WO2017065632A1 - Semi-finished product and feed products for farm animals including the semi-finished product - Google Patents

Abstract

The present inventions relate to feed production and can be used for preparing semi-finished products, a feed supplement base and a feed product for livestock and poultry. A semi-finished product contains expanded vermiculite and an active component, in the form of lactic acid and polyvinylpyrrolidone, which is located either in a near-surface layer or within the structure of the expanded vermiculite. The produced mixture is in a dry state. A feed supplement base contains the above semi-finished product and an active part formed from a mixture of succinic acid and/or salts thereof, citric acid, salt, bentonite and vermiculite. A feed product for food-producing livestock and poultry contains a set of active ingredients consisting of the feed supplement base and a mycelial biomass in a ratio of 1-99:1-99.

Description

 SEMI-FINISHED PRODUCTS AND FODDER PRODUCTS FOR

 AGRICULTURAL ANIMALS WITH SEMI-FINISHED PRODUCT

FIELD OF TECHNOLOGY

The present invention relates to veterinary medicine and can be used in the preparation of feed for farm animals and birds, when it is most important to strictly adhere to the formulation of the feed additives obtained for them with the possibility of its rapid change in order to achieve a decrease in the negative impact of toxins on their productivity.

BACKGROUND

As you know, high productivity means the genetically determined ability of animals to transform feed nutrients into elements of tissues, organs, and productive secrets that are used as food products or technological raw materials. This ability is due to the intense flow of metabolism.

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SUBSTITUTE SHEET (RULE 26) at all levels and stages. Moreover, all the organs of the animal involved in the transformation of the feed into the final product work in extreme conditions. Naturally, under such loads, the vital forces of the body are simply not enough to overcome the effects of negative external factors - diseases of various etiologies, stresses, poor or poorly balanced feeding, etc. The problem of using insufficiently high-quality feed raw materials is especially acute. Therefore, there is a problem of increasing the concentration of heavy metals, microbial contamination, mycotoxins. According to practical observations, more than 30% of compound feeds contain mold mycotoxins. It is generally recognized that safe levels of mycotoxins and, accordingly, safe feeds do not exist. And if animals with low productivity have enough internal reserves for neutralizing toxins, then highly productive animals are not able to withstand the harmful effects of pathogenic microorganisms and their metabolic products. In this regard, to maintain high productivity, it is advisable to use toxin converters, primarily produced by pathogenic fungi. In this case, it is extremely important that the formulation of mycotoxin-binding and neutralizing additives is strictly observed.

Currently, the most commonly used means to protect animals from the damaging effects of contaminated feeds are the use of mycotoxin-binding sorbents. The action of sorbents is based on the ability to bind and remove mycotoxins from the gastrointestinal tract. Sorbents must quickly bind and effectively retain mycotoxins at various levels of acidity of the gastrointestinal tract and the rate of removal of residual metabolic products from it, including mycotoxins.

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SUBSTITUTE SHEET (RULE 26) The negative quality of absorbent materials is their low specificity, which results in the binding of nutrients (essential fatty acids, vitamins, amino acids) and drugs (disposal of mycotoxins in animal feed with various adsorbents, Toxicology Letters, 122 (2001), 179-188 )

The use of organic acids with pronounced bactericidal activity is known. In recent years, highly effective preparations based on organic acids with bactericidal, antiseptic and fungicidal effects have been developed (Instructions for use Cuxacid S, LOMAN ANIVAL HELTH, Germany). They can effectively preserve feed and destroy the already formed toxins. In addition, many acids (succinic, lactic) stimulate the protective functions of the body and improve digestion.

The disadvantage of such drugs is the use of active acids such as formic and acetic acids, which at high dosages can lead to acidosis. Concentration, which is not sufficient to kill mold due to a change in the pH of the medium, can create stress for molds, which, in turn, stimulates the formation of toxins.

