[go: up one dir, main page]

SG11201506885UA - Synthesis of cyclic imide containing peptide products - Google Patents

Synthesis of cyclic imide containing peptide products

Info

Publication number
SG11201506885UA
SG11201506885UA SG11201506885UA SG11201506885UA SG11201506885UA SG 11201506885U A SG11201506885U A SG 11201506885UA SG 11201506885U A SG11201506885U A SG 11201506885UA SG 11201506885U A SG11201506885U A SG 11201506885UA SG 11201506885U A SG11201506885U A SG 11201506885UA
Authority
SG
Singapore
Prior art keywords
synthesis
containing peptide
cyclic imide
peptide products
imide containing
Prior art date
Application number
SG11201506885UA
Inventor
Bernd Henkel
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of SG11201506885UA publication Critical patent/SG11201506885UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/30—Low-molecular-weight compounds
    • C08G18/38—Low-molecular-weight compounds having heteroatoms other than oxygen
    • C08G18/3819—Low-molecular-weight compounds having heteroatoms other than oxygen having nitrogen
    • C08G18/3842—Low-molecular-weight compounds having heteroatoms other than oxygen having nitrogen containing heterocyclic rings having at least one nitrogen atom in the ring
    • C08G18/3844—Low-molecular-weight compounds having heteroatoms other than oxygen having nitrogen containing heterocyclic rings having at least one nitrogen atom in the ring containing one nitrogen atom in the ring
    • C08G18/3846—Low-molecular-weight compounds having heteroatoms other than oxygen having nitrogen containing heterocyclic rings having at least one nitrogen atom in the ring containing one nitrogen atom in the ring containing imide groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33331—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201506885UA 2013-03-21 2014-03-19 Synthesis of cyclic imide containing peptide products SG11201506885UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13160380 2013-03-21
PCT/EP2014/055511 WO2014147129A1 (en) 2013-03-21 2014-03-19 Synthesis of cyclic imide containing peptide products

Publications (1)

Publication Number Publication Date
SG11201506885UA true SG11201506885UA (en) 2015-09-29

Family

ID=47900953

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201506885UA SG11201506885UA (en) 2013-03-21 2014-03-19 Synthesis of cyclic imide containing peptide products

Country Status (11)

Country Link
US (1) US10450343B2 (en)
EP (1) EP2976325B1 (en)
CN (1) CN105102427B (en)
AU (1) AU2014234314B2 (en)
CA (1) CA2907521C (en)
DK (1) DK2976325T3 (en)
ES (1) ES2624961T3 (en)
HU (1) HUE033371T2 (en)
MX (1) MX365465B (en)
SG (1) SG11201506885UA (en)
WO (1) WO2014147129A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018032521A1 (en) * 2016-08-19 2018-02-22 深圳市健元医药科技有限公司 Method for synthesizing liraglutide

