PL2757107T3 - Sposób syntezy w fazie stałej liraglutydu - Google Patents

Sposób syntezy w fazie stałej liraglutydu

Info

Publication number: PL2757107T3
Authority: PL; Poland
Prior art keywords: liraglutide; solid phase; phase synthesis; synthesis; solid
Prior art date: 2011-09-14

Application number

PL12831927.4T

Other languages

English (en)

Inventor

Junfeng Pan

Jian Liu

Yaping Ma

Jiancheng Yuan

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-09-14

Filing date

2012-08-30

Publication date

2016-12-30

2012-08-30 Application filed filed Critical

2016-12-30 Publication of PL2757107T3 publication Critical patent/PL2757107T3/pl

Links

YSDQQAXHVYUZIW-QCIJIYAXSA-N Liraglutide Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC)C(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 YSDQQAXHVYUZIW-QCIJIYAXSA-N 0.000 title 1
108010019598 Liraglutide Proteins 0.000 title 1
229960002701 liraglutide Drugs 0.000 title 1
238000000034 method Methods 0.000 title 1
238000010532 solid phase synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/064—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Analytical Chemistry (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Peptides Or Proteins (AREA)

PL12831927.4T 2011-09-14 2012-08-30 Sposób syntezy w fazie stałej liraglutydu PL2757107T3 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CN201110271342.3A CN102286092B (zh)	2011-09-14	2011-09-14	利拉鲁肽的固相合成方法

Publications (1)

Publication Number	Publication Date
PL2757107T3 true PL2757107T3 (pl)	2016-12-30

Family

ID=45332864

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL12831927.4T PL2757107T3 (pl)	2011-09-14	2012-08-30	Sposób syntezy w fazie stałej liraglutydu

Country Status (7)

Country	Link
US (1)	US9260474B2 (pl)
EP (1)	EP2757107B1 (pl)
CN (1)	CN102286092B (pl)
DK (1)	DK2757107T3 (pl)
ES (1)	ES2592634T3 (pl)
PL (1)	PL2757107T3 (pl)
WO (1)	WO2013037266A1 (pl)

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CN103980358B (zh) *	2014-01-03	2016-08-31	杭州阿诺生物医药科技股份有限公司	一种制备利拉鲁肽的方法
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WO2016067271A1 (en)	2014-10-31	2016-05-06	Auro Peptides Ltd	A process for the preparation of liraglutide
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CN105732798B (zh) *	2015-11-03	2018-10-02	江苏诺泰澳赛诺生物制药股份有限公司	一种利拉鲁肽的合成方法
CN106928343A (zh) *	2015-12-30	2017-07-07	深圳翰宇药业股份有限公司	索玛鲁肽的制备方法
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EP3405476B1 (en)	2016-01-20	2022-05-18	Polypeptide Laboratories Holding (PPL) AB	METHOD FOR PREPARATION OF PEPTIDES WITH psWANG LINKER
EP3205664A1 (en) *	2016-02-11	2017-08-16	Polypeptide Laboratories Holding (PPL) AB	Method for preparation of liraglutide using bal linker
WO2017162650A1 (en)	2016-03-23	2017-09-28	Bachem Holding Ag	Method for preparing glucagon-like peptides
WO2018032521A1 (zh) *	2016-08-19	2018-02-22	深圳市健元医药科技有限公司	一种利拉鲁肽的合成方法
CN106478806B (zh) *	2016-10-24	2019-08-30	合肥国肽生物科技有限公司	一种索玛鲁肽的固相合成方法
MX2019006711A (es)	2016-12-10	2019-10-30	Biocon Ltd	Sintesis de liraglutida.
CN106699871B (zh) *	2016-12-27	2020-06-12	哈药集团技术中心	一种利拉鲁肽的制备方法
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CN107056927B (zh) *	2017-01-16	2021-03-02	四川吉晟生物医药有限公司	一种利拉鲁肽的制备方法
CN107417771B (zh) *	2017-05-04	2021-06-29	苏州强耀生物科技有限公司	一种法尼基修饰的半胱氨酸多肽的制备方法
CN107827973A (zh) *	2017-09-15	2018-03-23	吴忠臣	一种利拉鲁肽的固相合成方法
CN111566123A (zh)	2017-10-04	2020-08-21	佩特雷化学和生物制药学实验室有限公司	胰高血糖素样肽的制备方法
WO2019170895A1 (en) *	2018-03-09	2019-09-12	Enzypep B.V.	Chemo-enzymatic synthesis of semaglutide, liraglutide and glp-1
CN110845600B (zh) *	2018-08-21	2022-12-27	鲁南制药集团股份有限公司	一种制备利拉鲁肽的方法
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EP3897570A1 (en)	2018-12-19	2021-10-27	KRKA, d.d., Novo mesto	Pharmaceutical composition comprising glp-1 analogue
CN109836368B (zh) *	2019-03-14	2020-12-08	美药星（南京）制药有限公司	一种高纯度利拉鲁肽侧链的制备方法
TWI738260B (zh) *	2019-03-25	2021-09-01	台灣神隆股份有限公司	純化利拉魯肽之方法
WO2021007703A1 (en) *	2019-07-12	2021-01-21	Shanghai Space Peptides Pharmaceutical Co., Ltd.	A method for preparing liraglutide via a solid phase peptide synthesis
JP7598325B2 (ja) *	2019-09-25	2024-12-11	日産化学株式会社	ペプチド化合物の製造方法
EP3819308A1 (en)	2019-11-07	2021-05-12	Fresenius Kabi iPSUM S.r.l.	Process for the manufacture of derivatized amino acids
CN110835369A (zh) *	2019-12-02	2020-02-25	苏州天马医药集团天吉生物制药有限公司	一种合成利拉鲁肽的方法
WO2021123228A1 (en)	2019-12-18	2021-06-24	Krka, D.D., Novo Mesto	Pharmaceutical composition comprising glp-1 analogue
WO2021130645A1 (en) *	2019-12-23	2021-07-01	Shilpa Medicare Limited	An improved process for preparation of liraglutide
CN113135989B (zh) *	2020-01-20	2023-10-03	深圳市健元医药科技有限公司	一种制备利拉鲁肽的方法
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2011
- 2011-09-14 CN CN201110271342.3A patent/CN102286092B/zh active Active
2012
- 2012-08-30 DK DK12831927.4T patent/DK2757107T3/en active
- 2012-08-30 ES ES12831927.4T patent/ES2592634T3/es active Active
- 2012-08-30 PL PL12831927.4T patent/PL2757107T3/pl unknown
- 2012-08-30 EP EP12831927.4A patent/EP2757107B1/en active Active
- 2012-08-30 US US14/344,660 patent/US9260474B2/en active Active
- 2012-08-30 WO PCT/CN2012/080756 patent/WO2013037266A1/zh not_active Ceased

Also Published As

Publication number	Publication date
CN102286092B (zh)	2014-01-01
EP2757107A4 (en)	2015-04-22
US9260474B2 (en)	2016-02-16
EP2757107B1 (en)	2016-07-27
CN102286092A (zh)	2011-12-21
DK2757107T3 (en)	2016-09-05
EP2757107A1 (en)	2014-07-23
ES2592634T3 (es)	2016-11-30
US20140350219A1 (en)	2014-11-27
WO2013037266A1 (zh)	2013-03-21

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