[go: up one dir, main page]

FR2872715B1 - Microreacteur goutte - Google Patents

Microreacteur goutte

Info

Publication number
FR2872715B1
FR2872715B1 FR0407623A FR0407623A FR2872715B1 FR 2872715 B1 FR2872715 B1 FR 2872715B1 FR 0407623 A FR0407623 A FR 0407623A FR 0407623 A FR0407623 A FR 0407623A FR 2872715 B1 FR2872715 B1 FR 2872715B1
Authority
FR
France
Prior art keywords
microreactor
drop
microreactor drop
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0407623A
Other languages
English (en)
Other versions
FR2872715A1 (fr
Inventor
Gilles Marchand
Francoise Vinet
Guillaume Delapierre
Fatima Hassine
Said Gmouh
Michel Vaultier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Centre National de la Recherche Scientifique CNRS
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Commissariat a lEnergie Atomique CEA filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR0407623A priority Critical patent/FR2872715B1/fr
Priority to EP05790710A priority patent/EP1771244A1/fr
Priority to US11/631,554 priority patent/US20080124252A1/en
Priority to JP2007519852A priority patent/JP2008505747A/ja
Priority to PCT/FR2005/050544 priority patent/WO2006018560A1/fr
Publication of FR2872715A1 publication Critical patent/FR2872715A1/fr
Application granted granted Critical
Publication of FR2872715B1 publication Critical patent/FR2872715B1/fr
Priority to US14/270,799 priority patent/US20140322767A1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/18Ring systems of four or more rings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers
    • B01F33/302Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers
    • B01F33/3031Micromixers using electro-hydrodynamic [EHD] or electro-kinetic [EKI] phenomena to mix or move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J14/00Chemical processes in general for reacting liquids with liquids; Apparatus specially adapted therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093Microreactors, e.g. miniaturised or microfabricated reactors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01Preparation of ethers
    • C07C41/14Preparation of ethers by exchange of organic parts on the ether-oxygen for other organic parts, e.g. by trans-etherification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10Nitrogen as only ring hetero atom
    • C12P17/12Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/089Virtual walls for guiding liquids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406Moving fluids with specific forces or mechanical means specific forces capillary forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427Electrowetting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027General features of the devices
    • G01N2035/1034Transferring microquantities of liquid
    • G01N2035/1046Levitated, suspended drops

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
FR0407623A 2004-07-08 2004-07-08 Microreacteur goutte Expired - Fee Related FR2872715B1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR0407623A FR2872715B1 (fr) 2004-07-08 2004-07-08 Microreacteur goutte
EP05790710A EP1771244A1 (fr) 2004-07-08 2005-07-05 Microreacteur goutte
US11/631,554 US20080124252A1 (en) 2004-07-08 2005-07-05 Droplet Microreactor
JP2007519852A JP2008505747A (ja) 2004-07-08 2005-07-05 液滴マイクロリアクター
PCT/FR2005/050544 WO2006018560A1 (fr) 2004-07-08 2005-07-05 Microreacteur goutte
US14/270,799 US20140322767A1 (en) 2004-07-08 2014-05-06 Droplet microreactor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0407623A FR2872715B1 (fr) 2004-07-08 2004-07-08 Microreacteur goutte

Publications (2)

Publication Number Publication Date
FR2872715A1 FR2872715A1 (fr) 2006-01-13
FR2872715B1 true FR2872715B1 (fr) 2006-11-17

Family

ID=34946983

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0407623A Expired - Fee Related FR2872715B1 (fr) 2004-07-08 2004-07-08 Microreacteur goutte

Country Status (5)