Family Cites Families (224)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3835175A (en) 1971-03-15 1974-09-10 Research Corp 9-fluorenylmethanol haloformates, carbonates and thiocarbonates
US3906031A (en) 1971-03-15 1975-09-16 Research Corp Novel 9-fluorenylmethoxycarbonyl compounds
US4108846A (en) 1977-02-01 1978-08-22 Hoffmann-La Roche Inc. Solid phase synthesis with base N alpha-protecting group cleavage
DE3542442A1 (en) 1985-11-30 1987-06-04 Hoechst Ag METHOD FOR PRODUCING PEPTIDES USING PERCHLORATES
US5175254A (en) 1988-09-24 1992-12-29 Societe D'expansion Scientifque Expansia Solid phase peptide synthesis using a polyacrylic support in aqueous solution
GB8913089D0 (en) 1989-06-07 1989-07-26 Ciba Geigy Japan Ltd Novel endothelin derivative
US5580957A (en) 1989-10-30 1996-12-03 The Salk Institute For Biological Studies GnRH analogs
US5169932A (en) 1989-10-30 1992-12-08 The Salk Institute For Biological Studies Gnrh analogs
US5352796A (en) 1989-10-30 1994-10-04 The Salk Institute For Biological Studies Amino acids useful in making GnRH analogs
US5296468A (en) 1989-10-30 1994-03-22 The Salk Institute For Biological Studies GnRH analogs
EP0445801A3 (en) 1990-03-08 1992-07-01 Kuraray Co., Ltd. Peptide and its use
IT1241395B (en) 1990-04-02 1994-01-10 Eniricerche Spa IMMUNOGENIC COMPOUNDS, THE PROCEDURE FOR THEIR SYNTHESIS AND THEIR USE FOR THE PREPARATION OF ANIMALARY VACCINES
DE4014655A1 (en) 1990-05-08 1991-11-14 Behringwerke Ag PEPTIDAMIDES, METHOD FOR THE PRODUCTION THEREOF AND METHODS CONTAINING THEM AS FIBRIN / THROMBIN COOLING INHIBITORS
TW295589B (en) 1990-08-30 1997-01-11 Hoechst Ag
US6040423A (en) 1990-08-31 2000-03-21 Gsellschaft Fur Biotechnologische Forschung Mbh (Gbf) Process for synthesis of peptides
IL101074A (en) 1991-03-14 1997-09-30 Salk Inst For Biological Studi GnRH ANALOGS AND THEIR PREPARATION
US5744450A (en) 1991-03-14 1998-04-28 The Salk Institute For Biological Studies GnRH analogs
US5576296A (en) 1991-05-15 1996-11-19 Aktiebolaget Astra Galanin antagonist
SE9101472D0 (en) 1991-05-15 1991-05-15 Trion Forskning & Utveckling GALANIN ANTAGONIST
GB9112825D0 (en) 1991-06-14 1991-07-31 Ici Plc Process for making peptides
US6028168A (en) 1991-08-09 2000-02-22 Winfried Kolbeck Lanthionine bridged peptides
DE69225597T2 (en) 1991-08-09 1998-11-26 Kolbeck, Winfried, 81247 Muenchen PEPTIDE WITH A LANTHIONIN BRIDGE
DK0604552T3 (en) 1991-09-18 1997-08-04 Affymax Tech Nv Process for the synthesis of different assemblies of oligomers
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
EP0602194A1 (en) 1991-12-18 1994-06-22 Centocor, Inc. Peptide inhibitors of inflammation mediated by selectins
BR9305435A (en) 1992-03-06 1994-12-27 Innogenetics Nv Process for determining peptides corresponding to immunologically important epitopes and their use in a process for determining biotinylated antibodies or peptides corresponding to immunologically important epitopes, process for preparing them and compositions containing them
US6667387B1 (en) 1996-09-30 2003-12-23 N.V. Innogenetics S.A. HCV core peptides
US6709828B1 (en) 1992-03-06 2004-03-23 N.V. Innogenetics S.A. Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them
JPH07507302A (en) 1992-05-28 1995-08-10 セントコー・インコーポレーテッド Peptide inhibitor of selectin binding
IE921942A1 (en) 1992-06-16 1993-12-29 Gary A Siwruk John S Eynon Liquid phase synthesis of peptides and peptide derivatives
US5516891A (en) 1992-06-16 1996-05-14 Kinerton, Ltd. Liquid phase synthesis of peptides and peptide derivatives
WO1994005314A1 (en) 1992-09-08 1994-03-17 Centocor, Inc. Peptide inhibitors of leukocyte adhesion
US5563032A (en) 1992-10-21 1996-10-08 The United States Of America As Represented By The Department Of Health And Human Services Mosaic polypeptide and methods for detecting the hepatitis E virus
US5736315A (en) 1992-10-21 1998-04-07 National Institute Of Health Methods and compositions for detecting anti-hepatitis E virus activity
US5710123A (en) 1992-12-18 1998-01-20 Centocor, Inc. Peptide inhibitors of selectin binding
DE4244565A1 (en) 1992-12-30 1994-07-07 Forssmann Wolf Georg Lymphocytoma proliferation activating peptide structure and peptide
EP0611774B1 (en) 1993-02-19 1999-05-26 F. Hoffmann-La Roche Ag Production of amides and peptides without racemization in the presence of catalytic amounts of a N-hydroxy-compound
JPH06256384A (en) 1993-02-26 1994-09-13 Shimadzu Corp Cleavage apparatus
GB9319776D0 (en) 1993-09-24 1993-11-10 Medical Res Council Azapeptide synthesis
EP0726906A4 (en) 1993-11-02 1998-10-07 Affymax Tech Nv Synthesizing and screening molecular diversity
US5503805A (en) 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
