PL2610258T3 - Podstawione piperydyno-dihydrotienopirymidyny - Google Patents

Podstawione piperydyno-dihydrotienopirymidyny

Info

Publication number: PL2610258T3
Authority: PL; Poland
Prior art keywords: substituted piperidino; dihydrothieno; pyrimidines; dihydrothieno pyrimidines; piperidino
Prior art date: 2007-10-19

Application number

PL13154790T

Other languages

English (en)

Inventor

Pascale Pouzet

Klaus Klinder

Ralf Anderskewitz

Horst Dollinger

Dennis Fiegen

Thomas Fox

Rolf Goeggel

Christoph Hoenke

Domnic Martyres

Peter Nickolaus

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-19

Filing date

2008-10-16

Publication date

2015-02-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39154006&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2610258(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-10-16 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2015-02-27 Publication of PL2610258T3 publication Critical patent/PL2610258T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Immunology (AREA)
Otolaryngology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Gastroenterology & Hepatology (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL13154790T 2007-10-19 2008-10-16 Podstawione piperydyno-dihydrotienopirymidyny PL2610258T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP07118901		2007-10-19
EP08839793A EP2215092B1 (de)	2007-10-19	2008-10-16	Substituierte piperidino-dihydrothienopyrimidine
EP11174754.9A EP2380891B1 (de)	2007-10-19	2008-10-16	Substituierte Piperidino-Dihydrothienopyrimidine
EP13154790.3A EP2610258B1 (de)	2007-10-19	2008-10-16	Substituierte Piperidino-Dihydrothienopyrimidine

Publications (1)

Publication Number	Publication Date
PL2610258T3 true PL2610258T3 (pl)	2015-02-27

Family

ID=39154006

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL13154790T PL2610258T3 (pl)	2007-10-19	2008-10-16	Podstawione piperydyno-dihydrotienopirymidyny
PL08839793T PL2215092T3 (pl)	2007-10-19	2008-10-16	Podstawione piperydyno-dihydrotienopirymidyny

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL08839793T PL2215092T3 (pl)	2007-10-19	2008-10-16	Podstawione piperydyno-dihydrotienopirymidyny

Country Status (33)

Country	Link
US (1)	US8754073B2 (pl)
EP (3)	EP2380891B1 (pl)
JP (2)	JP5150728B2 (pl)
KR (1)	KR101548975B1 (pl)
CN (2)	CN101827852B (pl)
AR (1)	AR069075A1 (pl)
AT (1)	ATE542825T1 (pl)
AU (1)	AU2008313660B2 (pl)
BR (1)	BRPI0818006B8 (pl)
CA (1)	CA2705414C (pl)
CL (1)	CL2008003096A1 (pl)
CY (2)	CY1112703T1 (pl)
DK (2)	DK2215092T3 (pl)
EA (1)	EA019480B1 (pl)
EC (1)	ECSP10010156A (pl)
ES (2)	ES2381452T3 (pl)
HR (2)	HRP20120334T1 (pl)
MA (1)	MA31845B1 (pl)
ME (1)	ME01330B (pl)
MX (1)	MX2010004026A (pl)
MY (1)	MY153979A (pl)
NZ (1)	NZ585346A (pl)
PE (2)	PE20091386A1 (pl)
PL (2)	PL2610258T3 (pl)
PT (2)	PT2215092E (pl)
RS (1)	RS52271B (pl)
SI (2)	SI2610258T1 (pl)
TN (1)	TN2010000175A1 (pl)
TW (1)	TWI421077B (pl)
UA (1)	UA99309C2 (pl)
UY (1)	UY31405A1 (pl)
WO (1)	WO2009050248A1 (pl)
ZA (1)	ZA201001683B (pl)

