NO822722L - PROCEDURE FOR THE PREPARATION OF BENZAZEPIN-2-ONER. - Google Patents

PROCEDURE FOR THE PREPARATION OF BENZAZEPIN-2-ONER.

Info

Publication number: NO822722L
Authority: NO; Norway
Prior art keywords: oner; benzazepin; procedure; preparation
Prior art date: 1981-08-11

Application number

NO822722A

Other languages

Norwegian (no)

Other versions

NO161558B (en

NO161558C (en

Inventor

Jeffrey W H Watthey

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-08-11

Filing date

1982-08-10

Publication date

1983-02-14

1982-08-10 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1983-02-14 Publication of NO822722L publication Critical patent/NO822722L/en

1989-05-22 Publication of NO161558B publication Critical patent/NO161558B/en

1989-08-30 Publication of NO161558C publication Critical patent/NO161558C/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO822722A 1981-08-11 1982-08-10 ANALOGY PROCEDURE FOR THE PREPARATION OF ANTIHYPERTENSIVE BENZAZEPIN-2-ONER. NO161558C (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US29190781A	1981-08-11	1981-08-11
US31986381A	1981-11-09	1981-11-09

Publications (3)

Publication Number	Publication Date
NO822722L true NO822722L (en)	1983-02-14
NO161558B NO161558B (en)	1989-05-22
NO161558C NO161558C (en)	1989-08-30

Family

ID=26967047

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO822722A NO161558C (en)	1981-08-11	1982-08-10	ANALOGY PROCEDURE FOR THE PREPARATION OF ANTIHYPERTENSIVE BENZAZEPIN-2-ONER.

Country Status (22)

