PL3067067T3 - Sposoby leczenia stanów związanych z aktywacją dopełniacza zależnego od MASP-2 - Google Patents
Sposoby leczenia stanów związanych z aktywacją dopełniacza zależnego od MASP-2Info
- Publication number
- PL3067067T3 PL3067067T3 PL16164436T PL16164436T PL3067067T3 PL 3067067 T3 PL3067067 T3 PL 3067067T3 PL 16164436 T PL16164436 T PL 16164436T PL 16164436 T PL16164436 T PL 16164436T PL 3067067 T3 PL3067067 T3 PL 3067067T3
- Authority
- PL
- Poland
- Prior art keywords
- masp
- methods
- conditions associated
- complement activation
- treating conditions
- Prior art date
Links
- 230000024203 complement activation Effects 0.000 title 1
- 230000001419 dependent effect Effects 0.000 title 1
Classifications
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- C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
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- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
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- Diabetes (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Environmental Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
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- Mycology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78887606P | 2006-04-03 | 2006-04-03 | |
| US11/645,359 US7919094B2 (en) | 2004-06-10 | 2006-12-22 | Methods for treating conditions associated with MASP-2 dependent complement activation |
| EP16164436.4A EP3067067B1 (en) | 2006-04-03 | 2007-03-27 | Methods for treating conditions associated with masp-2 dependent complement activation |
| PCT/US2007/065274 WO2007117996A2 (en) | 2006-04-03 | 2007-03-27 | Methods for treating conditions associated with masp-2 dependent complement activation |
| EP07759500.7A EP2007425B1 (en) | 2006-04-03 | 2007-03-27 | Methods for treating conditions associated with masp-2 dependent complement activation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3067067T3 true PL3067067T3 (pl) | 2020-08-24 |
Family
ID=38581755
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16164436T PL3067067T3 (pl) | 2006-04-03 | 2007-03-27 | Sposoby leczenia stanów związanych z aktywacją dopełniacza zależnego od MASP-2 |
| PL07759500T PL2007425T3 (pl) | 2006-04-03 | 2007-03-27 | Sposoby leczenia stanów związanych z aktywacją dopełniacza zależną od masp-2 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07759500T PL2007425T3 (pl) | 2006-04-03 | 2007-03-27 | Sposoby leczenia stanów związanych z aktywacją dopełniacza zależną od masp-2 |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US7919094B2 (pl) |
| EP (2) | EP3067067B1 (pl) |
| JP (1) | JP5567328B2 (pl) |
| KR (1) | KR101522258B1 (pl) |
| CN (2) | CN101460195B (pl) |
| BR (1) | BRPI0709900A2 (pl) |
| CA (2) | CA2923053C (pl) |
| CY (1) | CY1125274T1 (pl) |
| DK (2) | DK2007425T3 (pl) |
| ES (2) | ES2589315T3 (pl) |
| HU (2) | HUE048745T2 (pl) |
| LT (2) | LT3067067T (pl) |
| MX (2) | MX2008011704A (pl) |
| NZ (1) | NZ597489A (pl) |
| PL (2) | PL3067067T3 (pl) |
| PT (2) | PT2007425T (pl) |
| RU (1) | RU2484097C2 (pl) |
| SI (1) | SI3067067T1 (pl) |
| WO (1) | WO2007117996A2 (pl) |
Families Citing this family (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6969601B2 (en) | 1997-04-03 | 2005-11-29 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
| US7803931B2 (en) | 2004-02-12 | 2010-09-28 | Archemix Corp. | Aptamer therapeutics useful in the treatment of complement-related disorders |