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MX2010003346A (es)	2007-10-19	2010-04-09	Boehringer Ingelheim Int	Piperazino-dihidrotienopirimidinas sustituidas en heterociclo.
WO2009050236A1 (de)	2007-10-19	2009-04-23	Boehringer Ingelheim International Gmbh	Neue piperazino-dihydrothienopyrimidin-derivate
WO2009050248A1 (de) *	2007-10-19	2009-04-23	Boehringer Ingelheim International Gmbh	Substituierte piperidino-dihydrothienopyrimidine
EP2400962B1 (de)	2009-02-27	2017-11-08	Boehringer Ingelheim International GmbH	Arzneimittelkombinationen enthaltend pde4-inhibitoren und nsaids
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WO2011124525A1 (de)	2010-04-08	2011-10-13	Boehringer Ingelheim International Gmbh	Arnzeimittelkombinationen enthaltend pde4-inhibitoren und ep4-rezeptor-antagonisten
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WO2018003962A1 (ja) *	2016-06-30	2018-01-04	国立研究開発法人理化学研究所	新規化合物又はその薬理学的に許容される塩
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RS67241B1 (sr)	2017-10-23	2025-10-31	Boehringer Ingelheim Int	Nova kombinacija aktivnih agensa za lečenje progresivnih fibroznih intersticijalnih bolesti pluća (pf-ild)
CN111727191B (zh)	2017-12-15	2024-01-05	联合疗法公司	取代的氮杂环丁烷二氢噻吩并吡啶类化合物及其作为磷酸二酯酶抑制剂的用途
CN111712502B (zh)	2017-12-15	2023-10-27	联合疗法公司	取代的氮杂环丁烷二氢噻吩并嘧啶类化合物及其作为磷酸二酯酶抑制剂的用途
CN111712503B (zh) *	2017-12-15	2024-04-09	联合疗法公司	取代的四氢吡喃二氢噻吩并嘧啶类化合物及其作为磷酸二酯酶抑制剂的用途
WO2020048827A1 (en) *	2018-09-03	2020-03-12	Bayer Aktiengesellschaft	1, 3, 9-triazaspiro[5.5] undecan-2-one compounds
ES3041145T3 (en)	2021-12-09	2025-11-07	Boehringer Ingelheim Int	New oral pharmaceutical composition and dose regimen for the therapy of progressive fibrosing interstitial lung diseases
JP2024541514A (ja)	2021-12-09	2024-11-08	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	進行性線維化を伴う間質性肺疾患を処置するための、新たな治療的組合せ
KR20250018499A (ko) *	2022-06-02	2025-02-06	시젱 하이스코 파마수티칼 씨오., 엘티디.	Pde4b 억제제 및 이의 용도
CN117247395A (zh) *	2022-06-16	2023-12-19	武汉人福创新药物研发中心有限公司	Pde4b抑制剂
CN115040503B (zh) *	2022-07-26	2023-10-10	云南民族大学	螺环二烯酮型木脂素类化合物在制药中的应用
JP2025528779A (ja) *	2022-08-09	2025-09-02	シーザンハイスークファーマシューティカルカンパニーリミテッド	Ｐｄｅ４ｂ阻害剤及びその用途
CN119947728A (zh)	2022-09-28	2025-05-06	勃林格殷格翰国际有限公司	生物标志物在用pde4b抑制剂治疗纤维化病症中的用途
CN119698422A (zh) *	2022-09-29	2025-03-25	苏州爱科百发生物医药技术有限公司	氮杂稠环类化合物、其制备方法及其在医药上的应用
CN118871444A (zh) *	2023-02-28	2024-10-29	上海翊石医药科技有限公司	二氢噻吩并嘧啶衍生物的制备方法和用途
WO2024208225A1 (zh) *	2023-04-03	2024-10-10	上海壹迪生物技术有限公司	二氢噻吩并嘧啶类化合物、其制备方法和应用
CN120752243A (zh) *	2023-04-13	2025-10-03	上海壹迪生物技术有限公司	取代的二氢噻吩并嘧啶类化合物、其制备方法和应用
CN116925099B (zh) *	2023-07-21	2025-06-03	厦门大学	手性二氢噻吩并嘧啶亚砜的制备方法及其应用与其2、4位取代化合物
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NL122810C (pl)	1963-06-17
DE1470356A1 (de)	1964-01-15	1970-04-30	Thomae Gmbh Dr K	Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung
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2008
- 2008-10-16 WO PCT/EP2008/063999 patent/WO2009050248A1/de not_active Ceased
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Publication number	Publication date
JP2013064001A (ja)	2013-04-11
ATE542825T1 (de)	2012-02-15
PE20091386A1 (es)	2009-10-17
ES2524910T3 (es)	2014-12-15
ME01330B (me)	2013-12-20
WO2009050248A1 (de)	2009-04-23
PT2610258E (pt)	2014-10-24
ZA201001683B (en)	2010-10-27
TN2010000175A1 (fr)	2011-11-11
BRPI0818006B1 (pt)	2019-10-22
BRPI0818006B8 (pt)	2021-05-25
CN104069112A (zh)	2014-10-01
JP2011500640A (ja)	2011-01-06
CL2008003096A1 (es)	2010-02-12
SI2215092T1 (sl)	2012-04-30
PL2215092T3 (pl)	2012-07-31
JP5615889B2 (ja)	2014-10-29
EP2380891A1 (de)	2011-10-26
KR101548975B1 (ko)	2015-09-01
CA2705414A1 (en)	2009-04-23
BRPI0818006A2 (pt)	2015-12-22
PT2215092E (pt)	2012-04-10
MY153979A (en)	2015-04-30
MX2010004026A (es)	2010-04-30
RS52271B (sr)	2012-10-31
CN101827852B (zh)	2014-07-30
HRP20141153T1 (hr)	2015-02-13
AR069075A1 (es)	2009-12-30
EP2610258B1 (de)	2014-08-27
AU2008313660A1 (en)	2009-04-23
EP2215092B1 (de)	2012-01-25
PE20131463A1 (es)	2013-12-23
UA99309C2 (ru)	2012-08-10
ECSP10010156A (es)	2010-06-29
KR20100100807A (ko)	2010-09-15
EA201000609A1 (ru)	2010-10-29
UY31405A1 (es)	2009-05-29
DK2610258T3 (da)	2014-11-10
EP2215092A1 (de)	2010-08-11
EP2380891B1 (de)	2013-12-11
AU2008313660B2 (en)	2013-11-07
CY1112703T1 (el)	2016-02-10
US8754073B2 (en)	2014-06-17
DK2215092T3 (da)	2012-05-07
EP2610258A1 (de)	2013-07-03
MA31845B1 (fr)	2010-11-01
US20110021501A1 (en)	2011-01-27
CN101827852A (zh)	2010-09-08
TW200918074A (en)	2009-05-01
HK1145677A1 (en)	2011-04-29
NZ585346A (en)	2011-09-30
ES2381452T3 (es)	2012-05-28
CA2705414C (en)	2016-05-24
CY1115858T1 (el)	2017-01-25
JP5150728B2 (ja)	2013-02-27
TWI421077B (zh)	2014-01-01
HRP20120334T1 (hr)	2012-05-31
SI2610258T1 (sl)	2014-12-31
EA019480B1 (ru)	2014-04-30

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