PT3539961T - Derivados de amida policíclica como inibidores de cdk9 - Google Patents

Derivados de amida policíclica como inibidores de cdk9

Info

Publication number: PT3539961T
Authority: PT; Portugal
Prior art keywords: amide derivatives; cdk9 inhibitors; polycyclic amide; polycyclic; cdk9
Prior art date: 2015-06-29

Application number

PT191657261T

Other languages

English (en)

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-06-29

Filing date

2016-06-27

Publication date

2021-12-20

2016-06-27 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2021-12-20 Publication of PT3539961T publication Critical patent/PT3539961T/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Polyesters Or Polycarbonates (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Detergent Compositions (AREA)

PT191657261T 2015-06-29 2016-06-27 Derivados de amida policíclica como inibidores de cdk9 PT3539961T (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201562185852P	2015-06-29	2015-06-29

Publications (1)

Publication Number	Publication Date
PT3539961T true PT3539961T (pt)	2021-12-20

Family

ID=56292699

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT16733459T PT3313838T (pt)	2015-06-29	2016-06-27	Derivados de amida policíclica como inibidores de cdk9
PT191657261T PT3539961T (pt)	2015-06-29	2016-06-27	Derivados de amida policíclica como inibidores de cdk9

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PT16733459T PT3313838T (pt)	2015-06-29	2016-06-27	Derivados de amida policíclica como inibidores de cdk9

Country Status (38)

Country	Link
US (4)	US9845331B2 (pt)
EP (2)	EP3313838B1 (pt)
JP (1)	JP6997627B2 (pt)
KR (1)	KR102663113B1 (pt)
CN (1)	CN107873028B (pt)
AR (1)	AR105179A1 (pt)
AU (1)	AU2016286200B2 (pt)
BR (1)	BR122019013677B1 (pt)
CA (1)	CA2989499C (pt)
CL (1)	CL2017003306A1 (pt)
CO (1)	CO2017013713A2 (pt)
CR (2)	CR20170596A (pt)
CY (2)	CY1122111T1 (pt)
DK (2)	DK3539961T3 (pt)
DO (2)	DOP2017000295A (pt)
EA (1)	EA035383B1 (pt)
ES (2)	ES2902148T3 (pt)
HR (2)	HRP20190748T1 (pt)
HU (2)	HUE057343T2 (pt)
IL (1)	IL256393B (pt)
LT (2)	LT3539961T (pt)
ME (1)	ME03404B (pt)
MX (1)	MX371034B (pt)
MY (1)	MY201673A (pt)
NI (1)	NI201700174A (pt)
PE (1)	PE20180530A1 (pt)
PH (1)	PH12017502334B1 (pt)
PL (2)	PL3313838T3 (pt)
PT (2)	PT3313838T (pt)
RS (2)	RS62781B1 (pt)
SI (2)	SI3539961T1 (pt)
SM (2)	SMT201900298T1 (pt)
SV (1)	SV2017005598A (pt)
TN (1)	TN2017000486A1 (pt)
TR (1)	TR201909286T4 (pt)
TW (1)	TWI723028B (pt)
WO (1)	WO2017001354A1 (pt)
ZA (1)	ZA201800563B (pt)

