SG151072A1 - Stabilization of macrolides - Google Patents

Stabilization of macrolides

Info

Publication number: SG151072A1
Authority: SG; Singapore
Prior art keywords: stabilization; macrolides; poly; relates; crystalline form
Prior art date: 1998-12-07

Application number

SG200302502-0A

Other languages

English (en)

Inventor

Francois Navarro

Samuel Petit

Guy Stone

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-07

Filing date

1999-12-06

Publication date

2009-06-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26314797&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG151072(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-12-06 Application filed by Novartis Ag filed Critical Novartis Ag

2009-06-29 Publication of SG151072A1 publication Critical patent/SG151072A1/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)

SG200302502-0A 1998-12-07 1999-12-06 Stabilization of macrolides SG151072A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9826882.4A GB9826882D0 (en)	1998-12-07	1998-12-07	Organic compounds
GBGB9904934.8A GB9904934D0 (en)	1998-12-07	1999-03-04	Organic compounds

Publications (1)

Publication Number	Publication Date
SG151072A1 true SG151072A1 (en)	2009-06-29

Family

ID=26314797

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG200302502-0A SG151072A1 (en)	1998-12-07	1999-12-06	Stabilization of macrolides

Country Status (38)

Country	Link
US (5)	US6605613B2 (es)
EP (4)	EP1743657A3 (es)
JP (3)	JP3805625B2 (es)
KR (2)	KR100695834B1 (es)
CN (2)	CN1876657B (es)
AR (3)	AR026102A1 (es)
AT (1)	ATE365051T1 (es)
AU (1)	AU759219B2 (es)
BE (1)	BE1012869A3 (es)
BR (1)	BR9915986A (es)
CA (3)	CA2651609A1 (es)
CO (1)	CO4980847A1 (es)
CY (1)	CY1106870T1 (es)
CZ (2)	CZ303006B6 (es)
DE (1)	DE69936352T3 (es)
DK (1)	DK1137439T4 (es)
ES (1)	ES2288033T5 (es)
FR (1)	FR2786771B1 (es)
GB (2)	GB9826882D0 (es)
HK (1)	HK1038889B (es)
HU (2)	HU230174B1 (es)
ID (1)	ID29250A (es)
IL (1)	IL143092A0 (es)
IT (1)	IT1319701B1 (es)
MY (2)	MY127579A (es)
NO (2)	NO332698B1 (es)
NZ (2)	NZ511936A (es)
PE (1)	PE20001333A1 (es)
PL (2)	PL196627B1 (es)
PT (1)	PT1137439E (es)
RU (1)	RU2243769C2 (es)
SG (1)	SG151072A1 (es)
SI (1)	SI1137439T2 (es)
SK (2)	SK286688B6 (es)
TR (2)	TR200201428T2 (es)
TW (2)	TWI270550B (es)
WO (1)	WO2000033878A2 (es)
ZA (1)	ZA200104360B (es)

