RU2061494C1 - Method of digestibility and metabolism stimulation in growing pig organism - Google Patents

Abstract

FIELD: swine breeding. SUBSTANCE: method involves the use of alfalfa plant extract as a medicinal preparation stimulating digestibility and metabolism. Extract is prepared by treatment of raw with extractant containing trace elements mixture which is added to the food at the dose 20-40 mg/kg animal living mass, 1-2 times per 24 hr for 13-15 days. Method is used for animal fattening in swine breeding. EFFECT: improved method of stimulation. 6 tbl

Description

 The invention relates to methods of stimulating digestibility and metabolism in animals and can be used in animal feed, for example, in pig farming.

 A known drug for the normalization of metabolic processes in young pigs containing components, mg / goal: copper methionate 9.22-27.66 zinc methionate 1.35-4.05 cobalt methionate 32.64-97.90; iodine methionate 0.096-0.286.

 The use of ergotropic substances that regulate digestion processes in animals is known, such as antibiotics, steroid hormones, coccidiostatics, antioxidants, tranquilizers, sex hormones (see Ergotropics: regulators of metabolism and feed use by farm animals. M: Agropromizdat, 1986).

 Currently, bacterial preparations, in particular from lactic acid bacteria, are of great importance. Lack of toxicity, ease of use, low cost are the main criteria for increased interest in these drugs. For example, the use of a dry acidophilus preparation with food helps to improve the physiological state, body resistance and productivity of animals and birds. The use of propionic acidophilus-broth culture (PABA) contributes to the normalization of the functions of the gastrointestinal tract. A beneficial effect on health, weight gain, the microflora of the gastrointestinal tract of piglets, a decrease in the number of diseases has the drug lactiferm, dry bifidumbacterin, azotbakterin. The drug Bacillus nato, isolated from fermented soy, contributes to better absorption of nutrients, increase the resistance of animals and birds (J. Agriculture Abroad, 1981, N 2, p. 43-47).

 Organic acids of microbiological synthesis are also widely used in animal husbandry and in veterinary medicine as growth stimulants and therapeutic and prophylactic agents (J. Veterinary, 1985, No. 5, pp. 61-62).

 It is known that Baliz-2, developed by Rostov State University, as a top dressing, is used in animal husbandry and poultry farming. The growth-promoting effect of Baliza-2 was tested on broiler chickens. Gastrointestinal diseases were tested on pigs (dysbiosis, colibacteriosis, dyspepsia). It was revealed that Baliz-2 is not inferior to tetracycline in therapeutic properties and significantly exceeds dry acidophilus. Suckling pigs for preventive and therapeutic purposes Baliz-2 is given through the mouth with a syringe with a rubber cannula 20 ml / kg body weight for 10-15 days, and then poured into wooden or plastic feeders before morning feeding.

Baliz-2 is a complex of organic acids formed by microbiological synthesis. The preparation is a colorless or slightly yellowish liquid with a weak specific odor, density 1.0 g / cm ³ , specific gravity 1.0 g / cm ³ , freezing point 0 ^o C, boiling point 100 ^o C. When heated, the drug turns yellow, biological activity is retained (Shurygin A.Ya. et al. Use of Baliz in livestock and poultry, 1989, Rostov-on-Don, p. 12).

 A known method of regulating the growth and fattening of farm animals, comprising co-administering hormonal drugs of estrogen and androgenic action sequentially throughout the entire fattening, and diethylstilbestrol is used as an estrogenic drug, and D1-1.9-HOP-D-homotestosterone is an androgenic drug, in Betazine as a thyreostatic drug (A.S.SSSR N 54336 dated 02.15.77 A 61K 37/24).

 An object of the invention is to improve the digestibility and metabolism in the body of growing animals (pigs) by using a biologically active substance, a plant condensed extract (Herakonda).

 Heracond is obtained as follows (application N 4736234/30 -15, according to which the decision of the examination on the grant of a patent of the Russian Federation N 1839723 was received).

A solution of salts of trace elements based on the steam condensate of distilled water is prepared, including, for example, mg: Mo-8.0 g, Ba-10, Rv-20, Co-1.05, U-1.0, C; -0.5, Zp-200, 0, Fe300, 0, Sp-40 per 1 kg of plant mass;
plant mass, for example alfalfa hay, is crushed and placed in an autoclave;
fill the plant mass with the prepared solution in a ratio of 1: 5 and seal the autoclave;
carry out heating of the pulp to a temperature of 120 ^o C and kept under pressure for 10 minutes;
the primary extract is poured into a storage tank;
re-fill the plant mass with the same solution in the same ratio and seal the autoclave;
carry out heating of the pulp to a temperature of 180 ^o C and incubated under pressure for 10 minutes;
the secondary extract is poured into a storage tank;
mix the primary and secondary extracts in a storage tank and evaporate it until a mixture of numerous bubbles appears on the mirror surface;
filter the mixture through a cotton-gauze filter;
the obtained filtrate is placed on a baking sheet covered with a plastic film;
continue to evaporate the extract in an oven at a temperature of 60 ^o With the formation of a resinous mass throughout the thickness of the extract poured onto a baking sheet;
the resulting resinous mass is molded into a lump for future use or storage.

 To use Heraconda to solve the problem, take 20-40 mg per 1 kg of live weight of the animal, dissolve it in water and add to the feed.

 The Trinity Veterinary Institute in the clinic tested a method of stimulating digestibility and metabolism in the body of growing pigs in pigs aged 3.5-4.0 months with the addition of a plant condensed Herakond extract in standard compound feed.

 For the exchange experience, animals were selected taking into account gender, live weight, age and breed. The experiments were carried out according to the scheme (see the end of the text).

