FI822770A0 - BENSAZEPIN-2-ONER, FOERFARANDE FOER DERAS FRAMSTAELLNING, PHARMACEUTICAL PREPARATION INNEHAOLLANDE DESSA FOERENINGAR SAMT DERAS THERAPEUTIC ANVAENDNING - Google Patents

BENSAZEPIN-2-ONER, FOERFARANDE FOER DERAS FRAMSTAELLNING, PHARMACEUTICAL PREPARATION INNEHAOLLANDE DESSA FOERENINGAR SAMT DERAS THERAPEUTIC ANVAENDNING

Info

Publication number: FI822770A0
Authority: FI; Finland
Prior art keywords: deras; bensazepin; anvaendning; oner; therapeutic
Prior art date: 1981-08-11

Application number

FI822770A

Other languages

Finnish (fi)

Other versions

FI822770L (en

FI76074B (en

FI76074C (en

Inventor

Jeffrey W H Watthey

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-08-11

Filing date

1982-08-09

Publication date

1982-08-09

1982-08-09 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1982-08-09 Publication of FI822770A0 publication Critical patent/FI822770A0/en

1983-02-12 Publication of FI822770L publication Critical patent/FI822770L/en

1988-05-31 Publication of FI76074B publication Critical patent/FI76074B/en

1988-09-09 Application granted granted Critical

1988-09-09 Publication of FI76074C publication Critical patent/FI76074C/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

FI822770A 1981-08-11 1982-08-09 Process for the preparation of antihypertensive 3-amino- / 1 / benzazepine-2-one-1-alkanoic acids FI76074C (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US29190781A	1981-08-11	1981-08-11
US29190781		1981-08-11
US31986381A	1981-11-09	1981-11-09
US31986381		1981-11-09

Publications (4)

Publication Number	Publication Date
FI822770A0 true FI822770A0 (en)	1982-08-09
FI822770L FI822770L (en)	1983-02-12
FI76074B FI76074B (en)	1988-05-31
FI76074C FI76074C (en)	1988-09-09

Family

ID=26967047

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI822770A FI76074C (en)	1981-08-11	1982-08-09	Process for the preparation of antihypertensive 3-amino- / 1 / benzazepine-2-one-1-alkanoic acids

Country Status (22)

