161281A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG201002641-7A 2005-04-15 2006-04-17 Hgf beta chain variants SG161281A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67161005P 2005-04-15 2005-04-15

Publications (1)

Publication Number Publication Date
SG161281A1 true SG161281A1 (en) 2010-05-27

Family

ID=37011985

Family Applications (1)

Application Number Title Priority Date Filing Date
SG201002641-7A SG161281A1 (en) 2005-04-15 2006-04-17 Hgf beta chain variants

Country Status (16)

Country Link
US (2) US7737115B2 (fr)
EP (1) EP1869070B1 (fr)
JP (1) JP5222720B2 (fr)
KR (1) KR101259655B1 (fr)
CN (1) CN101193910A (fr)
AU (1) AU2006236360B2 (fr)
BR (1) BRPI0611464A2 (fr)
CA (1) CA2605037C (fr)
ES (1) ES2446923T3 (fr)
IL (1) IL186157A0 (fr)
MX (1) MX2007012687A (fr)
NZ (1) NZ561704A (fr)
RU (1) RU2403261C2 (fr)
SG (1) SG161281A1 (fr)
WO (1) WO2006113767A2 (fr)
ZA (1) ZA200710599B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5620626B2 (ja) 2005-03-31 2014-11-05 中外製薬株式会社 会合制御によるポリペプチド製造方法
EP2009101B1 (fr) 2006-03-31 2017-10-25 Chugai Seiyaku Kabushiki Kaisha Procede de modification d'anticorps pour purifier un anticorps bispecifique
DK2006381T3 (en) 2006-03-31 2016-02-22 Chugai Pharmaceutical Co Ltd PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS
DK2202245T3 (en) 2007-09-26 2016-11-21 Chugai Pharmaceutical Co Ltd A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR
ES2687808T3 (es) 2007-09-26 2018-10-29 Chugai Seiyaku Kabushiki Kaisha Región constante de anticuerpo modificado
TWI646193B (zh) 2009-03-19 2019-01-01 中外製藥股份有限公司 抗體恆定區域改變體
WO2010107110A1 (fr) 2009-03-19 2010-09-23 中外製薬株式会社 Variant d'une région constante d'anticorps
JP5837821B2 (ja) 2009-09-24 2015-12-24 中外製薬株式会社 抗体定常領域改変体
US20110206704A1 (en) * 2009-10-19 2011-08-25 Genentech, Inc. Methods and compositions for modulating hepatocyte growth factor activator
JP5889794B2 (ja) * 2009-10-19 2016-03-22 ジェネンテック， インコーポレイテッド 肝細胞増殖因子アクチベーターの調節
SI2522724T1 (sl) * 2009-12-25 2020-07-31 Chuqai Seiyaku Kabushiki Kaisha Postopek za spremembo polipeptida za čiščenje polipetidnih multimerov
EP2543730B1 (fr) 2010-03-04 2018-10-31 Chugai Seiyaku Kabushiki Kaisha Variante de région constante d'anticorps
TR201802772T4 (tr) 2010-11-17 2018-03-21 Chugai Pharmaceutical Co Ltd Kan pıhtılaşma faktörü VIII in işlevi için alternatif işleve sahip multi-spesifik antijen bağlayıcı molekül.
LT2647707T (lt) 2010-11-30 2018-11-12 Chugai Seiyaku Kabushiki Kaisha Citotoksiškumą indukuojantis terapinis agentas
ES2881306T3 (es) 2013-09-27 2021-11-29 Chugai Pharmaceutical Co Ltd Método para la producción de heteromultímeros de polipéptidos
EP3122900A1 (fr) 2014-03-24 2017-02-01 F. Hoffmann-La Roche AG Traitement du cancer avec des antagonistes de c-met et corrélation de ces derniers avec l'expression de hgf
WO2016159213A1 (fr) 2015-04-01 2016-10-06 中外製薬株式会社 Procédé pour la production d'un hétéro-oligomère polypeptidique
JP7219005B2 (ja) 2015-12-28 2023-02-07 中外製薬株式会社 Ｆｃ領域含有ポリペプチドの精製を効率化するための方法
JP7320943B2 (ja) 2016-04-28 2023-08-04 中外製薬株式会社 抗体含有製剤
AU2018361430B2 (en) 2017-11-01 2025-08-14 Chugai Seiyaku Kabushiki Kaisha Antibody variant and isoform with lowered biological activity

Family Cites Families (24)