US6165778A (en) 1993-11-02 2000-12-26 Affymax Technologies N.V. Reaction vessel agitation apparatus
WO1995014787A1 (en) 1993-11-22 1995-06-01 Centocor, Inc. Peptide inhibitors of selecting binding
DE4341471A1 (en) 1993-12-02 1995-06-08 Schering Ag New small peptide(s) that inhibit tumour necrosis factor
US5502165A (en) 1994-04-04 1996-03-26 Merck & Co., Inc. Process for peptide segment condensation
US5614608A (en) 1995-01-20 1997-03-25 Selectide Corporation Apparatus and method for multiple synthesis of organic compounds on polymer support
EP0822939A1 (en) 1995-04-28 1998-02-11 Takeda Chemical Industries, Ltd. Cyclic pentapeptide lh-rh receptor antagonists
GB9511474D0 (en) 1995-06-07 1995-08-02 Ciba Geigy Ag Antiviral peptoid compounds
DE19534988A1 (en) 1995-09-21 1997-03-27 Forssmann Wolf Georg Process for the production and use of synthetic, biotinylated peptides
DE19543628A1 (en) 1995-11-24 1997-05-28 Forssmann Wolf Georg Human circulating peptide with insulinotropic activity (GCAP-II- (89-112), (guanylyl cyclase C activating peptide II) and its GCAP analogues, in particular GCAP-I- (99-115), its use as a pharmacological Active ingredient and use of its principle of action to provide new GC-C-dependent insulinotropic active ingredients
TW505654B (en) 1996-07-30 2002-10-11 Hoffmann La Roche Synthesis of analogs of PTH and PTHrP
WO1998011126A1 (en) 1996-09-09 1998-03-19 Zealand Pharmaceuticals A/S Peptide prodrugs containing an alpha-hydroxyacid linker
US7176282B1 (en) 1996-09-09 2007-02-13 Zealand Pharma A/S Solid-phase peptide synthesis and agent for use in such synthesis
AU723268B2 (en) 1996-09-09 2000-08-24 Zealand Pharma A/S Improved solid-phase peptide synthesis and agent for use in such synthesis
DK0895537T3 (en) 1997-01-21 2005-03-29 Max Planck Gesellschaft IGA1 protease fragment as carrier peptide
JP4394279B2 (en) 1998-03-09 2010-01-06 ジーランド ファーマ アクティーゼルスカブ Pharmacologically active peptide conjugates with reduced propensity to enzymatic hydrolysis
DE69912827T2 (en) * 1998-09-29 2004-10-21 Loke Diagnostics Aps Aarhus "LIGAND PRESENTING ASSEMBLY" (LPA), METHOD FOR THE PRODUCTION AND USE THEREOF
JP3786533B2 (en) 1998-11-12 2006-06-14 善彦 西村 Peptide and osteogenesis promoter
EP1144011B1 (en) 1998-12-11 2010-03-10 Coulter Pharmaceutical, Inc. Prodrug compounds and process for preparation thereof
US7425541B2 (en) 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
FR2792631B1 (en) 1999-04-21 2004-03-19 Pasteur Institut SOLID FUNCTIONALIZED SUPPORT FOR THE SYNTHESIS OF COMPOUNDS COMPRISING AT LEAST ONE ALPHA OXOALDEHYDE FUNCTION AND ITS APPLICATIONS.
US6469136B1 (en) 1999-07-07 2002-10-22 Trimeris, Inc. Methods and composition for peptide synthesis
US6703480B1 (en) 1999-11-24 2004-03-09 Palani Balu Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use
FR2803594B1 (en) 2000-01-11 2002-07-19 Centre Nat Rech Scient OLIGOMERS OF NON-PEPTIDE CONSTRAINED MIMES OF DIPEPTIDES OR TRIPEPTIDES, AND USES THEREOF
HUP0204281A3 (en) 2000-01-27 2007-03-28 Lilly Co Eli Process for sulubilizing glucagon-like peptide 1 (glp-1) compounds
US6476186B1 (en) 2000-05-23 2002-11-05 Institute Of Nuclear Energy Research Process for preparing octreotide and derivatives thereof
AU2001271301B2 (en) 2000-06-14 2006-08-31 Medarex, Inc. Prodrug compounds cleavable by thimet oligopeptidase
US20020058788A1 (en) 2000-08-25 2002-05-16 Sheppeck James E. Facile deprotection of Fmoc protected amino groups
NO314588B1 (en) 2000-09-04 2003-04-14 Bionor Immuno As HIV peptides, antigens, vaccine composition, immunoassay test kits and a method for detecting antibodies induced by HIV
AU2002227925A1 (en) 2000-11-14 2002-05-27 Ipf Pharmaceuticals Gmbh Human beta-defensin-3
WO2002053606A1 (en) 2001-01-04 2002-07-11 Council Of Scientific And Industrial Research A new linker based solid support for peptide and small molecule organic synthesis
GB0105069D0 (en) 2001-03-01 2001-04-18 Univ Ulster The Modified peptide
US20090281032A1 (en) 2001-03-01 2009-11-12 Peter Raymond Flatt Modified CCK peptides
