RU2005128124A - Фармацевтические препараты и их применение для профилактики удара, диабета и/или застойной сердечной недостаточности - Google Patents
Фармацевтические препараты и их применение для профилактики удара, диабета и/или застойной сердечной недостаточности Download PDFInfo
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- RU2005128124A RU2005128124A RU2005128124/15A RU2005128124A RU2005128124A RU 2005128124 A RU2005128124 A RU 2005128124A RU 2005128124/15 A RU2005128124/15 A RU 2005128124/15A RU 2005128124 A RU2005128124 A RU 2005128124A RU 2005128124 A RU2005128124 A RU 2005128124A
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- 206010019280 Heart failures Diseases 0.000 title claims 4
- 206010012601 diabetes mellitus Diseases 0.000 title claims 3
- 229940079593 drug Drugs 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 230000035939 shock Effects 0.000 title 1
- GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 claims 8
- 102000015427 Angiotensins Human genes 0.000 claims 7
- 108010064733 Angiotensins Proteins 0.000 claims 7
- 239000002464 receptor antagonist Substances 0.000 claims 7
- 229940044551 receptor antagonist Drugs 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 6
- RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 claims 6
- 239000002053 C09CA06 - Candesartan Substances 0.000 claims 4
- 229960000932 candesartan Drugs 0.000 claims 4
- 229960004349 candesartan cilexetil Drugs 0.000 claims 4
- 239000002083 C09CA01 - Losartan Substances 0.000 claims 3
- 239000002080 C09CA02 - Eprosartan Substances 0.000 claims 3
- 239000004072 C09CA03 - Valsartan Substances 0.000 claims 3
- 239000002947 C09CA04 - Irbesartan Substances 0.000 claims 3
- 239000002081 C09CA05 - Tasosartan Substances 0.000 claims 3
- 239000005537 C09CA07 - Telmisartan Substances 0.000 claims 3
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 3
- 208000005764 Peripheral Arterial Disease Diseases 0.000 claims 3
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims 3
- 208000029078 coronary artery disease Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000002526 effect on cardiovascular system Effects 0.000 claims 3
- 229960004563 eprosartan Drugs 0.000 claims 3
- OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical compound C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 claims 3
- 229960002198 irbesartan Drugs 0.000 claims 3
- YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 claims 3
- 229960004773 losartan Drugs 0.000 claims 3
- KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 208000023516 stroke disease Diseases 0.000 claims 3
- 229960000651 tasosartan Drugs 0.000 claims 3
- ADXGNEYLLLSOAR-UHFFFAOYSA-N tasosartan Chemical compound C12=NC(C)=NC(C)=C2CCC(=O)N1CC(C=C1)=CC=C1C1=CC=CC=C1C=1N=NNN=1 ADXGNEYLLLSOAR-UHFFFAOYSA-N 0.000 claims 3
- 229960005187 telmisartan Drugs 0.000 claims 3
- 229960004699 valsartan Drugs 0.000 claims 3
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 claims 3
- 230000004217 heart function Effects 0.000 claims 2
- 208000001953 Hypotension Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000012866 low blood pressure Diseases 0.000 claims 1
Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
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- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
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Claims (9)
1. Применение антагониста рецептора ангиотензина (II) (ATII) типа 1 или его фармацевтически приемлемой соли для изготовления лекарственного средства для предотвращения или снижения риска удара у пациента, который имеет, по существу, поддерживаемую функцию сердца, и пациент подвержен высокому риску сердечно-сосудистого приступа ввиду истории предшествующей ишемической болезни, удара или периферической артериальной болезни.
2. Применение антагониста рецептора ангиотензина (II) (ATII) типа 1 или его фармацевтически приемлемой соли для изготовления лекарственного средства для предотвращения или снижения риска возникновения диабета у пациента, подверженного высокому риску сердечно-сосудистого приступа ввиду предыдущей истории ишемической болезни сердца, удара или периферической артериальной болезни.
3. Применение антагониста рецептора ангиотензина (II) (ATII) типа 1 или его фармацевтически приемлемой соли для изготовления лекарственного средства для предотвращения или снижения риска застойной сердечной недостаточности (CHF) у пациента, ранее не имевшего CHF и который имеет по существу поддерживаемую функцию сердца, где пациент подвержен высокому риску сердечно-сосудистого приступа вследствие истории предыдущей ишемической болезни сердца, удара или периферической артериальной болезни.
4. Применение по любому из пп.1-3, отличающееся тем, что пациент имеет нормальное или пониженное кровяное давление.
5. Применение по любому из пп.1-3, отличающееся тем, что пациент страдает диабетом.
6. Применение по любому из пп.1-3, где антагонист рецептора ангиотензина (II) (ATII) типа 1 или его фармацевтически приемлемая соль выбраны из группы, состоящей из кандесартана, кандесартана цилексетила, лозартана, валсартана, ирбесартана, тасосартана, телмисартана и эпросартана.
7. Применение по п.4, где антагонист рецептора ангиотензина (II) (ATII) типа 1 или его фармацевтически приемлемая соль выбраны из группы, состоящей из кандесартана, кандесартана цилексетила, лозартана, валсартана, ирбесартана, тасосартана, телмисартана и эпросартана.