Country Link
US (2) US20080124252A1 (fr)
EP (1) EP1771244A1 (fr)
JP (1) JP2008505747A (fr)
FR (1) FR2872715B1 (fr)
WO (1) WO2006018560A1 (fr)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1859330T3 (da) 2005-01-28 2012-10-15 Univ Duke Apparater og fremgangsmåder til håndtering af små dråber på et trykt kredsløbskort
EP1885885A4 (fr) 2005-05-11 2008-08-27 Nanolytics Inc Procédé ou dispositif pour conduire des réactions chimiques ou biochimiques à des températures multiples
JP5089116B2 (ja) * 2005-09-21 2012-12-05 國立清華大学 レンズ装置
US20140193807A1 (en) 2006-04-18 2014-07-10 Advanced Liquid Logic, Inc. Bead manipulation techniques
US9476856B2 (en) 2006-04-13 2016-10-25 Advanced Liquid Logic, Inc. Droplet-based affinity assays
US8980198B2 (en) * 2006-04-18 2015-03-17 Advanced Liquid Logic, Inc. Filler fluids for droplet operations
WO2007123908A2 (fr) 2006-04-18 2007-11-01 Advanced Liquid Logic, Inc. Opérations en puits multiples à base de gouttelettes
US7851184B2 (en) 2006-04-18 2010-12-14 Advanced Liquid Logic, Inc. Droplet-based nucleic acid amplification method and apparatus
US8809068B2 (en) 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
US7901947B2 (en) 2006-04-18 2011-03-08 Advanced Liquid Logic, Inc. Droplet-based particle sorting
US10078078B2 (en) 2006-04-18 2018-09-18 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US7439014B2 (en) 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US8637324B2 (en) 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US8658111B2 (en) 2006-04-18 2014-02-25 Advanced Liquid Logic, Inc. Droplet actuators, modified fluids and methods
US8716015B2 (en) 2006-04-18 2014-05-06 Advanced Liquid Logic, Inc. Manipulation of cells on a droplet actuator
US9675972B2 (en) 2006-05-09 2017-06-13 Advanced Liquid Logic, Inc. Method of concentrating beads in a droplet
FR2901884B1 (fr) * 2006-05-31 2008-09-05 Commissariat Energie Atomique Procede, dispositif et systeme de microanalyse d'ions
CN100542663C (zh) * 2006-12-22 2009-09-23 中国科学院过程工程研究所 一种永磁体旋转搅拌装置
US8685344B2 (en) * 2007-01-22 2014-04-01 Advanced Liquid Logic, Inc. Surface assisted fluid loading and droplet dispensing
EP2570812B1 (fr) 2007-02-09 2018-07-18 Advanced Liquid Logic, Inc. Procédé d'assemblage d'un dispositif actionneurs de gouttelettes
EP2109774B1 (fr) 2007-02-15 2018-07-04 Advanced Liquid Logic, Inc. Détection de capacité sur un actuateur goutte
WO2011084703A2 (fr) 2009-12-21 2011-07-14 Advanced Liquid Logic, Inc. Analyses d'enzymes sur un diffuseur à gouttelettes
EP2126038B1 (fr) 2007-03-22 2015-01-07 Advanced Liquid Logic, Inc. Essais enzymatique pour actionneur à gouttelettes
WO2008124846A2 (fr) * 2007-04-10 2008-10-16 Advanced Liquid Logic, Inc. Dispositif de distribution de gouttelettes et procédés
WO2009002920A1 (fr) 2007-06-22 2008-12-31 Advanced Liquid Logic, Inc. Amplification d'acide nucléique à base de gouttelette dans un gradient de température
US8591830B2 (en) * 2007-08-24 2013-11-26 Advanced Liquid Logic, Inc. Bead manipulations on a droplet actuator
US8702938B2 (en) 2007-09-04 2014-04-22 Advanced Liquid Logic, Inc. Droplet actuator with improved top substrate
US20100236928A1 (en) * 2007-10-17 2010-09-23 Advanced Liquid Logic, Inc. Multiplexed Detection Schemes for a Droplet Actuator
US8460528B2 (en) * 2007-10-17 2013-06-11 Advanced Liquid Logic Inc. Reagent storage and reconstitution for a droplet actuator
US9631244B2 (en) 2007-10-17 2017-04-25 Advanced Liquid Logic, Inc. Reagent storage on a droplet actuator
US20100236929A1 (en) * 2007-10-18 2010-09-23 Advanced Liquid Logic, Inc. Droplet Actuators, Systems and Methods
EP2232535A4 (fr) * 2007-12-10 2016-04-13 Advanced Liquid Logic Inc Configurations d'actionneur de gouttelette et procédés
CA2709928A1 (fr) 2007-12-23 2009-07-09 Advanced Liquid Logic, Inc. Configurations d'actionneur de formation de gouttelettes, et procedes de realisation d'operations de formation de gouttelettes
US8852952B2 (en) 2008-05-03 2014-10-07 Advanced Liquid Logic, Inc. Method of loading a droplet actuator
US20110097763A1 (en) * 2008-05-13 2011-04-28 Advanced Liquid Logic, Inc. Thermal Cycling Method