| CA3102252A1 (en) | 2004-06-10 | 2005-12-29 | Omeros Corporation | Methods for treating conditions associated with masp-2 dependent complement activation |
| US7919094B2 (en) * | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| WO2006007560A2 (en) | 2004-07-01 | 2006-01-19 | University Of Pennsylvania | Targeted protein replacement for the treatment of lysosomal storage disorders |
| US7745389B2 (en) * | 2005-02-14 | 2010-06-29 | University Of Iowa Research Foundation | Methods for treatment of age-related macular degeneration |
| US20080269730A1 (en) | 2005-04-14 | 2008-10-30 | Dotson Robert S | Ophthalmic Phototherapy Device and Associated Treatment Method |
| US20130079759A1 (en) | 2005-04-14 | 2013-03-28 | Robert S. Dotson | Ophthalmic Phototherapy Device and Associated Treatment Method |
| WO2007095154A2 (en) * | 2006-02-10 | 2007-08-23 | The Brigham And Women's Hospital, Inc. | Lectin complement pathway assays and related compositions and methods |
| SI1991275T1 (sl) * | 2006-03-08 | 2015-03-31 | Archemix Llc | Komplement vezavni aptameri in sredstva proti C5, uporabni pri zdravljenju očesnih motenj |
| ES2523640T3 (es) | 2006-06-21 | 2014-11-28 | Musc Foundation For Research Development | Direccionamiento del factor H del complemento para el tratamiento de enfermedades |
| US20110190221A1 (en) * | 2008-03-28 | 2011-08-04 | Apellis Ag | Modulation and repletion/enhancement of the complement system for treatment of trauma |
| US8445190B2 (en) | 2008-09-30 | 2013-05-21 | The Trustees Of The University Of Pennsylvania | Method of inhibiting biomaterial-induced procoagulant activity using complement inhibitors |
| EP2894166A1 (en) | 2008-11-10 | 2015-07-15 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating complement-associated disorders |
| US9291622B2 (en) | 2009-05-21 | 2016-03-22 | Apellis Pharmaceuticals, Inc. | Complement assays and uses thereof |
| HUP0900319A2 (en) * | 2009-05-25 | 2011-01-28 | Eotvos Lorand Tudomanyegyetem | New peptides, method of producing therof and use thereof |
| AU2010266127B2 (en) | 2009-07-02 | 2015-11-05 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| WO2011047346A1 (en) * | 2009-10-16 | 2011-04-21 | Omeros Corporation | Methods for treating disseminated intravascular coagulation by inhibiting masp-2 dependent complement activation |
| NZ600393A (en) | 2009-11-05 | 2014-08-29 | Alexion Cambridge Corp | Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis |
| EP2504039A4 (en) | 2009-11-25 | 2014-07-02 | Univ Loma Linda Med | HEMOSTATIC TEXTILE BASED ON CHITOSAN |
| AU2011222883B2 (en) | 2010-03-05 | 2016-05-26 | Omeros Corporation | Chimeric inhibitor molecules of complement activation |
| NZ603226A (en) | 2010-04-30 | 2015-02-27 | Alexion Pharma Inc | Anti-c5a antibodies and methods for using the antibodies |
| AU2011252864B2 (en) | 2010-05-14 | 2015-11-05 | The Regents Of The University Of Colorado, A Body Corporate | Improved complement receptor 2 (CR2) targeting groups |
| US9815890B2 (en) | 2010-06-22 | 2017-11-14 | The Regents Of The University Of Colorado, A Body Corporate | Antibodies to the C3d fragment of complement component 3 |
| HUP1000366A2 (en) * | 2010-07-13 | 2012-03-28 | Mta Enzimologiai Intezet | Novel proteins, their production process and use tereof |