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WO2019058348A1 (en)	2017-09-25	2019-03-28	Astrazeneca Ab	COMBINATION OF A BTK INHIBITOR AND A CDK9 INHIBITOR TO TREAT CANCER
WO2019074748A1 (en) *	2017-10-09	2019-04-18	Merck Sharp & Dohme Corp.	NOVEL SUBSTITUTED PHENYL-OXETANE AND PHENYLTETRAHYDROFURAN COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE (IDO)
CN108129288B (zh) *	2017-12-27	2021-01-22	上海毕得医药科技股份有限公司	一种反式-3-羟基环丁基甲酸的合成方法
TWI810397B (zh)	2018-11-14	2023-08-01	瑞典商阿斯特捷利康公司	治療癌症之方法
CN114008046B (zh) *	2019-06-27	2023-08-18	南京明德新药研发有限公司	作为cdk9抑制剂的氮杂吲哚连吡唑类化合物
WO2021050824A1 (en)	2019-09-11	2021-03-18	Prelude Therapeutics Incorporated	Cdk inhibitors and their use as pharmaceuticals
EP4074699A4 (en) *	2019-12-09	2024-01-03	CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.	COMPOUND USEFUL AS CYCLIN-DEPENDENT KINASE 9 INHIBITOR AND USE THEREOF
EP4140997A4 (en) *	2020-05-12	2023-09-06	Suzhou Alphama Biotechnology Co., Ltd.	PYRIDINE ACETAMIDE DERIVATIVE AS CDK INHIBITOR, PREPARATION METHOD AND USE THEREOF
EP4141004A4 (en) *	2020-05-12	2023-08-23	Suzhou Alphama Biotechnology Co., Ltd.	POLYCYCLIC AMIDE DERIVATIVE SERVING AS A CDK9 INHIBITOR, METHOD FOR PREPARING IT AND ITS USE
EP4171654A1 (en)	2020-06-24	2023-05-03	AstraZeneca UK Limited	Combination of antibody-drug conjugate and cdk9 inhibitor
US20230271942A1 (en)	2020-08-07	2023-08-31	Pharmablock Sciences (Nanjing), Inc.	Cdk9 inhibitor and use thereof
TWI809330B (zh) *	2020-11-20	2023-07-21	大陸商勁方醫藥科技(上海)有限公司	Cdk9抑制劑的多晶型物及其製法和用途
WO2022247785A1 (zh) *	2021-05-24	2022-12-01	石药集团中奇制药技术（石家庄）有限公司	一种周期蛋白依赖性激酶9抑制剂的用途
CN115381824B (zh) *	2021-05-24	2024-11-05	石药集团中奇制药技术（石家庄）有限公司	周期蛋白依赖性激酶9抑制剂的用途
CN117813289A (zh) *	2021-07-14	2024-04-02	上海海雁医药科技有限公司	吡唑衍生物及其中间体和制备方法
CN115703738B (zh) *	2021-08-16	2024-06-21	中国科学院上海药物研究所	含2-芳杂环取代的脲类化合物、其制备方法和用途
JP2025501773A (ja) *	2021-12-23	2025-01-23	ザ・カトリック・ユニヴェルシテイト・ルーバン	Ｙａｐ／ｔａｚ－ｔｅａｄを阻害するためのテトラヒドロピラゾロピリミジン及び関連類似体
JP2025528223A (ja)	2022-08-17	2025-08-26	コリアリサーチインスティテュートオブケミカルテクノロジー	Ｃｄｋ２及び／又はｃｄｋ９の抑制又は分解用化合物及びこれらの医薬用途
CN117659022A (zh) *	2022-09-06	2024-03-08	苏州阿尔脉生物科技有限公司	脲基取代吡啶类化合物、包含其的药物组合物及其医药用途
US20240360075A1 (en) *	2023-04-19	2024-10-31	Alcon Inc.	N-substituted c6 cyclyl carboxamide compounds and uses thereof
WO2025076115A1 (en) *	2023-10-02	2025-04-10	Prelude Therapeutics Incorporated	Cdk inhibitors and their use as pharmaceuticals