US8093064B2 (en) * 2008-05-15 2012-01-10 The Regents Of The University Of California Method for using magnetic particles in droplet microfluidics
EP2286228B1 (fr) * 2008-05-16 2019-04-03 Advanced Liquid Logic, Inc. Dispositifs et procédés actionneurs de gouttelettes pour manipuler des billes
US8877512B2 (en) * 2009-01-23 2014-11-04 Advanced Liquid Logic, Inc. Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator
US8926065B2 (en) 2009-08-14 2015-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
US8846414B2 (en) 2009-09-29 2014-09-30 Advanced Liquid Logic, Inc. Detection of cardiac markers on a droplet actuator
US9005544B2 (en) * 2009-10-15 2015-04-14 The Regents Of The University Of California Digital microfluidic platform for radiochemistry
US9091649B2 (en) 2009-11-06 2015-07-28 Advanced Liquid Logic, Inc. Integrated droplet actuator for gel; electrophoresis and molecular analysis
CA2781598C (fr) * 2009-11-23 2020-06-02 Bayer Cropscience N.V. Plantes de soja tolerant un herbicide et leurs procedes d'identification
WO2011063411A1 (fr) * 2009-11-23 2011-05-26 Bayer Bioscience N.V. Événement élite ee-gm3 et procédés et ensembles pour identifier un tel événement dans des échantillons biologiques
PL2539450T3 (pl) 2010-02-25 2016-08-31 Advanced Liquid Logic Inc Sposób wytwarzania bibliotek kwasu nukleinowego
US8262880B2 (en) * 2010-03-09 2012-09-11 Empire Technology Development Llc Electrokinetic pumping of nonpolar solvents using ionic fluid
US9248450B2 (en) 2010-03-30 2016-02-02 Advanced Liquid Logic, Inc. Droplet operations platform
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
CA2794522C (fr) 2010-04-05 2019-11-26 Prognosys Biosciences, Inc. Tests biologiques a codage spatial
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
EP2588322B1 (fr) 2010-06-30 2015-06-17 Advanced Liquid Logic, Inc. Ensembles actionneurs à gouttelettes et leurs procédés de fabrication
EP3193180A1 (fr) 2010-11-17 2017-07-19 Advanced Liquid Logic, Inc. Détection de capacité dans un actionneur de gouttelettes
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
CN103562729A (zh) 2011-05-02 2014-02-05 先进流体逻辑公司 分子诊断平台
CA2833897C (fr) 2011-05-09 2020-05-19 Advanced Liquid Logic, Inc. Retroaction microfluidique utilisant une detection d'impedance
EP2707724A4 (fr) 2011-05-10 2015-01-21 Advanced Liquid Logic Inc Concentration d'enzymes et dosages
US8901043B2 (en) 2011-07-06 2014-12-02 Advanced Liquid Logic, Inc. Systems for and methods of hybrid pyrosequencing
US9513253B2 (en) 2011-07-11 2016-12-06 Advanced Liquid Logic, Inc. Droplet actuators and techniques for droplet-based enzymatic assays
US9446404B2 (en) 2011-07-25 2016-09-20 Advanced Liquid Logic, Inc. Droplet actuator apparatus and system
JP5823778B2 (ja) * 2011-08-29 2015-11-25 国立大学法人京都大学 媒体の加熱方法
US10731199B2 (en) 2011-11-21 2020-08-04 Advanced Liquid Logic, Inc. Glucose-6-phosphate dehydrogenase assays
US9223317B2 (en) 2012-06-14 2015-12-29 Advanced Liquid Logic, Inc. Droplet actuators that include molecular barrier coatings
BR112014032727B1 (pt) 2012-06-27 2021-12-14 Illumina France Método e sistema para realizar operações de gotícula em uma gotícula em um atuador de gotículas para redução da formação de bolhas
US9437474B2 (en) 2012-09-05 2016-09-06 Commissariat à l'énergie atomique et aux énergies alternative Method for fabricating microelectronic devices with isolation trenches partially formed under active regions
US9396984B2 (en) 2012-09-05 2016-07-19 Commissariat A L'energie Atomique Et Aux Energies Alternatives Method of producing a microelectronic device in a monocrystalline semiconductor substrate with isolation trenches partially formed under an active region
US9863913B2 (en) 2012-10-15 2018-01-09 Advanced Liquid Logic, Inc. Digital microfluidics cartridge and system for operating a flow cell
DK3511423T4 (da) 2012-10-17 2024-07-29 Spatial Transcriptomics Ab Fremgangsmåder og produkt til optimering af lokaliseret eller rumlig detektion af genekspression i en vævsprøve
US9868979B2 (en) 2013-06-25 2018-01-16 Prognosys Biosciences, Inc. Spatially encoded biological assays using a microfluidic device
CN111957453B (zh) 2013-08-13 2022-08-19 先进流体逻辑公司 使用作为流体输入的接通致动器储液器来提高液滴计量的准确度和精度的方法
