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RU2009149451A - Лечение антителами против vegf - Google Patents

Лечение антителами против vegf Download PDF

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Publication number
RU2009149451A
RU2009149451A RU2009149451/15A RU2009149451A RU2009149451A RU 2009149451 A RU2009149451 A RU 2009149451A RU 2009149451/15 A RU2009149451/15 A RU 2009149451/15A RU 2009149451 A RU2009149451 A RU 2009149451A RU 2009149451 A RU2009149451 A RU 2009149451A
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RU
Russia
Prior art keywords
cancer
patient
vegf antibody
chemotherapeutic agent
group
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RU2009149451/15A
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English (en)
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RU2519669C2 (ru
Inventor
Гвендолин ФАЙФ (US)
Гвендолин ФАЙФ
Эрик ХОУЛМГРЕН (US)
Эрик ХОУЛМГРЕН
Роберт Д. МАСС (US)
Роберт Д. МАСС
Уилльям НОВОТНИ (US)
Уилльям НОВОТНИ
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Дженентек, Инк. (Us)
Дженентек, Инк.
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Application filed by Дженентек, Инк. (Us), Дженентек, Инк. filed Critical Дженентек, Инк. (Us)
Publication of RU2009149451A publication Critical patent/RU2009149451A/ru
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Publication of RU2519669C2 publication Critical patent/RU2519669C2/ru

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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

1. Способ лечения рака у пациента человека, включающий введение пациенту эффективного количества антитела против VEGF и отслеживание пациента на желудочно-кишечное прободение. ! 2. Способ по п.1, дополнительно включающий введение пациенту антинеопластического агента, где указанный антинеопластический агент включает, по меньшей мере, один химиотерапевтический агент. ! 3. Способ по любому из пп.1 или 2, где рак выбран из группы, состоящей из рака молочной железы, колоректального рака, ректального рака, немелкоклеточного рака легких, не-ходжкинской лимфомы (NHL), почечно-клеточного рака, рака простаты, рака печени, рака поджелудочной железы, саркомы мягких тканей, саркомы Капоши, карциноидной карциномы, рака головы и шеи, меланомы, рака яичников, мезотелиомы, множественной миеломы и глиобластомы. ! 4. Способ по любому из пп.1 или 2, где рак является метастатическим. ! 5. Способ по любому из пп.1 или 2, где больной ранее не подвергался лечению. ! 6. Способ по п.2, где химиотерапевтический агент выбран из группы, состоящей из алкилирующих агентов, антиметаболитов, аналогов фолиевой кислоты, аналогов пиримидина, аналогов пурина и относящихся к этому ингибиторов, алкалоидов барвинка, токсинов эпиподофилла, антибиотиков, L-аспарагиназы, ингибитора топоизомеразы, интерферонов, координационных комплексов платины, замещенной антрацендионом мочевины, производных метилгидразина, супрессанта коры надпочечников, адренокортикостероидов, прогестинов, эстрогенов, антиэстрогена, андрогенов, антиандрогена и аналога гонадотропин-рилизинг гормона. ! 7. Способ по п.6, где химиотерапевтический агент выбран из группы, состоящей из 5-фторурацила (5-F

Claims (26)