Country	Link
EP (1)	EP0072352B1 (en)
KR (3)	KR890003425B1 (en)
AR (3)	AR240806A1 (en)
AT (1)	ATE18397T1 (en)
AU (1)	AU561395B2 (en)
CA (1)	CA1196636A (en)
CY (1)	CY1403A (en)
DD (1)	DD202546A5 (en)
DE (1)	DE3269625D1 (en)
DK (1)	DK157881C (en)
ES (6)	ES514856A0 (en)
FI (1)	FI76074C (en)
GB (1)	GB2103614B (en)
GR (1)	GR77256B (en)
HK (1)	HK93387A (en)
HU (1)	HU189628B (en)
IE (1)	IE53668B1 (en)
IL (1)	IL66501A (en)
NL (1)	NL930112I2 (en)
NO (1)	NO161558C (en)
NZ (1)	NZ201555A (en)
PT (1)	PT75395B (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3242599A1 (en) *	1982-11-18	1984-05-24	Dr. Karl Thomae Gmbh, 7950 Biberach	NEW BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
US4473575A (en) *	1982-07-19	1984-09-25	Ciba-Geigy Corporation	3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
EP0107095B1 (en) *	1982-09-30	1987-09-09	Merck & Co. Inc.	1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
US4575503A (en) *	1983-02-10	1986-03-11	Ciba-Geigy Corporation	3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4564612A (en) *	1983-04-22	1986-01-14	Takeda Chemical Industries, Ltd.	Condensed, seven-membered ring compounds and their use
US4539150A (en) *	1983-06-29	1985-09-03	Mitsui Toatsu Chemicals, Inc.	Benzothiazepine derivatives and their methods of preparation
JPS608284A (en) *	1983-06-29	1985-01-17	Mitsui Toatsu Chem Inc	Benzothiazepine derivative and its preparation
IL72523A (en) *	1983-08-12	1988-06-30	Takeda Chemical Industries Ltd	3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them
US4638000A (en) *	1983-08-12	1987-01-20	Takeda Chemical Industries, Ltd.	Condensed seven-membered ring compounds, their production and use
AU570710B2 (en) *	1983-08-12	1988-03-24	Takeda Chemical Industries Ltd.	4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzoxazepine derivatives
EP0166354B1 (en) *	1984-06-26	1992-08-05	Merck & Co. Inc.	Benzofused lactam compounds and pharmaceutical compositions containing them
CA1266647A (en) *	1984-06-26	1990-03-13	William H. Parsons	Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists
EP0166357A3 (en) *	1984-06-26	1988-10-26	Merck & Co. Inc.	Benzofused lactams and pharmaceutical compositions containing them
US4785089A (en) *	1985-06-13	1988-11-15	Ciba-Geigy Corporation	Novel sulfonic acid esters and their preparation
DE3704661A1 (en) *	1987-02-14	1988-08-25	Hoechst Ag	FELECTED AZEPINONE AND AZOCINONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR CONTAINERS AND THEIR USE, AND INTERMEDIATE PRODUCTS IN THEIR PRODUCTION
EP0322779A3 (en) *	1987-12-29	1991-05-08	Yoshitomi Pharmaceutical Industries, Ltd.	Benzolactam compounds and pharmaceutical uses thereof
TW197945B (en) *	1990-11-27	1993-01-11	Hoechst Ag
GB9100028D0 (en) *	1991-01-02	1991-02-20	Ici Plc	Compounds
GB9212308D0 (en) *	1992-06-10	1992-07-22	Ici Plc	Therapeutic compositions
US5504080A (en) *	1992-10-28	1996-04-02	Bristol-Myers Squibb Co.	Benzo-fused lactams
US5610153A (en) *	1992-12-11	1997-03-11	Ciba-Geigy Corporation	Benzazepinone derivatives
GB9310075D0 (en) *	1993-05-17	1993-06-30	Fujisawa Pharmaceutical Co	New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
GB9311948D0 (en) *	1993-06-10	1993-07-28	Zeneca Ltd	Substituted nitrogen heterocycles
US5801168A (en) *	1994-06-09	1998-09-01	Zeneca Limited	Substituted nitrogen heterocycles
US5597922A (en) *	1994-07-29	1997-01-28	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon	Glycine receptor antagonist pharmacophore
CA2391498A1 (en) *	1999-11-18	2001-05-25	Antexpharma, Inc.	Substituted 1-benzazepines and derivatives thereof
CA2668823A1 (en)	2000-12-27	2002-07-04	Merck Patent Gesellschaft Mit Beschraenkter Haftung	Process for the preparation of .alpha.-aminosubstituted carboxylic acid amides
WO2002076375A2 (en)	2001-03-27	2002-10-03	Ranbaxy Laboratories Limited	Process for the preparation of benazepril
EP1443919A4 (en)	2001-11-16	2006-03-22	Bristol Myers Squibb Co	Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
US20050107359A1 (en) *	2002-07-26	2005-05-19	Van Der Schaaf Paul A.	Crystalline polymorphic and amorphous forms of benazepril hydrochloride
KR100710548B1 (en) *	2002-12-26	2007-04-24	에스케이 주식회사	(s) -3-amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid and a method for producing an ester compound thereof
US7459474B2 (en)	2003-06-11	2008-12-02	Bristol-Myers Squibb Company	Modulators of the glucocorticoid receptor and method
US8080579B2 (en)	2005-10-03	2011-12-20	The Regents Of The University Of Michigan	Compositions and methods for treatment of inflammatory bowel disease
US7592461B2 (en)	2005-12-21	2009-09-22	Bristol-Myers Squibb Company	Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7968577B2 (en)	2006-11-01	2011-06-28	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
CN101573340A (en)	2006-11-01	2009-11-04	百时美施贵宝公司	Modulators of glucocorticoid receptor AP-1 and/or NF-kB activity and uses thereof
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2559319T3 (en)	2007-06-04	2016-02-11	Synergy Pharmaceuticals Inc.	Guanylate cliclas agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US7828840B2 (en)	2007-11-15	2010-11-09	Med Institute, Inc.	Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
CA2726917C (en)	2008-06-04	2018-06-26	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011525537A (en)	2008-06-24	2011-09-22	ブリストル−マイヤーズスクイブカンパニー	Cyclopentathiophene modulators of glucocorticoid receptor, AP-1, and / or NF-κB activity and uses thereof
EP3241839B1 (en)	2008-07-16	2019-09-04	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
EP2968439A2 (en)	2013-03-15	2016-01-20	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
EA201592263A1 (en)	2013-06-05	2016-05-31	Синерджи Фармасьютикалз, Инк.	ULTRASCULAR AGONISTS OF GUANYLACYCLASE C, METHOD OF THEIR RECEIVING AND USING
US9593113B2 (en)	2013-08-22	2017-03-14	Bristol-Myers Squibb Company	Imide and acylurea derivatives as modulators of the glucocorticoid receptor
CN113292495B (en) *	2021-06-18	2022-09-13	迪嘉药业集团有限公司	Synthesis method of (S) -amino compound

