[go: up one dir, main page]

PL3334839T3 - Systemy i sposoby wykorzystujące czujniki reagujące na pole magnetyczne do określania informacji genetycznej - Google Patents

Systemy i sposoby wykorzystujące czujniki reagujące na pole magnetyczne do określania informacji genetycznej

Info

Publication number
PL3334839T3
PL3334839T3 PL16757119T PL16757119T PL3334839T3 PL 3334839 T3 PL3334839 T3 PL 3334839T3 PL 16757119 T PL16757119 T PL 16757119T PL 16757119 T PL16757119 T PL 16757119T PL 3334839 T3 PL3334839 T3 PL 3334839T3
Authority
PL
Poland
Prior art keywords
systems
methods
magnetic field
genetic information
field sensors
Prior art date
Application number
PL16757119T
Other languages
English (en)
Inventor
Jeffrey G. Mandell
Lisa KWOK
Original Assignee
Illumina, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina, Inc. filed Critical Illumina, Inc.
Publication of PL3334839T3 publication Critical patent/PL3334839T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/02—Measuring direction or magnitude of magnetic fields or magnetic flux
    • G01R33/06—Measuring direction or magnitude of magnetic fields or magnetic flux using galvano-magnetic devices
    • G01R33/09—Magnetoresistive devices
    • G01R33/093—Magnetoresistive devices using multilayer structures, e.g. giant magnetoresistance sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/02—Measuring direction or magnitude of magnetic fields or magnetic flux
    • G01R33/06—Measuring direction or magnitude of magnetic fields or magnetic flux using galvano-magnetic devices
    • G01R33/09—Magnetoresistive devices
    • G01R33/098—Magnetoresistive devices comprising tunnel junctions, e.g. tunnel magnetoresistance sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
    • G01R33/1276—Measuring magnetic properties of articles or specimens of solids or fluids of magnetic particles, e.g. imaging of magnetic nanoparticles
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C11/00—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor
    • G11C11/02—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using magnetic elements
    • G11C11/16—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
    • G11C11/161—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect details concerning the memory cell structure, e.g. the layers of the ferromagnetic memory cell
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/143—Magnetism, e.g. magnetic label
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/607—Detection means characterised by use of a special device being a sensor, e.g. electrode

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Electrochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Dispersion Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Computer Hardware Design (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
PL16757119T 2015-08-14 2016-08-12 Systemy i sposoby wykorzystujące czujniki reagujące na pole magnetyczne do określania informacji genetycznej PL3334839T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562205336P 2015-08-14 2015-08-14
PCT/US2016/046888 WO2017030999A1 (en) 2015-08-14 2016-08-12 Systems and methods using magnetically-responsive sensors for determining a genetic characteristic
EP16757119.9A EP3334839B1 (en) 2015-08-14 2016-08-12 Systems and methods using magnetically-responsive sensors for determining a genetic characteristic

Publications (1)

Publication Number Publication Date
PL3334839T3 true PL3334839T3 (pl) 2021-08-02

Family

ID=56800368

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16757119T PL3334839T3 (pl) 2015-08-14 2016-08-12 Systemy i sposoby wykorzystujące czujniki reagujące na pole magnetyczne do określania informacji genetycznej

Country Status (18)

