RU2179848C1 - Application of antidepressant amitriptiline in patients with cancer of lung - Google Patents
Application of antidepressant amitriptiline in patients with cancer of lung Download PDFInfo
- Publication number
- RU2179848C1 RU2179848C1 RU2001108558/14A RU2001108558A RU2179848C1 RU 2179848 C1 RU2179848 C1 RU 2179848C1 RU 2001108558/14 A RU2001108558/14 A RU 2001108558/14A RU 2001108558 A RU2001108558 A RU 2001108558A RU 2179848 C1 RU2179848 C1 RU 2179848C1
- Authority
- RU
- Russia
- Prior art keywords
- antidepressant
- patients
- lung
- cancer
- amitriptiline
- Prior art date
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Изобретение относится к медицине, а именно к клинической фармакологии. The invention relates to medicine, namely to clinical pharmacology.
Цель изобретения - применение амитриптилина для противоаллергической терапии больных раком легкого. The purpose of the invention is the use of amitriptyline for antiallergic therapy of patients with lung cancer.
Для лечения и предупреждения паранеопластической аллергии в настоящее время используют антигистаминные препараты (блокаторы H1-рецепторов); препараты, тормозящие высвобождение и активность гистамина и других "медиаторов" аллергии (стабилизаторы мембран); антисеротонинные, анти-srs-А (медленно реагирующая субстанция апафилаксии) вещества; глюкокортикоиды; иммунодепрессанты (Большая медицинская энциклопедия. - М., 1974.-T.1. - С.284-286).For the treatment and prevention of paraneoplastic allergies, antihistamines (H 1 receptor blockers) are currently used; drugs that inhibit the release and activity of histamine and other "mediators" of allergies (membrane stabilizers); antiserotonin, anti-srs-A (slow-reacting apaphylaxis substance) substances; glucocorticoids; immunosuppressants (Big Medical Encyclopedia. - M., 1974.-T.1. - P.284-286).
Антидепрессанты, одновременно обладающие противоаллергическим действием, не описаны. Antidepressants that simultaneously have anti-allergic effects are not described.
Предлагается применение трициклического антидепрессанта амитриптилина для коррекции аллергического статуса больных раком легкого. The use of tricyclic antidepressant amitriptyline for the correction of the allergic status of patients with lung cancer is proposed.
Амитриптилин является одним из основных представителей трициклических антидепрессантов. Тимолептическое действие сочетается у амитриптилина с выраженным седативным эффектом. Препарат относительно широко применяется в соматической медицине при депрессивных и невротических состояниях (Машковский М.Д. Лекарственные средства. - Харьков, 1997. - T.1. - С.98-99). Amitriptyline is one of the main representatives of tricyclic antidepressants. The timoleptic effect is combined in amitriptyline with a pronounced sedative effect. The drug is relatively widely used in somatic medicine for depressive and neurotic conditions (Mashkovsky MD Drugs. - Kharkov, 1997. - T.1. - P.98-99).
Амитриптилин назначался внутрь по 0,0125 г 2 раза в день. Контрольное исследование аллергического статуса по данным реакции дегрануляции базофилов проводилось до и через 7 дней лечения амитриптилином. Amitriptyline was administered orally at 0.0125 g 2 times a day. A control study of allergic status according to the reaction of basophil degranulation was carried out before and after 7 days of treatment with amitriptyline.
По данным реакции дегрануляции базофилов (Тимашева Е.Д., Ковязина А.И.// Лаб.дел. - 1969. 3. - С.135-138) амитриптилин оказывал выраженное положительное влияние на больных. Спонтанная дегрануляция базофилов у больных раком легкого (5,4±0,14) была достоверно увеличенной (Р<0,05) по сравнению со здоровыми (2,4±0,1). According to the reaction of basophil degranulation (Timasheva E.D., Kovyazina A.I. // Lab.del. - 1969. 3. - P.135-138) amitriptyline had a pronounced positive effect on patients. Spontaneous degranulation of basophils in patients with lung cancer (5.4 ± 0.14) was significantly increased (P <0.05) compared with healthy ones (2.4 ± 0.1).
На фоне терапии амитриптилином обнаружена определенная закономерность в динамике спонтанной дегрануляции базофилов, которая проявилась достоверным ослаблением этой реакции в конце лечения препаратом (2,7±0,15; Р<0,05). On the background of amitriptyline therapy, a certain pattern was found in the dynamics of spontaneous degranulation of basophils, which was manifested by a significant weakening of this reaction at the end of drug treatment (2.7 ± 0.15; P <0.05).