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US20070032853A1 (en)	2002-03-27	2007-02-08	Hossainy Syed F	40-O-(2-hydroxy)ethyl-rapamycin coated stent
CN100338043C (zh)	2002-02-13	2007-09-19	特瓦药厂私人有限公司	从生物物质中提取大环内酯的方法
US7452692B2 (en)	2002-02-13	2008-11-18	Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság	Method for extracting a macrolide from biomatter
WO2004011000A1 (en)	2002-07-30	2004-02-05	Wyeth	Parenteral formulations containing a rapamycin hydroxyester
DE04758730T1 (de)	2003-03-31	2005-06-23	Biogal Gyogyszergyar Rt.	Kristallisierung und Reinigung von Makroliden
US20050118344A1 (en)	2003-12-01	2005-06-02	Pacetti Stephen D.	Temperature controlled crimping
KR20060052874A (ko)	2003-07-24	2006-05-19	테바 기오기스제르갸르 레스즈베니타르사사그	마크로라이드의 정제 방법
AU2004274026A1 (en)	2003-09-18	2005-03-31	Macusight, Inc.	Transscleral delivery
US9114198B2 (en) *	2003-11-19	2015-08-25	Advanced Cardiovascular Systems, Inc.	Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same
US20070255197A1 (en) *	2003-12-10	2007-11-01	Acrux Dds Pty Ltd	Method of Treatment for Undesired Effect Following Transdermal or Topical Drug Delivery
US8551512B2 (en) *	2004-03-22	2013-10-08	Advanced Cardiovascular Systems, Inc.	Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS
CA2581169A1 (en) *	2004-09-29	2006-04-13	Cordis Corporation	Pharmaceutical dosage forms of stable amorphous rapamycin like compounds
US20060258698A1 (en)	2005-02-09	2006-11-16	Sreenivasu Mudumba	Liquid formulations for treatment of diseases or conditions
AU2006322030A1 (en) *	2005-12-07	2007-06-14	Wyeth	Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry
US7700614B2 (en) *	2005-12-14	2010-04-20	Abbott Laboratories	One pot synthesis of tetrazole derivatives of rapamycin
KR20080077989A (ko) *	2005-12-20	2008-08-26	와이어쓰	약물의 불순물 조절을 통한 ｃｃｉ-779 제형의 안정성 조절
BRPI0707612B8 (pt) *	2006-02-09	2021-05-25	Macusight Inc	vaso lacrado e formulações líquidas contidas no mesmo
EP2001466B1 (en)	2006-03-23	2016-01-06	Santen Pharmaceutical Co., Ltd	Low-dose rapamycin for the treatment of vascular permeability-related diseases
JP2013527223A (ja)	2010-06-02	2013-06-27	フレゼニウス・カビ・オンコロジー・リミテッド	ラパマイシンエステルの安定な医薬組成物
EP2576590A1 (en) *	2010-06-07	2013-04-10	Telik, Inc.	Crystalline ezatiostat hydrochloride ansolvate
WO2012017449A1 (en) *	2010-08-04	2012-02-09	Meril Life Sciences Pvt. Ltd	Process for preparation of novel 42-0-(heteroalkoxyalkyl) rapamycin compounds with anti-proliferative properties"
WO2012066502A1 (en)	2010-11-19	2012-05-24	Biocon Limited	Processes for preparation of everolimus and intermediates thereof
EP2717884A1 (en)	2011-06-06	2014-04-16	Chevron Phillips Chemical Company LP	Use of metallocene compounds for cancer treatment
WO2013022201A1 (en) *	2011-08-11	2013-02-14	Dong-A Pharm. Co., Ltd.	Process of preparing a stabilized and solubilized formulation of sirolimus derivatives
US9610385B2 (en)	2013-03-07	2017-04-04	Abbott Cardiovascular Systems Inc.	Method of fabricating an implantable medical device comprising a rapamycin derivative
IN2013MU02532A (es)	2013-07-31	2015-06-26	Sahajanand Medical Technologies Pvt Ltd
CN104721158B (zh) *	2013-12-24	2018-01-30	正大天晴药业集团股份有限公司	一种稳定的依维莫司片剂
CN104892632B (zh) *	2015-06-03	2017-12-26	道中道（菏泽）制药有限公司	一种晶体形式的依维莫司及其制备方法
WO2017018433A1 (ja)	2015-07-28	2017-02-02	日本化薬株式会社	ラパマイシン又はその誘導体を含有する医薬組成物及びその製造方法
JP6793651B2 (ja) *	2015-08-28	2020-12-02	日本化薬株式会社	ラパマイシン又はその誘導体を含有する医薬組成物
EP3351245A4 (en) *	2015-09-18	2019-05-22	Nippon Kayaku Kabushiki Kaisha	PHARMACEUTICAL COMPOSITION COMPRISING RAPAMYCIN OR A DERIVATIVE THEREOF
WO2017129772A1 (en)	2016-01-29	2017-08-03	Xellia Phamaceuticals Aps	Stable pharmaceutical compositions of temsirolimus
JP6855470B2 (ja)	2016-05-27	2021-04-07	日本化薬株式会社	ラパマイシン又はその誘導体を含有する医薬組成物
KR102051806B1 (ko) *	2018-01-12	2019-12-04	주식회사 종근당	에베로리무스를 포함하는 안정화된 약제학적 제제
AU2021242202B2 (en) *	2020-03-27	2024-01-11	Boston Scientific Scimed, Inc.	Methods for crystallization of drugs
JP2023028473A (ja) *	2021-08-19	2023-03-03	日本マイクロバイオファーマ株式会社	エベロリムスの製造方法