| CN107661491A (zh) * | 2010-09-15 | 2018-02-06 | 赛尔戴克斯治疗公司 | 用可溶性I型补体受体(sCR1)治疗慢性肾病 |
| US9644035B2 (en) | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| BR112013025917A2 (pt) * | 2011-04-08 | 2016-12-20 | Omeros Corp | uso de um anticorpo masp-2 ou fragmento do mesmo que inibe ativação de complemento dependente de masp-2 |
| AU2015271989B2 (en) * | 2011-04-08 | 2017-09-21 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| AU2013201626B2 (en) * | 2011-04-08 | 2016-02-11 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| AU2013201779B2 (en) * | 2011-05-04 | 2016-01-07 | Omeros Corporation | Compositions for inhibiting MASP-2 dependent complement activation |
| HRP20200887T1 (hr) * | 2011-05-04 | 2020-09-04 | Omeros Corporation | Smjese za inhibiciju masp-2 ovisne aktivacije komplementa |
| ES3044832T3 (en) | 2011-06-22 | 2025-11-27 | Apellis Pharmaceuticals Inc | Methods of treating chronic disorders with complement inhibitors |
| CA2839683A1 (en) * | 2011-06-28 | 2013-01-03 | Rigshospitalet | Therapeutic targeting of ficolin-3 |
| ES2791760T3 (es) * | 2011-09-07 | 2020-11-05 | Sinai School Medicine | Ceramidasa y diferenciación celular |
| JP2015504674A (ja) * | 2012-01-11 | 2015-02-16 | アリゾナ ボード オブ リージェンツ ア ボディ コーポレート オブ ザ ステイト オブ アリゾナ アクティング フォー アンド オン ビハーフ オブ アリゾナ ステイト ユニバーシティーArizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | 神経疾患タンパク質の二重特異性抗体フラグメントおよび使用方法 |
| US20150297674A1 (en) * | 2012-03-12 | 2015-10-22 | Loma Linda University Medical Center | Substances and methods for the treatment of cerebral amyloid angiopathy related conditions or disease |
| HRP20180671T1 (hr) * | 2012-04-06 | 2018-07-13 | Omeros Corporation | Pripravci za i postupci inhibiranja masp-1 i/ili masp-3 u liječenju paroksizmalne noćne hemoglobinurije |
| HUE051020T2 (hu) | 2012-06-01 | 2021-01-28 | Icahn School Med Mount Sinai | A ceramid szintjei a fertõzések kezelésében és megelõzésében |
| ES2864857T3 (es) * | 2012-06-18 | 2021-10-14 | Omeros Corp | Composiciones y métodos para la inhibición de MASP-1 y/o MASP-2 y/o MASP-3 para el tratamiento de diversas enfermedades y trastornos |
| AU2013302441B2 (en) | 2012-08-17 | 2018-05-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for detecting complement activation |
| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| EP2912065A4 (en) | 2012-10-25 | 2016-10-19 | True North Therapeutics Inc | ANTI COMPLEMENT C1S ANTIBODIES AND USES THEREOF |
| WO2014071206A1 (en) | 2012-11-02 | 2014-05-08 | True North Therapeutics, Inc. | Anti-complement c1s antibodies and uses thereof |
| ME03043B (me) | 2013-03-14 | 2018-10-20 | Alnylam Pharmaceuticals Inc | Irnk sastavi komponente komplementa c5 i metode za njihovu upotrebu |
| JP6832158B2 (ja) | 2013-03-14 | 2021-02-24 | アイカーン スクール オブ メディシン アット マウント サイナイ | 治療用酸性セラミダーゼ組成物ならびにそれを作製および使用する方法 |
| US20140363433A1 (en) | 2013-03-15 | 2014-12-11 | Omeros Corporation | Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same |
| NZ729747A (en) | 2013-03-15 | 2020-03-27 | Omeros Corp | Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same |
| JP6505079B2 (ja) | 2013-03-29 | 2019-04-24 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 補体c5を標的とする治療薬の血清半減期を増加させるための組成物及び方法 |
| RU2549468C2 (ru) * | 2013-08-09 | 2015-04-27 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт нормальной физиологии имени П.К. Анохина" Российской академии медицинских наук (ФГБУ "НИИНФ им. П.К. Анохина" РАМН") | Способ определения стабилизации с3-конвертазы классического пути активации комплемента человека |