JP2016539343A (ja) 2013-08-30 2016-12-15 イルミナ インコーポレイテッド 親水性または斑状親水性表面上の液滴の操作
AU2015253299B2 (en) 2014-04-29 2018-06-14 Illumina, Inc. Multiplexed single cell gene expression analysis using template switch and tagmentation
EP3204148B1 (fr) 2014-10-09 2020-07-08 Illumina, Inc. Procédé et dispositif de séparation de liquides immiscibles, permettant d'isoler efficacement au moins l'un des liquides
JP6514776B2 (ja) 2014-12-08 2019-05-15 バークレー ライツ,インコーポレイテッド 横方向/垂直方向トランジスタ構造を含むマイクロ流体デバイスならびにそれを作製および使用するプロセス
KR20240091073A (ko) 2015-02-10 2024-06-21 일루미나, 인코포레이티드 세포 성분을 분석하기 위한 방법 및 조성물
CN107847930B (zh) 2015-03-20 2020-06-30 亿明达股份有限公司 在竖直或大致竖直的位置中使用的流体盒
WO2016162309A1 (fr) 2015-04-10 2016-10-13 Spatial Transcriptomics Ab Analyse de plusieurs acides nucléiques spatialement différenciés de spécimens biologiques
WO2016172454A1 (fr) 2015-04-22 2016-10-27 Berkeley Lights, Inc. Structure cellulaire microfluidique
CA2983932C (fr) 2015-05-11 2023-07-25 Illumina, Inc. Plateforme de decouverte et d'analyse d'agents therapeutiques
US10857537B2 (en) 2015-07-06 2020-12-08 Illumina, Inc. Balanced AC modulation for driving droplet operations electrodes
WO2017030999A1 (fr) 2015-08-14 2017-02-23 Illumina, Inc. Systèmes et procédés mettant en œuvre des capteurs à sensibilité magnétique pour la détermination d'une caractéristique génétique
CA2997035A1 (fr) 2015-08-28 2017-03-09 Illumina, Inc. Analyse de sequences d'acides nucleiques provenant de cellules isolees
WO2017037078A1 (fr) 2015-09-02 2017-03-09 Illumina Cambridge Limited Systèmes et procédés d'amélioration du comportement des gouttelettes dans des systèmes fluidiques
EP3365108B1 (fr) 2015-10-22 2024-06-12 Illumina, Inc. Fluide de remplissage pour dispositifs fluidiques
US10799865B2 (en) 2015-10-27 2020-10-13 Berkeley Lights, Inc. Microfluidic apparatus having an optimized electrowetting surface and related systems and methods
WO2017095845A1 (fr) 2015-12-01 2017-06-08 Illumina, Inc. Mécanismes et procédés de stockage et de distribution de liquides
EP3384046B1 (fr) 2015-12-01 2021-04-28 Illumina, Inc. Système microfluidique numérique pour l'isolement de cellules uniques et la caractérisation d'analytes
CN109312396A (zh) 2016-04-07 2019-02-05 伊鲁米那股份有限公司 用于构建标准化核酸文库的方法和系统
CN109689213B (zh) 2016-05-26 2022-10-14 伯克利之光生命科技公司 共价修饰的表面、试剂盒及制备方法和用途
US11819782B2 (en) * 2017-04-25 2023-11-21 The University Of Akron Electrowetting coalescence device with porous layers
CN112041459B (zh) 2018-01-29 2024-09-10 圣祖德儿童研究医院 核酸扩增方法
CN113348036A (zh) 2018-11-19 2021-09-03 伯克利之光生命科技公司 具有可编程开关元件的微流体装置
US11499189B2 (en) 2019-02-14 2022-11-15 Pacific Biosciences Of California, Inc. Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes
WO2021102134A1 (fr) 2019-11-20 2021-05-27 E Ink Corporation Couches hydrophobes spatialement variables pour la microfluidique numérique
CN114945426A (zh) 2020-01-17 2022-08-26 核酸有限公司 用于数字微流体的空间可变介电层
US11946901B2 (en) 2020-01-27 2024-04-02 Nuclera Ltd Method for degassing liquid droplets by electrical actuation at higher temperatures
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
KR20220141862A (ko) 2020-02-18 2022-10-20 뉴클라 뉴클레익스 리미티드 전기습윤 장치 구동을 위한 적응형 게이트 구동
US11410621B2 (en) 2020-02-19 2022-08-09 Nuclera Nucleics Ltd. Latched transistor driving for high frequency ac driving of EWoD arrays
WO2021222061A1 (fr) 2020-04-27 2021-11-04 Nuclera Nucleics Ltd. Plaque supérieure segmentée pour entraînement variable et protection courte destinée à la microfluidique numérique
JP7479606B2 (ja) * 2020-05-19 2024-05-09 国立研究開発法人産業技術総合研究所 放射性組成物の製造方法
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
JP2023540754A (ja) 2020-09-04 2023-09-26 バービーズ インコーポレイテッド 非結合型ビリルビンのためのマイクロ流体に基づく検定評価
TW202228845A (zh) 2020-10-08 2022-08-01 英商核酸有限公司 微流體系統中試劑特異驅動ewod(介電質上電潤濕)陣列的方法
CN116635153A (zh) 2020-11-04 2023-08-22 核蛋白有限公司 用于数字微流体设备的电介质层
WO2022256514A1 (fr) 2021-06-02 2022-12-08 Baebies, Inc. Régulation thermique micro-régionale pour la microfluidique numérique
CN116550252B (zh) * 2023-05-31 2025-07-22 北京化工大学 一种基于液滴网络的微反应器及其制备方法
US20250060333A1 (en) 2023-08-16 2025-02-20 E Ink Corporation Devices, methods, and systems for visualizing electrowetting pathing using electrophoretic materials