1. Способ лечения рака у пациента человека, включающий введение пациенту эффективного количества антитела против VEGF и отслеживание пациента на желудочно-кишечное прободение.
2. Способ по п.1, дополнительно включающий введение пациенту антинеопластического агента, где указанный антинеопластический агент включает, по меньшей мере, один химиотерапевтический агент.
3. Способ по любому из пп.1 или 2, где рак выбран из группы, состоящей из рака молочной железы, колоректального рака, ректального рака, немелкоклеточного рака легких, не-ходжкинской лимфомы (NHL), почечно-клеточного рака, рака простаты, рака печени, рака поджелудочной железы, саркомы мягких тканей, саркомы Капоши, карциноидной карциномы, рака головы и шеи, меланомы, рака яичников, мезотелиомы, множественной миеломы и глиобластомы.
4. Способ по любому из пп.1 или 2, где рак является метастатическим.
5. Способ по любому из пп.1 или 2, где больной ранее не подвергался лечению.
6. Способ по п.2, где химиотерапевтический агент выбран из группы, состоящей из алкилирующих агентов, антиметаболитов, аналогов фолиевой кислоты, аналогов пиримидина, аналогов пурина и относящихся к этому ингибиторов, алкалоидов барвинка, токсинов эпиподофилла, антибиотиков, L-аспарагиназы, ингибитора топоизомеразы, интерферонов, координационных комплексов платины, замещенной антрацендионом мочевины, производных метилгидразина, супрессанта коры надпочечников, адренокортикостероидов, прогестинов, эстрогенов, антиэстрогена, андрогенов, антиандрогена и аналога гонадотропин-рилизинг гормона.
7. Способ по п.6, где химиотерапевтический агент выбран из группы, состоящей из 5-фторурацила (5-FU), лейковорина, иринотекана, оксалиплатина, капецитабина, паклитаксела и доксетаксела.
8. Способ по п.2, где антинеопластическая композиция включает сочетание, по меньшей мере, двух химиотерапевтических агентов.
9. Способ по п.8, где антинеопластическая композиция включает 5-FU и лейковорин.
10. Способ по п.8, где антинеопластическая композиция включает 5-FU, лейковорин и иринотекан.
11. Способ по п.1, где после завершения лечения антителом против VEGF и антинеопластической композицией больной дополнительно получает химиотерапевтическое лечение, по меньшей мере, одним химиотерапевтическим агентом.
12. Способ по п.11, где химиотерапевтический агент, применяемый для дополнительного химиотерапевтического лечения, выбран из группы, состоящей из 5-FU, лейковорина, иринотекана, оксалиплатина, капецитабина, паклитаксела и доксетаксела.
13. Способ по п.12, где химиотерапевтический агент представляет собой оксалиплатин.
14. Способ лечения пациента человека, предрасположенного к колоректальному раку или с его диагнозом, включающий введение пациенту эффективного количества антитела против VEGF и отслеживание пациента на желудочно-кишечное прободение.
15. Способ по п.13, где колоректальный рак является метастатическим.
16. Способ по любому из пп.1, 2 или 14, где указанное антитело против VEGF связывает тот же эпитоп, что и моноклональное антитело A4.6.1 против VEGF, продуцируемое гибридомой ATCC HB 10709.
17. Способ по любому из пп.1, 2 или 14, где антитело против VEGF представляет собой антитело человека.
18. Способ по любому из пп.1, 2 или 14, где антитело против VEGF представляет собой гуманизированное антитело.
19. Способ по п.18, где антитело против VEGF представляет собой гуманизированное антитело A4.6.1 или его фрагмент.
20. Способ по любому из пп.1, 2 или 14, где антитело против VEGF вводят внутривенной инфузией.
21. Способ по любому из пп.1, 2 или 14, где антитело против VEGF вводят пациенту в дозе приблизительно 5 мг/кг каждые 2-3 недели.
22. Способ по п.14, дополнительно включающий введение пациенту одного или более химиотерапевтических агентов.
23. Способ по п.22, где химиотерапевтический агент выбран из группы, состоящей из алкилирующих агентов, антиметаболитов, аналогов фолиевой кислоты, аналогов пиримидина, аналогов пурина и относящихся к этому ингибиторов, алкалоидов барвинка, токсинов эпиподофилла, антибиотиков, L-аспарагиназы, ингибитора топоизомеразы, интерферонов, координационных комплексов платины, замещенной антрацендионом мочевины, производных метилгидразина, супрессанта коры надпочечников, адренокортикостероидов, прогестинов, эстрогенов, антиэстрогена, андрогенов, антиандрогена и аналога гонадотропин-рилизинг гормона.
24. Способ по п.23, где химиотерапевтический агент выбран из группы, состоящей из 5-фторурацила, лейковорина, иринотекана, оксалиплатина, капецитабина, паклитаксела и доксетаксела.
25. Промышленный продукт, включающий
1) контейнер,
2) композицию в контейнере, включающую антитело против VEGF, и
3) вложенную в упаковку инструкцию по использованию композиции для введения пациенту, больному раком, композиции антитела против VEGF и предупреждающую использующего композицию о риске желудочно-кишечного прободения.
26. Набор для лечения рака у пациента человека, включающий
1) упаковку, включающую композицию антитела против VEGF, и
2) инструкции по использованию композиции антитела против VEGF, и предупреждающие использующего композицию о риске желудочно-кишечного прободения.
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