RU2758055C1 - Remedy for treatment of acute postpartum endometritis in cows - Google Patents

Abstract

FIELD: veterinary medicine.

SUBSTANCE: invention relates to the field of veterinary medicine, namely to medicines used for the treatment of acute postpartum endometritis in cows. A remedy for the treatment of acute postpartum endometritis in cows is proposed, it includes pharmoxidin, povidone-iodine, allantoin, aloe extract, retinol palmitate (vitamin A), tocopherol acetate, renin, trypsin, chymotrypsin, propranolol, glycerin, petrolatum oil (base), with the following component ratios, wt.%: pharmoxidin - 15.0; povidone-iodine - 1.0; alantoin - 5.0; aloe extract - 2.5; retinol palmitate (vitamin A) - 15.0; tocopherol acetate-4.0; renin-10.0; trypsin-10.0; chymotrypsin-10.0; propranolol-5.0; glycerin-2.5; petrolatum oil (base) - 20.0.

EFFECT: development and creation of a new highly effective remedy for the treatment of postpartum endometritis in cows, which has a disinfecting, regenerative, antihistamine effect.

1 cl, 2 tbl

Description

The invention relates to the field of veterinary medicine, namely to drugs used for the treatment of acute postpartum endometritis in cows.

The product has a high level of therapeutic efficacy, combining disinfectant, proteolytic, antihistamine and regenerative effects.

In veterinary medicine, drugs are known: "Tylosinokar" (Instructions for use of the veterinary drug "Tylosinokar", 2015). The drug has a wide spectrum of antimicrobial action, promotes the regeneration of the uterine mucosa, the restoration of the contractile function of the uterus of cows. It is used for postpartum, subclinical endometritis, and also as a prophylactic agent after calving, contains tylosin tartrate, β-carotene as an active ingredient, polyethylene glycol and distilled water as auxiliary substances).

The disadvantage of this drug is that in the case of using tylosinocar and the subsequent forced slaughter of an animal, the slaughter of cows for meat is allowed no earlier than 72 hours after the last injection of the drug. For food purposes, milk is used no earlier than 48 hours after the last injection. During treatment and within 2 days after the last use of the drug, milk from the affected quarters is disposed of.

Also known is the drug "Nioxityl forte" (Instructions for the use of the veterinary drug "Nioxityl forte", 2013). The drug is used to treat and prevent endometritis. The combination of active ingredients in the preparation has a synergistic effect on the pathogenic microflora involved in the occurrence of endometritis. Contains as active ingredients: rifampicin, tylosin tartrate, nitroxoline, excipients and fillers.

The disadvantages of the drug "Nioxitil Forte" include all the same restrictions on the slaughter and use of milk during the treatment period. Restrictions on meat in case of slaughter are 72 hours, restrictions on the use of milk for human consumption after the last injection of the drug for 72 hours.

The technical challenge is the development and creation of a new highly effective drug for the treatment of postpartum endometritis in cows, which has a disinfecting, regenerative, antihistamine effect, has no restrictions on the use of animal products, since it does not contain antibiotics, contains proteolytic enzymes and additives of biological origin.

A remedy for the treatment of acute postpartum endometritis in cows includes pharmacoxidin, povidone-iodine, allantoin, aloe extract, retinol palmitate, tocopherol acetate, renin, trypsin, chymotrypsin, propranolol, glycerin, liquid paraffin (base), with the following ratios of components, ... %.

pharmacoxidin - 15.0;

povidone iodine - 1.0;

allantoin - 5.0;

aloe extract - 2.5;

retinol palmitate (vitamin A) - 15.0;

tocopherol acetate - 4.0;

renin - 10.0;

trypsin - 10.0;

chymotrypsin - 10.0;

propranolol - 5.0;

glycerin - 2.5;

liquid paraffin (base) - 20.0.

Pharmoksidin. An antibacterial drug of the quinoxaline group, distinguished by activity against Proteus vulgaris (Proteus vulgaris), Friedlander's bacillus, Pseudomonas aeruginosa, causative agents of bacterial dysentery from the genus Shigella (Shigella dysenteria, Shigella Flexnerii, Shigella flexnerii), , salmonella, E. coli (Escherichia coli), staphylococci (Staphylococcus spp.), streptococci (Streptococcus spp.). Pharmoksidin is able to act on strains of bacteria that are resistant to other antimicrobial agents (including antibiotics) without causing local irritation.