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1998
- 1998-12-07 GB GBGB9826882.4A patent/GB9826882D0/en not_active Ceased
1999
- 1999-03-04 GB GBGB9904934.8A patent/GB9904934D0/en not_active Ceased
- 1999-11-29 CO CO99074905A patent/CO4980847A1/es unknown
- 1999-12-02 IT IT1999MI002520A patent/IT1319701B1/it active
- 1999-12-03 PE PE1999001209A patent/PE20001333A1/es not_active IP Right Cessation
- 1999-12-03 AR ARP990106171A patent/AR026102A1/es active IP Right Grant
- 1999-12-03 FR FR9915256A patent/FR2786771B1/fr not_active Expired - Lifetime
- 1999-12-04 TW TW094104943A patent/TWI270550B/zh not_active IP Right Cessation
- 1999-12-04 TW TW088121250A patent/TWI248938B/zh not_active IP Right Cessation
- 1999-12-06 SK SK766-2001A patent/SK286688B6/sk not_active IP Right Cessation
- 1999-12-06 CZ CZ20012001A patent/CZ303006B6/cs not_active IP Right Cessation
- 1999-12-06 TR TR2002/01428T patent/TR200201428T2/xx unknown
- 1999-12-06 DK DK99959381.7T patent/DK1137439T4/da active
- 1999-12-06 PL PL348333A patent/PL196627B1/pl unknown
- 1999-12-06 PT PT99959381T patent/PT1137439E/pt unknown
- 1999-12-06 SG SG200302502-0A patent/SG151072A1/en unknown
- 1999-12-06 HK HK02100663.4A patent/HK1038889B/en not_active IP Right Cessation
- 1999-12-06 AU AU16573/00A patent/AU759219B2/en not_active Expired
- 1999-12-06 KR KR1020017007009A patent/KR100695834B1/ko not_active Expired - Lifetime
- 1999-12-06 CZ CZ20050170A patent/CZ302210B6/cs not_active IP Right Cessation
- 1999-12-06 ID IDW00200101156A patent/ID29250A/id unknown
- 1999-12-06 EP EP06122628A patent/EP1743657A3/en not_active Ceased
- 1999-12-06 EP EP99959381A patent/EP1137439B2/en not_active Expired - Lifetime
- 1999-12-06 HU HU1300289A patent/HU230174B1/hu unknown
- 1999-12-06 CA CA002651609A patent/CA2651609A1/en not_active Abandoned
- 1999-12-06 JP JP2000586368A patent/JP3805625B2/ja not_active Expired - Lifetime
- 1999-12-06 BR BR9915986-4A patent/BR9915986A/pt not_active Application Discontinuation
- 1999-12-06 PL PL380082A patent/PL208854B1/pl unknown
- 1999-12-06 CA CA2351580A patent/CA2351580C/en not_active Expired - Lifetime
- 1999-12-06 AT AT99959381T patent/ATE365051T1/de active
- 1999-12-06 IL IL14309299A patent/IL143092A0/xx not_active IP Right Cessation
- 1999-12-06 WO PCT/EP1999/009521 patent/WO2000033878A2/en not_active Ceased
- 1999-12-06 NZ NZ511936A patent/NZ511936A/en not_active IP Right Cessation
- 1999-12-06 CN CN2006100798040A patent/CN1876657B/zh not_active Expired - Lifetime
- 1999-12-06 SI SI9930985T patent/SI1137439T2/sl unknown
- 1999-12-06 CA CA2732620A patent/CA2732620C/en not_active Expired - Lifetime
- 1999-12-06 KR KR1020067017352A patent/KR20060096477A/ko not_active Ceased
- 1999-12-06 ES ES99959381T patent/ES2288033T5/es not_active Expired - Lifetime
- 1999-12-06 HU HU0104489A patent/HU228939B1/hu unknown
- 1999-12-06 DE DE69936352T patent/DE69936352T3/de not_active Expired - Lifetime
- 1999-12-06 EP EP10179096A patent/EP2279751A3/en not_active Withdrawn
- 1999-12-06 EP EP10179099A patent/EP2269651A3/en not_active Withdrawn
- 1999-12-06 CN CNB998141240A patent/CN1261163C/zh not_active Expired - Lifetime
- 1999-12-06 TR TR2001/01416T patent/TR200101416T2/xx unknown
- 1999-12-06 RU RU2001118266/15A patent/RU2243769C2/ru active
- 1999-12-06 SK SK5032-2008A patent/SK287325B6/sk not_active IP Right Cessation
- 1999-12-07 BE BE9900799A patent/BE1012869A3/fr not_active IP Right Cessation
- 1999-12-07 MY MYPI20043386A patent/MY127579A/en unknown
- 1999-12-07 MY MYPI99005309A patent/MY120594A/en unknown
2001
- 2001-05-16 NO NO20012424A patent/NO332698B1/no not_active IP Right Cessation
- 2001-05-28 ZA ZA200104360A patent/ZA200104360B/en unknown
- 2001-05-29 US US09/866,977 patent/US6605613B2/en not_active Expired - Lifetime
