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AR240806A1 - PROCEDURE FOR THE PREPARATION OF 3-AMINO- (1) BENZAZEPIN-2-ONA-1-ALKANOIC ACIDS AND ITS SALTS. - Google Patents

PROCEDURE FOR THE PREPARATION OF 3-AMINO- (1) BENZAZEPIN-2-ONA-1-ALKANOIC ACIDS AND ITS SALTS.

Info

Publication number
AR240806A1
AR240806A1 AR290295A AR29029582A AR240806A1 AR 240806 A1 AR240806 A1 AR 240806A1 AR 290295 A AR290295 A AR 290295A AR 29029582 A AR29029582 A AR 29029582A AR 240806 A1 AR240806 A1 AR 240806A1
Authority
AR
Argentina
Prior art keywords
benzazepin
ona
salts
amino
procedure
Prior art date
Application number
AR290295A
Other languages
Spanish (es)
Other versions
AR240806A2 (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Application granted granted Critical
Publication of AR240806A2 publication Critical patent/AR240806A2/en
Publication of AR240806A1 publication Critical patent/AR240806A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
AR290295A 1981-08-11 1982-08-11 PROCEDURE FOR THE PREPARATION OF 3-AMINO- (1) BENZAZEPIN-2-ONA-1-ALKANOIC ACIDS AND ITS SALTS. AR240806A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29190781A 1981-08-11 1981-08-11
US31986381A 1981-11-09 1981-11-09

Publications (2)

Publication Number Publication Date
AR240806A2 AR240806A2 (en) 1991-02-28
AR240806A1 true AR240806A1 (en) 1991-02-28

Family

ID=26967047

Family Applications (3)

Application Number Title Priority Date Filing Date
AR290295A AR240806A1 (en) 1981-08-11 1982-08-11 PROCEDURE FOR THE PREPARATION OF 3-AMINO- (1) BENZAZEPIN-2-ONA-1-ALKANOIC ACIDS AND ITS SALTS.
AR295866A AR240807A1 (en) 1981-08-11 1984-02-28 PROCEDURE FOR OBTAINING DERIVATIVES OF BENZAZEPIN-2-ONA AND ITS SALTS
AR84295865A AR241222A1 (en) 1981-08-11 1984-02-28 Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and their therapeutical use

Family Applications After (2)

Application Number Title Priority Date Filing Date
AR295866A AR240807A1 (en) 1981-08-11 1984-02-28 PROCEDURE FOR OBTAINING DERIVATIVES OF BENZAZEPIN-2-ONA AND ITS SALTS
AR84295865A AR241222A1 (en) 1981-08-11 1984-02-28 Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and their therapeutical use

Country Status (22)

Country Link
EP (1) EP0072352B1 (en)
KR (3) KR890003425B1 (en)
AR (3) AR240806A1 (en)
AT (1) ATE18397T1 (en)
AU (1) AU561395B2 (en)
CA (1) CA1196636A (en)
CY (1) CY1403A (en)
DD (1) DD202546A5 (en)
DE (1) DE3269625D1 (en)
DK (1) DK157881C (en)
ES (6) ES8502974A1 (en)
FI (1) FI76074C (en)
GB (1) GB2103614B (en)
GR (1) GR77256B (en)
HK (1) HK93387A (en)
HU (1) HU189628B (en)
IE (1) IE53668B1 (en)
IL (1) IL66501A (en)
NL (1) NL930112I2 (en)
NO (1) NO161558C (en)
NZ (1) NZ201555A (en)
PT (1) PT75395B (en)