| RU2718850C2 (ru) | 2013-10-17 | 2020-04-15 | Омерос Корпорейшн | Способы лечения состояний, ассоциированных с masp-2-зависимой активацией комплемента |
| KR102736538B1 (ko) | 2013-12-12 | 2024-12-03 | 알닐람 파마슈티칼스 인코포레이티드 | 보체 성분 iRNA 조성물 및 이의 이용 방법 |
| NZ631007A (en) | 2014-03-07 | 2015-10-30 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
| US20150353623A1 (en) * | 2014-04-03 | 2015-12-10 | Loma Linda University | Substances and methods for the treatment of cerebral amyloid angiopathy related conditions or diseases |
| US9259357B2 (en) | 2014-04-16 | 2016-02-16 | Loma Linda University | Composition, preparation, and use of chitosan shards for biomedical applications |
| CN107072821B (zh) | 2014-09-09 | 2022-07-01 | 卢米希拉公司 | 用于损伤或患病组织的非侵入性治疗的多波长光疗装置、系统和方法 |
| EP3191591A1 (en) | 2014-09-12 | 2017-07-19 | Alnylam Pharmaceuticals, Inc. | Polynucleotide agents targeting complement component c5 and methods of use thereof |
| MX2017004742A (es) | 2014-10-20 | 2017-07-20 | Nestec Sa | Métodos para la predicción de niveles de farmacos anti-tnf alfa y formación de autoanticuerpos. |
| US11031102B2 (en) | 2014-11-17 | 2021-06-08 | Alexion Pharmaceuticals, Inc. | Risk evaluation and management strategy involving patient follow-ups relating to the use or discontinuation of a complement inhibitor |
| AU2016246452B2 (en) | 2015-04-06 | 2022-03-10 | Bioverativ Usa Inc. | Humanized anti-C1s antibodies and methods of use thereof |
| EP4365291A3 (en) | 2015-06-12 | 2024-08-14 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions and methods of use thereof |
| PH12018500745B1 (en) | 2015-10-14 | 2023-03-15 | Massachusetts Eye & Ear Infirmary | High-dose statins for age-related macular degeneration |
| US20170137537A1 (en) | 2015-11-09 | 2017-05-18 | Omeros Corporation | Methods for Treating Conditions Associated with MASP-2 Dependent Complement Activation |
| CA3010593C (en) * | 2016-01-05 | 2024-02-13 | University Of Leicester | Methods for inhibiting fibrosis in a subject in need thereof |
| AU2017240129B2 (en) * | 2016-03-31 | 2020-04-02 | Omeros Corporation | Methods for inhibiting angiogenesis in a subject in need thereof |
| KR20190005944A (ko) * | 2016-05-09 | 2019-01-16 | 애넥슨, 인코포레이티드 | 척수성 근위축 치료용 조성물 및 방법 |
| MX2018014560A (es) | 2016-05-27 | 2019-08-12 | Alexion Pharma Inc | Metodos para el tratamiento de la miastenia gravis generalizada refractaria. |
| EP3469083A1 (en) | 2016-06-10 | 2019-04-17 | Alnylam Pharmaceuticals, Inc. | COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) |
| US20190247373A1 (en) * | 2016-07-14 | 2019-08-15 | Children's Hospital Medical Center | Methods for treating fibrosis |
| JOP20170154B1 (ar) | 2016-08-01 | 2023-03-28 | Omeros Corp | تركيبات وطرق لتثبيط masp-3 لعلاج أمراض واضطرابات مختلفة |
| JOP20170170B1 (ar) | 2016-08-31 | 2022-09-15 | Omeros Corp | صيغ لجسم مضاد تثبيطية لـ masp-2 بتركيز عالي ولزوجة منخفضة وأطقم، وطرق |
| LT3525583T (lt) | 2016-10-12 | 2025-11-10 | Anti-c1s antikūnai ir jų naudojimo būdai | |
| JOP20190068A1 (ar) * | 2016-10-13 | 2019-04-01 | Omeros Corp | طرق لتقليل البول البروتيني في خاضع بشري يعاني من الاعتلال الكلوي a الناتج عن الجلوبيولين المناعي |
