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EA199700346A1 - Диазепино-индоловые ингибиторы фосфодиэстераз iv - Google Patents

Диазепино-индоловые ингибиторы фосфодиэстераз iv

Info

Publication number
EA199700346A1
EA199700346A1 EA199700346A EA199700346A EA199700346A1 EA 199700346 A1 EA199700346 A1 EA 199700346A1 EA 199700346 A EA199700346 A EA 199700346A EA 199700346 A EA199700346 A EA 199700346A EA 199700346 A1 EA199700346 A1 EA 199700346A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nr2r3
pcooh
ch2och2
nhr2
diazepine
Prior art date
Application number
EA199700346A
Other languages
English (en)
Other versions
EA001593B1 (ru
Inventor
Ив Паскаль
Анри Жакобелли
Ален Кальве
Адриан Пен
Свен Ж. Даль
Original Assignee
Жувеналь
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Жувеналь filed Critical Жувеналь
Publication of EA199700346A1 publication Critical patent/EA199700346A1/ru
Publication of EA001593B1 publication Critical patent/EA001593B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)

Abstract

Предложены диазепиноиндолы формулы (I), где А представляет собой алкил или гетероарил, имеющий от одного до трех заместителей, и В представляет собой -ORили -NRRгруппу, где R, Rи Rпредставляют собой, в частности, водород; их рацемические формы, этантиомеры и фармацевтически приемлемые соли, являющиеся ингибиторами фосфодиэстераз IV.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700346A 1996-03-29 1997-03-27 Диазепино-индоловые ингибиторы фосфодиэстераз iv EA001593B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9604013A FR2746800B1 (fr) 1996-03-29 1996-03-29 Diazepino-indoles inhibiteurs de phosphodiesterases 4
PCT/FR1997/000557 WO1997036905A1 (fr) 1996-03-29 1997-03-27 Diazepino-indoles inhibiteurs de phosphodiesterases 4

Publications (2)

Publication Number Publication Date
EA199700346A1 true EA199700346A1 (ru) 1998-10-29
EA001593B1 EA001593B1 (ru) 2001-06-25

Family

ID=9490742

Family Applications (2)

Application Number Title Priority Date Filing Date
EA199900624A EA002189B1 (ru) 1996-03-29 1997-03-27 Применение диазепиноиндолов для приготовления лекарственного продукта, ингибирующего фосфодиэстеразу 4
EA199700346A EA001593B1 (ru) 1996-03-29 1997-03-27 Диазепино-индоловые ингибиторы фосфодиэстераз iv

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA199900624A EA002189B1 (ru) 1996-03-29 1997-03-27 Применение диазепиноиндолов для приготовления лекарственного продукта, ингибирующего фосфодиэстеразу 4

Country Status (18)

Country Link
US (1) US5972927A (ru)
EP (2) EP1132390A3 (ru)
JP (1) JP2001510441A (ru)
KR (1) KR19990022100A (ru)
CN (1) CN1066149C (ru)
AT (1) ATE211141T1 (ru)
AU (1) AU735631B2 (ru)
BR (1) BR9702180A (ru)
CA (1) CA2220407A1 (ru)
DE (1) DE69709272T2 (ru)
DK (1) DK0828742T3 (ru)
EA (2) EA002189B1 (ru)
ES (1) ES2168627T3 (ru)
FR (1) FR2746800B1 (ru)
IL (1) IL122291A (ru)
NZ (1) NZ329532A (ru)
PT (1) PT828742E (ru)
WO (1) WO1997036905A1 (ru)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU229439B1 (hu) 1999-08-21 2013-12-30 Takeda Gmbh Roflumilast és salmeterol szinergetikus kombinációja
AU3217501A (en) * 2000-03-03 2001-09-12 Pfizer Prod Inc Pyrazole ether derivatives as anti-inflammatory/analgesic agents
EP1161949A1 (en) 2000-06-09 2001-12-12 Warner-Lambert Company Use od diazepinoindoles for the treatment of chronic obstructive pulmonary disease
EP1161950A1 (en) * 2000-06-09 2001-12-12 Warner-Lambert Company Use of diazepinoindoles for the treatment of chronic obstructive pulmonary disease
US6953774B2 (en) * 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation
EP1199074A1 (en) * 2000-09-15 2002-04-24 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production
EP1188438A1 (en) * 2000-09-15 2002-03-20 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
DE602004023921D1 (de) 2003-03-10 2009-12-17 Nycomed Gmbh Neues verfahren zur herstellung vonroflumilast
WO2004087211A2 (en) 2003-04-01 2004-10-14 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
CN102976984B (zh) 2003-08-29 2015-04-08 三井化学株式会社 农园艺用杀虫剂的制备中间体
US8663694B2 (en) 2005-03-16 2014-03-04 Takeda Gmbh Taste masked dosage form containing roflumilast
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
AU2006282896A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US7998971B2 (en) 2006-09-08 2011-08-16 Braincells Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
CN101641094A (zh) * 2007-04-11 2010-02-03 爱尔康研究有限公司 TNFα抑制剂联合抗组胺药治疗变应性鼻炎和变应性结膜炎的用途
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
BR112012007091A2 (pt) * 2009-10-01 2016-04-19 Alcon Res Ltd composições de olopatadina e seus usos
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
CN117757730B (zh) * 2023-12-26 2024-06-07 浙江普罗亭健康科技有限公司 一种人心脏组织消化专用试剂盒及消化方法、检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840947A (en) * 1986-10-14 1989-06-20 Hoechst-Roussel Pharmaceuticals, Inc. Antiinflammatory and analgesic piperidin-4-yl-tetracyclic benzodiazepines and use thereas
FR2652352A1 (fr) * 1989-09-28 1991-03-29 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique.
FR2725719B1 (fr) * 1994-10-14 1996-12-06 Jouveinal Inst Rech Diazepino-indoles inhibiteurs de phosphodiesterases iv

Also Published As

Publication number Publication date
NZ329532A (en) 2000-03-27
EA001593B1 (ru) 2001-06-25
EP1132390A3 (fr) 2001-10-10
PT828742E (pt) 2002-06-28
EA199900624A1 (ru) 2000-06-26
AU735631B2 (en) 2001-07-12
FR2746800B1 (fr) 1998-06-05
IL122291A0 (en) 1998-04-05
JP2001510441A (ja) 2001-07-31
CA2220407A1 (fr) 1997-10-09
ATE211141T1 (de) 2002-01-15
BR9702180A (pt) 1999-12-28
EP0828742A1 (fr) 1998-03-18
KR19990022100A (ko) 1999-03-25
DE69709272T2 (de) 2002-08-08
EP1132390A2 (fr) 2001-09-12
WO1997036905A1 (fr) 1997-10-09
AU2391397A (en) 1997-10-22
EP0828742B1 (fr) 2001-12-19
DK0828742T3 (da) 2002-04-15
IL122291A (en) 2000-12-06
EA002189B1 (ru) 2002-02-28
CN1189832A (zh) 1998-08-05
DE69709272D1 (de) 2002-01-31
HK1018051A1 (en) 1999-12-10
US5972927A (en) 1999-10-26
FR2746800A1 (fr) 1997-10-03
ES2168627T3 (es) 2002-06-16
CN1066149C (zh) 2001-05-23

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU