RU2005118108A - Ингибиторы гистондеацетилазы для лечения дегенеративных заболеваний глаз - Google Patents
Ингибиторы гистондеацетилазы для лечения дегенеративных заболеваний глаз Download PDFInfo
- Publication number
- RU2005118108A RU2005118108A RU2005118108/14A RU2005118108A RU2005118108A RU 2005118108 A RU2005118108 A RU 2005118108A RU 2005118108/14 A RU2005118108/14 A RU 2005118108/14A RU 2005118108 A RU2005118108 A RU 2005118108A RU 2005118108 A RU2005118108 A RU 2005118108A
- Authority
- RU
- Russia
- Prior art keywords
- retinal
- disease
- condition
- eye diseases
- histondeacetylase
- Prior art date
Links
- 230000003412 degenerative effect Effects 0.000 title claims 2
- 208000030533 eye disease Diseases 0.000 title claims 2
- 239000003112 inhibitor Substances 0.000 title 1
- 238000000034 method Methods 0.000 claims 4
- 230000006378 damage Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 208000017442 Retinal disease Diseases 0.000 claims 2
- 208000011325 dry age related macular degeneration Diseases 0.000 claims 2
- 230000002207 retinal effect Effects 0.000 claims 2
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 206010025421 Macule Diseases 0.000 claims 1
- 206010038848 Retinal detachment Diseases 0.000 claims 1
- 206010057430 Retinal injury Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 230000005779 cell damage Effects 0.000 claims 1
- 208000037887 cell injury Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 230000000642 iatrogenic effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 238000002647 laser therapy Methods 0.000 claims 1
- 238000002428 photodynamic therapy Methods 0.000 claims 1
- 238000004321 preservation Methods 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 230000004264 retinal detachment Effects 0.000 claims 1
- 208000032253 retinal ischemia Diseases 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000005945 translocation Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (4)
1. Способ лечения людей, страдающих от острых или хронических дегенеративных состояний или заболеваний глаз, включающий введение фармацевтически эффективного количества ингибитора гистондеацетилазы.
2. Способ по п.1, в котором состояние или заболевание выбрано из группы, состоящей из глаукомы, сухой AMD; RP и других форм гередодегенеративных ретинальных заболеваний; отслоения и поражения сетчатки; сморщивания желтого пятна; ишемии, поражающей внешнюю часть сетчатки; клеточного повреждения, связанного с диабетической ретинопатией и ретинальной ишемией; повреждения, связанного с лазерной терапией (растровой, фокальной и панретинальной), включая фотодинамическую терапию (PDT); травмы; хирургической (ретинальной транслокации, субретинальной хирургии или витректомии) или индуцированной светом ятрогенной ретинопатии, и сохранения ретинальных трансплантатов.
3. Способ по п.2, в котором состояние или заболевание является сухой AMD.
4. Способ по п.2, в котором состояние или заболевание является глаукомой.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42557602P | 2002-11-12 | 2002-11-12 | |
| US60/425,576 | 2002-11-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005118108A true RU2005118108A (ru) | 2006-01-20 |
| RU2324483C2 RU2324483C2 (ru) | 2008-05-20 |
Family
ID=32313019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005118108/14A RU2324483C2 (ru) | 2002-11-12 | 2003-10-27 | Ингибиторы гистондеацетилазы для лечения дегенеративных заболеваний глаз |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20070088045A1 (ru) |
| EP (1) | EP1562592A4 (ru) |
| JP (1) | JP2006508120A (ru) |
| KR (1) | KR20050074547A (ru) |
| CN (1) | CN1711086A (ru) |
| AU (1) | AU2003286686B2 (ru) |
| BR (1) | BR0316163A (ru) |
| CA (1) | CA2504226A1 (ru) |
| MX (1) | MXPA05004738A (ru) |
| RU (1) | RU2324483C2 (ru) |
| WO (1) | WO2004043348A2 (ru) |
| ZA (1) | ZA200503230B (ru) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| MXPA05004485A (es) * | 2002-11-12 | 2005-11-23 | Alcon Inc | Inhibidores de la histona desacetilasa para el tratamiento de enfermedades y trastornos neovasculares o edematosos oculares. |