| BR112020001703B1 (pt) | 2017-07-27 | 2024-01-02 | Alexion Pharmaceuticals, Inc | Solução aquosa estável compreendendo um anticorpo anti-c5, método para produção desta solução, uso da mesma para tratar uma condição associada ao complemento e kit terapêutico compreendendo a mesma |
| TWI881481B (zh) | 2017-08-15 | 2025-04-21 | 美商歐米諾斯公司 | 用於治療和/或預防與造血幹細胞移植有關的移植物抗宿主病和/或瀰漫性肺泡出血和/或靜脈閉塞性病的方法 |
| CN107288615B (zh) * | 2017-08-17 | 2023-05-16 | 西南石油大学 | 一种激光固相沉积仪器及其测试方法 |
| CA3080187A1 (en) | 2017-10-26 | 2019-05-02 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) and atypical hemolytic uremic syndrome (ahus) |
| AU2018360697A1 (en) | 2017-11-01 | 2020-05-14 | Alnylam Pharmaceuticals, Inc. | Complement component C3 iRNA compositions and methods of use thereof |
| US11584714B2 (en) | 2018-05-29 | 2023-02-21 | Omeros Corporation | MASP-2 inhibitors and methods of use |
| KR20210016545A (ko) | 2018-05-29 | 2021-02-16 | 오메로스 코포레이션 | Masp-2 억제제 및 사용 방법 |
| EP3802593B1 (en) | 2018-05-31 | 2024-09-11 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) in pediatric patients |
| WO2019236345A1 (en) | 2018-06-04 | 2019-12-12 | Alexion Pharmaceuticals, Inc. | DOSAGE AND ADMINISTRATION OF ANTI-C5 ANTIBODIES FOR TREATMENT OF ATYPICAL HEMOLYTIC UREMIC SYNDROME (aHUS) IN PEDIATRIC PATIENTS |
| US12312394B2 (en) | 2018-06-28 | 2025-05-27 | Alexion Pharmaceuticals, Inc. | Methods of producing anti-C5 antibodies |
| WO2020092549A1 (en) | 2018-10-30 | 2020-05-07 | Alexion Pharmaceuticals, Inc. | Subcutaneous dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) |
| PE20220431A1 (es) | 2019-05-07 | 2022-03-29 | Bayer Ag | Compuestos inhibidores de la masp y usos de estos |
| KR102180733B1 (ko) * | 2019-07-12 | 2020-11-19 | 건국대학교 산학협력단 | 탈지우유를 유효성분으로 포함하는 줄기세포 분리용 조성물 |
| RU2732765C1 (ru) * | 2019-07-25 | 2020-09-22 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ коррекции реперфузионно-ишемического повреждения при резекции почки по поводу локализованного рака в условиях тепловой ишемии |
| EP4054634A1 (en) | 2019-11-08 | 2022-09-14 | Alexion Pharmaceuticals, Inc. | High concentration anti-c5 antibody formulations |
| JP2023503611A (ja) * | 2019-11-26 | 2023-01-31 | オメロス コーポレーション | 造血幹細胞移植に関連する特発性肺炎症候群(ips)および/または毛細血管漏出症候群(cls)および/または生着症候群(es)および/または体液過剰(fo)を治療および/または予防するための方法 |
| IL293551A (en) | 2019-12-04 | 2022-08-01 | Omeros Corp | 2-masp inhibitor compounds, preparations containing them and their uses |
| CN115103709A (zh) | 2019-12-04 | 2022-09-23 | 奥默罗斯公司 | Masp-2抑制剂和使用方法 |
| IL293588A (en) | 2019-12-04 | 2022-08-01 | Omeros Corp | 2-masp inhibitor compounds, preparations containing them and their uses |
| AU2020395306B2 (en) | 2019-12-04 | 2025-04-24 | Omeros Corporation | MASP-2 inhibitors and methods of use |
| WO2021163980A1 (zh) * | 2020-02-21 | 2021-08-26 | 中国人民解放军军事科学院军事医学研究院 | 靶向masp-2、n蛋白或其结合的物质预防和/或治疗冠状病毒感染 |
| TWI834025B (zh) | 2020-03-06 | 2024-03-01 | 美商奥默羅斯公司 | 用於治療和/或預防冠狀病毒誘導的急性呼吸窘迫症候群的抑制masp-2的方法 |
| EP4142738A1 (en) | 2020-04-30 | 2023-03-08 | Alnylam Pharmaceuticals, Inc. | Complement factor b (cfb) irna compositions and methods of use thereof |
| CN111893090B (zh) * | 2020-08-17 | 2023-10-27 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 一种动脉粥样硬化防治药物筛选细胞模型及其构建和应用 |
| EP4240750A1 (en) | 2020-11-04 | 2023-09-13 | Bayer Aktiengesellschaft | Masp inhibitory compounds and uses thereof |
| EP4011904A1 (en) | 2020-12-14 | 2022-06-15 | Bayer Aktiengesellschaft | Masp inhibitory compounds and uses thereof |
