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PL3436461T3 - Związki pirolotriazynowe jako inhibitory tam - Google Patents

Związki pirolotriazynowe jako inhibitory tam

Info

Publication number
PL3436461T3
PL3436461T3 PL17715620.5T PL17715620T PL3436461T3 PL 3436461 T3 PL3436461 T3 PL 3436461T3 PL 17715620 T PL17715620 T PL 17715620T PL 3436461 T3 PL3436461 T3 PL 3436461T3
Authority
PL
Poland
Prior art keywords
pyrrolotriazine compounds
tam inhibitors
tam
inhibitors
pyrrolotriazine
Prior art date
Application number
PL17715620.5T
Other languages
English (en)
Inventor
Yun-Long Li
Xiaozhao Wang
Joseph Barbosa
David M. Burns
Hao Feng
Joseph Glenn
Chunhong He
Taisheng Huang
Song MEI
Jincong Zhuo
Original Assignee
Incyte Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corporation filed Critical Incyte Corporation
Publication of PL3436461T3 publication Critical patent/PL3436461T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL17715620.5T 2016-03-28 2017-03-27 Związki pirolotriazynowe jako inhibitory tam PL3436461T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662314066P 2016-03-28 2016-03-28
US201662362934P 2016-07-15 2016-07-15
US201662438750P 2016-12-23 2016-12-23
PCT/US2017/024270 WO2017172596A1 (en) 2016-03-28 2017-03-27 Pyrrolotriazine compounds as tam inhibitors

Publications (1)

Publication Number Publication Date
PL3436461T3 true PL3436461T3 (pl) 2024-03-18

Family

ID=58489114

Family Applications (1)

Application Number Title Priority Date Filing Date
PL17715620.5T PL3436461T3 (pl) 2016-03-28 2017-03-27 Związki pirolotriazynowe jako inhibitory tam

Country Status (32)

Country Link
US (5) US9981975B2 (pl)
EP (2) EP4321513A3 (pl)
JP (4) JP7034084B2 (pl)
KR (3) KR102483020B1 (pl)
CN (3) CN114456176B (pl)
AU (3) AU2017241524B2 (pl)
CA (1) CA3019145A1 (pl)
CL (1) CL2018002759A1 (pl)
CO (1) CO2018011550A2 (pl)
CR (1) CR20180516A (pl)
DK (1) DK3436461T3 (pl)
EC (3) ECSP18081153A (pl)
ES (1) ES2967866T3 (pl)
FI (1) FI3436461T3 (pl)
HR (1) HRP20231614T1 (pl)
HU (1) HUE064656T2 (pl)
IL (2) IL261957B (pl)
LT (1) LT3436461T (pl)
MD (1) MD3436461T2 (pl)
MX (1) MX2018011792A (pl)
MY (1) MY202022A (pl)
PE (1) PE20190175A1 (pl)
PH (1) PH12018502102A1 (pl)
PL (1) PL3436461T3 (pl)
PT (1) PT3436461T (pl)
RS (1) RS65129B1 (pl)
SG (2) SG10202009423QA (pl)
SI (1) SI3436461T1 (pl)
SM (1) SMT202300480T1 (pl)
TW (3) TWI876724B (pl)
UA (1) UA123785C2 (pl)
WO (1) WO2017172596A1 (pl)

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WO2017172596A1 (en) 2016-03-28 2017-10-05 Incyte Corporation Pyrrolotriazine compounds as tam inhibitors
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US12023319B2 (en) 2016-12-23 2024-07-02 Bayer Pharma Aktiengesellschaft Carboxylic acid aromatic amides
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CA3077308A1 (en) * 2017-09-27 2019-04-04 Incyte Corporation Salts of pyrrolotriazine derivatives useful as tam inhibitors
US11826363B2 (en) 2017-10-13 2023-11-28 Ono Pharmaceutical Co., Ltd. Therapeutic agent for solid cancers, which comprises Axl inhibitor as active ingredient
WO2019141202A1 (zh) * 2018-01-17 2019-07-25 南京药捷安康生物科技有限公司 Tam家族激酶/和csf1r激酶抑制剂及其用途
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CN110627796B (zh) * 2018-06-21 2022-07-12 北京越之康泰生物医药科技有限公司 含氮杂环类衍生物及其在医药上的应用
PL3813800T3 (pl) * 2018-06-29 2025-08-18 Incyte Corporation Formulacje inhibitora axl/mer
UY38349A (es) 2018-08-30 2020-03-31 Array Biopharma Inc Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met
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CN111689991B (zh) * 2019-03-13 2023-06-09 习峰 取代的杂芳基化合物及其组合物和用途
CN110156836A (zh) * 2019-06-10 2019-08-23 成家钢 一种环丙基羰基亚甲基三苯基磷的制备方法
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CN112409361B (zh) * 2019-08-23 2022-08-16 山东轩竹医药科技有限公司 Tam抑制剂及其用途
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CN113336758B (zh) * 2020-03-03 2022-08-19 北京桦冠医药科技有限公司 化合物7-碘吡咯并[2，1-f][1，2，4]三嗪-4-胺的一种新合成方法
AU2021230385A1 (en) 2020-03-06 2022-09-22 Incyte Corporation Combination therapy comprising AXL/MER and PD-1/PD-L1 inhibitors
CN111233870A (zh) * 2020-03-11 2020-06-05 中国科学技术大学 用于快速制备瑞德西韦药物中间体的方法
CN113683629B (zh) * 2020-05-18 2023-07-04 北京范恩柯尔生物科技有限公司 取代的杂芳基化合物及其组合物和用途
JP7556604B2 (ja) * 2020-07-10 2024-09-26 範恩柯爾生物科技（中山）有限公司 トリアジン系化合物およびその組成物と用途
WO2022166610A1 (zh) * 2021-02-05 2022-08-11 四川科伦博泰生物医药股份有限公司 一类哒嗪酮杂环化合物及其制备方法和用途
CN117561260A (zh) * 2021-08-12 2024-02-13 四川科伦博泰生物医药股份有限公司 一类杂环化合物及其制备方法和用途
TW202330519A (zh) * 2021-09-29 2023-08-01 香港商德琪研發有限公司 作為ｔａｍ抑制劑的吡唑并吡啶化合物
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