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DE3242599A1 (en) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach NEW BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
DE3373469D1 (en) * 1982-09-30 1987-10-15 Merck & Co Inc 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
US4575503A (en) * 1983-02-10 1986-03-11 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4564612A (en) * 1983-04-22 1986-01-14 Takeda Chemical Industries, Ltd. Condensed, seven-membered ring compounds and their use
US4539150A (en) * 1983-06-29 1985-09-03 Mitsui Toatsu Chemicals, Inc. Benzothiazepine derivatives and their methods of preparation
JPS608284A (en) * 1983-06-29 1985-01-17 Mitsui Toatsu Chem Inc Benzothiazepine derivative and its preparation
US4638000A (en) * 1983-08-12 1987-01-20 Takeda Chemical Industries, Ltd. Condensed seven-membered ring compounds, their production and use
AU570710B2 (en) * 1983-08-12 1988-03-24 Takeda Chemical Industries Ltd. 4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzoxazepine derivatives
IL72523A (en) * 1983-08-12 1988-06-30 Takeda Chemical Industries Ltd 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them
EP0166354B1 (en) * 1984-06-26 1992-08-05 Merck & Co. Inc. Benzofused lactam compounds and pharmaceutical compositions containing them
CA1266647A (en) * 1984-06-26 1990-03-13 William H. Parsons Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzofused lactams and pharmaceutical compositions containing them
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
DE3704661A1 (en) * 1987-02-14 1988-08-25 Hoechst Ag FELECTED AZEPINONE AND AZOCINONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR CONTAINERS AND THEIR USE, AND INTERMEDIATE PRODUCTS IN THEIR PRODUCTION
EP0322779A3 (en) * 1987-12-29 1991-05-08 Yoshitomi Pharmaceutical Industries, Ltd. Benzolactam compounds and pharmaceutical uses thereof
TW197945B (en) * 1990-11-27 1993-01-11 Hoechst Ag
GB9100028D0 (en) * 1991-01-02 1991-02-20 Ici Plc Compounds
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
CA2151384A1 (en) * 1992-12-11 1994-06-23 Peter Buhlmayer Benzazepinone derivatives
GB9310075D0 (en) * 1993-05-17 1993-06-30 Fujisawa Pharmaceutical Co New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
US5801168A (en) * 1994-06-09 1998-09-01 Zeneca Limited Substituted nitrogen heterocycles
US5597922A (en) * 1994-07-29 1997-01-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Glycine receptor antagonist pharmacophore
EP1229913A4 (en) * 1999-11-18 2005-01-19 Antexpharma Inc Substituted 1-benzazepines and derivatives thereof
US7053211B2 (en) 2000-12-27 2006-05-30 Merck Patent Gmbh Process for the preparation of α-aminosubstituted carboxylic acid amides
CA2442573A1 (en) 2001-03-27 2002-10-03 Rajesh Kumar Thaper Process for the preparation of benazepril
US6984645B2 (en) 2001-11-16 2006-01-10 Bristol-Myers Squibb Company Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
AU2003250086A1 (en) * 2002-07-26 2004-02-23 Ciba Specialty Chemicals Holging Inc. Crystalline polymorphic and amorphous forms of benazepril hydrochloride
KR100710548B1 (en) * 2002-12-26 2007-04-24 에스케이 주식회사 (s) -3-amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid and a method for producing an ester compound thereof
US7459474B2 (en) 2003-06-11 2008-12-02 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US8080579B2 (en) 2005-10-03 2011-12-20 The Regents Of The University Of Michigan Compositions and methods for treatment of inflammatory bowel disease
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
EP2089355A2 (en) 2006-11-01 2009-08-19 Brystol-Myers Squibb Company Modulators of glucocorticoid receptor, ap-1, and/or nf- kappa b activity and use thereof
JP2010508358A (en) 2006-11-01 2010-03-18 ブリストル−マイヤーズ スクイブ カンパニー Glucocorticoid receptor, AP-1 and / or modulator of NF-κB activity, and use thereof
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7828840B2 (en) 2007-11-15 2010-11-09 Med Institute, Inc. Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8106046B2 (en) 2008-06-24 2012-01-31 Bristol-Myers Squibb Company Cyclopentathiophene modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
CN105764916B (en) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 Ultrapure agonists of guanylate cyclase C, methods of making and using the same
US9593113B2 (en) 2013-08-22 2017-03-14 Bristol-Myers Squibb Company Imide and acylurea derivatives as modulators of the glucocorticoid receptor
CN113292495B (en) * 2021-06-18 2022-09-13 迪嘉药业集团有限公司 Synthesis method of (S) -amino compound

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395150A (en) * 1965-02-26 1968-07-30 Squibb & Sons Inc Benzothiazepine carboxamides and derivatives thereof
GB1305278A (en) * 1970-03-12 1973-01-31

Also Published As

Publication number Publication date
ES526888A0 (en) 1985-04-16
ES8604523A1 (en) 1986-02-01
AU561395B2 (en) 1987-05-07
NO161558C (en) 1989-08-30
IL66501A0 (en) 1982-12-31
ATE18397T1 (en) 1986-03-15
DE3269625D1 (en) 1986-04-10
PT75395A (en) 1982-09-01
AR240806A2 (en) 1991-02-28
NO822722L (en) 1983-02-14
ES514856A0 (en) 1985-02-01
IE821929L (en) 1983-02-11
KR900001190B1 (en) 1990-02-28
DK157881B (en) 1990-02-26
IL66501A (en) 1987-10-20
NL930112I2 (en) 1996-11-01
ES526886A0 (en) 1985-11-01
GR77256B (en) 1984-09-11
ES8504728A1 (en) 1985-04-16
NZ201555A (en) 1986-06-11
HK93387A (en) 1987-12-18
ES8601142A1 (en) 1985-11-01
CY1403A (en) 1987-12-18
GB2103614B (en) 1984-11-21
DK157881C (en) 1990-07-23
EP0072352B1 (en) 1986-03-05
AR240807A1 (en) 1991-02-28
NO161558B (en) 1989-05-22
FI822770L (en) 1983-02-12
ES530658A0 (en) 1985-12-01
KR900001191B1 (en) 1990-02-28
AR241222A1 (en) 1992-02-28
CA1196636A (en) 1985-11-12
ES8502974A1 (en) 1985-02-01
ES8602682A1 (en) 1985-12-01
FI822770A0 (en) 1982-08-09
AR240807A2 (en) 1991-02-28
PT75395B (en) 1985-11-15
ES526887A0 (en) 1986-04-16
NL930112I1 (en) 1993-10-18
ES8606285A1 (en) 1986-04-16
EP0072352A1 (en) 1983-02-16
DK358682A (en) 1983-02-12
KR890003425B1 (en) 1989-09-20
AU8701482A (en) 1983-05-12
IE53668B1 (en) 1989-01-04
ES526889A0 (en) 1986-02-01
FI76074B (en) 1988-05-31
KR840001139A (en) 1984-03-28
HU189628B (en) 1986-07-28
FI76074C (en) 1988-09-09
DD202546A5 (en) 1983-09-21
GB2103614A (en) 1983-02-23

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