 The digestibility and metabolism experiment was carried out in individual metabolic metal cells. Every day, each animal received strictly 2 kg of mixed feed, in which heracond dissolved in water was added for animals of groups II and III: group II once 1 g per head during evening feeding, group III twice / morning and evening / 1 g / 2 g per head per day.

 At the end of the reference period, blood was taken from each animal after weighing it for morphological and biochemical analyzes.

The data of morphological studies of blood serum of experimental animals show that the addition to the diet of pigs of various amounts of heraconda / 20 and 40 mg per 1 kg of live weight / did not affect the number of leukocytes / table I / and changes in the leukoformula. At the same time, with an increase in the dose of heraconda to 40 mg per 1 kg of live weight in the blood of animals, a significant increase in the number of red blood cells / td = 8.37, P <0.001 / and hemoglobin / td = 2.69; P <0.05 /. In all likelihood, this is due to an increase in redox processes in animals. This is also confirmed by the amount of lactic acid in the blood serum of experimental pigs. So, if in animals of group I its level was 7.59 mg, then in II -7.53, and in group III 6.84 mg
The amount of pyruvic acid in the blood of animals of groups I and III was the same, and in pigs of group II it tended to increase. Therefore, when animals were given heraconda at a dose of 20 mg / kg live weight, it did not affect bioenergetic processes associated with the use of protein for energy purposes.

 When studying indicators of lipid metabolism, more significant changes in the body of growing pigs were observed when testing the dosage of 20 mg / kg body weight (table 2).

 General clinical indicators of serum of pigs.

 With a relatively equal level of total lipids in the blood serum of experimental animals, the addition of heraconda at a dose of 20 mg / kg body weight led to a decrease in cholesterol by 13.5 and in animals of group III by 13.8 in comparison with the control group. A similar trend was observed in the cholesterol content in β lipoproteins.

 Considering that b-lipoproteins are the main source of fat transfer in animals, the dose of heraconda of 20 mg / kg body weight contributes to better absorption of fats in feed. So, the content of b-lipoproteins in the blood serum of pigs of group II increased in comparison with animals of group I by 0.24 g / l, or by 20.7 / td = 2.6; P <0.05 /.

 The most significant changes in the blood serum of experimental animals were observed in terms of protein metabolism / table 3 /.

 The total protein content in the blood serum of animals of all groups was almost the same. Qualitatively, in animals treated with 40 mg / kg of body weight of heraconda, more albumin was observed in blood serum and the ratio of albumin to globulin was highest of all.

 The low content of urea and amine nitrogen in pigs of group III confirms the best use of amino acids of feed in comparison with animals of groups I and II. The differences in the amount of amine nitrogen are significant / td = 2.7; P <, 0.05 and td = 2.9; P <0.05 /.

 An increase in the amount of creatinine in the blood serum of pigs of groups II and III by 2.05 mg% compared with animals of group I confirms that the addition of heraconda contributes to better absorption of dietary protein.

 The differences in the indicators of protein and lipid metabolism in blood serum are explained by the digestibility of nutrients in diets of experimental animals / table 4 /.

 Testing the addition of heraconda to a standard compound feed at a dose of 20 mg / kg body weight leads to an increase in the digestibility of the dietary protein by 4.4 fat by 9.6 in comparison with the animals of the control group. Increasing the dose of heraconda to 40 mg / kg body weight has an effect only on increasing the digestibility of feed protein. Thus, protein digestibility in animals of group III was 9.4 higher than in pigs of group I.

 Differences in the digestibility of dietary nutrients in experimental animals influenced the nitrogen balance in pigs / table 5 /.

 The addition of heraconda to the diet of animals of groups II and III at a dose of 20 and 40 mg / kg body weight contributes to better protein digestion and less nitrogen excretion with undigested feces with a relatively identical excretion of nitrogen in the urine. According to the results of the balance experiment, 16.33 g of nitrogen is deposited in the body of animals of group I on average per day, in pigs of group II -17.08 g, or 4.6 more, and in animals of group III -18.21 g, or 11.5 higher than pigs of group I. Accordingly, in animals of groups II and III there is a better use of nitrogen, both taken with food and from overcooked.

 Differences in the digestibility of nutrients in diets and their use in the body of experimental animals, in turn, influenced the average daily gain of pigs / table 6 /.

 The average daily gain in live weight in pigs of group I for the reference period was 493 g, while in animals of group II it was higher by 17 g, or by 3.4 / td = 2.8; P <0.05 /, and in pigs of group III by 34 g, or 6.9 more than in group I / td = 2.2; P <0.05 /.

Thus, the addition of heraconda to the diet of growing pigs at a dose of 20 mg / kg live weight helps to increase protein digestibility by 4.4% fat by 9.6%, their better absorption in the body and increase the average daily gain by 3.4%
A dose of heraconda in an amount of 40 mg / kg body weight affects protein metabolism: protein digestibility increases by 9.4; metabolic processes of protein metabolism occur; as a result, the average daily increase increases by 6.9 TTT1 TTT2 TTT3 TTT4 TTT5 TTT6 TTT7

Claims (1)

 A method of stimulating the digestibility and metabolism in the body of growing pigs by introducing a preparation from plant materials into their diet, characterized in that an extract obtained by processing alfalfa with a solution containing trace elements in the following ratio, in mg per 1, is used as a preparation from plant materials kg of plant mass Mo - 8, Ba 10, Pb 20, Co 1.05; J 1, Cr 0.5; Zn 200, Fe 300, Sn 4, and the introduction of the drug is carried out at the rate of 20-40 mg per kg of live weight of the animal 1-2 times a day for 13 to 15 days.

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