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ES2168627T3 - Diazepino-indoles inhibidores de fosfodiesterasas 4. - Google Patents

Diazepino-indoles inhibidores de fosfodiesterasas 4.

Info

Publication number
ES2168627T3
ES2168627T3 ES97919432T ES97919432T ES2168627T3 ES 2168627 T3 ES2168627 T3 ES 2168627T3 ES 97919432 T ES97919432 T ES 97919432T ES 97919432 T ES97919432 T ES 97919432T ES 2168627 T3 ES2168627 T3 ES 2168627T3
Authority
ES
Spain
Prior art keywords
nr2r3
diazepino
indoles
pcooh
ch2och2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97919432T
Other languages
English (en)
Inventor
Yves Pascal
Henry Jacobelli
Alain Calvet
Adrian Payne
Svein G Dahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut de Recherche Jouveinal
Original Assignee
Institut de Recherche Jouveinal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut de Recherche Jouveinal filed Critical Institut de Recherche Jouveinal
Application granted granted Critical
Publication of ES2168627T3 publication Critical patent/ES2168627T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)

Abstract

DIACEPINOINDOLES DE FORMULA (I) EN LA QUE A REPRESENTA UN GRUPO ARIL O HETEROARIL MONO A TRISUSTITUIDO, B REPRESENTA UN GRUPO OR1O Y R3 SON PRINCIPALMENTE HIDROGENOS, SUS FORMAS RACEMICAS, SUS ENANTIOMEROS Y SUS SALES FARMACEUTICAMENTE ACEPTABLES; QUE SON INHIBIDORES DE FOSFODIESTERASAS IV.
ES97919432T 1996-03-29 1997-03-27 Diazepino-indoles inhibidores de fosfodiesterasas 4. Expired - Lifetime ES2168627T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9604013A FR2746800B1 (fr) 1996-03-29 1996-03-29 Diazepino-indoles inhibiteurs de phosphodiesterases 4

Publications (1)

Publication Number Publication Date
ES2168627T3 true ES2168627T3 (es) 2002-06-16

Family

ID=9490742

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97919432T Expired - Lifetime ES2168627T3 (es) 1996-03-29 1997-03-27 Diazepino-indoles inhibidores de fosfodiesterasas 4.

Country Status (18)

Country Link
US (1) US5972927A (es)
EP (2) EP1132390A3 (es)
JP (1) JP2001510441A (es)
KR (1) KR19990022100A (es)
CN (1) CN1066149C (es)
AT (1) ATE211141T1 (es)
AU (1) AU735631B2 (es)
BR (1) BR9702180A (es)
CA (1) CA2220407A1 (es)
DE (1) DE69709272T2 (es)
DK (1) DK0828742T3 (es)
EA (2) EA002189B1 (es)
ES (1) ES2168627T3 (es)
FR (1) FR2746800B1 (es)
IL (1) IL122291A (es)
NZ (1) NZ329532A (es)
PT (1) PT828742E (es)
WO (1) WO1997036905A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ302882B6 (cs) 1999-08-21 2012-01-04 Nycomed Gmbh Farmaceutický prostredek
BR0108908A (pt) 2000-03-03 2002-12-24 Pfizer Prod Inc Derivados de éteres de pirazol como agentes antiinflamatórios/analgésicos
EP1161950A1 (en) * 2000-06-09 2001-12-12 Warner-Lambert Company Use of diazepinoindoles for the treatment of chronic obstructive pulmonary disease
EP1161949A1 (en) 2000-06-09 2001-12-12 Warner-Lambert Company Use od diazepinoindoles for the treatment of chronic obstructive pulmonary disease
US6953774B2 (en) * 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation
EP1199074A1 (en) * 2000-09-15 2002-04-24 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production
EP1188438A1 (en) * 2000-09-15 2002-03-20 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
ES2335498T3 (es) 2003-03-10 2010-03-29 Nycomed Gmbh Nuevo proceso para la preparacion de reflumilast.
BRPI0409229A (pt) 2003-04-01 2006-03-28 Applied Research Systems inibidores das fosfodiesterases na infertilidade
KR100878737B1 (ko) 2003-08-29 2009-01-14 미쓰이 가가쿠 가부시키가이샤 농업용 또는 원예용 살충제 및 그의 이용 방법
EP2258350B1 (en) 2005-03-16 2014-12-24 Takeda GmbH Taste masked dosage form containing roflumilast
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
JP2010502722A (ja) 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20080254029A1 (en) * 2007-04-11 2008-10-16 Alcon Research, Ltd. Use of an Inhibitor of TNFa Plus an Antihistamine to Treat Allergic Rhinitis and Allergic Conjunctivitis
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CN102548536A (zh) * 2009-10-01 2012-07-04 爱尔康研究有限公司 奥洛他定组合物及其用途
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
CN117757730B (zh) * 2023-12-26 2024-06-07 浙江普罗亭健康科技有限公司 一种人心脏组织消化专用试剂盒及消化方法、检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840947A (en) * 1986-10-14 1989-06-20 Hoechst-Roussel Pharmaceuticals, Inc. Antiinflammatory and analgesic piperidin-4-yl-tetracyclic benzodiazepines and use thereas
FR2652352A1 (fr) * 1989-09-28 1991-03-29 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique.
FR2725719B1 (fr) * 1994-10-14 1996-12-06 Jouveinal Inst Rech Diazepino-indoles inhibiteurs de phosphodiesterases iv

Also Published As

Publication number Publication date
DE69709272D1 (de) 2002-01-31
CN1066149C (zh) 2001-05-23
HK1018051A1 (en) 1999-12-10
ATE211141T1 (de) 2002-01-15
BR9702180A (pt) 1999-12-28
CA2220407A1 (fr) 1997-10-09
FR2746800B1 (fr) 1998-06-05
EP0828742A1 (fr) 1998-03-18
AU735631B2 (en) 2001-07-12
EP0828742B1 (fr) 2001-12-19
NZ329532A (en) 2000-03-27
EP1132390A2 (fr) 2001-09-12
WO1997036905A1 (fr) 1997-10-09
IL122291A (en) 2000-12-06
JP2001510441A (ja) 2001-07-31
DK0828742T3 (da) 2002-04-15
EA199700346A1 (ru) 1998-10-29
US5972927A (en) 1999-10-26
EA199900624A1 (ru) 2000-06-26
EA001593B1 (ru) 2001-06-25
EP1132390A3 (fr) 2001-10-10
DE69709272T2 (de) 2002-08-08
CN1189832A (zh) 1998-08-05
EA002189B1 (ru) 2002-02-28
IL122291A0 (en) 1998-04-05
FR2746800A1 (fr) 1997-10-03
KR19990022100A (ko) 1999-03-25
PT828742E (pt) 2002-06-28
AU2391397A (en) 1997-10-22

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