Famous FODDER PRODUCT FOR PRODUCTIVE AGRICULTURAL ANIMALS AND BIRDS (see Patent R.F. 2425587, IPC A23K 1/00, published on 08/10/2011 1). This feed product contains aluminosilicate as a sorption material and additionally includes a silver complex with polyvinylpyrrolidone, lactic acid, succinic acid or its salts, citric acid and iodine in the following ratio of ingredients, wt.%: Lactic acid - 8.0-12.0

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SUBSTITUTE SHEET (RULE 26) succinic acid (or its salts) - 2.0-5.0 citric acid - 5.0-12.0 polyvinylpyrrolidone - 5.0-8.0 silver - 0.0001-0.0002 iodine - 0.005-0.01 aluminosilicate - the rest is up to 100%

This known feed product is prepared as follows.

1. Take purified water corresponding to Purified Water SanPiN 2.1.4.1074-01, GOST R 51232 and serve in an ionizer in which it is saturated with silver to a concentration of 2-25 mg / liter;

2. Then, in a blending vessel, polyvinylpyrrolidone (PVP) is mixed with ionized water;

3. Then the PVP solution with silver enters mixer 1 and the liquid fractions of organic acids enter the same. All this is mixed with aluminosilicates, characterized by sorption properties: water capacity 320-468%, fat capacity 208-324%;

4. From the mixer, the product enters the oven to remove excess moisture;

5. From the drying cabinet, the mixture enters the mixer 2, where the final mixing with organic acids and filler-aluminosilicate;

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 6. From the mixer 2, the finished product enters the packaging and labeling line.

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SUBSTITUTE SHEET (RULE 26) Indicated from West, ι s th food ovo th _. the product is already used to neutralize toxins in the feed and gastrointestinal tract of highly productive animals and birds, since it contains only natural components that do not have negative side effects on the animal’s body in acceptable concentrations. It performs the following functions: inhibits the development and destroys existing toxins, improves the detoxification function of the liver. The presence of mycotoxins in feed leads to a decrease in productivity, reproductive qualities and the immune state of animals. Although mycotoxins differ in chemical structure, toxicity and mechanism of action, the main sign of all mycotoxins is toxicity relative to eukaryotic organisms. The most commonly used classification of mycotoxins is molecular structure, according to which aflatoxins, zearalenone and its derivatives, fumonisins, ochratoxins, etc. are distinguished.

As can be seen from this known invention, the preparation of such a feed additive requires accurate calibrated compliance with the use of the components necessary for its preparation.

The aforementioned well-known invention "FODDER PRODUCT FOR PRODUCTIVE AGRICULTURAL ANIMALS AND BIRDS" is selected as a prototype, since it contains the largest number of essential features coinciding with the claimed inventions and is the best solution in this known direction of development of feed additives for animals and birds. So from this description of the invention, the action of sorbents is known, which is based on the ability to remove mycotoxins from the gastrointestinal tract. Sorbents must quickly bind and effectively retain mycotoxins at various levels of acidity. The negative quality of sorbent materials is their low specificity, due to which

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SUBSTITUTE SHEET (RULE 26) the binding of nutrients (essential fatty acids, vitamins, amino acids) and drugs (The neutralization of mycotoxins in animal feed by various adsorbents, Toxicology Letters, 122 (2001), 179-188). In the known invention, lactic acid is 8.0-12.0; succinic acid (or its salts) - 2.0-5, precipitated (mixed) with aluminosilicates, characterized by sorption properties: water capacity 320-468%, fat capacity 208-324%; Moreover, this mixture, in essence, is able to perform the function of a semi-finished product for the subsequent formation on it of the basis for the preparation of the feed product. For this, other components are introduced into the continuous process of mixing the components, as noted earlier, and they are introduced in sufficiently small doses, which are difficult to calibrate.

Thus, from this well-known invention follows such well-known products: a semi-finished product containing expanded vermiculite; a base containing a semi-finished product and an active part from organic acids, and the final product is a feed additive containing a base with a semi-finished product formed from vermiculite and an active part using organic acids and salts. Moreover, they all have the same drawback, namely, in the process of preparing the final product, it is difficult to ensure the calibrated use of the introduced components. In addition, with such technological application of the components for the preparation of a feed additive, it is practically impossible to promptly make changes in it both in quantitative composition and in quality, to create feed products for groups of animals and birds with different physiological needs.