8. Применение по п.5, где антагонист рецептора ангиотензина (II) (ATII) типа 1 или его фармацевтически приемлемая соль выбраны из группы, состоящей из кандесартана, кандесартана цилексетила, лозартана, валсартана, ирбесартана, тасосартана, телмисартана и эпросартана.
9. Применение по любому из пп.1-3,7 и 8, где антагонист рецептора ангиотензина (II) (ATII) типа 1 выбран из группы, состоящей из кандесартана и кандесартана цилексетила.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9903028-0 | 1999-08-27 | ||
| SE9903028A SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | New use |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002107673/15A Division RU2272651C2 (ru) | 1999-08-27 | 2000-08-25 | Фармацевтические препараты и их применение для профилактики удара, диабета и/или застойной сердечной недостаточности |
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| Publication Number | Publication Date |
|---|---|
| RU2005128124A true RU2005128124A (ru) | 2007-03-20 |
| RU2378018C2 RU2378018C2 (ru) | 2010-01-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002107673/15A RU2272651C2 (ru) | 1999-08-27 | 2000-08-25 | Фармацевтические препараты и их применение для профилактики удара, диабета и/или застойной сердечной недостаточности |
| RU2005128124/15A RU2378018C2 (ru) | 1999-08-27 | 2005-09-08 | Фармацевтические препараты и их применение для профилактики удара, диабета и/или застойной сердечной недостаточности |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2002107673/15A RU2272651C2 (ru) | 1999-08-27 | 2000-08-25 | Фармацевтические препараты и их применение для профилактики удара, диабета и/или застойной сердечной недостаточности |
Country Status (35)
| Country | Link |
|---|---|
| US (6) | US20060194868A1 (ru) |
| EP (4) | EP1437131B1 (ru) |
| JP (1) | JP4843172B2 (ru) |
| KR (2) | KR20020060167A (ru) |
| CN (2) | CN100408093C (ru) |
| AT (2) | ATE307604T1 (ru) |
| AU (3) | AU7648400A (ru) |
| BG (2) | BG110479A (ru) |
| BR (1) | BR0013540A (ru) |
| CA (1) | CA2382387C (ru) |
| CY (2) | CY1112987T1 (ru) |
| CZ (1) | CZ303433B6 (ru) |
| DE (1) | DE60023518T3 (ru) |
| DK (3) | DK1212081T4 (ru) |
| EE (1) | EE05130B1 (ru) |
| ES (3) | ES2525699T3 (ru) |
| HR (1) | HRP20020169A2 (ru) |
| HU (1) | HU229107B1 (ru) |
| IL (1) | IL148126A (ru) |
| ME (1) | ME00181B (ru) |
| MX (1) | MXPA02001633A (ru) |
| NO (2) | NO329245B1 (ru) |
| NZ (1) | NZ571901A (ru) |
| PL (1) | PL353066A1 (ru) |
| PT (2) | PT1925303E (ru) |
| RS (1) | RS52907B (ru) |
| RU (2) | RU2272651C2 (ru) |
| SE (1) | SE9903028D0 (ru) |
| SI (3) | SI1437131T1 (ru) |
| SK (1) | SK288239B6 (ru) |
| TR (5) | TR200202466T2 (ru) |
| UA (2) | UA76702C2 (ru) |
| WO (1) | WO2001015673A2 (ru) |
| YU (1) | YU3602A (ru) |
| ZA (1) | ZA200201471B (ru) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE05670B1 (et) * | 1999-08-30 | 2013-08-15 | Aventis Pharma Deutschland Gmbh | Ramipriil kardiovaskulaarsete haigusjuhtude rahoidmiseks |
| BR0206436A (pt) * | 2001-03-26 | 2004-07-06 | Kotobuki Pharmaceutical Co Ltd | Composto, método de preparação do composto, e, agentes antidiabéticos orais |
| IL161388A0 (en) * | 2001-10-17 | 2004-09-27 | Aventis Pharma Gmbh | Method of reducing type 2 diabetes in high risk patients |
| US6844361B2 (en) | 2002-02-04 | 2005-01-18 | Aventis Pharma Deutschland Gmbh | Pharmaceutical composition comprising a sodium hydrogen exchange inhibitor and an angiotensin converting enzyme inhibitor |
| DE10230272A1 (de) * | 2002-07-05 | 2004-01-22 | Solvay Pharmaceuticals Gmbh | AT1-Rezeptorantagonisten zur Prävention von Folgeschlaganfällen |
| EP1382334A1 (en) * | 2002-07-11 | 2004-01-21 | Université de Picardie Jules Verne | Use of angiotensin II AT1-receptor blockers (ARB), alone or combined with thiazide or angiotensin II for the treatment of stroke |
| US7232828B2 (en) * | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
| DE10306179A1 (de) * | 2003-02-13 | 2004-08-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Dipyridamol in Kombination mit Acetylsalicylsäure und einem Angiotensin II-Antagonisten zur Schlaganfall-Prophylaxe |
| US20040229901A1 (en) * | 2003-02-24 | 2004-11-18 | Lauren Otsuki | Method of treatment of disease using an adenosine A1 receptor antagonist |
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