RU2018137037A - Антинеопластические комбинации, содержащие hki-272 и винорелбин - Google Patents
Антинеопластические комбинации, содержащие hki-272 и винорелбин Download PDFInfo
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- RU2018137037A RU2018137037A RU2018137037A RU2018137037A RU2018137037A RU 2018137037 A RU2018137037 A RU 2018137037A RU 2018137037 A RU2018137037 A RU 2018137037A RU 2018137037 A RU2018137037 A RU 2018137037A RU 2018137037 A RU2018137037 A RU 2018137037A
- Authority
- RU
- Russia
- Prior art keywords
- treatment regimen
- hki
- administered
- analogue
- vinorelbine
- Prior art date
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- ZNHPZUKZSNBOSQ-BQYQJAHWSA-N neratinib Chemical compound C=12C=C(NC\C=C\CN(C)C)C(OCC)=CC2=NC=C(C#N)C=1NC(C=C1Cl)=CC=C1OCC1=CC=CC=N1 ZNHPZUKZSNBOSQ-BQYQJAHWSA-N 0.000 title claims 15
- 229950008835 neratinib Drugs 0.000 title claims 15
- 229960002066 vinorelbine Drugs 0.000 title claims 10
- 229940046044 combinations of antineoplastic agent Drugs 0.000 title 1
- FKBHRUQOROFRGD-IELIFDKJSA-N vinorelbine Chemical compound C1N(CC=2[C]3C=CC=CC3=NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC FKBHRUQOROFRGD-IELIFDKJSA-N 0.000 title 1
- 238000011269 treatment regimen Methods 0.000 claims 29
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 208000035269 cancer or benign tumor Diseases 0.000 claims 6
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 210000003679 cervix uteri Anatomy 0.000 claims 2
- 208000017891 HER2 positive breast carcinoma Diseases 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 208000019065 cervical carcinoma Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000003445 large cell neuroendocrine carcinoma Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 208000000649 small cell carcinoma Diseases 0.000 claims 1
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Radiation-Therapy Devices (AREA)
Claims (28)
1. Схема лечения новообразования у субъекта, где указанная схема включает введение винорелбина или его аналога; и введение HKI-272 или его аналога.
2. Схема лечения по п.1, где стадии введения осуществляются одновременно, последовательно, совместно, в определенном порядке или согласно определенной временной зависимости.
3. Схема лечения по п.1, где указанные винорелбин или его аналог вводят в виде разовой дозы.
4. Схема лечения по п.1, где указанные HKI-272 или его аналог вводят в виде разовой дозы.
5. Схема лечения по п.1, где указанные винорелбин или его аналог означают винорелбин.
6. Схема лечения по п.1, где указанные HKI-272 или его аналог означают HKI-272.
7. Схема лечения по п.1, где один или оба указанных компонента, т.е. винорелбин или его аналог и HKI-272 или его аналог, вводят указанному субъекту внутривенно.
8. Схема лечения по п.1, где один или оба указанных компонента, т.е. винорелбин или его аналог и HKI-272 или его аналог, вводят указанному субъекту перорально.
9. Схема лечения по п.1, где указанное новообразование связано с избыточной экспрессией или амплификацией HER-2.
10. Схема лечения по п.1, где указанное новообразование является метастатическим.
11. Схема лечения по п.1, где указанное новообразование выбрано из группы, состоящей из рака легких, рака груди, миеломы, рака простаты, раковых образований головы и шеи, переходно-клеточной карциномы, мелкоклеточной нейроэндокринной карциномы шейки матки и крупноклеточной нейроэндокринной карциномы шейки матки.
12. Схема лечения по п.11, где указанное новообразование является раком груди.
13. Схема лечения по п.12, где указанный рак груди является HER-2-положительным раком груди с метастазами.
14. Схема лечения по п.1, где указанное новообразование является солидной опухолью на поздней стадии.
15. Схема лечения по п.1, где указанные винорелбин или его аналог вводят в количестве не менее чем примерно 20 мг/л.
16. Схема лечения по п.15, где указанные винорелбин или его аналог вводят в количестве от примерно 20 до примерно 25 мг/л.
17. Схема лечения по п.16, где указанные винорелбин или его аналог вводят в количестве примерно 25 мг/л.
18. Схема лечения по п.1, где указанные HKI-272 или его аналог вводят в количестве не менее примерно 120 мг.
19. Схема лечения по п.18, где указанные HKI-272 или его аналог вводят в количестве не менее примерно 160 мг.
20. Схема лечения по п.19, где указанные HKI-272 или его аналог вводят в количестве не менее примерно 240 мг.
21. Схема лечения по п.4, где указанная разовая доза представляет собой таблетку.
22. Схема лечения по п.1, где указанные HKI-272 или его аналог вводят ежедневно.
23. Схема лечения по п.1, где указанные HKI-272 или его аналог вводят по меньшей мере один раз в день.
24. Схема лечения по п.1, где указанные HKI-272 или его аналог вводят в день 1 указанной схемы лечения.
