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RU93033687A - Method of producing a complex possessing fibrinolytic, thrombolytic and anti-coagulant activity - Google Patents

Method of producing a complex possessing fibrinolytic, thrombolytic and anti-coagulant activity

Info

Publication number
RU93033687A
RU93033687A RU93033687/14A RU93033687A RU93033687A RU 93033687 A RU93033687 A RU 93033687A RU 93033687/14 A RU93033687/14 A RU 93033687/14A RU 93033687 A RU93033687 A RU 93033687A RU 93033687 A RU93033687 A RU 93033687A
Authority
RU
Russia
Prior art keywords
fibrinolytic
thrombolytic
minutes
complex
producing
Prior art date
Application number
RU93033687/14A
Other languages
Russian (ru)
Other versions
RU2055591C1 (en
Inventor
В.С. Новиков
Л.А. Ляпина
В.Е. Пасторова
М.С. Успенская
Original Assignee
Московский государственный университет им.М.В.Ломоносова, биологический факультет
Filing date
Publication date
Application filed by Московский государственный университет им.М.В.Ломоносова, биологический факультет filed Critical Московский государственный университет им.М.В.Ломоносова, биологический факультет
Priority to RU93033687A priority Critical patent/RU2055591C1/en
Priority claimed from RU93033687A external-priority patent/RU2055591C1/en
Publication of RU93033687A publication Critical patent/RU93033687A/en
Application granted granted Critical
Publication of RU2055591C1 publication Critical patent/RU2055591C1/en

Links

Claims (1)

Предлагаемое изобретение обеспечивает получение комплекса, обладающего одновременно фибринолитической, тромболитической и антикоагулянтной активностью. Комплекс получают путем экстрагирования водой из растительной ткани. В качестве сырья используют корни древовидного пиона (Paeonia suffruticosa), которые измельчают и помещают в дистиллированную воду или физиологический раствор в концентрации 0,85-0,9%, выдерживают в кипящей водяной бане в течение 10-20 мин при помешивании, затем выдерживают в течение 30 мин и центрифугируют при 1800-2000 об/мин в течение 20-30 мин при обычной температуре, супернатант замораживают и лиофильно высушивают. Предлагаемый способ менее трудоемок (отсутствует операция наслоения сахарозы на раствор препарата), более экономичен, так как отсутствуют операции, связанные с ультрацентрифугированием на дорогостоящем оборудовании, занимает 2-3 ч и может быть использован в физиологии, патофизиологии, медицинской и химикофармацевтической промышленности.The present invention provides a complex with both fibrinolytic, thrombolytic and anticoagulant activity. The complex is obtained by extraction with water from plant tissue. As a raw material, tree peony roots (Paeonia suffruticosa) are used, which are ground and placed in distilled water or saline at a concentration of 0.85-0.9%, kept in a boiling water bath for 10-20 minutes with stirring, then kept in for 30 minutes and centrifuged at 1800-2000 rpm for 20-30 minutes at ordinary temperature, the supernatant is frozen and freeze dried. The proposed method is less time consuming (there is no operation of layering sucrose on the solution of the drug), more economical, since there are no operations associated with ultracentrifugation on expensive equipment, takes 2-3 hours and can be used in physiology, pathophysiology, medical and chemical-pharmaceutical industry.
RU93033687A 1993-06-30 1993-06-30 Method of preparing complex showing fibrinolytic, thrombolytic and anticoagulative activities RU2055591C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU93033687A RU2055591C1 (en) 1993-06-30 1993-06-30 Method of preparing complex showing fibrinolytic, thrombolytic and anticoagulative activities

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU93033687A RU2055591C1 (en) 1993-06-30 1993-06-30 Method of preparing complex showing fibrinolytic, thrombolytic and anticoagulative activities

Publications (2)

Publication Number Publication Date
RU93033687A true RU93033687A (en) 1995-11-20
RU2055591C1 RU2055591C1 (en) 1996-03-10

Family

ID=20144174

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93033687A RU2055591C1 (en) 1993-06-30 1993-06-30 Method of preparing complex showing fibrinolytic, thrombolytic and anticoagulative activities

Country Status (1)

Country Link
RU (1) RU2055591C1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2129435C1 (en) * 1997-12-10 1999-04-27 Ульянов Александр Михайлович Antidiabetogenic agent
RU2143270C1 (en) * 1998-12-11 1999-12-27 Успенская Марианна Сергеевна Method of preparing preparation showing fibrinolytic, antithrombocytic, anticoagulant and antidiabetogenic activities
RU2199331C1 (en) * 2001-10-24 2003-02-27 Успенская Марианна Сергеевна Method of preparing agent eliciting anticoagulant, fibrinolytic, antiplateletic, antithrombotic and thrombolytic effect

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