Country Link
US (2) US11512348B2 (pl)
EP (2) EP3334839B1 (pl)
JP (2) JP6612421B2 (pl)
KR (1) KR102873461B1 (pl)
CN (2) CN115369155A (pl)
AU (2) AU2016308460B2 (pl)
BR (1) BR112018002173B8 (pl)
CA (1) CA2992597C (pl)
DK (1) DK3334839T3 (pl)
ES (1) ES2868195T3 (pl)
IL (2) IL295355B2 (pl)
MX (2) MX392084B (pl)
PL (1) PL3334839T3 (pl)
RU (2) RU2709986C2 (pl)
SA (1) SA518390819B1 (pl)
SG (1) SG10202106413SA (pl)
WO (1) WO2017030999A1 (pl)
ZA (1) ZA201800251B (pl)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017030999A1 (en) * 2015-08-14 2017-02-23 Illumina, Inc. Systems and methods using magnetically-responsive sensors for determining a genetic characteristic
EP4382474A3 (en) * 2017-09-01 2024-09-25 MGI Tech Co., Ltd. An injection molded microfluidic/fluidic cartridge integrated with silicon-based sensor
TWI685960B (zh) * 2018-02-03 2020-02-21 美商伊路米納有限公司 使用感測器的主動表面的結構和方法
US20220244323A9 (en) * 2018-06-01 2022-08-04 Lexmark International, Inc. Magnetic Sensor Array Device Optimizations and Hybrid Magnetic Camera
US11718870B2 (en) 2018-06-21 2023-08-08 Roche Sequencing Solutions, Inc. Tunneling junctions for sequencing
CA3106319A1 (en) * 2018-07-27 2020-01-30 Zepto Life Technology, LLC System and method for sample preparation in gmr-based detection of biomarkers
WO2020055872A1 (en) * 2018-09-14 2020-03-19 Delos Living Llc Systems and methods for air remediation
CN112955569B (zh) * 2018-10-19 2024-04-09 豪夫迈·罗氏有限公司 用于测序的电场辅助结
TWI857000B (zh) * 2019-01-29 2024-10-01 美商伊路米納有限公司 流體槽以及將複合物引入至流體槽之方法
TWI873119B (zh) * 2019-01-29 2025-02-21 美商伊路米納有限公司 流通槽及製備其之方法
CN113905822B (zh) * 2019-04-12 2023-09-22 西部数据技术公司 使用磁传感器阵列边合成边核酸测序
US11609208B2 (en) * 2019-04-12 2023-03-21 Western Digital Technologies, Inc. Devices and methods for molecule detection based on thermal stabilities of magnetic nanoparticles
US11579217B2 (en) * 2019-04-12 2023-02-14 Western Digital Technologies, Inc. Devices and methods for frequency- and phase-based detection of magnetically-labeled molecules using spin torque oscillator (STO) sensors
US11327073B2 (en) 2019-04-12 2022-05-10 Western Digital Technologies, Inc. Thermal sensor array for molecule detection and related detection schemes
US11738336B2 (en) * 2019-04-12 2023-08-29 Western Digital Technologies, Inc. Spin torque oscillator (STO) sensors used in nucleic acid sequencing arrays and detection schemes for nucleic acid sequencing
US11112468B2 (en) 2019-04-12 2021-09-07 Western Digital Technologies, Inc. Magnetoresistive sensor array for molecule detection and related detection schemes
EP3976751A4 (en) 2019-05-31 2023-01-11 Illumina, Inc. FLOW CELL WITH ONE OR MORE BARRIER PROPERTIES
US11591648B2 (en) * 2019-08-13 2023-02-28 Seagate Technology Llc Nanochannel with magnetic sensor for the detection of molecules
US11208682B2 (en) 2019-09-13 2021-12-28 Western Digital Technologies, Inc. Enhanced optical detection for nucleic acid sequencing using thermally-dependent fluorophore tags
US11747329B2 (en) 2019-11-22 2023-09-05 Western Digital Technologies, Inc. Magnetic gradient concentrator/reluctance detector for molecule detection
CN115297964A (zh) * 2020-03-10 2022-11-04 西部数据技术公司 用于核酸定序的磁性传感器阵列以及制造及使用其的方法
EP4139052A4 (en) * 2020-04-21 2023-10-18 Roche Diagnostics GmbH High-throughput nucleic acid sequencing with single-molecule sensor arrays
CN112596005A (zh) * 2020-11-18 2021-04-02 苏州德睿电力科技有限公司 一种基于磁流体的fp磁场传感器及磁场测试系统
WO2022182631A1 (en) 2021-02-26 2022-09-01 NearField Atomics Inc. Systems and methods to keep drivers, pilots, or others alert or focused by electromagnetic delivery of signals
WO2022203904A1 (en) * 2021-03-22 2022-09-29 NearField Atomics Inc. Systems and methods for measuring magnetic fields from solvated target molecules using a magnetoresistive sensor
CN116368240A (zh) * 2021-10-29 2023-06-30 京东方科技集团股份有限公司 检测芯片及其制备方法
US20230243778A1 (en) * 2022-01-28 2023-08-03 Western Digital Technologies, Inc. Self-aligned surface modification for magnetochemical sensors
US20240125687A1 (en) * 2022-10-13 2024-04-18 Western Digital Technologies, Inc. Sensitivity amplification techniques for magnetochemical sensors
TWI839944B (zh) * 2022-11-09 2024-04-21 財團法人工業技術研究院 兆赫波檢測晶片及兆赫波量測系統