Country	Link
EP (1)	EP0072352B1 (en)
KR (3)	KR890003425B1 (en)
AR (3)	AR240806A1 (en)
AT (1)	ATE18397T1 (en)
AU (1)	AU561395B2 (en)
CA (1)	CA1196636A (en)
CY (1)	CY1403A (en)
DD (1)	DD202546A5 (en)
DE (1)	DE3269625D1 (en)
DK (1)	DK157881C (en)
ES (6)	ES8502974A1 (en)
FI (1)	FI76074C (en)
GB (1)	GB2103614B (en)
GR (1)	GR77256B (en)
HK (1)	HK93387A (en)
HU (1)	HU189628B (en)
IE (1)	IE53668B1 (en)
IL (1)	IL66501A (en)
NL (1)	NL930112I2 (en)
NO (1)	NO161558C (en)
NZ (1)	NZ201555A (en)
PT (1)	PT75395B (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3242599A1 (en) *	1982-11-18	1984-05-24	Dr. Karl Thomae Gmbh, 7950 Biberach	NEW BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
US4473575A (en) *	1982-07-19	1984-09-25	Ciba-Geigy Corporation	3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
DE3373469D1 (en) *	1982-09-30	1987-10-15	Merck & Co Inc	1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
US4575503A (en) *	1983-02-10	1986-03-11	Ciba-Geigy Corporation	3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4564612A (en) *	1983-04-22	1986-01-14	Takeda Chemical Industries, Ltd.	Condensed, seven-membered ring compounds and their use
US4539150A (en) *	1983-06-29	1985-09-03	Mitsui Toatsu Chemicals, Inc.	Benzothiazepine derivatives and their methods of preparation
JPS608284A (en) *	1983-06-29	1985-01-17	Mitsui Toatsu Chem Inc	Benzothiazepine derivative and its preparation
US4638000A (en) *	1983-08-12	1987-01-20	Takeda Chemical Industries, Ltd.	Condensed seven-membered ring compounds, their production and use
AU570710B2 (en) *	1983-08-12	1988-03-24	Takeda Chemical Industries Ltd.	4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzoxazepine derivatives
IL72523A (en) *	1983-08-12	1988-06-30	Takeda Chemical Industries Ltd	3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them
EP0166354B1 (en) *	1984-06-26	1992-08-05	Merck & Co. Inc.	Benzofused lactam compounds and pharmaceutical compositions containing them
CA1266647A (en) *	1984-06-26	1990-03-13	William H. Parsons	Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists
EP0166357A3 (en) *	1984-06-26	1988-10-26	Merck & Co. Inc.	Benzofused lactams and pharmaceutical compositions containing them
US4785089A (en) *	1985-06-13	1988-11-15	Ciba-Geigy Corporation	Novel sulfonic acid esters and their preparation
DE3704661A1 (en) *	1987-02-14	1988-08-25	Hoechst Ag	FELECTED AZEPINONE AND AZOCINONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR CONTAINERS AND THEIR USE, AND INTERMEDIATE PRODUCTS IN THEIR PRODUCTION
EP0322779A3 (en) *	1987-12-29	1991-05-08	Yoshitomi Pharmaceutical Industries, Ltd.	Benzolactam compounds and pharmaceutical uses thereof
TW197945B (en) *	1990-11-27	1993-01-11	Hoechst Ag
GB9100028D0 (en) *	1991-01-02	1991-02-20	Ici Plc	Compounds
GB9212308D0 (en) *	1992-06-10	1992-07-22	Ici Plc	Therapeutic compositions
US5504080A (en) *	1992-10-28	1996-04-02	Bristol-Myers Squibb Co.	Benzo-fused lactams
CA2151384A1 (en) *	1992-12-11	1994-06-23	Peter Buhlmayer	Benzazepinone derivatives
GB9310075D0 (en) *	1993-05-17	1993-06-30	Fujisawa Pharmaceutical Co	New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
GB9311948D0 (en) *	1993-06-10	1993-07-28	Zeneca Ltd	Substituted nitrogen heterocycles
US5801168A (en) *	1994-06-09	1998-09-01	Zeneca Limited	Substituted nitrogen heterocycles
US5597922A (en) *	1994-07-29	1997-01-28	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon	Glycine receptor antagonist pharmacophore
EP1229913A4 (en) *	1999-11-18	2005-01-19	Antexpharma Inc	Substituted 1-benzazepines and derivatives thereof
US7053211B2 (en)	2000-12-27	2006-05-30	Merck Patent Gmbh	Process for the preparation of α-aminosubstituted carboxylic acid amides
CA2442573A1 (en)	2001-03-27	2002-10-03	Rajesh Kumar Thaper	Process for the preparation of benazepril
US6984645B2 (en)	2001-11-16	2006-01-10	Bristol-Myers Squibb Company	Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
AU2003250086A1 (en) *	2002-07-26	2004-02-23	Ciba Specialty Chemicals Holging Inc.	Crystalline polymorphic and amorphous forms of benazepril hydrochloride
KR100710548B1 (en) *	2002-12-26	2007-04-24	에스케이 주식회사	(s) -3-amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid and a method for producing an ester compound thereof
US7459474B2 (en)	2003-06-11	2008-12-02	Bristol-Myers Squibb Company	Modulators of the glucocorticoid receptor and method
US8080579B2 (en)	2005-10-03	2011-12-20	The Regents Of The University Of Michigan	Compositions and methods for treatment of inflammatory bowel disease
US7592461B2 (en)	2005-12-21	2009-09-22	Bristol-Myers Squibb Company	Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
EP2089355A2 (en)	2006-11-01	2009-08-19	Brystol-Myers Squibb Company	Modulators of glucocorticoid receptor, ap-1, and/or nf- kappa b activity and use thereof
JP2010508358A (en)	2006-11-01	2010-03-18	ブリストル−マイヤーズスクイブカンパニー	Glucocorticoid receptor, AP-1 and / or modulator of NF-κB activity, and use thereof
WO2008151257A2 (en)	2007-06-04	2008-12-11	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8034782B2 (en)	2008-07-16	2011-10-11	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7828840B2 (en)	2007-11-15	2010-11-09	Med Institute, Inc.	Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
EP2810951B1 (en)	2008-06-04	2017-03-15	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8106046B2 (en)	2008-06-24	2012-01-31	Bristol-Myers Squibb Company	Cyclopentathiophene modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
AU2014235209B2 (en)	2013-03-15	2018-06-14	Bausch Health Ireland Limited	Guanylate cyclase receptor agonists combined with other drugs
US9708367B2 (en)	2013-03-15	2017-07-18	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
CN105764916B (en)	2013-06-05	2021-05-18	博士医疗爱尔兰有限公司	Ultrapure agonists of guanylate cyclase C, methods of making and using the same
US9593113B2 (en)	2013-08-22	2017-03-14	Bristol-Myers Squibb Company	Imide and acylurea derivatives as modulators of the glucocorticoid receptor
CN113292495B (en) *	2021-06-18	2022-09-13	迪嘉药业集团有限公司	Synthesis method of (S) -amino compound

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3395150A (en) *	1965-02-26	1968-07-30	Squibb & Sons Inc	Benzothiazepine carboxamides and derivatives thereof
GB1305278A (en) *	1970-03-12	1973-01-31

