PT75395A - Process for preparation of new benzapin-2-onas from pharmaceutical preparations containing these compounds - Google Patents

Process for preparation of new benzapin-2-onas from pharmaceutical preparations containing these compounds

Info

Publication number: PT75395A
Authority: PT; Portugal
Prior art keywords: benzapin; onas; compounds; preparation; new
Prior art date: 1981-08-11

Application number

PT75395A

Other languages

Portuguese (pt)

Other versions

PT75395B (en

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-08-11

Filing date

1982-08-09

Publication date

1982-09-01

1982-08-09 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1982-09-01 Publication of PT75395A publication Critical patent/PT75395A/en

1985-11-15 Publication of PT75395B publication Critical patent/PT75395B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

PT75395A 1981-08-11 1982-08-09 Process for preparation of new benzapin-2-onas from pharmaceutical preparations containing these compounds PT75395B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US29190781A	1981-08-11	1981-08-11
US31986381A	1981-11-09	1981-11-09

Publications (2)

Publication Number	Publication Date
PT75395A true PT75395A (en)	1982-09-01
PT75395B PT75395B (en)	1985-11-15

Family

ID=26967047

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT75395A PT75395B (en)	1981-08-11	1982-08-09	Process for preparation of new benzapin-2-onas from pharmaceutical preparations containing these compounds

Country Status (22)