However, all of the above listed as the enlarged parts of the feed additive, and it itself has a significant drawback, in the manufacture of this feed known additives it is difficult to ensure the calibrated use of components, since there are many and most

SUBSTITUTE SHEET (RULE 26) used in small doses. Therefore, when preparing the mixture, these small doses are difficult to evenly calibrate and, accordingly, distribute throughout the mass of the feed additive, as well as in the diet of animals and birds. As a result, the effectiveness of the feed additive is reduced.

SUMMARY OF THE INVENTION

The objective of the present invention is to develop components of the feed product, which, when mixed, would provide a clear calibrated use both in the final product - feed additive, and in its main enlarged components: the semi-finished product and the basis on it, ensuring a uniform distribution of the components in them.

The technical result to which the present invention is directed is the creation of new enlarged composite active components, such as a semi-finished product to obtain the basis of a feed additive, a base of a feed additive from this semi-finished product and a feed additive for productive farm animals and birds on this basis. Each of them has its own application and at the same time can be stored for a long time for subsequent use during the preparation of the next appropriate feed additive, ensuring accurate calibrated use of the components in the final product, and increasing the manufacturability of their preparation. It should be noted that such crushing of the feed additive into enlarged components has been undertaken earlier (see the prototype previously given). However, all this was carried out in a continuously proceeding technological process without their independent removal and subsequent storage for new applications. So, for example, from the previously noted well-known feed additive, aluminosilicate can be selected as a semi-finished product, because it occupies the largest volume in the feed additive, and the remaining components are added to it in small quantities, and

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SUBSTITUTE SHEET (RULE 26) since there are many of them, it is difficult to withstand their required tared introduction. At the same time, as noted earlier, the use of mycotoxin-binding sorbents is a well-known means for protecting animals from the damaging effects of contaminated feeds. The action of sorbents is based on the ability to remove mycotoxins from the gastrointestinal tract. Sorbents quickly bind and effectively retain mycotoxins at various levels of acidity. In fact, this is a semi-finished product with a narrow scope, which has one negative quality, namely, low specificity, which is why it is very likely that the binding of nutrients (essential fatty acids, vitamins, amino acids) and drugs (Disinfection of mycotoxins in animal feed with various adsorbents, Toxicology Letters, 122 (2001), 179-188).

Therefore, the first task that this set of inventions solves is the creation of a semi-finished product that provides the following technical result, namely, obtaining an independent feed mixture and using it for more accurate calibration for preparing a feed additive. In addition, the semi-finished product could be used as a combination agent against mycotoxins and other toxic metabolites.

This problem is solved as follows. In the known semi-finished product comprising vermiculite according to the present invention, expanded vermiculite is used as expanded vermiculite and an active component is introduced into it to form a mixture in which lactic acid with polyvinylpyrrolidone is used as an active component in a general ratio of 3: 2. A variant is possible in which the active component is introduced at least into the near-surface layer of vermiculite, or into its porous structure, or it is completely saturated with it and, the resulting mixture is in a dry loose state, moreover, this mixture

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SUBSTITUTE SHEET (RULE 26) it is formed either by spraying-active, parts on expanded vermiculite, or by wetting or otherwise, followed by their mixing.

The proposed semi-finished product is made, for example, by mixing about 80% lactic acid solution with polyvinylpyrrolidone 1: 0.02, and then the resulting mixture is introduced into expanded vermiculite in a ratio of 2: 3 to obtain a dry and free-flowing mixture. As a result, the proposed semi-finished product has sorption properties, enhances the elimination of toxins and heavy metals from the body of the animal from the feed, which improves the quality of the final product, and can be used independently as a feed mixture.

The second task is to obtain a basis on the basis of a semi-finished product for the preparation of a feed additive. Its main components were already used in various feed additives in small quantities and often its components were not accurately calibrated in the composition of the final product. This reduced the effectiveness of its preparation and use.

In our case, the problem is solved as follows. In the known base containing the semi-finished product and the active part, according to the present invention, the active part is formed from a mixture of succinic acid and / or its salts, citric acid, salt (NaCl - marine, table, iodized, etc.), bentonite and vermiculite, and as a semi-finished product, a mixture of expanded vermiculite with an active component was used, which was used lactic acid with polyvinylpyrrolidone in a total ratio of 3: 2 to form a dry feed mixture.