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0450060A1 (en) 1989-10-26 1991-10-09 Sri International Dna sequencing
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
JP2002503954A (ja) 1997-04-01 2002-02-05 グラクソ、グループ、リミテッド 核酸増幅法
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
US6565727B1 (en) 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US7001792B2 (en) 2000-04-24 2006-02-21 Eagle Research & Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
CN101525660A (zh) 2000-07-07 2009-09-09 维西根生物技术公司 实时序列测定
US8529743B2 (en) 2000-07-25 2013-09-10 The Regents Of The University Of California Electrowetting-driven micropumping
US6773566B2 (en) 2000-08-31 2004-08-10 Nanolytics, Inc. Electrostatic actuators for microfluidics and methods for using same
EP1354064A2 (en) 2000-12-01 2003-10-22 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
AU2002359508A1 (en) 2001-11-26 2003-06-10 Keck Graduate Institute Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
FR2841063B1 (fr) 2002-06-18 2004-09-17 Commissariat Energie Atomique Dispositif de deplacement de petits volumes de liquide le long d'un micro-catenaire par des forces electrostatiques
EP3795577A1 (en) 2002-08-23 2021-03-24 Illumina Cambridge Limited Modified nucleotides
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
US7547380B2 (en) 2003-01-13 2009-06-16 North Carolina State University Droplet transportation devices and methods having a fluid surface
GB0321306D0 (en) 2003-09-11 2003-10-15 Solexa Ltd Modified polymerases for improved incorporation of nucleotide analogues
AU2004283721B2 (en) 2003-10-24 2009-08-13 Adhesives Research, Inc. Rapidly disintegrating film
CN100478075C (zh) 2003-11-17 2009-04-15 皇家飞利浦电子股份有限公司 用于操纵流体实体的系统
US20050136408A1 (en) * 2003-12-19 2005-06-23 May Tom-Moy Methods and systems for characterizing a polymer
EP3175914A1 (en) 2004-01-07 2017-06-07 Illumina Cambridge Limited Improvements in or relating to molecular arrays
FR2866493B1 (fr) 2004-02-16 2010-08-20 Commissariat Energie Atomique Dispositif de controle du deplacement d'une goutte entre deux ou plusieurs substrats solides
JP2005315678A (ja) * 2004-04-28 2005-11-10 Canon Inc 検出方法、検出デバイス及び検出用キット
FR2872715B1 (fr) 2004-07-08 2006-11-17 Commissariat Energie Atomique Microreacteur goutte
FR2872809B1 (fr) 2004-07-09 2006-09-15 Commissariat Energie Atomique Methode d'adressage d'electrodes
JP2006058031A (ja) 2004-08-17 2006-03-02 Hitachi High-Technologies Corp 化学分析装置
US7315019B2 (en) 2004-09-17 2008-01-01 Pacific Biosciences Of California, Inc. Arrays of optical confinements and uses thereof
CA2583469C (en) * 2004-10-06 2013-03-19 Research Foundation Of State University Of New York High flux and low fouling filtration media
EP1828412B2 (en) 2004-12-13 2019-01-09 Illumina Cambridge Limited Improved method of nucleotide detection
US7458661B2 (en) 2005-01-25 2008-12-02 The Regents Of The University Of California Method and apparatus for promoting the complete transfer of liquid drops from a nozzle
DK1859330T3 (da) 2005-01-28 2012-10-15 Univ Duke Apparater og fremgangsmåder til håndtering af små dråber på et trykt kredsløbskort
US8623628B2 (en) 2005-05-10 2014-01-07 Illumina, Inc. Polymerases
GB0514936D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Preparation of templates for nucleic acid sequencing
US20070023292A1 (en) 2005-07-26 2007-02-01 The Regents Of The University Of California Small object moving on printed circuit board
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
EP3722409A1 (en) 2006-03-31 2020-10-14 Illumina, Inc. Systems and devices for sequence by synthesis analysis
WO2010027894A2 (en) 2008-08-27 2010-03-11 Advanced Liquid Logic, Inc. Droplet actuators, modified fluids and methods
CA2680061C (en) 2006-04-18 2015-10-13 Duke University Droplet-based biochemistry
US8128798B2 (en) 2006-07-10 2012-03-06 Hitachi High-Technologies Corporation Liquid transfer device
WO2008042067A2 (en) 2006-09-28 2008-04-10 Illumina, Inc. Compositions and methods for nucleotide sequencing
WO2008051530A2 (en) 2006-10-23 2008-05-02 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
US9266076B2 (en) 2006-11-02 2016-02-23 The Regents Of The University Of California Method and apparatus for real-time feedback control of electrical manipulation of droplets on chip