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2016
- 2016-06-27 SI SI201631427T patent/SI3539961T1/sl unknown
- 2016-06-27 CR CR20170596A patent/CR20170596A/es unknown
- 2016-06-27 JP JP2017567737A patent/JP6997627B2/ja active Active
- 2016-06-27 TR TR2019/09286T patent/TR201909286T4/tr unknown
- 2016-06-27 PE PE2017002874A patent/PE20180530A1/es unknown
- 2016-06-27 HR HRP20190748TT patent/HRP20190748T1/hr unknown
- 2016-06-27 SI SI201630247T patent/SI3313838T1/sl unknown
- 2016-06-27 LT LTEP19165726.1T patent/LT3539961T/lt unknown
- 2016-06-27 RS RS20220005A patent/RS62781B1/sr unknown
- 2016-06-27 LT LTEP16733459.8T patent/LT3313838T/lt unknown
- 2016-06-27 PL PL16733459T patent/PL3313838T3/pl unknown
- 2016-06-27 ES ES19165726T patent/ES2902148T3/es active Active
- 2016-06-27 PH PH1/2017/502334A patent/PH12017502334B1/en unknown
- 2016-06-27 HR HRP20211970TT patent/HRP20211970T1/hr unknown
- 2016-06-27 HU HUE19165726A patent/HUE057343T2/hu unknown
- 2016-06-27 PT PT16733459T patent/PT3313838T/pt unknown
- 2016-06-27 PL PL19165726T patent/PL3539961T3/pl unknown
- 2016-06-27 SM SM20190298T patent/SMT201900298T1/it unknown
- 2016-06-27 HU HUE16733459A patent/HUE043440T2/hu unknown
- 2016-06-27 MX MX2017016244A patent/MX371034B/es active IP Right Grant
- 2016-06-27 ES ES16733459T patent/ES2728356T3/es active Active
- 2016-06-27 CA CA2989499A patent/CA2989499C/en active Active
- 2016-06-27 SM SM20220005T patent/SMT202200005T1/it unknown
- 2016-06-27 TN TNP/2017/000486A patent/TN2017000486A1/en unknown
- 2016-06-27 EP EP16733459.8A patent/EP3313838B1/en active Active
- 2016-06-27 KR KR1020187002262A patent/KR102663113B1/ko active Active
- 2016-06-27 BR BR122019013677-7A patent/BR122019013677B1/pt active IP Right Grant
- 2016-06-27 ME MEP-2019-138A patent/ME03404B/me unknown
- 2016-06-27 WO PCT/EP2016/064899 patent/WO2017001354A1/en not_active Ceased
- 2016-06-27 CN CN201680029447.9A patent/CN107873028B/zh active Active
- 2016-06-27 EA EA201890094A patent/EA035383B1/ru not_active IP Right Cessation
- 2016-06-27 DK DK19165726.1T patent/DK3539961T3/da active
- 2016-06-27 EP EP19165726.1A patent/EP3539961B1/en active Active
- 2016-06-27 PT PT191657261T patent/PT3539961T/pt unknown
- 2016-06-27 US US15/193,826 patent/US9845331B2/en active Active
- 2016-06-27 MY MYPI2017705054A patent/MY201673A/en unknown
- 2016-06-27 CR CR20210297A patent/CR20210297A/es unknown
- 2016-06-27 RS RS20190564A patent/RS58712B1/sr unknown
- 2016-06-27 AU AU2016286200A patent/AU2016286200B2/en active Active
- 2016-06-27 DK DK16733459.8T patent/DK3313838T3/da active
- 2016-06-28 TW TW105120362A patent/TWI723028B/zh active
- 2016-06-28 AR ARP160101956A patent/AR105179A1/es unknown
2017
- 2017-12-06 US US15/833,277 patent/US10717746B2/en active Active
- 2017-12-12 DO DO2017000295A patent/DOP2017000295A/es unknown
- 2017-12-18 IL IL256393A patent/IL256393B/en unknown
- 2017-12-20 SV SV2017005598A patent/SV2017005598A/es unknown
- 2017-12-21 CL CL2017003306A patent/CL2017003306A1/es unknown
- 2017-12-22 NI NI201700174A patent/NI201700174A/es unknown
- 2017-12-28 CO CONC2017/0013713A patent/CO2017013713A2/es unknown
2018
- 2018-01-26 ZA ZA2018/00563A patent/ZA201800563B/en unknown
- 2018-09-25 DO DO2018000207A patent/DOP2018000207A/es unknown
2019
- 2019-06-19 CY CY20191100636T patent/CY1122111T1/el unknown
2020
- 2020-07-17 US US16/931,786 patent/US11352369B2/en active Active
2021
- 2021-12-22 CY CY20211101125T patent/CY1125066T1/el unknown
2022
- 2022-04-27 US US17/660,935 patent/US20220340592A1/en active Pending

