RU2002122174A - Способ профилактики и лечения заболевания, опосредуемого csbp/rk/p38 киназой, и способ лечения воспаления - Google Patents
Способ профилактики и лечения заболевания, опосредуемого csbp/rk/p38 киназой, и способ лечения воспаления Download PDFInfo
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- RU2002122174A RU2002122174A RU2002122174/14A RU2002122174A RU2002122174A RU 2002122174 A RU2002122174 A RU 2002122174A RU 2002122174/14 A RU2002122174/14 A RU 2002122174/14A RU 2002122174 A RU2002122174 A RU 2002122174A RU 2002122174 A RU2002122174 A RU 2002122174A
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- disease
- atherosclerosis
- arthritis
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- csbp
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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Claims (4)
1. Способ профилактики и лечения опосредуемого CSBP/RK/p38 киназой заболевания у млекопитающего, нуждающегося в этом, который включает введение указанному млекопитающему эффективного количества 5-(4-пиридил)-4-(4-фторфенил)-1-(4-пиперидинил)-имидазола, или его фармацевтически приемлемой соли.
2. Способ по п.1, где заболевание выбрано из группы, включающей ревматоидный артрит, ревматоидный спондилит, остеоартрит, псориатический артрит, травматический артрит, артрит при краснухе, острый синовит, артрит при подагре и другие артритные состояния, сепсис, септический шок, эндотоксический шок, грамм-отрицательный сепсис, синдром токсического шока, астму, синдром недомогания у взрослых при респираторном заболевании, хроническое легочное воспалительное заболевание, силикоз, легочный саркоидоз, заболевания резорбции костных тканей, остеопороз, реакцию на прививку, отторжение алломорфных прививок, повышенную температуру, приступы стенокардии, сердечное и почечное реперфузионное повреждение, тромбоз, гломерулонефрит, церебральную малярию, диабет и β-клетки поджелудочной железы, рассеянный склероз, дегенерацию мышц, атеросклероз, болезнь Альцгеймера, экзему, псориаз, солнечный ожог, конъюнктивит, болезнь Крона, язвенный колит или воспалительное заболевание кишечника.
3. Способ по п.2, где заболевание выбрано из группы, включающей экзему, псориаз, солнечный ожог и конъюнктивит.
4. Способ лечения воспаления у млекопитающего, нуждающегося в этом, включающий введение указанному млекопитающему эффективного количества 5-(4-пиридил)-4-(4-фторфенил)-1-(4-пиперидинил) имидазола или его фармацевтически приемлемой соли.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36996495A | 1995-01-09 | 1995-01-09 | |
| US08/369,964 | 1995-01-09 | ||
| US08/472,366 US5593992A (en) | 1993-07-16 | 1995-06-07 | Compounds |
| US08/472,366 | 1995-06-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97113753/04A Division RU2196139C2 (ru) | 1995-01-09 | 1996-01-11 | 1,4,5-тризамещенные производные имидазола, способы их получения и фармацевтическая композиция на их основе |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2002122174A true RU2002122174A (ru) | 2004-02-27 |
Family
ID=27004764
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97113753/04A RU2196139C2 (ru) | 1995-01-09 | 1996-01-11 | 1,4,5-тризамещенные производные имидазола, способы их получения и фармацевтическая композиция на их основе |
| RU2002122174/14A RU2002122174A (ru) | 1995-01-09 | 2002-08-15 | Способ профилактики и лечения заболевания, опосредуемого csbp/rk/p38 киназой, и способ лечения воспаления |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97113753/04A RU2196139C2 (ru) | 1995-01-09 | 1996-01-11 | 1,4,5-тризамещенные производные имидазола, способы их получения и фармацевтическая композиция на их основе |
Country Status (33)
| Country | Link |
|---|---|
| US (5) | US5593992A (ru) |
| EP (2) | EP1264827A1 (ru) |
| JP (2) | JP3330952B2 (ru) |
| CN (1) | CN1138546C (ru) |