Таким образом, по данным проведенных исследований можно сделать вывод, что антидепрессант амитриптилин обладает не только тимолептическим и седативным действием, но и оказывает противоаллергический эффект. Полученные данные могут быть использованы у больных с различной локализацией опухоли. Преимущество предложенного метода противоаллергической терапии заключается в том, что назначение антидепрессанта амитриптилина, обладающего противоаллергическим действием, позволяет отказаться от назначения двух препаратов (противоаллергического и антидепрессанта) и тем самым избежать полипрагмазии, улучшить качество жизни больных, создать положительный фармакоэкономический эффект. Thus, according to the data of the conducted studies, it can be concluded that the antidepressant amitriptyline has not only a timoleptic and sedative effect, but also has an anti-allergic effect. The data obtained can be used in patients with different localization of the tumor. The advantage of the proposed method of antiallergic therapy is that the appointment of amitriptyline antidepressant, which has an antiallergic effect, allows you to refuse the appointment of two drugs (antiallergic and antidepressant) and thereby avoid polypharmacy, improve the quality of life of patients, create a positive pharmacoeconomic effect.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2001108558/14A RU2179848C1 (en) | 2001-03-30 | 2001-03-30 | Application of antidepressant amitriptiline in patients with cancer of lung |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2001108558/14A RU2179848C1 (en) | 2001-03-30 | 2001-03-30 | Application of antidepressant amitriptiline in patients with cancer of lung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2179848C1 true RU2179848C1 (en) | 2002-02-27 |
Family
ID=20247842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001108558/14A RU2179848C1 (en) | 2001-03-30 | 2001-03-30 | Application of antidepressant amitriptiline in patients with cancer of lung |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2179848C1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2239441C1 (en) * | 2003-08-13 | 2004-11-10 | Государственный Научный Центр социальной и судебной психиатрии им. В.П.Сербского | Method for treatment of patient with neurotic and somatoformic disorders |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2051672C1 (en) * | 1988-10-24 | 1996-01-10 | Волгоградский медицинский институт | Agent showing antidepressant and nootropic activity |
| RU2125553C1 (en) * | 1992-01-16 | 1999-01-27 | Хехст АГ | Arylcycloalkyl derivatives and pharmaceutical compositions based thereof |
| RU2138486C1 (en) * | 1993-06-29 | 1999-09-27 | Ниссан Кемикал Индастриз Лтд. | Derivatives of 3(2h)-pyridazinones or their pharmaceutically acceptable additive acid salts and pharmaceutical composition on said |
-
2001
- 2001-03-30 RU RU2001108558/14A patent/RU2179848C1/en not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2051672C1 (en) * | 1988-10-24 | 1996-01-10 | Волгоградский медицинский институт | Agent showing antidepressant and nootropic activity |
| RU2125553C1 (en) * | 1992-01-16 | 1999-01-27 | Хехст АГ | Arylcycloalkyl derivatives and pharmaceutical compositions based thereof |
| RU2138486C1 (en) * | 1993-06-29 | 1999-09-27 | Ниссан Кемикал Индастриз Лтд. | Derivatives of 3(2h)-pyridazinones or their pharmaceutically acceptable additive acid salts and pharmaceutical composition on said |
Non-Patent Citations (1)
| Title |
|---|
| ZHU J et al. Effect of monoamine reuptake inhibiting antidepressants on major histocompatibility complex expression on macrophages in normal rats and rats with experimental allergic neuritis, Immunopharmacology, 1994, May-Jun, 27(3): 225- 44. SANGER MD. The treatment of anxiety and depression in the allergic patient, Ann Allergy, 1969, Oct; 27(10): 506-10. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2239441C1 (en) * | 2003-08-13 | 2004-11-10 | Государственный Научный Центр социальной и судебной психиатрии им. В.П.Сербского | Method for treatment of patient with neurotic and somatoformic disorders |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2992838T3 (en) | Treatment of irritability in autism spectrum disorder with cannabidiol | |
| BRPI0512075A (en) | compound, process for the preparation thereof, pharmaceutical composition, use of a compound, and methods for producing a b-raf inhibiting effect, and an anticancer effect on a warm-blooded animal, and for treating a disease | |
| WO2020263980A8 (en) | IMIDAZO[1,2-a]PYRIDINYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | |
| BRPI0111591B8 (en) | compound, pharmaceutical composition, and uses of a compound | |
| AR068901A1 (en) | USE OF THERAPEUTIC HUMAN ALBUMIN FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF PATIENTS AFFECTED BY COGNITIVE DISORDERS | |
| TW201309298A (en) | Pharmaceutical composition for treating malignant glioma | |
| CN108586443B (en) | A kind of drug and preparation method thereof for preventing and treating lung bronchogenic carcinoma | |
| RU2179848C1 (en) | Application of antidepressant amitriptiline in patients with cancer of lung | |
| CN110755432A (en) | Application of nicotinamide in preparation of preparation for treating hand-foot skin reaction | |
| US11369619B2 (en) | Composition for curing migraine headaches | |
| CA3262238A1 (en) | Use of manganese-containing compounds in reducing uric acid levels in mammalian individuals | |
| Maheshwari et al. | Methylene Blue in Septic Shock: Emerging Evidence, Clinical Applications, and Future Directions | |
| ZA202311237B (en) | Pharmaceutical composition comprising 1-(3-cyano-1-isopropyl-indol-5-yl)pyrazole-4-carboxylic acid | |
| Tankl et al. | To evaluate role of gabapentin as a preemptive analgesic in the patients undergoing modified radical mastectomy | |
| CN105963287B (en) | Compound and its medical usage | |
| CN110882240A (en) | Polyphenol derivative compound 6-CEPN as therapeutic agent for acute ischemic stroke | |
| CN111346093B (en) | Application of combination of lamivudine and domperidone in preparation of sedative drugs | |
| TW201136928A (en) | Treatment of dementia of Alzheimer's type with masitinib | |
| Pd | Oxcarbazepine-induced toxic epidermal necrolysis: A case report | |
| CN107375422A (en) | Treatment part catarrh symptom liniment and preparation method thereof | |
| RU2296567C1 (en) | Method for chemoradiation therapy of brain malignant glial tumor | |
| RU2293565C2 (en) | Method for treating cerebral lesions | |
| RU2564905C1 (en) | Method of treating patients with localised scleroderma | |
| US8252801B1 (en) | Treatment of schizophrenia and related disorders | |
| RU2334515C2 (en) | Application of "day" tranquilliser phenibute and anti-depressant - selective inhibitor of serotonin re-uptake trittico during treatment of psoriasis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20050331 |