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020010291A1 (en) * 1998-12-04 2002-01-24 Vince Murphy Ionic liquids and processes for production of high molecular weight polyisoolefins
AU2002245047A1 (en) * 2000-10-30 2002-07-24 Sequenom, Inc. Method and apparatus for delivery of submicroliter volumes onto a substrate
DE10100455A1 (de) * 2001-01-08 2002-07-11 Creavis Tech & Innovation Gmbh Neuartige Polymerbindersysteme mit ionischen Flüssigkeiten
US20030119193A1 (en) * 2001-04-25 2003-06-26 Robert Hess System and method for high throughput screening of droplets
JP4014418B2 (ja) * 2002-02-14 2007-11-28 セントラル硝子株式会社 電気化学ディバイス
US7147763B2 (en) * 2002-04-01 2006-12-12 Palo Alto Research Center Incorporated Apparatus and method for using electrostatic force to cause fluid movement
US7364647B2 (en) * 2002-07-17 2008-04-29 Eksigent Technologies Llc Laminated flow device
FR2845084B1 (fr) * 2002-09-26 2009-07-17 Centre Nat Rech Scient Compositions contenant des liquides ioniques et leurs utilisations, notamment en synthese organique

Also Published As

Publication number Publication date
US20140322767A1 (en) 2014-10-30
WO2006018560A1 (fr) 2006-02-23
US20080124252A1 (en) 2008-05-29
FR2872715A1 (fr) 2006-01-13
JP2008505747A (ja) 2008-02-28
EP1771244A1 (fr) 2007-04-11

Similar Documents

Publication Publication Date Title
FR2872715B1 (fr) Microreacteur goutte
NO20161521L (no) Antivirale forbindelser
FR2870596B1 (fr) Thermocouple multi-element
DK1778702T3 (da) Antivirale forbindelser
ATE414693T1 (de) Neuartige cis-imidazoline
NO20052027D0 (no) Katalysatorer
EP1725269A4 (fr) Radiofluoration catalytique
DE502005008168D1 (de) Pipette
EP1705025A4 (fr) Imprimante
DK1828148T3 (da) Triazolsubstituerede aminobenzophenonforbindelser
ATE404546T1 (de) Substituierte n-sulfonylaminobenzyl-2- phenoxyacetamidverbindungen
DE602004027003D1 (de) Ausziehbohle
DE602005007826D1 (de) Tintenstrahldrucker
DE602005009310D1 (de) Tintenstrahldrucker
EP1832432A4 (fr) Imprimante
FR2865904B1 (fr) Calecon remonte fesses
DE602005010026D1 (de) Tintenstrahldrucker
ATE384719T1 (de) Dioxazinyl-substituierte thienylsulfonylaminocarbonylverbindungen
SE0402103D0 (sv) Novel compounds
SE0400022D0 (sv) New compounds
SI1778702T1 (sl) Protivirusne spojine
SE0400254D0 (sv) New compounds
UA11588S (uk) Піпетка
PT103206A (pt) Novos elementos estruturais mistos gfrp-betao
UA10433S (uk) Буклетниця

Legal Events

Date Code Title Description
PLFP Fee payment

Year of fee payment: 13

ST Notification of lapse

Effective date: 20180330