BR0101088A (en) 2001-03-19 2003-03-18 Biolab Sanus Farmaceutica Ltda A process for isolating and purifying vasopeptidase-inhibiting peptides with specificity for the angiotensin-converting enzyme carboxylic site secreted by snake venom glands (bpps), particularly jararaca bothrops, or endogenously produced (evasins) having vasodilatory and anti- hypertensive; process of determining the starch sequence of inhibitor peptides secreted by the snake venom (bpps) or endogenous (evasin) venom; The process of determining the amino acid sequence of bpps by deducting the cdna from precursors of these molecules expressed in snake tissues, specifically bothrops jararaca. process of determining the amino acid sequence of evasins by deducing cdna from precursors of these molecules expressed in snake tissues, specifically bothrops jararaca, process of amplifying cdna from pancreatic and / or snake brain cdna libraries, specifically bothrops jararaca ; solid phase synthesis process of vasopeptidase inhibiting peptides with vasodilating and antihypertensive action, vasopeptidase inhibiting peptides with antihypertensive action; use of vasodilating and antihypertensive vasodidase inhibiting peptides in the manufacture of pharmaceutical compositions; process of determination of inhibitory activity on vasopeptidases and biological activity on smooth muscle, cardiovascular and microcirculatory system.
WO2002083606A1 (en) 2001-04-17 2002-10-24 University Of Alberta A linker system for the synthesis and screening of combinatorial libraries of polyamine derivatives on water compatible supports
CN1162446C (en) 2001-05-10 2004-08-18 上海华谊生物技术有限公司 Insulinotropic hormone secretion peptide derivative
FR2825095B1 (en) 2001-05-28 2003-09-26 Dev Des Antigenes Combinatoire DEVICE FOR PRESENTING POLYPEPTIDES, USEABLE AS A "CHIP" FOR THE MINIATURIZED DETECTION OF MOLECULES
WO2003018605A2 (en) 2001-08-24 2003-03-06 University Of British Columbia Solid-phase synthesis of oligosaccharides and glycopeptides using glycosynthases
AU2003236080B8 (en) 2002-04-11 2009-07-02 Daiichi Sankyo Company, Limited A method for producing a modified peptide
US6809190B2 (en) 2002-04-24 2004-10-26 Credia Japan Co., Ltd. Functional peptide nucleic acid and its production method
GB0210183D0 (en) 2002-05-03 2002-06-12 Avecia Ltd Process
MXPA04010910A (en) 2002-05-03 2005-01-25 Avecia Ltd Process for the synthesis of peptides.
MXPA04011142A (en) 2002-05-10 2005-02-17 Pharmacia Corp Peptide compounds and their use as protease substrates.
ES2195787B1 (en) 2002-05-20 2005-06-01 Diverdrugs, S.L. COMPOUNDS CAPABLE OF BLOCKING THE RESPONSE TO CHEMICAL SUBSTANCES OR THERMAL STIMULES OR MEDIATORS OF INFLAMMATION OF NOCICEPTORS, A METHOD FOR THEIR OBTAINMENT AND COMPOSITIONS THAT CONTINUE THEM.
WO2004018502A1 (en) 2002-08-09 2004-03-04 Yamanouchi Europe B.V. Compounds binding to p-selectin
DE60330182D1 (en) 2002-09-08 2009-12-31 Applera Corp Solid phase bound PNA dimers and their synthesis
MXPA05003335A (en) * 2002-10-02 2005-07-05 Zealand Pharma As Stabilized exendin-4 compounds.
EP1445260A1 (en) 2003-02-04 2004-08-11 Jerini AG Method of immobilising of chemical compounds to solid phases
EP1613409B1 (en) 2003-04-08 2019-08-07 Novo Nordisk A/S Regeneration of chromatographic stationary phases
CN1771080B (en) 2003-04-08 2010-12-15 诺沃挪第克公司 Method for producing a therapeutic polypeptide or a precursor thereof comprising at least one chromatographic step
JP3800245B2 (en) 2003-04-15 2006-07-26 株式会社クレディアジャパン Novel functional peptide nucleic acid and production method thereof
EP1631597A4 (en) 2003-05-22 2007-07-11 Gryphon Therapeutics Inc CHEMICAL SOLID PHASE LIGATION WITH INTERCHANGEABLE LINKER
WO2004105790A1 (en) 2003-06-03 2004-12-09 Novo Nordisk A/S Stabilized pharmaceutical peptide compositions
US7414106B2 (en) 2003-06-19 2008-08-19 Lawrence Livermore National Security, Llc Synthesis of peptide α-thioesters
US7902488B2 (en) 2003-06-23 2011-03-08 Cem Corporation Microwave-assisted peptide synthesis
US7393920B2 (en) 2003-06-23 2008-07-01 Cem Corporation Microwave-assisted peptide synthesis
EP1664109B1 (en) 2003-08-21 2009-07-22 Novo Nordisk A/S Purification of glucagon-like peptides
DE602004009710T2 (en) 2003-12-31 2008-08-07 F. Hoffmann-La Roche Ag METHOD OF PEPTIDE SYNTHESIS USING A REDUCED AMOUNT OF DETERGENT
FR2864830B1 (en) 2004-01-06 2006-03-10 Centre Nat Rech Scient PROCESS FOR THE SOLID-SUPPORT SYNTHESIS OF PEPTIDE COMPOUNDS, IN PARTICULAR PEPTIDE COMPOUNDS COMPRISING AN ARGININE RESIDUE
EP1713723A2 (en) * 2004-01-14 2006-10-25 William Marsh Rice University Fullerene based amino acids
EP1718671A2 (en) 2004-02-23 2006-11-08 Rheoscience A/S Peptide yy analogues
CA2458084A1 (en) 2004-03-12 2005-09-12 Dalton Chemical Laboratories Inc. Novel process for octreotide synthesis
US7534763B2 (en) 2004-07-02 2009-05-19 Bristol-Myers Squibb Company Sustained release GLP-1 receptor modulators
TW200611704A (en) 2004-07-02 2006-04-16 Bristol Myers Squibb Co Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions
WO2006008050A1 (en) 2004-07-16 2006-01-26 Lonza Ag Method of peptide synthesis
MX2007004184A (en) 2004-10-12 2007-06-07 Hoffmann La Roche Solid phase peptide sythesis.
