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ZA200710599B - HGF Beta chain variants - Google Patents

HGF Beta chain variants

Info

Publication number
ZA200710599B
ZA200710599B ZA200710599A ZA200710599A ZA200710599B ZA 200710599 B ZA200710599 B ZA 200710599B ZA 200710599 A ZA200710599 A ZA 200710599A ZA 200710599 A ZA200710599 A ZA 200710599A ZA 200710599 B ZA200710599 B ZA 200710599B
Authority
ZA
South Africa
Prior art keywords
beta chain
chain variants
hgf beta
hgf
variants
Prior art date
Application number
ZA200710599A
Other languages
English (en)
Inventor
Daniel K Kirchhoofer
Robert A Lazarus
Wiesmann Christian
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ZA200710599B publication Critical patent/ZA200710599B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ZA200710599A 2005-04-15 2006-04-17 HGF Beta chain variants ZA200710599B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67161005P 2005-04-15 2005-04-15

Publications (1)

Publication Number Publication Date
ZA200710599B true ZA200710599B (en) 2009-08-26

Family

ID=37011985

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200710599A ZA200710599B (en) 2005-04-15 2006-04-17 HGF Beta chain variants

Country Status (16)

Country Link
US (2) US7737115B2 (xx)
EP (1) EP1869070B1 (xx)
JP (1) JP5222720B2 (xx)
KR (1) KR101259655B1 (xx)
CN (1) CN101193910A (xx)
AU (1) AU2006236360B2 (xx)
BR (1) BRPI0611464A2 (xx)
CA (1) CA2605037C (xx)
ES (1) ES2446923T3 (xx)
IL (1) IL186157A0 (xx)
MX (1) MX2007012687A (xx)
NZ (1) NZ561704A (xx)
RU (1) RU2403261C2 (xx)
SG (1) SG161281A1 (xx)
WO (1) WO2006113767A2 (xx)
ZA (1) ZA200710599B (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3050963B1 (en) 2005-03-31 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Process for production of polypeptide by regulation of assembly
ES2654040T3 (es) 2006-03-31 2018-02-12 Chugai Seiyaku Kabushiki Kaisha Método de modificación de anticuerpos para la purificación de anticuerpos biespecíficos
IN2014DN10515A (xx) 2006-03-31 2015-08-21 Chugai Pharmaceutical Co Ltd
ES2687808T3 (es) 2007-09-26 2018-10-29 Chugai Seiyaku Kabushiki Kaisha Región constante de anticuerpo modificado
MX369784B (es) 2007-09-26 2019-11-21 Chugai Pharmaceutical Co Ltd Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
US20120071634A1 (en) 2009-03-19 2012-03-22 Chugai Seiyaku Kabushiki Kaisha Antibody Constant Region Variant
JP5717624B2 (ja) 2009-03-19 2015-05-13 中外製薬株式会社 抗体定常領域改変体
JP5837821B2 (ja) 2009-09-24 2015-12-24 中外製薬株式会社 抗体定常領域改変体
US20110206704A1 (en) * 2009-10-19 2011-08-25 Genentech, Inc. Methods and compositions for modulating hepatocyte growth factor activator
US8759491B2 (en) * 2009-10-19 2014-06-24 Genentech, Inc. Modulators of hepatocyte growth factor activator
KR102103093B1 (ko) * 2009-12-25 2020-04-21 추가이 세이야쿠 가부시키가이샤 폴리펩티드 다량체를 정제하기 위한 폴리펩티드의 개변방법
WO2011108714A1 (ja) 2010-03-04 2011-09-09 中外製薬株式会社 抗体定常領域改変体
TWI629355B (zh) 2010-11-17 2018-07-11 中外製藥股份有限公司 具有替代血液凝固第ｖｉｉｉ因子之功能的多重專一性抗原結合分子
TWI736437B (zh) 2010-11-30 2021-08-11 日商中外製藥股份有限公司 細胞傷害誘導治療劑
KR102441231B1 (ko) 2013-09-27 2022-09-06 추가이 세이야쿠 가부시키가이샤 폴리펩티드 이종 다량체의 제조방법
RU2016141385A (ru) 2014-03-24 2018-04-28 Дженентек, Инк. Лечение рака антагонистами с-мет и их корреляция с экспрессией hgf
US11142587B2 (en) 2015-04-01 2021-10-12 Chugai Seiyaku Kabushiki Kaisha Method for producing polypeptide hetero-oligomer
SG11201803989WA (en) 2015-12-28 2018-06-28 Chugai Pharmaceutical Co Ltd Method for promoting efficiency of purification of fc region-containing polypeptide
PE20181889A1 (es) 2016-04-28 2018-12-11 Chugai Pharmaceutical Co Ltd Preparaciones que contienen anticuerpos
EP3705496A4 (en) 2017-11-01 2021-12-08 Chugai Seiyaku Kabushiki Kaisha ANTIBODY VARIANT AND ISOFORM WITH REDUCED BIOLOGICAL ACTIVITY

