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GB2001627A - alpha -Vinyl and ethynyl amino acid derivatives - Google Patents

alpha -Vinyl and ethynyl amino acid derivatives

Info

Publication number
GB2001627A
GB2001627A GB7828006A GB7828006A GB2001627A GB 2001627 A GB2001627 A GB 2001627A GB 7828006 A GB7828006 A GB 7828006A GB 7828006 A GB7828006 A GB 7828006A GB 2001627 A GB2001627 A GB 2001627A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
carbon atoms
alpha
vinyl
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7828006A
Other versions
GB2001627B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merrell Toraude et Cie
Original Assignee
Merrell Toraude et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/812,113 external-priority patent/US4183858A/en
Priority claimed from US05/812,052 external-priority patent/US4180509A/en
Application filed by Merrell Toraude et Cie filed Critical Merrell Toraude et Cie
Publication of GB2001627A publication Critical patent/GB2001627A/en
Application granted granted Critical
Publication of GB2001627B publication Critical patent/GB2001627B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The compounds have the formula <IMAGE> wherein Q is -CH = CH2 or -C IDENTICAL CH; R1 is hydroxy, alkoxy of 1 to 8 carbon atoms, -NYY' wherein Y and Y' are the same or different and are each hydrogen or alkyl of 1 to 4 carbon atoms, or -NHCHR8-COOH wherein R8 is hydrogen, alkyl of 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R2 is hydrogen, (C1-4alkyl)carbonyl, (C1-4alkoxy)carbonyl or -CO-CHNH2-R9 wherein R9 is hydrogen, alkyl of 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R3 is hydrogen or methyl; and R4, R5, R6 and R7 are certain combinations of hydrogen, methyl, halogen, trifluoromethyl and OR10 wherein R10 is hydrogen, alkyl of 1 to 8 carbon atoms, (C1-4alkyl)carbonyl, benzoyl or phenyl(C1-6alkyl)carbonyl.
GB7828006A 1977-07-01 1978-06-27 Alpha-vinyl and acetylene amino acid derivatives Expired GB2001627B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/812,113 US4183858A (en) 1977-07-01 1977-07-01 α-Vinyl tryptophanes
US05/812,052 US4180509A (en) 1977-07-01 1977-07-01 α-Ethynyl tryptophanes

Publications (2)

Publication Number Publication Date
GB2001627A true GB2001627A (en) 1979-02-07
GB2001627B GB2001627B (en) 1982-04-28

Family

ID=27123558

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7828006A Expired GB2001627B (en) 1977-07-01 1978-06-27 Alpha-vinyl and acetylene amino acid derivatives

Country Status (2)

Country Link
GB (1) GB2001627B (en)
HK (1) HK76886A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007615A3 (en) * 1978-07-24 1980-05-28 Merck & Co. Inc. Process for preparing amino acids and esters, and intermediates therefor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007615A3 (en) * 1978-07-24 1980-05-28 Merck & Co. Inc. Process for preparing amino acids and esters, and intermediates therefor

Also Published As

Publication number Publication date
GB2001627B (en) 1982-04-28
HK76886A (en) 1986-10-17

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19940627