2003
- 2003-03-21 US US10/393,795 patent/US6852729B2/en not_active Expired - Lifetime
- 2003-08-25 NZ NZ527781A patent/NZ527781A/en not_active IP Right Cessation
2004
- 2004-12-23 US US11/020,860 patent/US7297703B2/en not_active Expired - Lifetime
2005
- 2005-02-28 AR ARP050100744A patent/AR048073A2/es active IP Right Grant
- 2005-04-01 JP JP2005106512A patent/JP5043308B2/ja not_active Expired - Lifetime
- 2005-12-28 JP JP2005378514A patent/JP5165199B2/ja not_active Expired - Lifetime
2006
- 2006-05-04 AR ARP060101807A patent/AR054444A2/es active IP Right Grant
2007
- 2007-09-14 CY CY20071101192T patent/CY1106870T1/el unknown
- 2007-10-11 US US11/973,927 patent/US7572804B2/en not_active Expired - Fee Related
2009
- 2009-07-06 US US12/497,728 patent/US7741338B2/en not_active Expired - Fee Related
2012
- 2012-10-01 NO NO20121113A patent/NO334612B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CO4980847A1 (es)	2000-11-27
EP1137439B1 (en)	2007-06-20
ES2288033T3 (es)	2007-12-16
HU230174B1 (hu)	2015-09-28
BE1012869A3 (fr)	2001-04-03
WO2000033878A2 (en)	2000-06-15
PT1137439E (pt)	2007-09-25
US7297703B2 (en)	2007-11-20
TW200540179A (en)	2005-12-16
US6852729B2 (en)	2005-02-08
JP2006111637A (ja)	2006-04-27
HK1038889B (en)	2008-01-25
DE69936352D1 (de)	2007-08-02
NO20012424D0 (no)	2001-05-16
US20030191148A1 (en)	2003-10-09
RU2243769C2 (ru)	2005-01-10
KR100695834B1 (ko)	2007-03-19
GB9826882D0 (en)	1999-01-27
MY127579A (en)	2006-12-29
CY1106870T1 (el)	2012-09-26
DK1137439T3 (da)	2007-09-10
AU759219B2 (en)	2003-04-10
US20080161334A1 (en)	2008-07-03
EP2269651A2 (en)	2011-01-05
HU228939B1 (en)	2013-07-29
CZ303006B6 (cs)	2012-02-22
CN1261163C (zh)	2006-06-28
ITMI992520A1 (it)	2001-06-02
MY120594A (en)	2005-11-30
ZA200104360B (en)	2002-01-16
DE69936352T2 (de)	2008-02-14
SK287325B6 (sk)	2010-07-07
FR2786771B1 (fr)	2002-12-27
JP5043308B2 (ja)	2012-10-10
DE69936352T3 (de)	2012-05-03
DK1137439T4 (da)	2012-03-19
CZ20012001A3 (cs)	2001-09-12
CA2651609A1 (en)	2000-06-15
SK286688B6 (sk)	2009-03-05
CN1876657A (zh)	2006-12-13
WO2000033878A3 (en)	2000-11-02
US20050107418A1 (en)	2005-05-19
HK1038889A1 (en)	2002-04-04
CA2351580C (en)	2012-03-20
EP1137439B2 (en)	2011-11-23
SI1137439T2 (sl)	2012-05-31
US6605613B2 (en)	2003-08-12
CA2732620A1 (en)	2000-06-15
AR048073A2 (es)	2006-03-29
ITMI992520A0 (it)	1999-12-02
TWI248938B (en)	2006-02-11
NZ527781A (en)	2004-11-26
US20090270441A1 (en)	2009-10-29
EP1743657A2 (en)	2007-01-17
KR20010101128A (ko)	2001-11-14
KR20060096477A (ko)	2006-09-11
SI1137439T1 (sl)	2008-06-30
CA2351580A1 (en)	2000-06-15
PE20001333A1 (es)	2000-12-12
PL196627B1 (pl)	2008-01-31
HUP0104489A3 (en)	2004-05-28
US7572804B2 (en)	2009-08-11
EP1137439A2 (en)	2001-10-04
ID29250A (id)	2001-08-16
FR2786771A1 (fr)	2000-06-09
NO20012424L (no)	2001-05-16
PL208854B1 (pl)	2011-06-30
CA2732620C (en)	2013-08-06
AR026102A1 (es)	2003-01-29
SK7662001A3 (en)	2001-12-03
CN1876657B (zh)	2013-01-09
NO20121113L (no)	2001-05-16
NO332698B1 (no)	2012-12-10
ATE365051T1 (de)	2007-07-15
EP2279751A3 (en)	2011-02-16
JP2005200429A (ja)	2005-07-28
CZ302210B6 (cs)	2010-12-22
CN1374872A (zh)	2002-10-16
ES2288033T5 (es)	2012-04-10
JP2002531527A (ja)	2002-09-24
US7741338B2 (en)	2010-06-22
NZ511936A (en)	2003-10-31
NO334612B1 (no)	2014-04-22
JP5165199B2 (ja)	2013-03-21
TR200201428T2 (tr)	2002-12-23
GB9904934D0 (en)	1999-04-28
PL348333A1 (en)	2002-05-20
HUP0104489A2 (hu)	2002-03-28
IL143092A0 (en)	2002-04-21
AU1657300A (en)	2000-06-26
AR054444A2 (es)	2007-06-27
TR200101416T2 (tr)	2002-01-21
TWI270550B (en)	2007-01-11
EP2269651A3 (en)	2011-03-09
IT1319701B1 (it)	2003-10-27
BR9915986A (pt)	2001-09-04
US20020032213A1 (en)	2002-03-14
EP2279751A2 (en)	2011-02-02
EP1743657A3 (en)	2007-03-28
JP3805625B2 (ja)	2006-08-02

