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WO2008117862A1 - ウレア構造を有する新規ピリジンカルボン酸（２－アミノフェニル）アミド誘導体 - Google Patents

ウレア構造を有する新規ピリジンカルボン酸（２－アミノフェニル）アミド誘導体 Download PDF

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Publication number
WO2008117862A1
WO2008117862A1 PCT/JP2008/056012 JP2008056012W WO2008117862A1 WO 2008117862 A1 WO2008117862 A1 WO 2008117862A1 JP 2008056012 W JP2008056012 W JP 2008056012W WO 2008117862 A1 WO2008117862 A1 WO 2008117862A1
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WIPO (PCT)
Prior art keywords
novel
aminophenyl
lower alkyl
derivative
urea structure
Prior art date
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Ceased
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PCT/JP2008/056012
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English (en)
French (fr)
Inventor
Hiroyuki Mogi
Hisashi Tajima
Noriko Mishina
Yusuke Yamazaki
Shinji Yoneda
Katsuhiko Watanabe
Junko Fujikawa
Minoru Yamamoto
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Santen Pharmaceutical Co Ltd
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Santen Pharmaceutical Co Ltd
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Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Priority to US12/450,387 priority Critical patent/US8012972B2/en
Priority to CA002680517A priority patent/CA2680517A1/en
Priority to EP08739136A priority patent/EP2133339A4/en
Publication of WO2008117862A1 publication Critical patent/WO2008117862A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Abstract

　本発明は、新規ウレア構造を有する新規ピリジンカルボン酸（２－アミノフェニル）アミド誘導体の合成研究及びその誘導体の薬理作用を見出すことを目的とする。本発明は式（１）で表される化合物又はその塩を提供する。式中、Ｒ1及びＲ2は水素原子、低級アルキル基等、Ｒ3はヒドロキシ基、低級アルコキシ基、低級シクロアルキルオキシ基、アリールオキシ基、カルボキシ基、低級アルコキシカルボニル基、－ＯＣＯＮＲaＲb、－ＮＲcＲd 等、Ｒ4及びＲ5はハロゲン原子、低級アルキル基、ヒドロキシ基、低級アルコキシ基等、Ｒa、Ｒbは水素原子、低級アルキル基、低級シクロアルキル基、アリール基、複素環基等、Ｒc及びＲdは水素原子、低級アルキル基、低級シクロアルキル基、アリール基等、Ｘは低級アルキレン基、Ｙは単結合、低級アルキレン基、Ｗ1－Ｗ2はＮ－Ｃ、Ｃ－Ｎ、ｌ及びｍは０、１、２又は３を示す。 　【化１】
PCT/JP2008/056012 2007-03-28 2008-03-28 ウレア構造を有する新規ピリジンカルボン酸（２－アミノフェニル）アミド誘導体 Ceased WO2008117862A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/450,387 US8012972B2 (en) 2007-03-28 2008-03-28 Pyridinecarboxylic acid (2-aminophenyl) amide derivative having urea structure
CA002680517A CA2680517A1 (en) 2007-03-28 2008-03-28 Novel pyridinecarboxylic acid (2-aminophenyl)amide derivative having urea structure
EP08739136A EP2133339A4 (en) 2007-03-28 2008-03-28 NOVEL (2-AMINOPHENYL) PYRIDINECARBOXAMIDE DERIVATIVE HAVING UREA STRUCTURE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-084258 2007-03-28
JP2007084258 2007-03-28

Publications (1)

Publication Number Publication Date
WO2008117862A1 true WO2008117862A1 (ja) 2008-10-02

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Application Number Title Priority Date Filing Date
PCT/JP2008/056012 Ceased WO2008117862A1 (ja) 2007-03-28 2008-03-28 ウレア構造を有する新規ピリジンカルボン酸（２－アミノフェニル）アミド誘導体

Country Status (7)

Country Link
US (1) US8012972B2 (ja)
EP (1) EP2133339A4 (ja)
JP (1) JP5150332B2 (ja)
KR (1) KR20090128513A (ja)
CN (1) CN101646651A (ja)
CA (1) CA2680517A1 (ja)
WO (1) WO2008117862A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009142321A1 (ja) * 2008-05-23 2009-11-26 参天製薬株式会社 ウレア構造を有する新規チオフェンジアミン誘導体
EP2107052A4 (en) * 2006-12-26 2009-12-23 Santen Pharmaceutical Co Ltd NOVEL N- (2-AMINOPHENYL) BENZAMIDE DERIVATIVE HAVING A UREA STRUCTURE

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101646460A (zh) * 2007-03-28 2010-02-10 参天制药株式会社 含有具有组蛋白脱乙酰化酶抑制作用的化合物作为有效成分的降眼压剂
EP2330894B8 (en) 2008-09-03 2017-04-19 BioMarin Pharmaceutical Inc. Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
CA3061239A1 (en) 2011-02-28 2012-09-07 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
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