US8435800B2 (en) 2004-11-22 2013-05-07 Biosight Ltd. Activated labeling reagents and methods for preparing and using the same
WO2006127048A2 (en) 2004-12-17 2006-11-30 Kansas State University Research Foundation NOVEL pH DEPENDENT ADHESIVE PEPTIDES
EP2505207B1 (en) 2005-01-14 2015-04-22 Wuxi Grandchamp Pharmaceutical Technology Co., Ltd. Modified exendins and uses thereof
US8716221B2 (en) 2005-01-14 2014-05-06 Wuxi Grandchamp Pharmaceutical Technology Co., Ltd. Modified exendins and uses thereof
PT1869066E (en) 2005-04-08 2010-02-03 Lonza Ag Peptide synthesis of alpha-helixes on peg resin
WO2006117227A2 (en) 2005-05-04 2006-11-09 Lonza Ag Solid phase bound thymosin alpha-1 and its synthesis
CN1298732C (en) 2005-05-17 2007-02-07 南京工业大学 Polypeptide Microwave Solid Phase Synthesis
PE20061448A1 (en) 2005-05-26 2006-12-17 Bristol Myers Squibb Co POLYPEPTIDE COMPOUNDS AS MODULATORS OF PEPTIDE 1 SIMILAR TO HUMAN GLUCAGON
JP2008543884A (en) 2005-09-14 2008-12-04 ノベタイド，リミティド Method for producing Bivalirudin
SI1965823T1 (en) 2005-11-04 2016-09-30 Glaxosmithkline Llc Corporation Service Company Methods for administering hypoglycemic agents
CN100374462C (en) 2005-11-21 2008-03-12 大连帝恩生物工程有限公司 Truncated glucagon-like peptide 1 (sGLP-1), preparation method and application
CN101379077A (en) 2005-12-07 2009-03-04 夏洛特·豪泽 Small peptide or peptidomimetic affinity ligands for factor VIII and factor VIII-like proteins
JP5328345B2 (en) 2006-03-29 2013-10-30 株式会社糖鎖工学研究所 Method for producing peptide thioester compound
US20070231258A1 (en) 2006-03-31 2007-10-04 Karyon Ctt Ltd. Peptide conjugates
FI20065208A0 (en) 2006-03-31 2006-03-31 Karyon Oy peptide conjugates
ES2283212B1 (en) 2006-03-31 2008-08-16 Lipotec S.A. USEFUL SYNTHETIC PEPTIDES IN THE TREATMENT OF SKIN AND ITS USE IN COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS.
EP2021014A1 (en) 2006-05-26 2009-02-11 Brystol-Myers Squibb Company Sustained release glp-1 receptor modulators
GB2440388A (en) 2006-06-30 2008-01-30 Ucl Biomedica Plc Methods of linking a carbohydrate or polyalkylene oxide to a protein, precursors and the resultant products
US9766217B2 (en) 2006-09-08 2017-09-19 Novo Nordisk A/S Methods of optimizing chromatographic separation of polypeptides
WO2008044890A1 (en) 2006-10-12 2008-04-17 Dong Kook Pharm. Co., Ltd A method for preparing peptides using by solid phase synthesis
ES2322882B1 (en) 2006-10-25 2010-04-22 Lipotec Sa INHIBITING PEPTIDES OF NEURONAL EXOCITOSIS.
EP1923397B1 (en) 2006-11-14 2009-10-28 NERVIANO MEDICAL SCIENCES S.r.l. Fluorinated amino acids and peptides
TWI428346B (en) 2006-12-13 2014-03-01 Imp Innovations Ltd Novel compounds and their effects on feeding behaviour
US7981998B2 (en) 2006-12-14 2011-07-19 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
EP2094721B1 (en) 2006-12-14 2018-02-14 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
CA2677932A1 (en) 2007-02-15 2008-08-21 Indiana University Research And Technology Corporation Glucagon/glp-1 receptor co-agonists
EP2057183A2 (en) 2007-03-01 2009-05-13 Novetide Ltd. High purity peptides
WO2008137165A1 (en) 2007-05-07 2008-11-13 President And Fellows Of Harvard College Anti-glycated cd59 antibodies and uses thereof
JP5385266B2 (en) 2007-06-15 2014-01-08 ジーランド ファーマ アクティーゼルスカブ Glucagon analog
US20100249370A1 (en) 2007-06-29 2010-09-30 Lonza Ag Process for the production of pramlintide
CN101357937B (en) 2007-07-31 2012-11-07 上海苏豪逸明制药有限公司 Method for synthesizing atosiban acetate from solid phase polypeptide
CN101357938B (en) 2007-07-31 2013-07-03 周逸明 Method for synthesizing Exenatide from solid phase polypeptide
WO2009059002A2 (en) * 2007-10-30 2009-05-07 The Regents Of The University Of Michigan Office Of Technology Transfer Macrocyclization of compounds from solid support using thioesterases
AU2008334783A1 (en) 2007-12-11 2009-06-18 F. Hoffmann-La Roche Ag Insulinotropic peptide synthesis using solid and solution phase combination techniques
KR101257330B1 (en) 2008-02-06 2013-04-23 바이오콘 리미티드 A method of purifying a peptide
ES2330291B1 (en) 2008-02-29 2010-10-18 Lipotec Sa USEFUL PEPTIDES IN THE TREATMENT OF SKIN, MUCOSAS AND / OR LEATHER HAIR AND ITS USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS.
CN101525368B (en) 2008-03-06 2012-05-30 海南建邦制药科技有限公司 Deprotection agent for polypeptide synthesis
CN101525370A (en) 2008-03-06 2009-09-09 海南建邦制药科技有限公司 Novel efficient condensing agent for synthesizing polypeptide
CN101255191A (en) 2008-03-12 2008-09-03 中国药科大学 Microwave-promoted solid-phase synthesis of glucagon-like peptide-1 (GLP-1) analogs and its application
CN102088992B (en) 2008-04-24 2016-02-24 赛里姆耐克斯医药公司 Peptidyl diacylglycerides