There is an option for the development of the proposed technical solution based on when the ratio of the components of the active mixture in the base, namely succinic acid and / or its salts, citric acid, salt (NaCl - marine,

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SUBSTITUTE SHEET (RULE 26) cooked, iodized, etc.), bentonite and vermiculite are in a ratio of 1: 1: 1: 1: 0.5

In addition, there is a further development of this version of the technical solution based on when to the ratio of the active mixture in the basis of succinic acid and / or its salts, citric acid, salt (NaCl - sea, cooked, iodized, etc.), bentonite and vermiculite in a ratio of 1: 1: 1: 1: 1: 0,5 added semi-finished product in a ratio of 1, 8: 1

The proposed base can be made by adding to the semi-finished product an active mixture of succinic acid and / or its salt, citric acid, salt (NaCl - sea, table, iodized, etc.), bentonite and vermiculite, taken in a ratio of 1: 1: 1: 1: 0.5) and in relation to the semi-finished product in the ratio of 1, 8: 1. The base itself is a feed additive and can be added to the diet of productive agricultural animals and birds. In addition, it can be stored separately and then be used, like a semi-finished product for the preparation of other feed additives. In this case, the best option is offered.

The third task is to obtain a new feed product, solved as follows. The feed product for productive farm animals and birds contains a set of active components according to the present invention, part of the components is the basis disclosed earlier, and as another part, the mycelium biomass is used, which are in the ratio:

Base - 1-99

Mycelium biomass - 1-99

It should be noted that the ratio of the basis to mycelium is calculated depending on the physiological needs, level

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SUBSTITUTE SHEET (RULE 26) productivity, feed table (diet), season, stress, and other factors.

The applicant conducted a patent search, which showed that the proposed technical solutions with their essential features are unknown - therefore, they can be considered new.

The proposed inventions have an inventive step, since for a specialist they do not logically follow the known level of technology for manufacturing feed additives by dividing the feed additive into components, such as a semi-finished product to obtain a base, a base with a semi-finished product, and a feed product based on a semi-finished product. However, it is known from the patent discussed earlier that multi-stage preparation of a feed additive is possible, but all stages are included in a single technological process and obtaining individual semi-finished products and the basis for obtaining a feed mixture is impossible and it is difficult to ensure a calibrated introduction of ingredients. In our case, the technology of preparation of the product and the special ratio of all ingredients of the composition can minimize the disadvantages of the prototype (patent N ° RU 2 425 587 C 1) and enhance the positive effect on the body of productive farm animals and birds. Since we simplify the process of preparing the feed mixture, breaking it into several parts, we increase the quality of the calibration of ingredients in the final product, while each of the components of our feed mixture can be used as a separate feed product.

Thus, the claimed invention allows to achieve the following technical results: to create new constituent components for the preparation of a feed additive, which have both independent functional value and are necessary and sufficient to obtain a feed additive having a clearly calibrated composition of components and therefore having a high beneficial effect on

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SUBSTITUTE SHEET (RULE 26) animals and birds. In addition, the manufacture of the claimed invention simplifies the technology of obtaining the final product.

DETAILED DESCRIPTION OF THE INVENTION

 The practical application of the proposed invention is disclosed in the following description with illustrative examples.

 1) Prefabricated to obtain the basis of a feed additive. For its preparation, the following components are used: lactic acid, polyvinylpyrrolidone, expanded vermiculite in a total ratio of 2: 0.04: 3.

 1.1) In a solution of lactic acid, for example, of the order of 80%, polyvinylpyrrolidone (liquid viscous mass) was added in a ratio of 1: 0.02 and stirred until a homogeneous liquid.

 1.2) Then they took three parts of expanded vermiculite and introduced into it by spraying, mixing, wetting or other known methods two parts of a previously prepared homogeneous liquid n 1.1.

 1.3) The resulting mixture remains dry and free-flowing, evenly calibrated, made as a separate component of the production technology of the feed additive base and stored in a separate container, and can also go directly to the preparation of the feed additive base.

 The resulting semi-finished product is used to prepare our base, but can also be used independently as a feed additive. For example: when 80 grams of cattle is added to the diet per head per day, the excretion of toxins and heavy metals from the animal’s body feed increases significantly, which improves the quality of the final product obtained.

 A known method of adding liquid fractions to a feed additive in the prototype (patent JY ° RU 2 425 587 C1), but the process is integral to the technology for the production of feed additives.