| AP (1) | AP1270A (ru) |
| AR (1) | AR002267A1 (ru) |
| AT (1) | ATE254613T1 (ru) |
| AU (1) | AU705207C (ru) |
| BG (1) | BG63769B1 (ru) |
| BR (1) | BR9606904A (ru) |
| CA (1) | CA2209938A1 (ru) |
| CZ (1) | CZ215897A3 (ru) |
| DE (1) | DE69630777T2 (ru) |
| DK (1) | DK0809499T3 (ru) |
| DZ (1) | DZ1961A1 (ru) |
| ES (1) | ES2210348T3 (ru) |
| FI (1) | FI972901L (ru) |
| HU (1) | HUP9702409A3 (ru) |
| ID (3) | ID23273A (ru) |
| IL (7) | IL134322A (ru) |
| IN (3) | IN184957B (ru) |
| MA (1) | MA23770A1 (ru) |
| MX (1) | MX9705142A (ru) |
| NO (3) | NO973167L (ru) |
| NZ (1) | NZ301204A (ru) |
| OA (1) | OA10738A (ru) |
| PL (1) | PL322249A1 (ru) |
| PT (1) | PT809499E (ru) |
| RU (2) | RU2196139C2 (ru) |
| SI (1) | SI0809499T1 (ru) |
| SK (1) | SK90297A3 (ru) |
| TW (1) | TW523511B (ru) |
| WO (1) | WO1996021452A1 (ru) |
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916891A (en) | 1992-01-13 | 1999-06-29 | Smithkline Beecham Corporation | Pyrimidinyl imidazoles |
| EP0724588B1 (en) * | 1993-09-17 | 1999-11-10 | Smithkline Beecham Corporation | Drug binding protein |
| US6203803B1 (en) | 1994-12-14 | 2001-03-20 | Societe L'oreal S.A. | Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained |
| EP0802908A4 (en) * | 1995-01-12 | 2001-04-11 | Smithkline Beecham Corp | NEW CONNECTIONS |
| EP0737471A3 (fr) * | 1995-04-10 | 2000-12-06 | L'oreal | Utilisation d'un sel d'une métal alcalino-terreux comme inhibiteur de TNF-alpha dans une composition unique et composition obtenue |
| US6369068B1 (en) | 1995-06-07 | 2002-04-09 | Smithkline Beecham Corporation | Amino substituted pyrimidine containing compounds |
| US5739143A (en) * | 1995-06-07 | 1998-04-14 | Smithkline Beecham Corporation | Imidazole compounds and compositions |
| US5658903A (en) * | 1995-06-07 | 1997-08-19 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
| FR2740341B1 (fr) * | 1995-10-26 | 1997-12-19 | Oreal | Utilisation de sel de lanthanide, d'etain, de zinc, de manganese, d'yttrium, de cobalt, de baryum, de strontium dans une composition pour la peau |
| ZA9610687B (en) * | 1995-12-22 | 1997-09-29 | Smithkline Beecham Corp | Novel synthesis. |
| US6046208A (en) * | 1996-01-11 | 2000-04-04 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US5977103A (en) * | 1996-01-11 | 1999-11-02 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| ZA97175B (en) | 1996-01-11 | 1997-11-04 | Smithkline Beecham Corp | Novel substituted imidazole compounds. |
| AP9700912A0 (en) * | 1996-01-11 | 1997-01-31 | Smithkline Beecham Corp | Novel cycloalkyl substituted imidazoles |
| JP2000507224A (ja) * | 1996-03-08 | 2000-06-13 | スミスクライン・ビーチャム・コーポレイション | Ｃｓａｉｄ化合物の血管形成の抑制物質としての使用 |
| JP2000507558A (ja) * | 1996-03-25 | 2000-06-20 | スミスクライン・ビーチャム・コーポレイション | Ｃｎｓ損傷についての新規な治療 |
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- 2000-01-27 IN IN60DE2000 patent/IN188338B/en unknown
- 2000-01-27 IN IN61DE2000 patent/IN188339B/en unknown
- 2000-02-01 IL IL13432400A patent/IL134324A0/xx unknown
- 2000-02-01 IL IL13432300A patent/IL134323A0/xx unknown
- 2000-02-01 IL IL13432200A patent/IL134322A0/xx unknown
- 2000-02-11 US US09/502,763 patent/US6222036B1/en not_active Expired - Fee Related
-
2001
- 2001-02-27 US US09/795,009 patent/US20020188122A1/en not_active Abandoned
- 2001-07-16 JP JP2001215404A patent/JP2002105047A/ja active Pending
- 2001-12-19 NO NO20016225A patent/NO20016225D0/no not_active Application Discontinuation
- 2001-12-19 NO NO20016226A patent/NO20016226D0/no not_active Application Discontinuation
-
2002
- 2002-08-15 RU RU2002122174/14A patent/RU2002122174A/ru not_active Application Discontinuation
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| FA93 | Acknowledgement of application withdrawn (no request for examination) |
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