EP2280993A1 (en) 2008-05-15 2011-02-09 Novo Nordisk A/S Purification of peptides prepared by solid phase synthesis
JP6108659B2 (en) 2008-06-17 2017-04-05 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ GIP-based mixed agonist for the treatment of metabolic diseases and obesity
CL2009001424A1 (en) 2008-06-17 2010-04-30 Univ Indiana Res & Tech Corp Glucagon-like peptide; dimer comprising two of said peptides; pharmaceutical composition comprising it; and its use to treat diabetes or induce weight loss.
KR101634830B1 (en) 2008-09-03 2016-06-29 시노팜 타이완 리미티드 Process for making bivalirudin
TW201012829A (en) 2008-09-22 2010-04-01 Ipsen Mfg Ireland Ltd Process for the synthesis of (Aib8,35)hGLP-1(7-36)-NH2
EP3492492A1 (en) 2008-09-22 2019-06-05 Aileron Therapeutics, Inc. Methods for preparing purified polypeptide compositions
AU2009322045A1 (en) 2008-12-05 2011-07-07 Angiochem Inc. Peptide therapeutic conjugates and uses thereof
US9914754B2 (en) 2008-12-05 2018-03-13 Angiochem Inc. Conjugates of neurotensin or neurotensin analogs and uses thereof
WO2010063123A1 (en) 2008-12-05 2010-06-10 Angiochem Inc. Leptin and leptin analog conjugates and uses thereof
WO2010070251A1 (en) 2008-12-15 2010-06-24 Zealand Pharma A/S Glucagon analogues
EA020596B1 (en) 2008-12-15 2014-12-30 Зилэнд Фарма А/С Glucagon analogues
CA2747155A1 (en) 2008-12-15 2010-06-24 Zealand Pharma A/S Glucagon analogues
MX2011006314A (en) 2008-12-15 2011-09-22 Zealand Pharma As Glucagon analogues.
CN101463078B (en) 2009-01-12 2011-07-27 华东师范大学 Exendin-4 derivative and solid phase chemical synthesis thereof
CN101463081B (en) 2009-01-12 2012-07-04 华东师范大学 GLP-1 derivative
CN101538324B (en) 2009-01-13 2013-01-16 深圳翰宇药业股份有限公司 Method for preparing Exenatide
ES2349972B1 (en) 2009-02-16 2011-11-24 Lipotec, S.A. USEFUL PEPTIDES IN THE TREATMENT AND / OR CARE OF SKIN, MUCOUSES AND / OR LEATHER LEATHER AND ITS USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS.
WO2010096052A1 (en) 2009-02-19 2010-08-26 Merck Sharp & Dohme Corp. Oxyntomodulin analogs
MX337830B (en) 2009-04-17 2016-03-16 Lipotec Sa Peptides used in the treatment and/or care of the skin and/or hair and their use in cosmetic or pharmaceutical compositions.
CN101555274B (en) 2009-05-15 2013-08-21 海南双成药业股份有限公司 Preparation method of polypeptide solid-phase synthesis bivalirudin crude product
US9150632B2 (en) 2009-06-16 2015-10-06 Indiana University Research And Technology Corporation GIP receptor-active glucagon compounds
AU2010272944B2 (en) 2009-07-13 2015-11-19 Zealand Pharma A/S Acylated glucagon analogues
BR112012001322B1 (en) 2009-07-24 2022-05-03 Lipotec S.A. Peptide and cosmetic or pharmaceutical composition
ES2358829B1 (en) 2009-10-23 2012-06-25 Lipotec, S.A. USEFUL PEPTIDES IN THE TREATMENT AND / OR CARE OF SKIN, MUCOSES AND / OR HAIR AND ITS USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS.
WO2011075393A2 (en) 2009-12-18 2011-06-23 Indiana University Research And Technology Corporation Glucagon/glp-1 receptor co-agonists
BR112012018585A2 (en) 2010-01-27 2017-01-10 Univ Indiana Res & Tech Corp antagonist-gon agonist glucagon compositions and compositions for the treatment of metabolic disorders and obesity
CN102770440A (en) 2010-03-01 2012-11-07 诺沃—诺迪斯克有限公司 Preparative RP-HPLC Method for Purified Peptides
KR20130018410A (en) 2010-03-26 2013-02-21 노보 노르디스크 에이/에스 Novel glucagon analogues
AR080592A1 (en) 2010-03-26 2012-04-18 Lilly Co Eli PEPTIDE WITH ACTIVITY FOR GIP-R AND GLP-1-R, FAMILY FORMULATION THAT UNDERSTANDS IT, ITS USE TO PREPARE A USEFUL MEDICINAL PRODUCT FOR THE TREATMENT OF MELLITUS DIABETES AND TO INDICATE WEIGHT LOSS
US8620595B2 (en) 2010-03-26 2013-12-31 University Of Manitoba Methods for determining the retention of peptides in reverse phase chromatography using linear solvent strength theory
JPWO2011152182A1 (en) 2010-05-31 2013-07-25 株式会社ジェイテクト Manufacturing method of covering member
JP5702376B2 (en) 2010-06-01 2015-04-15 本田技研工業株式会社 Control device for DC / DC converter
US20110313131A1 (en) 2010-06-21 2011-12-22 Christelle Carl Reversed phase hplc purification of a glp-1 analogue
AR081975A1 (en) 2010-06-23 2012-10-31 Zealand Pharma As GLUCAGON ANALOGS
CN101906150B (en) 2010-06-28 2013-01-09 上海昂博生物技术有限公司 Preparation method of Bivalirudin
WO2012057624A1 (en) 2010-10-25 2012-05-03 Pepscan Systems B.V. Novel bicyclic peptide mimetics
KR20130127446A (en) 2010-10-29 2013-11-22 론자 아게 (론자 엘티디.) Diketopiperazine forming dipeptidyl linker
KR20130132931A (en) 2010-12-22 2013-12-05 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 Glucagon analogs exhibiting gip receptor activity
WO2012085279A2 (en) 2010-12-23 2012-06-28 Universiteit Gent Method for cross-linking peptides