1982
- 1982-08-05 EP EP82810329A patent/EP0072352B1/en not_active Expired
- 1982-08-05 GB GB08222564A patent/GB2103614B/en not_active Expired
- 1982-08-05 DE DE8282810329T patent/DE3269625D1/en not_active Expired
- 1982-08-05 CY CY140382A patent/CY1403A/en unknown
- 1982-08-05 AT AT82810329T patent/ATE18397T1/en active
- 1982-08-09 IL IL66501A patent/IL66501A/en not_active IP Right Cessation
- 1982-08-09 ES ES514856A patent/ES8502974A1/en not_active Expired
- 1982-08-09 GR GR68996A patent/GR77256B/el unknown
- 1982-08-09 FI FI822770A patent/FI76074C/en not_active IP Right Cessation
- 1982-08-09 CA CA000409019A patent/CA1196636A/en not_active Expired
- 1982-08-09 PT PT75395A patent/PT75395B/en unknown
- 1982-08-10 DK DK358682A patent/DK157881C/en active
- 1982-08-10 NO NO822722A patent/NO161558C/en not_active IP Right Cessation
- 1982-08-10 AU AU87014/82A patent/AU561395B2/en not_active Expired
- 1982-08-10 IE IE1929/82A patent/IE53668B1/en not_active IP Right Cessation
- 1982-08-10 DD DD82242400A patent/DD202546A5/en not_active IP Right Cessation
- 1982-08-10 NZ NZ201555A patent/NZ201555A/en unknown
- 1982-08-10 KR KR8203588A patent/KR890003425B1/en not_active Expired
- 1982-08-10 HU HU822585A patent/HU189628B/en unknown
- 1982-08-11 AR AR290295A patent/AR240806A1/en active
1983
- 1983-10-28 ES ES526888A patent/ES8504728A1/en not_active Expired
- 1983-10-28 ES ES526889A patent/ES8604523A1/en not_active Expired
- 1983-10-28 ES ES526887A patent/ES8606285A1/en not_active Expired
- 1983-10-28 ES ES526886A patent/ES8601142A1/en not_active Expired
1984
- 1984-02-28 AR AR295866A patent/AR240807A1/en active
- 1984-02-28 AR AR84295865A patent/AR241222A1/en active
- 1984-03-15 ES ES530658A patent/ES8602682A1/en not_active Expired
1987
- 1987-12-10 HK HK933/87A patent/HK93387A/en not_active IP Right Cessation
1989
- 1989-05-13 KR KR8906486A patent/KR900001190B1/en not_active Expired
- 1989-05-13 KR KR1019890006487A patent/KR900001191B1/en not_active Expired
1993
- 1993-06-29 NL NL930112C patent/NL930112I2/en unknown

Also Published As

Publication number	Publication date
ES526888A0 (en)	1985-04-16
ES8604523A1 (en)	1986-02-01
AU561395B2 (en)	1987-05-07
NO161558C (en)	1989-08-30
IL66501A0 (en)	1982-12-31
ATE18397T1 (en)	1986-03-15
DE3269625D1 (en)	1986-04-10
PT75395A (en)	1982-09-01
AR240806A2 (en)	1991-02-28
NO822722L (en)	1983-02-14
ES514856A0 (en)	1985-02-01
IE821929L (en)	1983-02-11
KR900001190B1 (en)	1990-02-28
DK157881B (en)	1990-02-26
IL66501A (en)	1987-10-20
NL930112I2 (en)	1996-11-01
ES526886A0 (en)	1985-11-01
GR77256B (en)	1984-09-11
ES8504728A1 (en)	1985-04-16
NZ201555A (en)	1986-06-11
HK93387A (en)	1987-12-18
ES8601142A1 (en)	1985-11-01
CY1403A (en)	1987-12-18
GB2103614B (en)	1984-11-21
DK157881C (en)	1990-07-23
EP0072352B1 (en)	1986-03-05
AR240807A1 (en)	1991-02-28
NO161558B (en)	1989-05-22
FI822770L (en)	1983-02-12
ES530658A0 (en)	1985-12-01
KR900001191B1 (en)	1990-02-28
AR241222A1 (en)	1992-02-28
CA1196636A (en)	1985-11-12
ES8502974A1 (en)	1985-02-01
ES8602682A1 (en)	1985-12-01
AR240807A2 (en)	1991-02-28
PT75395B (en)	1985-11-15
ES526887A0 (en)	1986-04-16
NL930112I1 (en)	1993-10-18
ES8606285A1 (en)	1986-04-16
EP0072352A1 (en)	1983-02-16
DK358682A (en)	1983-02-12
KR890003425B1 (en)	1989-09-20
AU8701482A (en)	1983-05-12
IE53668B1 (en)	1989-01-04
ES526889A0 (en)	1986-02-01
FI76074B (en)	1988-05-31
KR840001139A (en)	1984-03-28
HU189628B (en)	1986-07-28
FI76074C (en)	1988-09-09
AR240806A1 (en)	1991-02-28
DD202546A5 (en)	1983-09-21
GB2103614A (en)	1983-02-23