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IL137004A0 (en)	2001-06-14	Crystallographically stable amorphous cephalosporin compositions and process for producing the same
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AP9801421A0 (en)	1998-12-31	Novel erythromycin derivatives
PL348114A1 (en)	2002-05-06	Novel macrolide antibiotics
AU4139799A (en)	1999-11-29	Improvements in macrolide production
ZA985655B (en)	1998-12-30	Crystalline macrolides
AU4549999A (en)	1999-12-30	Novel polyene macrolide compounds and uses
KR20010006560A (ko)	2001-01-26	터널시공장치
HK1005769B (en)	1999-01-22	Pillow
GB9828217D0 (en)	1999-02-17	Vacine
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GB9805464D0 (en)	1998-05-13	Construction of ioniser
AU3186599A (en)	1999-10-25	High speed combination router-switch
AU4358199A (en)	1999-11-08	First aid pillow
AU2003200370A1 (en)	2003-04-17	Stabilization of macrolides
AU1480801A (en)	2001-06-06	Compositions and methods for the diminution or elimination of various cancers
IL140003A0 (en)	2002-02-10	Erythromycin compositions
GB9826768D0 (en)	1999-01-27	Improvements relating to stabilising devices
HK1034976A (en)	2001-11-09	Improvements in macrolide production
ECSP993252A (es)	2000-02-24	Macrolidos