Country	Link
EP (1)	EP0072352B1 (en)
KR (3)	KR890003425B1 (en)
AR (3)	AR240806A1 (en)
AT (1)	ATE18397T1 (en)
AU (1)	AU561395B2 (en)
CA (1)	CA1196636A (en)
CY (1)	CY1403A (en)
DD (1)	DD202546A5 (en)
DE (1)	DE3269625D1 (en)
DK (1)	DK157881C (en)
ES (6)	ES8502974A1 (en)
FI (1)	FI76074C (en)
GB (1)	GB2103614B (en)
GR (1)	GR77256B (en)
HK (1)	HK93387A (en)
HU (1)	HU189628B (en)
IE (1)	IE53668B1 (en)
IL (1)	IL66501A (en)
NL (1)	NL930112I2 (en)
NO (1)	NO161558C (en)
NZ (1)	NZ201555A (en)
PT (1)	PT75395B (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3242599A1 (en) *	1982-11-18	1984-05-24	Dr. Karl Thomae Gmbh, 7950 Biberach	NEW BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
US4473575A (en) *	1982-07-19	1984-09-25	Ciba-Geigy Corporation	3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
EP0107095B1 (en) *	1982-09-30	1987-09-09	Merck & Co. Inc.	1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
US4575503A (en) *	1983-02-10	1986-03-11	Ciba-Geigy Corporation	3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4564612A (en) *	1983-04-22	1986-01-14	Takeda Chemical Industries, Ltd.	Condensed, seven-membered ring compounds and their use
US4539150A (en) *	1983-06-29	1985-09-03	Mitsui Toatsu Chemicals, Inc.	Benzothiazepine derivatives and their methods of preparation
JPS608284A (en) *	1983-06-29	1985-01-17	Mitsui Toatsu Chem Inc	Benzothiazepine derivative and its preparation
US4638000A (en) *	1983-08-12	1987-01-20	Takeda Chemical Industries, Ltd.	Condensed seven-membered ring compounds, their production and use
AU570710B2 (en) *	1983-08-12	1988-03-24	Takeda Chemical Industries Ltd.	4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzoxazepine derivatives
IL72523A (en) *	1983-08-12	1988-06-30	Takeda Chemical Industries Ltd	3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them
EP0166357A3 (en) *	1984-06-26	1988-10-26	Merck & Co. Inc.	Benzofused lactams and pharmaceutical compositions containing them
DE3586445T2 (en) *	1984-06-26	1993-01-14	Merck & Co Inc	CONDENSED BENZO LACTAM COMPOUNDS AND THEIR PHARMACEUTICAL COMPOSITIONS.
CA1266647A (en) *	1984-06-26	1990-03-13	William H. Parsons	Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists
US4785089A (en) *	1985-06-13	1988-11-15	Ciba-Geigy Corporation	Novel sulfonic acid esters and their preparation
DE3704661A1 (en) *	1987-02-14	1988-08-25	Hoechst Ag	FELECTED AZEPINONE AND AZOCINONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR CONTAINERS AND THEIR USE, AND INTERMEDIATE PRODUCTS IN THEIR PRODUCTION
EP0322779A3 (en) *	1987-12-29	1991-05-08	Yoshitomi Pharmaceutical Industries, Ltd.	Benzolactam compounds and pharmaceutical uses thereof
TW197945B (en) *	1990-11-27	1993-01-11	Hoechst Ag
GB9100028D0 (en) *	1991-01-02	1991-02-20	Ici Plc	Compounds
GB9212308D0 (en) *	1992-06-10	1992-07-22	Ici Plc	Therapeutic compositions
US5504080A (en) *	1992-10-28	1996-04-02	Bristol-Myers Squibb Co.	Benzo-fused lactams
US5610153A (en) *	1992-12-11	1997-03-11	Ciba-Geigy Corporation	Benzazepinone derivatives
GB9310075D0 (en) *	1993-05-17	1993-06-30	Fujisawa Pharmaceutical Co	New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
GB9311948D0 (en) *	1993-06-10	1993-07-28	Zeneca Ltd	Substituted nitrogen heterocycles
US5801168A (en) *	1994-06-09	1998-09-01	Zeneca Limited	Substituted nitrogen heterocycles
US5597922A (en) *	1994-07-29	1997-01-28	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon	Glycine receptor antagonist pharmacophore
MXPA02005070A (en) *	1999-11-18	2003-09-25	Antexpharma Inc	Substituted 1 benzazepines and derivatives thereof.
US7053211B2 (en)	2000-12-27	2006-05-30	Merck Patent Gmbh	Process for the preparation of α-aminosubstituted carboxylic acid amides
BR0208513A (en)	2001-03-27	2004-10-26	Ranbaxy Lab Ltd	Benazepril preparation process
US6984645B2 (en)	2001-11-16	2006-01-10	Bristol-Myers Squibb Company	Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
WO2004013105A1 (en) *	2002-07-26	2004-02-12	Ciba Specialty Chemicals Holging Inc.	Crystalline polymorphic and amorphous forms of benazepril hydrochloride
KR100710548B1 (en) *	2002-12-26	2007-04-24	에스케이 주식회사	(s) -3-amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid and a method for producing an ester compound thereof
US7459474B2 (en)	2003-06-11	2008-12-02	Bristol-Myers Squibb Company	Modulators of the glucocorticoid receptor and method
US8080579B2 (en)	2005-10-03	2011-12-20	The Regents Of The University Of Michigan	Compositions and methods for treatment of inflammatory bowel disease
US7592461B2 (en)	2005-12-21	2009-09-22	Bristol-Myers Squibb Company	Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
EP2099767A1 (en)	2006-11-01	2009-09-16	Brystol-Myers Squibb Company	Modulators of glucocorticoid receptor, ap-1, and/or nf- b activity and use thereof
US7968577B2 (en)	2006-11-01	2011-06-28	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US20100120694A1 (en)	2008-06-04	2010-05-13	Synergy Pharmaceuticals, Inc.	Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
JP5546451B2 (en)	2007-06-04	2014-07-09	シナジーファーマシューティカルズインコーポレイテッド	Agonyl cyclase agonists useful in the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7828840B2 (en)	2007-11-15	2010-11-09	Med Institute, Inc.	Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
EP2334671A1 (en)	2008-06-24	2011-06-22	Bristol-Myers Squibb Company	Cyclopentathiophene modulators of the glucocorticoid receptor, ap-1, and/or nf-kappa b activity and use thereof
EP3241839B1 (en)	2008-07-16	2019-09-04	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
HK1220696A1 (en)	2013-03-15	2017-05-12	Bausch Health Ireland Limited	Agonists of guanylate cyclase and their uses
AU2014235209B2 (en)	2013-03-15	2018-06-14	Bausch Health Ireland Limited	Guanylate cyclase receptor agonists combined with other drugs
EP4424697A3 (en)	2013-06-05	2024-12-25	Bausch Health Ireland Limited	Ultra-pure agonists of guanylate cyclase c, method of making and using same
WO2015027021A1 (en)	2013-08-22	2015-02-26	Bristol-Myers Squibb Company	Imide and acylurea derivatives as modulators of the glucocorticoid receptor
CN113292495B (en) *	2021-06-18	2022-09-13	迪嘉药业集团有限公司	Synthesis method of (S) -amino compound