CN102643339B (en) 2011-02-21 2014-04-09 天津药物研究院 GLP-1 analogs, preparation method thereof application thereof
CN102174082B (en) 2011-02-23 2014-08-27 上海昂博生物技术有限公司 Method for preparing exenatide
ES2397889B1 (en) 2011-03-25 2014-02-07 Lipotec, S.A. MODULATING PEPTIDES OF PGC-1 Alpha.
CN102718858B (en) 2011-03-29 2014-07-02 天津药物研究院 Glucagon-like peptide-1 (GLP-1) analogue monomer and dimer, preparation method therefor and application thereof
EP2694095B1 (en) 2011-04-05 2018-03-07 Longevity Biotech, Inc. Compositions comprising glucagon analogs and methods of making and using the same
CN102786590A (en) 2011-05-19 2012-11-21 江苏豪森药业股份有限公司 Branching-type PEG-modified GLP-1 analogs and pharmaceutically acceptable salts thereof
US8933196B2 (en) 2011-05-20 2015-01-13 National Central University Peptide chromatographic purification assisted by combining of solubility parameter and solution conformation energy calculations
CN102286076B (en) 2011-06-23 2014-03-12 成都圣诺科技发展有限公司 Preparation method for bivalirudin
CN102286092B (en) 2011-09-14 2014-01-01 深圳翰宇药业股份有限公司 Solid-phase synthesis method of liraglutide
NL2007536C2 (en) 2011-10-05 2013-04-08 Academisch Ziekenhuis Leiden Lumc Adjuvant compound.
HK1202125A1 (en) 2011-12-23 2015-09-18 Ipsen Manufacturing Ireland Limited Process for the synthesis of therapeutic peptides
CN102411801A (en) 2011-12-27 2012-04-11 湖南超氏信息集成有限公司 Suspension queuing method
CN102584944B (en) 2012-02-06 2014-12-17 成都圣诺生物科技股份有限公司 Preparation method of eptifibatide acetate
CN103242443A (en) 2012-02-06 2013-08-14 长春百克生物科技股份公司 Preparation method for thymosin [alpha]1 and analogues thereof
CN102558338B (en) 2012-02-10 2014-09-17 深圳翰宇药业股份有限公司 Method for synthesizing lixisenatide
CN102584982B (en) 2012-02-10 2014-02-05 深圳翰宇药业股份有限公司 Method for purifying solid-phase synthetic coarse liraglutide
CN104254339B (en) 2012-04-16 2020-01-21 路博润高级材料公司 Compounds for the treatment and/or care of the skin and/or mucous membranes and their use in cosmetic or pharmaceutical compositions
US20130289241A1 (en) 2012-04-26 2013-10-31 Shanghai Ambiopharm, Inc. Method for preparing exenatide
EP2850192B1 (en) 2012-05-16 2023-11-01 APTARION biotech AG Enzymatic synthesis of l-nucleic acids
CN102875663B (en) 2012-09-26 2014-06-11 深圳翰宇药业股份有限公司 Purification method of lixisenatide
US9724622B2 (en) 2013-01-29 2017-08-08 Neuland Health Sciences Private Limited Purification of organic compounds using surrogate stationary phases on reversed phase columns
CN103965285B (en) 2013-02-06 2016-12-28 北京大学 A kind of with superparamagnetic nanoparticle for solid phase carry out Peptide systhesis and synchronize build polypeptide magnetic nano-probe method
CN103333237B (en) 2013-05-07 2015-03-11 海南双成药业股份有限公司 Synthesis of exenatide through solid phase fragment method
WO2015009701A1 (en) 2013-07-15 2015-01-22 North Carolina State University Protease-resistant peptide ligands
US9263194B2 (en) 2013-09-06 2016-02-16 Gwangju Institute Of Science And Technology Porphyrin-peptoid conjugate and the preparation process thereof
US9605344B2 (en) 2013-09-15 2017-03-28 Stc.Unm Method for atomic layer deposition
CN103536912B (en) 2013-09-30 2015-05-13 重庆理工大学 Porcine circovirus II-type (PCV2) epitope peptide vaccine and preparation method thereof
CN103613655B (en) 2013-11-20 2015-05-13 陕西东大生化科技有限责任公司 Method for low-cost purification of exenatide
JP6633523B2 (en) 2013-12-01 2020-01-22 ユニバーシティ オブ コペンハーゲン Dimer inhibitor fatty acid derivative of PSD-95
HU230584B1 (en) 2014-02-28 2017-01-30 Szegedi Tudományegyetem Method for the production of peptides
CN104086631A (en) 2014-07-10 2014-10-08 成都天台山制药有限公司 Carbetocin and preparation method thereof
SG11201700877PA (en) 2014-08-07 2017-03-30 Hoffmann La Roche Processes for the preparation of oxytocin analogues
EP3204414B1 (en) 2014-10-07 2024-12-04 Ann and Robert H. Lurie Children's Hospital of Chicago Novel anti-nodal antibodies and methods of using same
CN105585612B (en) 2014-10-20 2020-05-05 北京益生康华医药技术有限公司 Octapeptide modified dexamethasone, preparation, nanostructure and application
WO2016067271A1 (en) 2014-10-31 2016-05-06 Auro Peptides Ltd A process for the preparation of liraglutide
WO2016084100A2 (en) 2014-11-26 2016-06-02 Alaparthi Lakshmi Prasad Novel and efficient method for large scale synthesis of romidepsin
US10308677B2 (en) 2014-12-19 2019-06-04 Cem Corporation Coupling method for peptide synthesis at elevated temperatures
CN105111303B (en) 2015-06-23 2019-07-26 济南康和医药科技有限公司 A kind of method that solid-liquid combination prepares Liraglutide
WO2017162653A1 (en) 2016-03-23 2017-09-28 Bachem Holding Ag Purification of glucagon-like peptide 1 analogs