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5A (en) * 1836-08-10 Thomas Blanchard Machine for mortising solid wooden shells of ships' tackle-blocks
US4342566A (en) 1980-02-22 1982-08-03 Scripps Clinic & Research Foundation Solid phase anti-C3 assay for detection of immune complexes
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5871959A (en) 1989-12-27 1999-02-16 The United States Of America As Represented By The Department Of Health And Human Services Method of producing hepatocycte growth factor/scatter factor and related cell lines
US5362716A (en) 1989-12-27 1994-11-08 The United States Of America As Represented By The Department Of Health And Human Services Methods for stimulating hematopoietic progenitors using hepatocyte growth factor and lymphokines
US5648273A (en) 1989-12-27 1997-07-15 The United States Of America, As Represented By The Department Of Health And Human Services Hepatic growth factor receptor is the MET proto-oncogene
JPH03255096A (ja) 1990-03-01 1991-11-13 Toyobo Co Ltd 組換ラット肝実質細胞増殖因子
JP3438888B2 (ja) 1990-09-14 2003-08-18 アメリカ合衆国 非分裂促進競合性ｈｇｆ拮抗剤
DE69220940T2 (de) 1991-05-10 1998-01-15 Pharmacia & Upjohn S.P.A., Mailand/Milano Verkürzte Formen den Hepatozyten Wachstumsfaktor (HGF) Rezeptors
US5227158A (en) 1991-06-10 1993-07-13 Genentech, Inc. Method of stimulating hepatocyte proliferation by administration of hepatocyte growth factor and gamma-interferon
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
US5316921A (en) 1992-05-18 1994-05-31 Genentech, Inc. Single-chain hepatocyte growth factor variants
US5328837A (en) * 1992-05-18 1994-07-12 Genentech, Inc. Hepatocyte growth factor protease domain variants
JPH07508420A (ja) 1992-05-18 1995-09-21 ジェネンテク，インコーポレイテッド 肝細胞成長因子変異体
JPH07508178A (ja) 1992-05-18 1995-09-14 ジェネンテク，インコーポレイテッド レセプター活性化
EP0662130B1 (en) 1992-09-18 1997-11-26 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES A method of producing hepatocyte growth factor and a cell line
ES2108460T3 (es) 1993-06-03 1997-12-16 Therapeutic Antibodies Inc Fragmentos de anticuerpos en terapeutica.
RU2146262C1 (ru) 1993-06-30 2000-03-10 Фармация Энд Апджон С.П.А. Пептиды, способ их получения, фармацевтическая композиция и способ ее получения
US5686292A (en) 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
US6214344B1 (en) 1995-06-02 2001-04-10 Genetech, Inc. Hepatocyte growth factor receptor antagonists and uses thereof
EP0941111A4 (en) 1996-11-05 2000-09-27 Smithkline Beecham Corp HEPATOCYTE GROWTH FACTOR ANTAGONISTS
WO2004087896A2 (en) 2003-03-31 2004-10-14 Pfizer Products Inc. Hepatocyte differentiation of stem cells
HRP20090324T1 (hr) * 2003-06-06 2010-02-28 Genentech Moduliranje interakcije između hgf beta lanca i c-met
US8609090B2 (en) 2003-07-18 2013-12-17 Amgen Inc. Specific binding agents to hepatocyte growth factor

Also Published As

Publication number Publication date
US20100210826A1 (en) 2010-08-19
MX2007012687A (es) 2008-03-14
HK1111706A1 (en) 2008-08-15
US20060293235A1 (en) 2006-12-28
SG161281A1 (en) 2010-05-27
CA2605037C (en) 2015-02-24
IL186157A0 (en) 2008-01-20
KR101259655B1 (ko) 2013-04-30
RU2403261C2 (ru) 2010-11-10
WO2006113767A3 (en) 2007-01-11
AU2006236360B2 (en) 2012-02-02
US7737115B2 (en) 2010-06-15
EP1869070B1 (en) 2013-11-27
AU2006236360A1 (en) 2006-10-26
ES2446923T3 (es) 2014-03-10
CA2605037A1 (en) 2006-10-26
RU2007142191A (ru) 2009-05-20
NZ561704A (en) 2009-10-30
EP1869070A2 (en) 2007-12-26
KR20080011191A (ko) 2008-01-31
CN101193910A (zh) 2008-06-04
US8110377B2 (en) 2012-02-07
BRPI0611464A2 (pt) 2010-09-08
JP5222720B2 (ja) 2013-06-26
JP2008536500A (ja) 2008-09-11
WO2006113767A2 (en) 2006-10-26

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