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3395150A (en) *	1965-02-26	1968-07-30	Squibb & Sons Inc	Benzothiazepine carboxamides and derivatives thereof
GB1305278A (en) *	1970-03-12	1973-01-31

1982
- 1982-08-05 EP EP82810329A patent/EP0072352B1/en not_active Expired
- 1982-08-05 CY CY140382A patent/CY1403A/en unknown
- 1982-08-05 AT AT82810329T patent/ATE18397T1/en active
- 1982-08-05 DE DE8282810329T patent/DE3269625D1/en not_active Expired
- 1982-08-05 GB GB08222564A patent/GB2103614B/en not_active Expired
- 1982-08-09 ES ES514856A patent/ES8502974A1/en not_active Expired
- 1982-08-09 GR GR68996A patent/GR77256B/el unknown
- 1982-08-09 IL IL66501A patent/IL66501A/en not_active IP Right Cessation
- 1982-08-09 PT PT75395A patent/PT75395B/en unknown
- 1982-08-09 FI FI822770A patent/FI76074C/en not_active IP Right Cessation
- 1982-08-09 CA CA000409019A patent/CA1196636A/en not_active Expired
- 1982-08-10 NO NO822722A patent/NO161558C/en not_active IP Right Cessation
- 1982-08-10 AU AU87014/82A patent/AU561395B2/en not_active Expired
- 1982-08-10 HU HU822585A patent/HU189628B/en unknown
- 1982-08-10 NZ NZ201555A patent/NZ201555A/en unknown
- 1982-08-10 DD DD82242400A patent/DD202546A5/en not_active IP Right Cessation
- 1982-08-10 KR KR8203588A patent/KR890003425B1/en not_active Expired
- 1982-08-10 DK DK358682A patent/DK157881C/en active
- 1982-08-10 IE IE1929/82A patent/IE53668B1/en not_active IP Right Cessation
- 1982-08-11 AR AR290295A patent/AR240806A1/en active
1983
- 1983-10-28 ES ES526888A patent/ES526888A0/en active Granted
- 1983-10-28 ES ES526886A patent/ES8601142A1/en not_active Expired
- 1983-10-28 ES ES526889A patent/ES8604523A1/en not_active Expired
- 1983-10-28 ES ES526887A patent/ES8606285A1/en not_active Expired
1984
- 1984-02-28 AR AR84295865A patent/AR241222A1/en active
- 1984-02-28 AR AR295866A patent/AR240807A1/en active
- 1984-03-15 ES ES530658A patent/ES8602682A1/en not_active Expired
1987
- 1987-12-10 HK HK933/87A patent/HK93387A/en not_active IP Right Cessation
1989
- 1989-05-13 KR KR1019890006487A patent/KR900001191B1/en not_active Expired
- 1989-05-13 KR KR8906486A patent/KR900001190B1/en not_active Expired
1993
- 1993-06-29 NL NL930112C patent/NL930112I2/en unknown

Also Published As

Publication number	Publication date
AU561395B2 (en)	1987-05-07
IE821929L (en)	1983-02-11
ES8504728A1 (en)	1985-04-16
EP0072352B1 (en)	1986-03-05
ES8604523A1 (en)	1986-02-01
ES530658A0 (en)	1985-12-01
AR240806A2 (en)	1991-02-28
NL930112I1 (en)	1993-10-18
IE53668B1 (en)	1989-01-04
IL66501A (en)	1987-10-20
CA1196636A (en)	1985-11-12
AU8701482A (en)	1983-05-12
GB2103614B (en)	1984-11-21
ATE18397T1 (en)	1986-03-15
EP0072352A1 (en)	1983-02-16
FI76074C (en)	1988-09-09
ES514856A0 (en)	1985-02-01
KR900001190B1 (en)	1990-02-28
IL66501A0 (en)	1982-12-31
ES8602682A1 (en)	1985-12-01
DK157881C (en)	1990-07-23
HK93387A (en)	1987-12-18
AR241222A1 (en)	1992-02-28
FI76074B (en)	1988-05-31
ES8606285A1 (en)	1986-04-16
DK358682A (en)	1983-02-12
NL930112I2 (en)	1996-11-01
DD202546A5 (en)	1983-09-21
FI822770L (en)	1983-02-12
FI822770A0 (en)	1982-08-09
GB2103614A (en)	1983-02-23
KR840001139A (en)	1984-03-28
NO822722L (en)	1983-02-14
CY1403A (en)	1987-12-18
ES526889A0 (en)	1986-02-01
ES526887A0 (en)	1986-04-16
ES8502974A1 (en)	1985-02-01
AR240806A1 (en)	1991-02-28
ES526886A0 (en)	1985-11-01
KR900001191B1 (en)	1990-02-28
DE3269625D1 (en)	1986-04-10
DK157881B (en)	1990-02-26
KR890003425B1 (en)	1989-09-20
HU189628B (en)	1986-07-28
AR240807A1 (en)	1991-02-28
NO161558B (en)	1989-05-22
NZ201555A (en)	1986-06-11
ES526888A0 (en)	1985-04-16
GR77256B (en)	1984-09-11
AR240807A2 (en)	1991-02-28
NO161558C (en)	1989-08-30
PT75395B (en)	1985-11-15
ES8601142A1 (en)	1985-11-01