25. Схема лечения по п.10, где указанные HKI-272 или его аналог вводят в день 2 указанной схемы лечения.
26. Схема лечения по п.1, где указанные HKI-272 или его аналог вводят в течение по меньшей мере 2 последовательных недель.
27. Фармацевтическая композиция по п.1, дополнительно включающая по меньшей мере один фармацевтически приемлемый носитель.
28. Схема лечения по п.1, дополнительно включающая радиационное лечение.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7333008P | 2008-06-17 | 2008-06-17 | |
| US61/073,330 | 2008-06-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013126140A Division RU2670974C2 (ru) | 2008-06-17 | 2013-06-06 | Антинеопластические комбинации, содержащие hki-272 и винорелбин |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2018137037A true RU2018137037A (ru) | 2020-04-22 |
Family
ID=41415366
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010151787/15A RU2492860C2 (ru) | 2008-06-17 | 2009-06-17 | Антиопластические комбинации, содержащие нкi-272 и винорелбин |
| RU2013126140A RU2670974C2 (ru) | 2008-06-17 | 2013-06-06 | Антинеопластические комбинации, содержащие hki-272 и винорелбин |
| RU2018137037A RU2018137037A (ru) | 2008-06-17 | 2018-10-22 | Антинеопластические комбинации, содержащие hki-272 и винорелбин |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010151787/15A RU2492860C2 (ru) | 2008-06-17 | 2009-06-17 | Антиопластические комбинации, содержащие нкi-272 и винорелбин |
| RU2013126140A RU2670974C2 (ru) | 2008-06-17 | 2013-06-06 | Антинеопластические комбинации, содержащие hki-272 и винорелбин |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20090312360A1 (ru) |
| EP (6) | EP3135285B1 (ru) |
| JP (6) | JP2011524423A (ru) |
| KR (4) | KR20110010787A (ru) |
| CN (2) | CN102641270A (ru) |
| AU (1) | AU2009271419B2 (ru) |
| BR (1) | BRPI0914790A2 (ru) |
| CA (1) | CA2725598C (ru) |
| CY (1) | CY1114552T1 (ru) |
| DK (2) | DK2310011T3 (ru) |
| ES (6) | ES2958968T3 (ru) |
| HR (1) | HRP20130842T1 (ru) |
| IL (2) | IL209412A (ru) |
| MX (2) | MX2010013196A (ru) |
| NZ (3) | NZ616613A (ru) |
| PL (2) | PL2656844T3 (ru) |
| PT (1) | PT2310011E (ru) |
| RU (3) | RU2492860C2 (ru) |
| SG (1) | SG191676A1 (ru) |
| SI (1) | SI2310011T1 (ru) |
| WO (1) | WO2010008744A2 (ru) |
| ZA (1) | ZA201008166B (ru) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007009317A (es) | 2005-02-03 | 2008-01-30 | Gen Hospital Corp | Metodo para tratar cancer resistente a gefitinib. |
| CN103110948A (zh) | 2005-11-04 | 2013-05-22 | 惠氏公司 | mTOR抑制剂、赫赛汀和/或HKI-272的抗肿瘤组合 |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| ES2958968T3 (es) * | 2008-06-17 | 2024-02-16 | Wyeth Llc | Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina |
| AU2016202225B2 (en) * | 2008-06-17 | 2017-09-28 | Wyeth Llc | Antineoplastic combinations containing HKI-272 and vinorelbine |
| SG10202102855RA (en) | 2008-08-04 | 2021-05-28 | Wyeth Llc | Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine |
| HUE061640T2 (hu) | 2009-04-06 | 2023-07-28 | Wyeth Llc | Gyógykezelési rendszer mellrákhoz neratinib alkalmazásával |
| ES2729677T3 (es) | 2009-11-09 | 2019-11-05 | Wyeth Llc | Esferoides de fármacos recubiertos y sus usos para eliminar o reducir condiciones, como la emesis y la diarrea |
| BR112014032346A2 (pt) * | 2012-06-26 | 2017-06-27 | Del Mar Pharmaceuticals | métodos para tratamento de malignidades resistentes ao inibidor de tirosina-quinase em pacientes com polimorfismos genéticos ou desregulações de ahi1 mutações empregando dianidrogalactitol, diacetildianidrogalactitol, dibromodulcitol, ou análogos ou derivados destes |
| CA2967322A1 (en) * | 2014-11-10 | 2016-05-19 | Del Mar Pharmaceuticals | Dianhydrogalactitol together with radiation to treat non-small-cell carcinoma of the lung and glioblastoma multiforme |
| WO2021185234A1 (zh) * | 2020-03-16 | 2021-09-23 | 正大天晴药业集团股份有限公司 | 作为c-Met激酶抑制剂的化合物的联用药物组合物及其用途 |
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| WO1992022653A1 (en) | 1991-06-14 | 1992-12-23 | Genentech, Inc. | Method for making humanized antibodies |
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