 A known method of using vermiculite with organic acids in the prototype (patent N ° RU 2 425 587 C1) and in others, in particular with milk

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SUBSTITUTE SHEET (RULE 26) acid for preservative feed. OBIA_sh .. storage. Our semi-finished product can also be used for preserving feed, but is more technologically advanced in production and is an integral part of the basis of a feed additive.

 2) The basis of the feed product:

 Composition: prefabricated to obtain the basis of the feed additive, succinic acid or its salts, citric acid, salt (NaCl - sea, table, iodized, etc.), aluminosilicates (bentonite and vermiculite).

 2.1) Semi-finished product is poured into the mixer (item 1) and succinic acid or its salts are added alternately, then aluminosilicates (bentonite and vermiculite), then citric acid and salt (NaCl - sea, cooked, iodized, etc.) in a ratio of 2 , 5: 1: 1, 5: 1: 1.

 2.2) As each constituent base is added, the mixer mixes the mass for 3-5 minutes.

 2.3) after adding all the components, the mixer mixes the mass for 10-20 minutes until a calibrated mass is obtained - the basis of our feed additive.

 2.4) The resulting mixture remains dry and loose, evenly calibrated. It is made as a separate component of the feed additive production technology and stored in a separate container, and can also be immediately used as a feed additive.

 The obtained base of the feed additive (p. 2) is used to prepare our feed additive, but can also be used independently as a feed additive. For example: when 80 grams of cattle are added to the diet per head per day, the excretion of toxins and heavy metals from the animal’s body from food is significantly increased; eatability of feed improves; liver function and carbohydrate metabolism in the body are stimulated, which improves the quality of the final product obtained and increases its quantity.

 Known feed product for productive farm animals and birds, the prototype (patent N ° RU 2 425 587 C 1), which in composition

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SUBSTITUTE SHEET (RULE 26) . resembles our basis (Clause 2) But it has a more complex production technology that increases the calibration error, and a different ratio of active ingredients.

 3) Preparation of the feed mixture:

 .Composition: the basis of the feed additive (item 2) and the biomass of the mycelium of the Aspergillus niger fungus (preferably according to TU 9291-001-00343237-2000).

 3.1) The base (item 2) is poured into the mixer or located there after cooking, the biomass of Aspergillus niger mycelium is added to it in a ratio of 1 -99: 1 -99 depending on the physiological needs of animals and birds.

 3.2) The base (item 2) with the biomass of the mycelium of the fungus Aspergillus niger is mixed in a mixer for 10-15 minutes.

 3.3) The resulting mixture remains dry and loose, evenly calibrated. It is a finished feed additive in the diets of farm animals and birds in this process. Packed in kraft bags 10.20.25 kg.

 The resulting feed additive is used to feed farm animals and birds with a basic diet to improve the overall health of the body and increase the qualitative and quantitative indicators of productivity.

 Known feed product for productive farm animals and birds, the prototype (patent N ° RU 2 425 587 C1), which in composition resembles our feed additive for productive farm animals and birds p.Z. But it has a different production technology, allowing a higher error in the calibration of the final product, other ingredients and their ratio. Also, due to a different ratio of biologically active substances and mycelium added to the biomass, our feed additive has a wider spectrum of beneficial effects on the body of animals and birds and their

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SUBSTITUTE SHEET (RULE 26) productivity and at the same time the technology of production of our feed additives allows us to increase the accuracy of calibration of the composition.

Example 1

 To identify the effect of our feed additive on the health of highly productive animals, studies were conducted in conjunction with the Belgorod company LLC APK-invest in farms in various regions of the Russian Federation (Leningrad, Yaroslavl, Belgorod).

Cows of different age groups participated in the studies and received our feed supplement of 35-85 grams per day with the main diet for a year.