| WO2022103638A1 (en) | 2020-11-16 | 2022-05-19 | Orcosa Inc. | Cannabinoids in the treatment of autism spectrum disorder |
| US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
| CN120173119B (zh) * | 2020-12-16 | 2025-09-30 | 康诺亚生物医药科技(成都)有限公司 | 一种补体抑制剂的开发和应用 |
| WO2022150260A1 (en) | 2021-01-05 | 2022-07-14 | Alnylam Pharmaceuticals, Inc. | COMPLEMENT COMPONENT 9 (C9) iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
| KR20240000543A (ko) * | 2021-04-25 | 2024-01-02 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 항-masp2 항체, 이의 항원-결합 단편 및 이의 의학적 용도 |
| US20240415807A1 (en) * | 2021-05-26 | 2024-12-19 | Kao Corporation | Agent for preventing or ameliorating pruritus |
| CA3221859A1 (en) * | 2021-06-08 | 2022-12-15 | Xiaowu Liu | Anti-masp-2 antibody and use thereof |
| EP4401742A2 (en) | 2021-09-17 | 2024-07-24 | Alnylam Pharmaceuticals, Inc. | Irna compositions and methods for silencing complement component 3 (c3) |
| KR20240095325A (ko) | 2021-10-29 | 2024-06-25 | 알닐람 파마슈티칼스 인코포레이티드 | 보체 인자 b (cfb) irna 조성물 및 이의 사용 방법 |
| TWI892695B (zh) * | 2021-12-10 | 2025-08-01 | 美商歐米諾斯公司 | 結合masp-2的絲氨酸蛋白酶結構域的治療性抗體及其用途 |
| WO2024118840A1 (en) | 2022-11-30 | 2024-06-06 | Omeros Corporation | Fused pyrimidines as masp-2 inhibitors |
| CN120475992A (zh) * | 2022-12-29 | 2025-08-12 | 苏州创胜医药集团有限公司 | 含有治疗性抗体的药物制剂及其用途 |
| WO2025076476A2 (en) | 2023-10-06 | 2025-04-10 | Omeros Corporation | Masp-2 inhibitors and methods of use |
| WO2025092910A1 (zh) * | 2023-10-31 | 2025-05-08 | 石药集团中奇制药技术(石家庄)有限公司 | 一种抑制补体MASP2基因表达的dsRNA分子及其应用 |
| WO2025199107A1 (en) | 2024-03-19 | 2025-09-25 | Alexion Pharmaceuticals, Inc. | Risk evaluation and management strategy involving patient follow-ups relating to the use or discontinuation of a complement inhibitor |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US552157A (en) * | 1895-12-31 | Sterilizer for bandages | ||
| US4331647A (en) * | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4394370A (en) * | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4526909A (en) * | 1984-01-09 | 1985-07-02 | Regents Of The University Of California | Polymethylmethacrylate delivery system for bone morphogenetic protein |
| US4563489A (en) * | 1984-02-10 | 1986-01-07 | University Of California | Biodegradable organic polymer delivery system for bone morphogenetic protein |
| JPH0662679B2 (ja) * | 1985-06-21 | 1994-08-17 | 新田ゼラチン株式会社 | 組織親和性コラ−ゲンとその製法 |
| US5453566A (en) | 1986-03-28 | 1995-09-26 | Calgene, Inc. | Antisense regulation of gene expression in plant/cells |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| RO114469B1 (ro) | 1987-12-15 | 1999-04-30 | Gene Shears Pty Ltd | Compus oligoribonucleotidic, procedeu de preparare si metoda de inactivare |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8822492D0 (en) | 1988-09-24 | 1988-10-26 | Considine J | Apparatus for removing tumours from hollow organs of body |
| US5211657A (en) * | 1988-11-07 | 1993-05-18 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5549910A (en) | 1989-03-31 | 1996-08-27 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
| US6075181A (en) * | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP0438803B1 (en) | 1990-01-26 | 1997-03-12 | Immunomedics, Inc. | Vaccines against cancer and infectious diseases |
| JP3218637B2 (ja) * | 1990-07-26 | 2001-10-15 | 大正製薬株式会社 | 安定なリポソーム水懸濁液 |