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3395150A (en) *	1965-02-26	1968-07-30	Squibb & Sons Inc	Benzothiazepine carboxamides and derivatives thereof
GB1305278A (en) *	1970-03-12	1973-01-31

1982
- 1982-08-05 EP EP82810329A patent/EP0072352B1/en not_active Expired
- 1982-08-05 DE DE8282810329T patent/DE3269625D1/en not_active Expired
- 1982-08-05 AT AT82810329T patent/ATE18397T1/en active
- 1982-08-05 CY CY140382A patent/CY1403A/en unknown
- 1982-08-05 GB GB08222564A patent/GB2103614B/en not_active Expired
- 1982-08-09 IL IL66501A patent/IL66501A/en not_active IP Right Cessation
- 1982-08-09 GR GR68996A patent/GR77256B/el unknown
- 1982-08-09 PT PT75395A patent/PT75395B/en unknown
- 1982-08-09 ES ES514856A patent/ES514856A0/en active Granted
- 1982-08-09 FI FI822770A patent/FI76074C/en not_active IP Right Cessation
- 1982-08-09 CA CA000409019A patent/CA1196636A/en not_active Expired
- 1982-08-10 IE IE1929/82A patent/IE53668B1/en not_active IP Right Cessation
- 1982-08-10 AU AU87014/82A patent/AU561395B2/en not_active Expired
- 1982-08-10 NZ NZ201555A patent/NZ201555A/en unknown
- 1982-08-10 KR KR8203588A patent/KR890003425B1/en not_active Expired
- 1982-08-10 DK DK358682A patent/DK157881C/en active
- 1982-08-10 HU HU822585A patent/HU189628B/en unknown
- 1982-08-10 NO NO822722A patent/NO161558C/en not_active IP Right Cessation
- 1982-08-10 DD DD82242400A patent/DD202546A5/en not_active IP Right Cessation
- 1982-08-11 AR AR290295A patent/AR240806A1/en active
1983
- 1983-10-28 ES ES526886A patent/ES8601142A1/en not_active Expired
- 1983-10-28 ES ES526888A patent/ES8504728A1/en not_active Expired
- 1983-10-28 ES ES526889A patent/ES8604523A1/en not_active Expired
- 1983-10-28 ES ES526887A patent/ES8606285A1/en not_active Expired
1984
- 1984-02-28 AR AR295866A patent/AR240807A1/en active
- 1984-02-28 AR AR84295865A patent/AR241222A1/en active
- 1984-03-15 ES ES530658A patent/ES8602682A1/en not_active Expired
1987
- 1987-12-10 HK HK933/87A patent/HK93387A/en not_active IP Right Cessation
1989
- 1989-05-13 KR KR8906486A patent/KR900001190B1/en not_active Expired
- 1989-05-13 KR KR1019890006487A patent/KR900001191B1/en not_active Expired
1993
- 1993-06-29 NL NL930112C patent/NL930112I2/en unknown

Also Published As

Publication number	Publication date
CY1403A (en)	1987-12-18
NL930112I1 (en)	1993-10-18
EP0072352A1 (en)	1983-02-16
NL930112I2 (en)	1996-11-01
EP0072352B1 (en)	1986-03-05
HU189628B (en)	1986-07-28
KR890003425B1 (en)	1989-09-20
FI76074C (en)	1988-09-09
ES8502974A1 (en)	1985-02-01
DD202546A5 (en)	1983-09-21
HK93387A (en)	1987-12-18
ES514856A0 (en)	1985-02-01
FI822770A0 (en)	1982-08-09
ES526887A0 (en)	1986-04-16
KR900001190B1 (en)	1990-02-28
ES526886A0 (en)	1985-11-01
GB2103614B (en)	1984-11-21
KR840001139A (en)	1984-03-28
AR240807A1 (en)	1991-02-28
AR241222A1 (en)	1992-02-28
AU8701482A (en)	1983-05-12
GR77256B (en)	1984-09-11
DK157881C (en)	1990-07-23
ES526888A0 (en)	1985-04-16
AR240806A1 (en)	1991-02-28
AR240806A2 (en)	1991-02-28
CA1196636A (en)	1985-11-12
DK358682A (en)	1983-02-12
DE3269625D1 (en)	1986-04-10
GB2103614A (en)	1983-02-23
DK157881B (en)	1990-02-26
ES8606285A1 (en)	1986-04-16
IL66501A0 (en)	1982-12-31
PT75395A (en)	1982-09-01
ES8601142A1 (en)	1985-11-01
IL66501A (en)	1987-10-20
ES526889A0 (en)	1986-02-01
IE53668B1 (en)	1989-01-04
ES530658A0 (en)	1985-12-01
ES8604523A1 (en)	1986-02-01
FI822770L (en)	1983-02-12
AR240807A2 (en)	1991-02-28
AU561395B2 (en)	1987-05-07
PT75395B (en)	1985-11-15
KR900001191B1 (en)	1990-02-28
NO161558B (en)	1989-05-22
ATE18397T1 (en)	1986-03-15
NO161558C (en)	1989-08-30
NZ201555A (en)	1986-06-11
ES8504728A1 (en)	1985-04-16
IE821929L (en)	1983-02-11
FI76074B (en)	1988-05-31
ES8602682A1 (en)	1985-12-01