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
EP4134667B1 (en) 2006-12-14 2025-11-12 Life Technologies Corporation Apparatus for measuring analytes using fet arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US20080153135A1 (en) * 2006-12-20 2008-06-26 Liu Timothy Z Methods and apparatus for conducting amplification reactions on high density hydrophilic patterned microplates
EP2570812B1 (en) 2007-02-09 2018-07-18 Advanced Liquid Logic, Inc. Method of assembling a droplet actuator assembly
EP2109774B1 (en) 2007-02-15 2018-07-04 Advanced Liquid Logic, Inc. Capacitance detection in a droplet actuator
US8093062B2 (en) 2007-03-22 2012-01-10 Theodore Winger Enzymatic assays using umbelliferone substrates with cyclodextrins in droplets in oil
CA2964611C (en) * 2007-03-28 2021-06-01 Bionano Genomics, Inc. Methods of macromolecular analysis using nanochannel arrays
US20080283414A1 (en) 2007-05-17 2008-11-20 Monroe Charles W Electrowetting devices
CN101679932A (zh) 2007-06-27 2010-03-24 数字化生物系统 用于热交换化学过程的基于数字微流体的装置
WO2009021173A1 (en) 2007-08-08 2009-02-12 Advanced Liquid Logic, Inc. Use of additives for enhancing droplet operations
CN101205560A (zh) * 2007-11-30 2008-06-25 李松 基于磁性纳米粒子与通用标签技术的高通量单核苷酸多态性检测方法
WO2009073201A2 (en) * 2007-12-04 2009-06-11 Pacific Biosciences Of California, Inc. Alternate labeling strategies for single molecule sequencing
US8173080B2 (en) 2008-02-14 2012-05-08 Illumina, Inc. Flow cells and manifolds having an electroosmotic pump
US8093064B2 (en) 2008-05-15 2012-01-10 The Regents Of The University Of California Method for using magnetic particles in droplet microfluidics
GB2461026B (en) * 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
US8921046B2 (en) * 2008-09-19 2014-12-30 Pacific Biosciences Of California, Inc. Nucleic acid sequence analysis
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
WO2010059206A2 (en) * 2008-11-19 2010-05-27 Pacific Biosciences Of California, Inc. Modular nucleotide compositions and uses therefor
EP2607496B1 (en) * 2008-12-23 2014-07-16 Illumina, Inc. Methods useful in nucleic acid sequencing protocols
KR101120520B1 (ko) * 2009-04-15 2012-03-09 임현우 소수성과 친수성 표면을 이용한 생체분자 분석용 고감도 어레이 칩 및 이의 제조방법
WO2011002957A2 (en) 2009-07-01 2011-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
US11225655B2 (en) * 2010-04-16 2022-01-18 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
US8865078B2 (en) * 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
EP2633069B1 (en) * 2010-10-26 2015-07-01 Illumina, Inc. Sequencing methods
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
CA2859660C (en) 2011-09-23 2021-02-09 Illumina, Inc. Methods and compositions for nucleic acid sequencing
US10378051B2 (en) 2011-09-29 2019-08-13 Illumina Cambridge Limited Continuous extension and deblocking in reactions for nucleic acids synthesis and sequencing
US9864846B2 (en) * 2012-01-31 2018-01-09 Life Technologies Corporation Methods and computer program products for compression of sequencing data
WO2013117595A2 (en) 2012-02-07 2013-08-15 Illumina Cambridge Limited Targeted enrichment and amplification of nucleic acids on a support
NO2694769T3 (pl) 2012-03-06 2018-03-03
JP6159391B2 (ja) 2012-04-03 2017-07-05 イラミーナ インコーポレーテッド 核酸シークエンシングに有用な統合化した読取りヘッド及び流体カートリッジ
US8906320B1 (en) 2012-04-16 2014-12-09 Illumina, Inc. Biosensors for biological or chemical analysis and systems and methods for same
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
EP2969212A1 (en) 2013-03-15 2016-01-20 Illumina, Inc. System and method for generating or analyzing a biological sample
CA3009218C (en) 2013-08-08 2020-10-27 Illumina, Inc. Fluidic system for reagent delivery to a flow cell
JP2016539343A (ja) 2013-08-30 2016-12-15 イルミナ インコーポレイテッド 親水性または斑状親水性表面上の液滴の操作
RU2539038C1 (ru) * 2013-11-02 2015-01-10 Общество с ограниченной ответственностью "Гамма" Способ секвенирования днк и устройство для его осуществления (варианты)
DK3080585T3 (da) 2013-12-10 2024-02-05 Illumina Inc Biosensorer til biologisk eller kemisk analyse og fremgangsmåder til fremstilling heraf
WO2015089238A1 (en) 2013-12-11 2015-06-18 Genapsys, Inc. Systems and methods for biological analysis and computation
WO2017030999A1 (en) * 2015-08-14 2017-02-23 Illumina, Inc. Systems and methods using magnetically-responsive sensors for determining a genetic characteristic