| BR0316163A (pt) * | 2002-11-12 | 2005-09-27 | Alcon Inc | Inibidores de histona desacetilase para tratamento de doenças degenerativas do olho |
| US20080004311A1 (en) * | 2002-11-12 | 2008-01-03 | Alcon, Inc. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
| JP2006520796A (ja) | 2003-03-17 | 2006-09-14 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼインヒビター |
| US20050197336A1 (en) * | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
| US7345043B2 (en) * | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
| GB2417682A (en) * | 2004-08-18 | 2006-03-08 | Univ East Anglia | Histone deacetylse inhibitor for treating connective tissue disorders |
| WO2006066133A2 (en) | 2004-12-16 | 2006-06-22 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP2008530136A (ja) | 2005-02-14 | 2008-08-07 | ミイカナ セラピューティクス インコーポレイテッド | ヒストンデアセチラーゼの阻害剤として有用な縮合複素環化合物 |
| WO2006122319A2 (en) | 2005-05-11 | 2006-11-16 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| KR20080032188A (ko) | 2005-07-14 | 2008-04-14 | 다케다 샌디에고, 인코포레이티드 | 히스톤 탈아세틸화 효소 억제제 |
| AU2006272497B2 (en) * | 2005-07-27 | 2012-07-19 | University Of Florida Research Foundation, Inc. | Small compounds that correct protein misfolding and uses thereof |
| CN101646460A (zh) * | 2007-03-28 | 2010-02-10 | 参天制药株式会社 | 含有具有组蛋白脱乙酰化酶抑制作用的化合物作为有效成分的降眼压剂 |
| JP2008266321A (ja) * | 2007-03-28 | 2008-11-06 | Santen Pharmaceut Co Ltd | フェニレンジアミン誘導体を有効成分とする眼圧下降剤 |
| WO2008117862A1 (ja) | 2007-03-28 | 2008-10-02 | Santen Pharmaceutical Co., Ltd. | ウレア構造を有する新規ピリジンカルボン酸（２－アミノフェニル）アミド誘導体 |
| CN102036978A (zh) | 2008-05-23 | 2011-04-27 | 参天制药株式会社 | 具有脲结构的新型噻吩二胺衍生物 |
| PT2575467T (pt) * | 2010-05-27 | 2016-10-14 | Univ Colorado Regents | Compostos macrocíclicos úteis como inibidores de histona desacetilases |
| CN107362148B (zh) * | 2017-07-27 | 2020-04-21 | 东曜药业有限公司 | 一种治疗肿瘤的药物组合物及其制备方法和应用 |
| IL298982A (en) * | 2020-06-11 | 2023-02-01 | Univ Columbia | Methods and compositions for preventing and treating myopia with trichostatin a, a histone deacetylase (hdac) inhibitor, and derivatives thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2534580A1 (fr) * | 1982-10-13 | 1984-04-20 | Synthelabo | Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent |
| US5151444B1 (en) * | 1987-09-18 | 1999-07-06 | R Tech Ueno Ltd | Ocular hypotensive agents |
| US5296504A (en) * | 1988-09-06 | 1994-03-22 | Kabi Pharmacia | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| EP0569046B1 (en) * | 1988-09-06 | 2002-11-13 | Pharmacia Aktiebolag | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| US5321128A (en) * | 1988-09-06 | 1994-06-14 | Kabi Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| US5464866A (en) * | 1992-08-17 | 1995-11-07 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
| US5688819A (en) * | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5352708A (en) * | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5510383A (en) * | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
| US5681854A (en) * | 1995-11-22 | 1997-10-28 | Alcon Laboratories, Inc. | Use of aliphatic carboxylic acid derivatives in ophthalmic disorders |
| IL135105A0 (en) * | 1997-10-06 | 2001-05-20 | American Cyanamid Co | The preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
| AUPP505798A0 (en) * | 1998-08-04 | 1998-08-27 | Fujisawa Pharmaceutical Co., Ltd. | Novel compound fr225497 substance |
| JP2004516328A (ja) * | 2000-12-22 | 2004-06-03 | ヒャン ウー リー | アピシジン誘導体、その合成方法、及び該誘導体を含む抗癌剤組成物 |
| US6905669B2 (en) * | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
| US7154002B1 (en) * | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) * | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20080004311A1 (en) * | 2002-11-12 | 2008-01-03 | Alcon, Inc. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
| BR0316163A (pt) * | 2002-11-12 | 2005-09-27 | Alcon Inc | Inibidores de histona desacetilase para tratamento de doenças degenerativas do olho |
