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PT828742E - Diazepino-indoles inibidores de fosfodiesterases 4 - Google Patents

Diazepino-indoles inibidores de fosfodiesterases 4

Info

Publication number
PT828742E
PT828742E PT97919432T PT97919432T PT828742E PT 828742 E PT828742 E PT 828742E PT 97919432 T PT97919432 T PT 97919432T PT 97919432 T PT97919432 T PT 97919432T PT 828742 E PT828742 E PT 828742E
Authority
PT
Portugal
Prior art keywords
nr2r3
diazepino
indoles
phosphodythereside
inhibitors
Prior art date
Application number
PT97919432T
Other languages
English (en)
Inventor
Alain Calvet
Yves Pascal
Henry Jacobelli
Adrian Payne
Svein G Dahl
Original Assignee
Jouveinal Inst Rech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jouveinal Inst Rech filed Critical Jouveinal Inst Rech
Publication of PT828742E publication Critical patent/PT828742E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)
PT97919432T 1996-03-29 1997-03-27 Diazepino-indoles inibidores de fosfodiesterases 4 PT828742E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9604013A FR2746800B1 (fr) 1996-03-29 1996-03-29 Diazepino-indoles inhibiteurs de phosphodiesterases 4

Publications (1)

Publication Number Publication Date
PT828742E true PT828742E (pt) 2002-06-28

Family

ID=9490742

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97919432T PT828742E (pt) 1996-03-29 1997-03-27 Diazepino-indoles inibidores de fosfodiesterases 4

Country Status (18)

Country Link
US (1) US5972927A (pt)
EP (2) EP1132390A3 (pt)
JP (1) JP2001510441A (pt)
KR (1) KR19990022100A (pt)
CN (1) CN1066149C (pt)
AT (1) ATE211141T1 (pt)
AU (1) AU735631B2 (pt)
BR (1) BR9702180A (pt)
CA (1) CA2220407A1 (pt)
DE (1) DE69709272T2 (pt)
DK (1) DK0828742T3 (pt)
EA (2) EA001593B1 (pt)
ES (1) ES2168627T3 (pt)
FR (1) FR2746800B1 (pt)
IL (1) IL122291A (pt)
NZ (1) NZ329532A (pt)
PT (1) PT828742E (pt)
WO (1) WO1997036905A1 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200909479T2 (tr) 1999-08-21 2012-02-21 Nycomed Gmbh Sinerjistik kombinasyon.
MXPA02008627A (es) * 2000-03-03 2003-02-24 Pfizer Prod Inc Derivados de eteres de pirazol como agentes antiinflamatorios/analgesicos.
EP1161950A1 (en) * 2000-06-09 2001-12-12 Warner-Lambert Company Use of diazepinoindoles for the treatment of chronic obstructive pulmonary disease
EP1161949A1 (en) * 2000-06-09 2001-12-12 Warner-Lambert Company Use od diazepinoindoles for the treatment of chronic obstructive pulmonary disease
US6953774B2 (en) * 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation
EP1199074A1 (en) * 2000-09-15 2002-04-24 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production
EP1188438A1 (en) * 2000-09-15 2002-03-20 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production
MY140561A (en) * 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
KR101179012B1 (ko) 2003-03-10 2012-09-03 니코메드 게엠베하 로플루미라스트 신규한 제조 방법
MXPA05010373A (es) 2003-04-01 2005-12-05 Applied Research Systems Inhibidores de fosfodiesterasas en infertilidad.
WO2005021488A1 (ja) 2003-08-29 2005-03-10 Mitsui Chemicals, Inc. 農園芸用殺虫剤及びその使用方法
EP1861074B1 (en) 2005-03-16 2013-04-24 Takeda GmbH Taste masked dosage form containing roflumilast
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
CA2625153A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
KR20100014565A (ko) * 2007-04-11 2010-02-10 알콘 리서치, 리미티드 알레르기성 비염 및 알레르기성 결막염을 치료하기 위한 ｔｎｆａ의 억제제 및 항히스타민의 용도
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
MX2012003693A (es) * 2009-10-01 2012-04-19 Alcon Res Ltd Composiciones de olopatadine y usos de las mismas.
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
CN117757730B (zh) * 2023-12-26 2024-06-07 浙江普罗亭健康科技有限公司 一种人心脏组织消化专用试剂盒及消化方法、检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840947A (en) * 1986-10-14 1989-06-20 Hoechst-Roussel Pharmaceuticals, Inc. Antiinflammatory and analgesic piperidin-4-yl-tetracyclic benzodiazepines and use thereas
FR2652352A1 (fr) * 1989-09-28 1991-03-29 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique.
FR2725719B1 (fr) * 1994-10-14 1996-12-06 Jouveinal Inst Rech Diazepino-indoles inhibiteurs de phosphodiesterases iv

Also Published As

Publication number Publication date
CA2220407A1 (fr) 1997-10-09
WO1997036905A1 (fr) 1997-10-09
EP1132390A2 (fr) 2001-09-12
EP1132390A3 (fr) 2001-10-10
JP2001510441A (ja) 2001-07-31
FR2746800A1 (fr) 1997-10-03
CN1066149C (zh) 2001-05-23
US5972927A (en) 1999-10-26
EA199900624A1 (ru) 2000-06-26
EA001593B1 (ru) 2001-06-25
DE69709272T2 (de) 2002-08-08
EP0828742A1 (fr) 1998-03-18
EA199700346A1 (ru) 1998-10-29
EA002189B1 (ru) 2002-02-28
AU2391397A (en) 1997-10-22
IL122291A0 (en) 1998-04-05
IL122291A (en) 2000-12-06
CN1189832A (zh) 1998-08-05
DK0828742T3 (da) 2002-04-15
FR2746800B1 (fr) 1998-06-05
BR9702180A (pt) 1999-12-28
NZ329532A (en) 2000-03-27
DE69709272D1 (de) 2002-01-31
HK1018051A1 (en) 1999-12-10
AU735631B2 (en) 2001-07-12
ES2168627T3 (es) 2002-06-16
EP0828742B1 (fr) 2001-12-19
ATE211141T1 (de) 2002-01-15
KR19990022100A (ko) 1999-03-25

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