Publication	Publication Date	Title
NO822722L (en)	1983-02-14	PROCEDURE FOR THE PREPARATION OF BENZAZEPIN-2-ONER.
NO821087L (en)	1982-10-07	PROCEDURE FOR THE PREPARATION OF CYCLOBUTAN DERIVATIVES.
NO821586L (en)	1982-11-19	PROCEDURE FOR THE PREPARATION OF 1,2-DIAMINO-CYCLOBUTEN-3,4-DIONE.
NO159667C (en)	1989-02-01	PROCEDURE FOR THE PREPARATION OF PICKHOST TOXIDE.
NO158752C (en)	1988-10-26	PROCEDURE FOR THE PREPARATION OF ETHANOL.
NO157861C (en)	1988-06-01	ANALOGUE PROCEDURE FOR THE PREPARATION OF AMINOPYRIDAZINES.
NO820959L (en)	1982-09-27	PROCEDURE FOR THE PREPARATION OF ACYL-QUINOLINO DERIVATIVES
NO158136C (en)	1988-07-20	PROCEDURE FOR THE PREPARATION OF TIADIAZOLD DERIVATIVES.
NO855067L (en)	1986-06-18	PROCEDURE FOR THE PREPARATION OF N-FORMYL-ALFA-ASPARTYL-PHENYLALANINE.
NO155693C (en)	1987-05-13	PROCEDURE FOR THE PREPARATION OF EBURNAMONIN DERIVATIVES.
NO822634L (en)	1983-02-04	PROCEDURE FOR THE MANUFACTURE OF CEFEM DERIVATIVES.
FI822408A7 (en)	1983-01-09	Method for the preparation of amidobenzamides.
NO853066L (en)	1986-02-07	PROCEDURE FOR THE PREPARATION OF 3-CARBONYL-1-AMINOALKYL-1H-INDOLES.
NO812519L (en)	1982-01-25	PROCEDURE FOR THE PREPARATION OF CHOLESTERASE.
NO823884L (en)	1983-05-24	PROCEDURE FOR THE PREPARATION OF 1,2-DICHLORETHANE
NO163061C (en)	1990-03-28	PROCEDURE FOR THE PREPARATION OF PERROMANGANE.
NO162018C (en)	1989-10-25	PROCEDURE FOR THE PREPARATION OF 4-METHYL-5-ALKYLTYOMETHYLIMIDAZOLES.
NO801142L (en)	1980-10-28	PROCEDURE FOR THE PREPARATION OF CHLORODIOXIDE.
NO154636C (en)	1986-11-19	PROCEDURE FOR THE PREPARATION OF CRYSTALLINIC AMINOCYCLITOL DERIVATIVES.
NO165637C (en)	1991-03-13	PROCEDURE FOR THE PREPARATION OF ETHOXYLED LIGINITE.
NO157422C (en)	1988-03-16	PROCEDURE FOR THE PREPARATION OF ANTI-T-Lymphocyte GLOBULIN.
ES510963A0 (en)	1983-02-01	PROCEDURE FOR THE PREPARATION OF ALCOXIAMINOHIDRIDOSILANOS.
NO810114L (en)	1981-07-20	PROCEDURE FOR THE PREPARATION OF KIJANIMICIN.
ES517428A0 (en)	1983-08-16	PROCEDURE FOR THE PREPARATION OF BENCILIDENIC DERIVATIVES.
NO159268C (en)	1988-12-14	PROCEDURE FOR THE PREPARATION OF 3-PICOLINE.

Legal Events

Date	Code	Title	Description
2002-09-30	MK1K	Patent expired	Free format text: EXPIRED IN AUGUST 2002