| US5789573A (en) | 1990-08-14 | 1998-08-04 | Isis Pharmaceuticals, Inc. | Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2 |
| JP2958076B2 (ja) * | 1990-08-27 | 1999-10-06 | 株式会社ビタミン研究所 | 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法 |
| CA2103059C (en) * | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| IL108367A0 (en) | 1993-01-27 | 1994-04-12 | Hektoen Inst For Medical Resea | Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells |
| US5801154A (en) | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
| US5856121A (en) | 1994-02-24 | 1999-01-05 | Case Western Reserve University | Growth arrest homebox gene |
| US5741516A (en) | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US6492332B1 (en) | 1995-12-12 | 2002-12-10 | Omeros Corporation | Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation |
| AU4467396A (en) | 1994-12-12 | 1996-07-10 | Omeros Medical Systems, Inc. | Irrigation solution and method for inhibition of pain, inflammation and spasm |
| US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| US5738868A (en) | 1995-07-18 | 1998-04-14 | Lipogenics Ltd. | Liposome compositions and kits therefor |
| US5739119A (en) | 1996-11-15 | 1998-04-14 | Galli; Rachel L. | Antisense oligonucleotides specific for the muscarinic type 2 acetylcholine receptor MRNA |
| US6969601B2 (en) | 1997-04-03 | 2005-11-29 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
| US6297024B1 (en) * | 1998-10-15 | 2001-10-02 | Cell Activation, Inc. | Methods for assessing complement activation |
| US7273925B1 (en) | 1998-12-15 | 2007-09-25 | Brigham And Women's Hospital, Inc. | Methods and products for regulating lectin complement pathway associated complement activation |
| WO2000035483A1 (en) | 1998-12-15 | 2000-06-22 | The Brigham And Women's Hospital, Inc. | Methods and products for regulating lectin complement pathway associated complement activation |
| US6235494B1 (en) * | 1999-02-08 | 2001-05-22 | The Scripps Research Institute | Substrates for assessing mannan-binding protein-associated serine protease activity and methods using the substrates |
| PT1181363E (pt) * | 1999-05-14 | 2007-05-31 | Steffen Thiel | Lectina de ligação a manano humana recombinante. |
| DE60039301D1 (de) | 1999-07-21 | 2008-08-07 | Omeros Corp | Spüllösungen und verfahren zur schmerzhemmung, entzündungshemmung und hemmung des knorpelabbaus |
| AU781805B2 (en) | 1999-08-13 | 2005-06-16 | Brigham And Women's Hospital | Inhibitors of the lectin complement pathway (LCP) and their use |
| US6794132B2 (en) * | 1999-10-02 | 2004-09-21 | Biosite, Inc. | Human antibodies |
| AU785149B2 (en) * | 1999-12-02 | 2006-10-05 | Jens Christian Jensenius | MASP-3, a complement-fixing enzyme, and uses for it |
| US6649592B1 (en) | 2000-01-14 | 2003-11-18 | Science & Technology Corporation @ Unm | Peptide inhibitors of LFA-1/ICAM-1 interaction |
| DK1287364T3 (da) | 2000-04-29 | 2009-03-02 | Univ Iowa Res Found | Diagnostisk og terapi til makulære degenerationsrelaterede lidelser |
| SG98393A1 (en) | 2000-05-19 | 2003-09-19 | Inst Materials Research & Eng | Injectable drug delivery systems with cyclodextrin-polymer based hydrogels |
| US7112414B2 (en) * | 2000-07-13 | 2006-09-26 | Jens Christian Jensenius | Masp-2, a complement-fixing enzyme, and uses for it |
| US20020094332A1 (en) | 2001-01-18 | 2002-07-18 | Alexion Pharmaceuticals | Method of prophylaxis against large myocardial infractions |