| WO2009002941A1 (en) * | 2007-06-22 | 2008-12-31 | Board Of Regents, The University Of Texas System | Composition and method for the treatment of diseases affected by histone deacetylase inhibitors |
-
2003
- 2003-10-27 BR BR0316163-3A patent/BR0316163A/pt not_active IP Right Cessation
- 2003-10-27 US US10/531,747 patent/US20070088045A1/en not_active Abandoned
- 2003-10-27 MX MXPA05004738A patent/MXPA05004738A/es active IP Right Grant
- 2003-10-27 JP JP2004551572A patent/JP2006508120A/ja not_active Withdrawn
- 2003-10-27 WO PCT/US2003/033873 patent/WO2004043348A2/en not_active Ceased
- 2003-10-27 CN CNA2003801029350A patent/CN1711086A/zh active Pending
- 2003-10-27 CA CA002504226A patent/CA2504226A1/en not_active Abandoned
- 2003-10-27 EP EP03777895A patent/EP1562592A4/en not_active Withdrawn
- 2003-10-27 RU RU2005118108/14A patent/RU2324483C2/ru not_active IP Right Cessation
- 2003-10-27 KR KR1020057008066A patent/KR20050074547A/ko not_active Ceased
- 2003-10-27 AU AU2003286686A patent/AU2003286686B2/en not_active Ceased
- 2003-10-27 US US10/694,309 patent/US20040092431A1/en not_active Abandoned
-
2005
- 2005-04-21 ZA ZA200503230A patent/ZA200503230B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1711086A (zh) | 2005-12-21 |
| US20040092431A1 (en) | 2004-05-13 |
| AU2003286686A1 (en) | 2004-06-03 |
| MXPA05004738A (es) | 2005-08-03 |
| ZA200503230B (en) | 2006-06-28 |
| EP1562592A4 (en) | 2009-01-21 |
| AU2003286686B2 (en) | 2009-07-16 |
| WO2004043348A3 (en) | 2004-07-15 |
| RU2324483C2 (ru) | 2008-05-20 |
| CA2504226A1 (en) | 2004-05-27 |
| WO2004043348A2 (en) | 2004-05-27 |
| US20070088045A1 (en) | 2007-04-19 |
| KR20050074547A (ko) | 2005-07-18 |
| BR0316163A (pt) | 2005-09-27 |
| JP2006508120A (ja) | 2006-03-09 |
| EP1562592A2 (en) | 2005-08-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2005118108A (ru) | Ингибиторы гистондеацетилазы для лечения дегенеративных заболеваний глаз | |
| US20040216749A1 (en) | Vasomodulation during glaucoma surgery | |
| JP2003527422A5 (ru) | ||
| Cantor et al. | Glaucoma in the Maroteaux-Lamy syndrome | |
| Nejat et al. | A novel approach to treatment of pinguecula using atmospheric low-temperature plasma: a clinical case series | |
| RU2110975C1 (ru) | Способ лечения миопии высокой степени и миопического астигматизма средней и высокой степени (варианты) | |
| US20050205101A1 (en) | Combined pharmocological and surgical method and system for the treatment of eye disorders | |
| Chuang et al. | Scleral buckling for stage 4 retinopathy of prematurity | |
| Gaasterland et al. | Threshold for Lens Damage During Q switched Nd: YAG Laser Iridectomy: A Study of Rhesus Monkey Eyes | |
| RU2199989C1 (ru) | Способ лечения заболеваний сетчатки и зрительного нерва дистрофического генеза | |
| RU2408335C1 (ru) | Способ лечения возрастной макулярной дегенерации сетчатки | |
| RU2136251C1 (ru) | Способ лечения эндофтальмита | |
| CA2266363C (en) | Corneal subepithelial opacity inhibitor | |
| Lewis et al. | Neovascular glaucoma after photoradiation therapy for uveal melanoma | |
| RU2268722C2 (ru) | Способ лечения и профилактики глазных болезней, связанных с ишемией тканей глаза | |
| JP2007513926A (ja) | 屈折矯正手術による眼表面の乾燥を治療するための化合物 | |
| Gezer | The role of patient's age in regression of holmium: YAG thermokeratoplasty-induced correction of hyperopia | |
| RU2251396C2 (ru) | Способ лечения осложнения после лазерного кератомилеза | |
| Andrews et al. | Surgical advances in retinopathy of prematurity | |
| RU2325887C2 (ru) | Способ лечения неоваскулярной глаукомы | |
| SU1179988A1 (ru) | Способ лечени гипотонии глаза | |
| RU2189209C1 (ru) | Модифицированный способ проведения лазерного кератомилеза | |
| Kontić et al. | Selective laser trabeculoplasty as adjunctive treatment in pseudoexfoliative glaucoma patients | |
| Laatikainen et al. | Combined use of argon laser photocoagulation and cryotherapy in the treatment of retinopathy of prematurity | |
| RU2359646C2 (ru) | Способ лечения глаукомы в терминальной стадии заболевания |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20111028 |