 The feed additive had the following composition:

Basis - 50%

Mycelium biomass - 50%

 As a result of the studies, it was found that regardless of geography and zonal geochemical features, the use of our feed additive had a positive effect not only on the health of the livestock, but also naturally on the profitability of production. When assessing health, both clinical examination data and the results of the study of biological material, primarily blood and milk, were taken into account. It was found that the use of our feed additive in diets containing poor-quality feed (hay, silage, haylage, etc.), including with a high level of mycotoxins (excess of the MPC of some toxins: DON, zearalenone, T-2 toxin, aflotoxin, ochratoxin in 1, 5 ... 7, 0-20.0 times), helped to reduce signs of intoxication, preservation and, often, increase productivity. An improvement in blood counts and liver function was revealed. A decrease in somatic cells in milk and an increase in average daily milk yields, an increase in milk fat, an increase in protein concentration were detected in most of the animals examined.

Example 2

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SUBSTITUTE SHEET (RULE 26) To identify the effect of our feed additives on the health and productive indicators of highly productive animals, studies were conducted in the SEC "Name Ilyich", Starorussky district, Novgorod region.

 The object of research was dry cows of Ayrshire breed, which additionally included our feed additive in the diet. Further research continued on the same animals during lactation.

 The feed additive had the following composition:

Base - 70%

Mycelium biomass - 30%

 The experiment was carried out according to the scheme for 60 days on pregnant cows and 90 days on lactating cows in the pasture period. Blood was taken for biochemical and hematological studies in the morning before feeding at the end of the third month of lactation. Of the reproduction indicators, we took into account: the duration of the dry period, the service period, the insemination index, calf output and calf body weight at birth. Milk productivity was taken into account according to the control milk 3 times a month. The amount of fat and protein was determined using a certified Lactan 1-4 milk quality analyzer. The inclusion of dry and lactating cows in the diet of our feed additives contributed to: an increase in average daily milk yields for the first month of lactation by 4.61%, the second 3.41% and the third by 7.42%; an increase in milk fat and protein in milk; provided 100% yield of calves and an increase in their body mass at birth by 2.3%. At the same time, there was a decrease in the dry period time by 6.44% and a service period by 8, 1%, as well as an improvement in the insemination index of 14.71%).

Example 3

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SUBSTITUTE SHEET (RULE 26) To identify the effect of our feed additive on the health and productivity indicators of birds, we observed its use at the Sinyavinskaya poultry farm, Leningrad Region.

 The object of research was laying hens. A feed additive was introduced into the diet from the age of two months at the rate of 1 kilogram per ton of feed.

 The feed additive had the following composition:

Base - 90%

Mycelium biomass - 10%

 In the course of the studies, no adverse effect of the additive on the clinical condition of the bird was noted. At the same time, an increase in the average daily egg production was revealed, as well as an increase in the quality of the egg - size, weight, shell thickness.

 Thus, the technical result of the claimed inventions is achieved: the creation of new constituent components for the preparation of a feed additive having both independent functional value and being necessary and sufficient to obtain a feed additive having a clearly calibrated composition of components and therefore having a high beneficial effect on animals and birds . In addition, the manufacture of the claimed invention simplifies the technology of obtaining the final product.

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 SUBSTITUTE SHEET (RULE 26)

Claims

Claim  1. The semi-finished product, to obtain the basis of a feed additive containing expanded vermiculite, is characterized in that it contains, at least partially, an active component in the form of lactic acid with polyvinylpyrrolidone, which is either in the surface layer or inside the expanded vermiculite structure and the resulting mixture is in a dry state.  2. The semi-finished product for obtaining the basis of the feed additive according to claim 1 is characterized in that the active component, which is used as a lactic acid with polyvinylpyrrolidone in a total ratio of 2: 3 to vermiculite.  3. The base of the feed additive contains a semi-finished product and an active part, characterized in that the active part is formed from a mixture of succinic acid and / or its salts, citric acid, salt (NaCl - marine, cooked, iodized, etc.), bentonite and vermiculite and as a semi-finished product, expanded vermiculite is used, having an active component, which is used as a lactic acid with polyvinylpyrrolidone.  4. The feed product for productive farm animals and birds contains a set of active components, characterized in that the first part is the base - a mixture of succinic acid and / or its salts, citric acid, salt (NaCl - marine, cooked, iodized, etc. ), bentonite and vermiculite, and as a semifinished product, expanded vermiculite was used, having an active component, which was used lactic acid with polyvinylpyrrolidone, and mycelium biomass, which are in the ratio 1-99: 1 -99. eighteen  SUBSTITUTE SHEET (RULE 26)