Povidone iodine. Antiseptic and disinfectant drug. It has a fast bactericidal effect on gram-positive and gram-negative bacteria (with the exception of Mycobacterium tuberculosis). It is also active against fungi, viruses, protozoa.

Alantoin. As a natural compound derived from Symphytum officinale, it has long been known for its beneficial effects on the skin. It has keratolytic, keratoplastic, soothing and healing properties. It works by reducing inflammation and stimulating the body's natural mechanisms to remove damaged tissue and stimulate the growth of new replacement tissue. Plus, it can prevent the growth of bacteria that can infect damaged areas. The exact mechanism of action is still unknown.

Aloe extract. Biogenic stimulant. It has an adaptogenic, tonic, anti-inflammatory effect. Improves cellular metabolism, trophism and tissue regeneration, increases the general nonspecific resistance of the body and the resistance of tissues, mucous membranes and skin to the action of damaging agents, accelerates regeneration processes. Possesses antimicrobial activity, immunostimulating properties.

Retinol palmitate (vitamin A). Provides optimal functioning of cells, mucous membranes, genitourinary organs and systems. Supports the general physiological resistance of the body to infections. With a lack of vitamin A, the general physiological resistance of the body to infections drops sharply, the secretory activity of the glands decreases: the stomach and intestines, degenerative changes occur in the cellular structures of the central and peripheral nervous system. Vitamin A plays an important role in the regulation of the reproductive cycle, in maintaining the normal state of the endometrium and in the contractile activity of the uterus.

Tocopherol acetate. Normalizes the function of the genitals, fertility, embryonic development of the fetus and prevents infertility. It is used for infertility, dysfunction of the reproductive system, low fertility, poor sperm quality, as a result of tocopherol deficiency, muscular dystrophies, inflammatory processes and degenerative changes.

Renin, trypsin and chymotrypsin are crystalline. Enzyme preparations of proteolytic action, obtained from the pancreas of cattle. They have pronounced anti-inflammatory and decongestant properties, are able to break down dead tissue, fibrinous formations, viscous secretions and exudates. In relation to healthy tissues, enzymes are inactive and safe due to the presence of inhibitors (specific and nonspecific) in them. They do not affect the hemostasis system, contribute to the rejection of necrotic tissues, dilute pus and facilitate its evacuation, improve the processes of wound regeneration. Proteolytic enzymes lyse microorganisms, decay products of damaged tissues and released exudate, which causes a decrease in the painfulness of the affected area of the endometrium, which contributes to the rapid restoration of the functions of the affected organ.

Propranolol. Stimulator of myometrial contractility, non-selective beta-blocker. It has a blocking effect on the β-adrenergic receptors of the myometrium, which contributes to the manifestation of the activity of endogenous oxytocin, as a result of which the contractions of the smooth muscles of the uterus and mammary gland increase, and has a pronounced anti-stress effect.

Glycerol. It is relatively easily absorbed through the mucous membranes, has a softening effect, but at the same time, it is somewhat astringent and irritating. As an alcohol, it has a bacteriostatic effect.

Vaseline oil. Synthetic product obtained in the process of oil refining. It is a colorless oily fraction that remains after the distillation of kerosene. Vaseline oil is characterized by a high degree of purification, and, in addition, it does not contain all kinds of impurities and additives that can be detrimental to the body. The use of vaseline oil, which has disinfecting properties, allows you to effectively fight pathogenic microorganisms. The oil is a mild toxic substance.

The claimed agent is obtained by mixing vaseline oil (base) with pharmacoxidine, povidone-iodine, allantoin, aloe extract, retinol palmitate (vitamin A), tocopherol acetate, propranolol, glycerin in an enamel container, stirring until a homogeneous consistency, then adding proteolytic enzymes (renin , trypsin, chymotrypsin). The resulting medicinal composition is mixed until homogeneous, then distributed in a glass container. Store the product in a dark place at a temperature of 2-4 ° C. The shelf life, subject to the conditions, is not limited.