Also Published As

Publication number Publication date
US10450343B2 (en) 2019-10-22
EP2976325A1 (en) 2016-01-27
EP2976325B1 (en) 2017-03-01
ES2624961T3 (en) 2017-07-18
WO2014147129A1 (en) 2014-09-25
HUE033371T2 (en) 2017-11-28
CN105102427A (en) 2015-11-25
MX365465B (en) 2019-06-04
AU2014234314B2 (en) 2018-02-15
CN105102427B (en) 2018-09-07
US20160289263A1 (en) 2016-10-06
CA2907521A1 (en) 2014-09-25
DK2976325T3 (en) 2017-06-06
CA2907521C (en) 2021-04-13
MX2015013463A (en) 2016-06-21
AU2014234314A1 (en) 2015-10-01

Similar Documents

Publication Publication Date Title
IL262055B (en) Synthesis of lactams
GB201421334D0 (en) Synthesis of aeizeolite
SG11201506876XA (en) Modification of polypeptides
PL2812372T3 (en) Heteroatom containing cyclic dimers
SG11201603028SA (en) Purification of proteins
IL244084A0 (en) Novel derivatives of uncialamycin and methods of synthesis
PT2900861T (en) Product made of silk
ZA201506765B (en) Production of pulse protein product
IL246299A0 (en) Survivin derivatives and compositions containing them
EP3066073A4 (en) Synthesis of fluorotrifluoromethylsulfonyl imide
EP2964261A4 (en) Stabilization of moisture-sensitive drugs
IL245771A0 (en) Synthesis and formulations of porphyrin compounds
ZA201502377B (en) Encapsulation of gases within cyclodextrins
PL3063152T3 (en) Convenient preparation of n-substituted morphinan-6-ols from morphinan-6-ones
PL2978750T3 (en) "synthesis of dabigatran"
IL246258A0 (en) Synthesis of ent-progesterone and intermediates thereof
IL246142A0 (en) Pharmaceutical compositions of carotenoid
IL242075B (en) Lyophilisate containing a cyclic peptide of formula x1-gqretpegaeakpwy-x2
IL241248A0 (en) Enhanced expression of picornavirus proteins
PL2819147T3 (en) Gas-tight packaging of detectors
SG11201508814SA (en) Synthesis of bace inhibitors
EP2948540A4 (en) Recombinant synthesis of alkanes
SG11201506804VA (en) Synthesis of hydantoin containing peptide products
SG11201506885UA (en) Synthesis of cyclic imide containing peptide products
ZA201506787B (en) Synthesis of ent-progesterone and intermediates thereof