Publication	Publication Date	Title
PT75395B (en)	1985-11-15	Process for preparation of new benzapin-2-onas from pharmaceutical preparations containing these compounds
HUT40579A (en)	1987-01-28	Process for preparing new pharmaceutical preparations of local application
IL68267A (en)	1987-03-31	Derivatives of cycloalka(c),pyrrolcarboxylic acids,process for their preparation,and pharmaceutical compositions containing them
DE3279470D1 (en)	1989-04-06	New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds
PT73916B (en)	1983-11-30	Process for preparing 1-carboxy-aza-alkanoyl-indoline-2- carboxylic acids pharmaceutical preparations containing these compounds and their therapeutic application
EG16223A (en)	1990-12-30	Process for the preparation of novel pharmaceutical compounds
MY8700806A (en)	1987-12-31	Quinoline-3-carboxylic acid derivatives process for their manufacture pharmaceutical preparations containing them & their use
PT75042B (en)	1984-10-09	Process for the preparation of apovincaminates and pharmaceutical compositions containing them
GB2073747B (en)	1983-09-07	Triazolopyridinone compounds process for the preparation thereof and pharmaceutical preparations containing them
PT75265A (en)	1982-08-01	Process for the preparation of diazabicyclicononanes substituted and pharmaceutical composition containing them
PT75084A (en)	1982-07-01	Process for the preparation of new imidazo (1,5-a)pyridines and pharmaceutical preparations containing these compounds
HUT34018A (en)	1985-01-28	Process for preparing 2-piperazinyl-quilazoline derivatives and pharmaceutical compositions containing compounds
PT76426A (en)	1983-04-01	Process for preparing novel 2-beta-d-ribofuranosylselenazole-4-carboxamide compounds and of pharmaceutical compositions containing the same
PT77657A (en)	1983-12-01	Processes for preparing novel heterocyclyl compounds and pharmaceutical preparations containing these compounds
PT71498A (en)	1980-08-01	Process for preparing aminothiadiazolyl compounds and pharmaceutical preparations containing such compounds
PT74937A (en)	1982-06-01	Process for the preparation of novel analgesic and antiinflammatory compounds and of pharmaceutical compositions containing the same
PT78531B (en)	1986-09-15	Process for preparing amino-lower alkylpenem compounds and pharmaceutical compositions containing them
IL69107A (en)	1986-03-31	15-hydroxyimino-14-oxo-eburnamenine derivatives,process for their preparation and pharmaceutical compositions containing these compounds
HUT40652A (en)	1987-01-28	Process for preparing new 8alpha-acyl-amino-ergoline derivatives and pharmaceutical compositions containing such compounds
PT86455A (en)	1988-01-01	Process for the preparation of pharmaceutical compositions containing pyranoquinoline derivatives
ZW20982A1 (en)	1983-04-27	Aminooxazolyl compounds processes for their manufacture pharmaceutical preparations containing these compounds and the use of the latter
ZA828213B (en)	1984-06-27	New bicyclic compounds,processes for their preparation and pharmaceutical formulations containing such compounds
PT76229A (en)	1983-03-01	Process for the preparation of a pharmaceutical composition containing oxazolidin-2-ones
AR244211A1 (en)	1993-10-29	Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and their therapeutical use
HUT38642A (en)	1986-06-30	Process for preparing diazepinoindole derivatives further pharmaceutical compositions containing such compounds

Legal Events

Date	Code	Title	Description
1997-09-30	PC3A	Transfer or assignment	Free format text: 970618 NOVARTIS AG CH