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Publication number Priority date Publication date Assignee Title
US5A (en) * 1836-08-10 Thomas Blanchard Machine for mortising solid wooden shells of ships' tackle-blocks
US4342566A (en) 1980-02-22 1982-08-03 Scripps Clinic & Research Foundation Solid phase anti-C3 assay for detection of immune complexes
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5362716A (en) 1989-12-27 1994-11-08 The United States Of America As Represented By The Department Of Health And Human Services Methods for stimulating hematopoietic progenitors using hepatocyte growth factor and lymphokines
US5648273A (en) 1989-12-27 1997-07-15 The United States Of America, As Represented By The Department Of Health And Human Services Hepatic growth factor receptor is the MET proto-oncogene
US5871959A (en) 1989-12-27 1999-02-16 The United States Of America As Represented By The Department Of Health And Human Services Method of producing hepatocycte growth factor/scatter factor and related cell lines
JPH03255096A (ja) 1990-03-01 1991-11-13 Toyobo Co Ltd 組換ラット肝実質細胞増殖因子
DE69133349T2 (de) 1990-09-14 2004-10-07 Us Health Ein nicht-mitogener kompetitiver hgf-antagonist
AU651452B2 (en) 1991-05-10 1994-07-21 Pharmacia & Upjohn S.P.A. Truncated forms of the hepatocyte growth factor receptor
US5227158A (en) 1991-06-10 1993-07-13 Genentech, Inc. Method of stimulating hepatocyte proliferation by administration of hepatocyte growth factor and gamma-interferon
WO1994004679A1 (fr) 1991-06-14 1994-03-03 Genentech, Inc. Procede pour fabriquer des anticorps humanises
EP0642585B1 (fr) 1992-05-18 2005-12-28 Genentech, Inc. Activation de recepteurs d'oligomerisation grace a des ligands de recepteurs fusionnes
US5328837A (en) * 1992-05-18 1994-07-12 Genentech, Inc. Hepatocyte growth factor protease domain variants
PT642580E (pt) 1992-05-18 2003-01-31 Genentech Inc Variantes de factor de crescimento dos hepatocitos
US5316921A (en) 1992-05-18 1994-05-31 Genentech, Inc. Single-chain hepatocyte growth factor variants
WO1994006909A2 (fr) 1992-09-18 1994-03-31 United States Of America, As Represented By The Secretary, Department Of Health And Human Services Procede de prevention de metastase tumorale
AU6852594A (en) 1993-06-03 1995-01-03 Therapeutic Antibodies Inc. Production of antibody fragments
HU219813B (hu) 1993-06-30 2001-08-28 Pharmacia S.P.A. Mitogenezis és motogenezis peptid inhibitorok
US5686292A (en) 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
US6214344B1 (en) 1995-06-02 2001-04-10 Genetech, Inc. Hepatocyte growth factor receptor antagonists and uses thereof
EP0941111A4 (fr) 1996-11-05 2000-09-27 Smithkline Beecham Corp Antagonistes du facteur de croissance hepatocytaire
WO2004087896A2 (fr) 2003-03-31 2004-10-14 Pfizer Products Inc. Mise en croissance et differenciation de cellules souches
EP2367008A3 (fr) * 2003-06-06 2014-12-24 Genentech, Inc. Modulation de l'interaction entre la chaîne HGF bêta et C-MET
RS53476B (sr) 2003-07-18 2014-12-31 Amgen Fremont Inc. Sredstva za specifično vezivanje faktora rasta hepatocita

Also Published As

Publication number Publication date
US8110377B2 (en) 2012-02-07
AU2006236360B2 (en) 2012-02-02
CA2605037C (fr) 2015-02-24
RU2403261C2 (ru) 2010-11-10
ZA200710599B (en) 2009-08-26
RU2007142191A (ru) 2009-05-20
WO2006113767A3 (fr) 2007-01-11
KR20080011191A (ko) 2008-01-31
CN101193910A (zh) 2008-06-04
US7737115B2 (en) 2010-06-15
CA2605037A1 (fr) 2006-10-26
US20060293235A1 (en) 2006-12-28
NZ561704A (en) 2009-10-30
IL186157A0 (en) 2008-01-20
JP2008536500A (ja) 2008-09-11
MX2007012687A (es) 2008-03-14
EP1869070A2 (fr) 2007-12-26
EP1869070B1 (fr) 2013-11-27
AU2006236360A1 (en) 2006-10-26
WO2006113767A2 (fr) 2006-10-26
KR101259655B1 (ko) 2013-04-30
ES2446923T3 (es) 2014-03-10
JP5222720B2 (ja) 2013-06-26
BRPI0611464A2 (pt) 2010-09-08
US20100210826A1 (en) 2010-08-19
HK1111706A1 (en) 2008-08-15

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