The resulting product has a liquid consistency, light brown color, a slight smell of iodine.

Before the introduction to the animal, the container with the agent is placed in warm water, the external genital organs are carried out. The drug is administered intrauterinely using a Janet syringe connected to a polystyrene pipette through a rubber tube.

Once in the affected cavity, the agent is completely absorbed and has a general and local effect on the affected tissues and organs.

Example 1. To determine the optimal ratio of components in the proposed tool and establish therapeutic efficacy, 3 groups of cows with postpartum endometritis, 10 heads each, were formed according to the principle of analogous pairs. The animals of the experimental groups were injected with the agent for the treatment of acute postpartum endometritis in highly productive cows in different ratios of the constituent components, the animals of the third group (control) were treated with the drug "Nioxityl forte".

At the beginning of treatment in animals of all groups, the uterus was enlarged, lowered into the abdominal cavity, the contours of the uterine horns are not always palpable; the wall of the uterus is flabby, edematous, doughy consistency, weakly responsive to palpation. Sometimes, with rectal palpation, fluctuation of the uterus was felt when exudate accumulated in its cavity. There was a periodic discharge from the uterus of cloudy mucus with flakes or mucopurulent exudate. The mucous membrane of the vagina is edematous, unevenly hyperemic. Analyzing the milk yield of all sick cows before pathology, milk yield varied from 25 to 35 liters per head per day. During acute endometritis, the average daily milk yield did not exceed 12 liters per head.

The animals of the first experimental group were injected with an agent for the treatment of acute postpartum endometritis with the following ratio of components, wt. %: pharmacoxidin - 15.0; povidone iodine - 1.0; allantoin - 5.0; aloe extract - 2.5; retinol palmitate (vitamin A) - 15.0; tocopherol acetate - 4.0; renin - 10.0; trypsin - 10.0; chymotrypsin - 10.0; propranolol - 5.0; glycerin - 2.5; liquid paraffin (base) - 20.0.

The animals of the second experimental group were injected with an agent for the treatment of acute postpartum endometritis with the following ratio of components, wt. %: pharmacoxidin - 10.0; povidone iodine - 5.0; allantoin - 10.0; aloe extract - 5.0; retinol palmitate (vitamin A) - 20.0; tocopherol acetate - 3.0; renin - 5.0; trypsin - 5.0; chymotrypsin - 5.0; propranolol - 10.0; glycerin - 5.0; liquid paraffin (base) - 17.0.

The animals of the third group (control) were injected with the finished drug "Nioxityl forte".

The animals underwent a course of treatment followed by examination of the animals, in particular the affected reproductive organs (Table 1).

Improvement of the general and local condition of the animals of the first experimental group began already on the 8th day after the start of the drug administration, the general therapeutic course was 10 days (Table 2).

When analyzing the results obtained, it was found that the proposed agent for the treatment of acute postpartum endometritis in high-yielding cows with the following percentage of components: pharmacoxidin - 15%, povidone-iodine - 1%, allantoin - 5%, aloe extract - 2.5 %, retinol palmitate (vitamin A) - 15%, tocopherol acetate - 4%, renin - 10%, trypsin - 10%, chymotrypsin - 10%, propranolol - 5%, glycerin - 2.5%, liquid paraffin (base) - 20%, used for the first experimental group.

Claims (13)

A remedy for the treatment of acute postpartum endometritis in cows, including pharmacoxidin, povidone-iodine, allantoin, aloe extract, retinol palmitate (vitamin A), tocopherol acetate, renin, trypsin, chymotrypsin, propranolol, glycerin, vaseline oil (base) for the following ratios of components, wt%: pharmacoxidin - 15.0; povidone iodine - 1.0; allantoin - 5.0; aloe extract - 2.5; retinol palmitate (vitamin A) - 15.0; tocopherol acetate - 4.0; renin - 10.0; trypsin - 10.0; chymotrypsin - 10.0; propranolol - 5.0; glycerin - 2.5; liquid paraffin (base) - 20.0.