Also Published As

Publication number	Publication date
ES2902148T3 (es)	2022-03-25
EP3539961B1 (en)	2021-10-06
PL3539961T3 (pl)	2022-02-14
TW201718573A (zh)	2017-06-01
AR105179A1 (es)	2017-09-13
LT3539961T (lt)	2021-12-27
DK3313838T3 (da)	2019-06-11
US20220340592A1 (en)	2022-10-27
PT3313838T (pt)	2019-06-24
US20160376287A1 (en)	2016-12-29
AU2016286200A1 (en)	2018-02-08
RS62781B1 (sr)	2022-01-31
CR20170596A (es)	2018-07-04
PL3313838T3 (pl)	2019-08-30
NI201700174A (es)	2018-10-19
ES2728356T3 (es)	2019-10-23
BR112017027394A2 (pt)	2018-11-06
CO2017013713A2 (es)	2018-03-28
DOP2017000295A (es)	2017-12-31
WO2017001354A1 (en)	2017-01-05
CA2989499C (en)	2023-10-31
CA2989499A1 (en)	2017-01-05
ZA201800563B (en)	2022-08-31
RS58712B1 (sr)	2019-06-28
CN107873028B (zh)	2021-02-02
CR20210297A (es)	2021-09-29
JP6997627B2 (ja)	2022-01-17
SI3539961T1 (sl)	2022-02-28
HRP20211970T1 (hr)	2022-03-18
DK3539961T3 (da)	2022-01-03
SI3313838T1 (sl)	2019-06-28
SV2017005598A (es)	2018-02-23
CL2017003306A1 (es)	2018-06-29
AU2016286200B2 (en)	2018-10-04
US11352369B2 (en)	2022-06-07
TR201909286T4 (tr)	2019-07-22
MY201673A (en)	2024-03-12
LT3313838T (lt)	2019-06-10
CN107873028A (zh)	2018-04-03
TN2017000486A1 (en)	2019-04-12
KR20180021830A (ko)	2018-03-05
MX371034B (es)	2020-01-13
DOP2018000207A (es)	2018-10-15
US20210171541A1 (en)	2021-06-10
BR122019013677B1 (pt)	2024-01-02
US10717746B2 (en)	2020-07-21
SMT202200005T1 (it)	2022-03-21
IL256393A (en)	2018-02-28
CY1125066T1 (el)	2023-03-24
SMT201900298T1 (it)	2019-07-11
EP3539961A1 (en)	2019-09-18
HUE043440T2 (hu)	2019-08-28
ME03404B (me)	2020-01-20
KR102663113B1 (ko)	2024-05-02
MX2017016244A (es)	2018-04-20
HRP20190748T1 (hr)	2019-06-14
US20180093998A1 (en)	2018-04-05
PE20180530A1 (es)	2018-03-19
EP3313838B1 (en)	2019-04-03
US9845331B2 (en)	2017-12-19
EA035383B1 (ru)	2020-06-04
EP3313838A1 (en)	2018-05-02
IL256393B (en)	2021-12-01
HUE057343T2 (hu)	2022-05-28
CY1122111T1 (el)	2020-11-25
EA201890094A1 (ru)	2018-07-31
JP2018522869A (ja)	2018-08-16
PH12017502334A1 (en)	2018-06-25
TWI723028B (zh)	2021-04-01
PH12017502334B1 (en)	2023-05-26

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