PL256374A1 - Process for preparing novel derivatives of silibinin - Google Patents

Process for preparing novel derivatives of silibinin

Info

Publication number: PL256374A1
Authority: PL; Poland
Prior art keywords: silibinin; novel derivatives; preparing novel; preparing; derivatives
Prior art date: 1984-11-22

Application number

PL25637485A

Other versions

PL146890B1 (en

Original Assignee

Madaus & Co Dr

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-11-22

Filing date

1985-11-21

Publication date

1986-12-02

1985-11-21 Application filed by Madaus & Co Dr filed Critical Madaus & Co Dr

1986-12-02 Publication of PL256374A1 publication Critical patent/PL256374A1/en

1989-03-31 Publication of PL146890B1 publication Critical patent/PL146890B1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Toxicology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Silicon Compounds (AREA)

PL1985256374A 1984-11-22 1985-11-21 Process for preparing novel derivatives of silibinin PL146890B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19843442639 DE3442639A1 (en)	1984-11-22	1984-11-22	FLAVOLIGNANE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

Publications (2)

Publication Number	Publication Date
PL256374A1 true PL256374A1 (en)	1986-12-02
PL146890B1 PL146890B1 (en)	1989-03-31

Family

ID=6250903

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL1985256374A PL146890B1 (en)	1984-11-22	1985-11-21	Process for preparing novel derivatives of silibinin

Country Status (29)

Country	Link
JP (1)	JPS61143377A (en)
KR (1)	KR870001020B1 (en)
AR (1)	AR240931A1 (en)
AT (1)	AT393268B (en)
BE (1)	BE903693A (en)
CA (1)	CA1337124C (en)
CH (1)	CH659473A5 (en)
CS (1)	CS273610B2 (en)
DD (1)	DD259191A1 (en)
DE (1)	DE3442639A1 (en)
DK (1)	DK164865C (en)
EG (1)	EG19424A (en)
ES (1)	ES8609311A1 (en)
FI (1)	FI84064C (en)
FR (1)	FR2573427B1 (en)
GB (1)	GB2167414B (en)
HU (1)	HU195503B (en)
IE (1)	IE58791B1 (en)
IT (1)	IT1190426B (en)
LU (1)	LU86163A1 (en)
MX (1)	MX168415B (en)
NL (1)	NL192387C (en)
NO (1)	NO160205C (en)
PL (1)	PL146890B1 (en)
PT (1)	PT81532B (en)
SE (1)	SE465676B (en)
SU (1)	SU1436875A3 (en)
YU (1)	YU43689B (en)
ZA (1)	ZA858951B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8716918D0 (en) *	1987-07-17	1987-08-26	Inverni Della Beffa Spa	Soluble derivatives of silybin
US5262439A (en) *	1992-04-30	1993-11-16	The Regents Of The University Of California	Soluble analogs of probucol
US8017649B2 (en) *	2005-03-11	2011-09-13	Howard Florey Institute Of Experimental Physiology And Medicine	Flavonoid compounds and uses thereof
RU2482844C2 (en) *	2007-11-15	2013-05-27	Мадаус Гмбх	Silibilin component for treating hepatitis
AU2008323156B2 (en)	2007-11-15	2012-05-31	Madaus Gmbh	Silibinin component for the treatment of hepatitis
JP5841048B2 (en) *	2009-05-14	2016-01-06	エウロメッド・エセ・ア	Amorphous silibinin for the treatment of viral hepatitis
EP2849737B1 (en)	2012-07-05	2019-09-11	Nutramax Laboratories, Inc.	Compositions comprising sulforaphane or a sulforaphane precursor and a mushroom extract or powder
CN103172622B (en) *	2013-02-22	2015-11-04	西安安健药业有限公司	The active isomer of silybin bis-bias succinate
CN103193768B (en) *	2013-02-22	2016-03-30	西安安健药业有限公司	The silybin bis-bias succinate isomer for the treatment of hepatopathy
CN103113359B (en) *	2013-02-22	2016-01-06	西安安健药业有限公司	Silybin bis-bias succinate and pharmaceutical salts thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1963318A1 (en) *	1969-12-17	1971-06-24	Schwabe Willmar Gmbh & Co	Silybin esters with hepotoprotactant acti- - vity