Also Published As

Publication number Publication date
US20180237850A1 (en) 2018-08-23
RU2018101293A3 (pl) 2019-09-16
ZA201800251B (en) 2020-08-26
WO2017030999A1 (en) 2017-02-23
EP3334839A1 (en) 2018-06-20
JP7005574B2 (ja) 2022-01-21
CN108138229A (zh) 2018-06-08
EP3854884A1 (en) 2021-07-28
IL295355B1 (en) 2023-07-01
JP2020042032A (ja) 2020-03-19
US11512348B2 (en) 2022-11-29
IL257087A (en) 2018-03-29
KR20180040669A (ko) 2018-04-20
IL257087B (en) 2022-10-01
BR112018002173B1 (pt) 2024-01-23
KR102873461B1 (ko) 2025-10-17
IL295355B2 (en) 2023-11-01
IL295355A (en) 2022-10-01
RU2018101293A (ru) 2019-09-16
ES2868195T3 (es) 2021-10-21
HK1256012A1 (zh) 2019-09-13
CN108138229B (zh) 2022-07-26
SA518390819B1 (ar) 2021-03-29
JP2018525980A (ja) 2018-09-13
AU2016308460B2 (en) 2020-02-06
RU2019141935A (ru) 2020-01-27
MX392084B (es) 2025-03-21
RU2709986C2 (ru) 2019-12-23
EP3334839B1 (en) 2021-03-03
MX2022000723A (es) 2022-02-24
BR112018002173A2 (en) 2018-11-06
AU2016308460A1 (en) 2018-02-08
CA2992597C (en) 2024-03-05
IL257087B2 (en) 2023-02-01
CA2992597A1 (en) 2017-02-23
AU2020202303A1 (en) 2020-04-23
BR112018002173B8 (pt) 2024-01-23
US20230082589A1 (en) 2023-03-16
JP6612421B2 (ja) 2019-11-27
AU2020202303B2 (en) 2022-10-13
DK3334839T3 (da) 2021-04-26
SG10202106413SA (en) 2021-07-29
CN115369155A (zh) 2022-11-22
MX2018001829A (es) 2018-05-28

Similar Documents

Publication Publication Date Title
PL3334839T3 (pl) Systemy i sposoby wykorzystujące czujniki reagujące na pole magnetyczne do określania informacji genetycznej
IL271580B (en) Vaporization device systems and methods
EP3473770A4 (en) MAGNETIC MARKER AND MARKER SYSTEM
BR112015027522A2 (pt) sistema e método de publicidade
DK3027204T3 (da) Flerdelte signaleringsproteiner og anvendelser deraf
HRP20181330T1 (hr) Sustav za optičku navigaciju i pozicioniranje
BR112017001794A2 (pt) sistema de refrigeração magnética com fluxos de entrada e saída separados
EP3003919C0 (en) ORDER DELIVERY SYSTEM
BR112015017386A2 (pt) sistema de orientação e vigilância de tráfego
BR112015029662A2 (pt) sistema, e método
SG11201509036QA (en) Coordinates information providing system and read information management system
DK2943423T3 (da) Modultransportsystemer og -fremgangsmåder
EP3731149A4 (en) MAGNETIC MARKER AND SYSTEM WITH MAGNETIC MARKER
BR112013012585A2 (pt) sistema multibarreira empilhável e método
SG10201913601UA (en) Magnetic marker and magnetic marker detection system
BR112016015132A2 (pt) Métodos e sistemas para amplificação de ácido nucleico
DK2978535T3 (da) Magnet og enhed til magnetisk tæthedsseparation
HRP20181358T1 (hr) Genetički markeri za predviđanje stupnja odgovora na terapiju
EP3060682C0 (en) GENETIC MARKERS AND THEIR USES
EP3367396A4 (en) MAGNETIC MARKER AND SYSTEM FOR DETECTING A MAGNETIC MARKER
FI20126284A7 (fi) Valvontajärjestelmä ja -menetelmä
ITMI20131584A1 (it) Sistema di controllo di contraffazione
EP3552321A4 (en) DISTRIBUTION OF SYSTEM INFORMATION
DE112014002718T8 (de) Führungssystem
EP2955934A4 (en) GAIN SYSTEM