Publication	Publication Date	Title
FI822770A0 (en)	1982-08-09	BENSAZEPIN-2-ONER, FOERFARANDE FOER DERAS FRAMSTAELLNING, PHARMACEUTICAL PREPARATION INNEHAOLLANDE DESSA FOERENINGAR SAMT DERAS THERAPEUTIC ANVAENDNING
ATE22007T1 (en)	1986-09-15	PHARMACEUTICAL MIXTURE.
FI860559A0 (en)	1986-02-07	11 -FENYL-GONANER, DERAS FRAMSTAELLNING OCH DESSA INNEHAOLLANDE PHARMACEUTICAL PREPARATION.
FI801876A7 (en)	1980-12-23	PHARMACEUTICAL PREPARATIONS
FI822813A7 (en)	1983-02-14	New pharmaceutical mixtures.
FI844199A7 (en)	1985-04-29	Pharmaceutical preparation.
FI853296A7 (en)	1986-03-01	Pharmaceutical granule preparation.
FI873630A7 (en)	1988-02-23	STABILT PHARMACEUTICAL PREPARATIONS.
IT8247937A0 (en)	1982-03-05	POLYPEPTIDES, THEIR PREPARATION AND THEIR USE AS MEDICINES
DK345682A (en)	1983-02-06	PHARMACEUTICAL EXPIENSES
FI820983L (en)	1982-09-25	ACYL-KINOLINONDERIVAT, FOERFARANDE FOER DERAS FRAMSTAELLNING, DESSA INNEHAOLLANDE PHARMACEUTICAL PREPARATION SAMT DERAS ANVAENDNING
FI822187L (en)	1982-12-25	PHARMACEUTICAL PREPARATION
FI890488A0 (en)	1989-02-01	VAEXTEXTRAKT INNEHAOLLANDE PHARMACEUTICAL PREPARATION SAMT FOERFARANDE FOER FRAMSTAELLNING DAERAV.
FI820877L (en)	1982-09-19	THERAPEUTIC PREPARATIONS
FI823217L (en)	1983-03-19	AMINOPROPANOLDERIVAT AV 2-HYDROXI- PHENYLPROPIOFENONER, FOERFARANDEN FOER DERAS FRAMSTAELLNING OCHDESSA INNEHAOLLANDE THERAPEUTIC MEDICINE
FI874382A0 (en)	1987-10-06	PHARMACEUTICAL PREPARATION.
FI882965A0 (en)	1988-06-21	AMINOCYCLOPENTYLETRAR OCH DERAS FRAMSTAELLNING OCH PHARMACEUTICAL PREPARAT.
FI834138A0 (en)	1983-11-11	HETEROCYKLYLFOERENINGAR, DESSA FOERENINGAR INNEHAOLLANDE PHARMACEUTICAL PREPARATION SAMT DERAS ANVAENDNING
FI810874L (en)	1981-09-26	PHARMACEUTICAL PREPARATION
FI823304A0 (en)	1982-09-27	AMINO-OXAZOLYLFOERENINGAR, FOERFARANDE FOER DERAS FRAMSTAELLNING, DESSA FOERENINGAR INNEHAOLLANDE PHARMACEUTICAL PREPARATION SAMT ANVAENDNING AV DE SISTNAEMNDA
FI883747A0 (en)	1988-08-12	TOPISKT ANVAENDBARA PHARMACEUTICAL PREPARAT.
FI812536L (en)	1982-02-20	NYA DIARYL-IMIDAZOLE-FOERENINGAR FOERFARANDEN FOER DERAS FRAMSTAELLNING DESSA FOERENINGAR INNEHAOLLANDE PHARMACEUTICAL PREPARATION SAMT DERAS ANVAENDNING
FI823690L (en)	1983-04-30	AMINOCYCLOPENTANESTRAR OCH DERAS FRAMSTAELLNING OCH PHARMACEUTICAL PREPARAT
FI834140A0 (en)	1983-11-11	HETEROCYCLYLTIOFOERENINGAR, DESSA FOERENINGAR INNEHAOLLANDE PHARMACEUTICAL PREPARATION SAMT DERAS ANVAENDNING
NL193821B (en)	2000-08-01	Pharmaceutical preparation.

Legal Events

Date	Code	Title	Description
1997-08-26	PC	Transfer of assignment of patent	Owner name: NOVARTIS AG
2004-08-31	MA	Patent expired	Owner name: NOVARTIS AG