1984
- 1984-11-22 DE DE19843442639 patent/DE3442639A1/en active Granted
1985
- 1985-11-11 IE IE280885A patent/IE58791B1/en not_active IP Right Cessation
- 1985-11-13 LU LU86163A patent/LU86163A1/en unknown
- 1985-11-14 YU YU1786/85A patent/YU43689B/en unknown
- 1985-11-14 AR AR302267A patent/AR240931A1/en active
- 1985-11-15 GB GB08528226A patent/GB2167414B/en not_active Expired
- 1985-11-18 FI FI854535A patent/FI84064C/en not_active IP Right Cessation
- 1985-11-18 NL NL8503171A patent/NL192387C/en not_active IP Right Cessation
- 1985-11-19 CH CH4935/85A patent/CH659473A5/en not_active IP Right Cessation
- 1985-11-19 AT AT3371/85A patent/AT393268B/en not_active IP Right Cessation
- 1985-11-20 CS CS837885A patent/CS273610B2/en unknown
- 1985-11-20 DD DD85283042A patent/DD259191A1/en not_active IP Right Cessation
- 1985-11-20 CA CA000495804A patent/CA1337124C/en not_active Expired - Fee Related
- 1985-11-20 SE SE8505487A patent/SE465676B/en not_active IP Right Cessation
- 1985-11-21 NO NO854655A patent/NO160205C/en not_active IP Right Cessation
- 1985-11-21 HU HU854448A patent/HU195503B/en not_active IP Right Cessation
- 1985-11-21 ZA ZA858951A patent/ZA858951B/en unknown
- 1985-11-21 SU SU853985401A patent/SU1436875A3/en active
- 1985-11-21 IT IT22932/85A patent/IT1190426B/en active
- 1985-11-21 ES ES549116A patent/ES8609311A1/en not_active Expired
- 1985-11-21 DK DK537785A patent/DK164865C/en not_active IP Right Cessation
- 1985-11-21 PT PT81532A patent/PT81532B/en not_active IP Right Cessation
- 1985-11-21 PL PL1985256374A patent/PL146890B1/en unknown
- 1985-11-21 EG EG74085A patent/EG19424A/en active
- 1985-11-22 MX MX009022A patent/MX168415B/en unknown
- 1985-11-22 JP JP60261629A patent/JPS61143377A/en active Granted
- 1985-11-22 FR FR858517321A patent/FR2573427B1/en not_active Expired
- 1985-11-22 BE BE2/60850A patent/BE903693A/en not_active IP Right Cessation
- 1985-11-22 KR KR1019850008733A patent/KR870001020B1/en not_active Expired

Also Published As

Publication number	Publication date
HU195503B (en)	1988-05-30
DK164865C (en)	1993-01-18
ES8609311A1 (en)	1986-09-01
FR2573427B1 (en)	1989-03-10
KR860004056A (en)	1986-06-16
DE3442639A1 (en)	1986-05-22
DK164865B (en)	1992-08-31
FI854535A0 (en)	1985-11-18
GB8528226D0 (en)	1985-12-18
AR240931A2 (en)	1991-03-27
KR870001020B1 (en)	1987-05-23
NL192387C (en)	1997-07-04
DE3442639C2 (en)	1989-08-10
LU86163A1 (en)	1986-03-24
PT81532B (en)	1987-11-11
IT8522932A0 (en)	1985-11-21
NL8503171A (en)	1986-06-16
ATA337185A (en)	1991-02-15
DK537785A (en)	1986-05-23
YU178685A (en)	1988-02-29
FI84064B (en)	1991-06-28
IT1190426B (en)	1988-02-16
DK537785D0 (en)	1985-11-21
JPH0432073B2 (en)	1992-05-28
CA1337124C (en)	1995-09-26
PL146890B1 (en)	1989-03-31
SE465676B (en)	1991-10-14
HUT40114A (en)	1986-11-28
CS837885A2 (en)	1990-08-14
PT81532A (en)	1985-12-01
FI84064C (en)	1991-10-10
NO160205B (en)	1988-12-12
EG19424A (en)	1995-02-28
SE8505487D0 (en)	1985-11-20
ZA858951B (en)	1986-08-27
ES549116A0 (en)	1986-09-01
JPS61143377A (en)	1986-07-01
CH659473A5 (en)	1987-01-30
SU1436875A3 (en)	1988-11-07
NL192387B (en)	1997-03-03
BE903693A (en)	1986-05-22
DD259191A1 (en)	1988-08-17
IE58791B1 (en)	1993-11-17
GB2167414B (en)	1989-01-11
NO160205C (en)	1989-03-22
NO854655L (en)	1986-05-23
GB2167414A (en)	1986-05-29
CS273610B2 (en)	1991-03-12
SE8505487L (en)	1986-05-23
YU43689B (en)	1989-10-31
MX168415B (en)	1993-05-24
FR2573427A1 (en)	1986-05-23
IE852808L (en)	1986-05-22
AR240931A1 (en)	1991-03-27
AT393268B (en)	1991-09-25
FI854535A7 (en)	1986-05-23

Publication	Publication Date	Title
PT81000A (en)	1985-09-01	Process for the preparation of heterocyclic derivatives
HU906232D0 (en)	1991-03-28	Process for the preparation of pyridile derivatives
PT84938A (en)	1987-06-01	Process for the preparation of imidazoquinolinylether derivatives
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YU198187A (en)	1988-10-31	Process for obtaining derivatives of 2-oxidol-1-carboxamide
GB8527809D0 (en)	1985-12-18	Process for preparation of silibinin
PL256374A1 (en)	1986-12-02	Process for preparing novel derivatives of silibinin
PT80202A (en)	1985-05-01	Process for preparing of pyrrolidone derivatives
DE3573598D1 (en)	1989-11-16	Process for the preparation of hydrochinone derivatives
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HUT37757A (en)	1986-02-28	Process for preparing 2-substituted-5-methyl-pyridina derivatives
GB2157287B (en)	1987-10-07	Process for preparing 3-exomethylenecepham derivatives
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PL253585A1 (en)	1986-02-25	Process for preparing derivatives of d-/-/-alpha-aminopenicillins
YU60386A (en)	1988-08-31	Process for preparing derivatives of eburnamenine
YU87487A (en)	1988-10-31	Process for obtaining new derivatives of benzothiazindioxide
YU204987A (en)	1988-10-31	Process for obtaining derivatives of 2-guanadinothiazole
GB8809137D0 (en)	1988-05-18	Novel bisbenzotrifluoride derivatives & method of preparing same
PT81554A (en)	1985-12-01	Process for preparing substituted naphtopyran derivatives