| WO2003009803A2 (en) | 2001-07-26 | 2003-02-06 | Alexion Pharmaceuticals Inc. | Method of improving cognitive function |
| JP2006502089A (ja) | 2002-01-22 | 2006-01-19 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 広範囲の心筋梗塞に対する予防方法 |
| CA2474645C (en) | 2002-02-01 | 2011-08-09 | Omeros Corporation | Compositions and methods for systemic inhibition of cartilage degradation |
| US7538195B2 (en) * | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| US6644119B1 (en) * | 2002-06-28 | 2003-11-11 | The Regents Of The University Of California | Noninvasive characterization of a flowing multiphase fluid using ultrasonic interferometry |
| WO2004009664A2 (en) | 2002-07-19 | 2004-01-29 | Omeros Corporation | Biodegradable triblock copolymers, synthesis methods therefor, and hydrogels and biomaterials made there from |
| SI1534313T1 (sl) | 2002-07-30 | 2013-03-29 | Omeros Corporation | Oftalmološke raztopine in postopek za izpiranje |
| WO2004022096A1 (en) | 2002-09-06 | 2004-03-18 | Alexion Pharmaceuticals, Inc. | Method of treatment of asthma using antibodies to complement component c5 |
| AU2003283217A1 (en) | 2002-12-03 | 2004-06-23 | Aarhus Amt | Method for determing predisposition to manifestation of immune system related diseases |
| US7361339B2 (en) | 2003-01-09 | 2008-04-22 | Alexion Pharmaceuticals, Inc. | Methods for reducing morality associated with acute myocardial infarction |
| EP1601377A4 (en) | 2003-02-21 | 2009-07-15 | Genentech Inc | METHOD FOR THE PREVENTION AND TREATMENT OF TISSUE DAMAGE IN CONNECTION WITH ISCHEMIC REPERFUSION DAMAGE |
| AU2004221982B2 (en) * | 2003-03-17 | 2011-10-13 | Km Biologics Co., Ltd. | Construct comprising recognition domain of antibody against von Willebrand factor-specific cleaving enzyme |
| DE10324862A1 (de) * | 2003-05-05 | 2005-03-03 | Dirr, Josef, Dipl.-Ing. (FH) | Verfahren zur Verschlüsselung digitalisierter Information |
| PT2374819T (pt) | 2003-05-12 | 2017-07-04 | Helion Biotech Aps | Anticorpos para masp-2 |
| WO2005014849A2 (en) | 2003-07-03 | 2005-02-17 | Euro-Celtique, S.A. | Genes associated with responses to neuropathic pain |
| US7482376B2 (en) | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
| WO2005024013A1 (en) | 2003-09-05 | 2005-03-17 | Natimmune A/S | Masp-2 crystal structure and uses thereof |
| US20050169921A1 (en) * | 2004-02-03 | 2005-08-04 | Leonard Bell | Method of treating hemolytic disease |
| GB0412966D0 (en) * | 2004-06-10 | 2004-07-14 | Univ Leicester | Genetically modified non-human mammals and cells |
| CA3102252A1 (en) | 2004-06-10 | 2005-12-29 | Omeros Corporation | Methods for treating conditions associated with masp-2 dependent complement activation |
| WO2005123776A1 (en) * | 2004-06-10 | 2005-12-29 | Omeros Corporation | Methods for treating conditions associated with lectin-dependent complement activation |
| US7919094B2 (en) * | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| AU2005262070B2 (en) * | 2004-07-09 | 2011-01-27 | Ferrosan Medical Devices A/S | Haemostatic composition comprising hyaluronic acid |
| ATE544866T1 (de) * | 2005-06-17 | 2012-02-15 | Baxter Int | Adamts13-haltige zusammensetzungen mit thrombolytischer wirkung |
| KR20120105405A (ko) * | 2009-06-23 | 2012-09-25 | 알렉시온 파마슈티칼스, 인코포레이티드 | 보체 단백질에 결합하는 이중특이적 항체 |
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